Zoltan Laszik, MD, PhD
Professor
Pathology
School of Medicine

Education & Training

Show all (3) Hide

• Residency Pathology University of Oklahoma 1998
• Fellowship Pathology University of Oklahoma 1995
• Medical University of Szeged 1981

Grants and Projects

Show all (3) Hide

• Multidimensional cellular interrogation of the kidney in AKI and CKD, NIH, 2017-2022
• Multiplex in situ gene expression and phenotypical profiling of inflamed tissues, NIH, 2015-2021
• Multidimensional cellular interrogation of the kidney in AKI and CKD, NIH, 2017-2019

Publications (78)

Top publication keywords:
Antigens, CD34Paraffin EmbeddingKidney TransplantationKidney DiseasesCollagen Type IVIn Situ HybridizationGlomerulosclerosis, Focal SegmentalGlomerulonephritisGraft RejectionFluorescent Antibody TechniqueTissue FixationKidneyKidney GlomerulusMolecular ImagingImmune Complex Diseases

• Multimodal Molecular Imaging Reveals Tissue-Based T Cell Activation and Viral RNA Persistence for Up to 2 Years Following COVID-19.
  medRxiv : the preprint server for health sciences 2023 Peluso MJ, Ryder D, Flavell R, Wang Y, Levi J, LaFranchi BH, Deveau TM, Buck AM, Munter SE, Asare KA, Aslam M, Koch W, Szabo G, Hoh R, Deswal M, Rodriguez A, Buitrago M, Tai V, Shrestha U, Lu S, …
• Non-Full House Membranous Lupus Nephritis Represents a Clinically Distinct Subset.
  Kidney360 2023 Ye J, Croom N, Troxell ML, Kambham N, Zuckerman JE, Andeen N, Dall'Era M, Hsu R, Walavalkar V, Laszik ZG, Urisman A
• A reference tissue atlas for the human kidney.
  Science advances 2022 Hansen J, Sealfon R, Menon R, Eadon MT, Lake BB, Steck B, Anjani K, Parikh S, Sigdel TK, Zhang G, Velickovic D, Barwinska D, Alexandrov T, Dobi D, Rashmi P, Otto EA, Rivera M, Rose MP, Anderton CR, …
• Solid-Phase C1q/C3d Fixing Readouts Correlate with High Median Fluorescence Intensity (MFI) De Novo Donor-Specific HLA Antibodies and C4d⁺ Antibody-Mediated Rejection in Kidney Transplant Recipients.
  Annals of transplantation 2021 Tatapudi VS, Kopchaliiska D, da Gente GJ, Buenaventura OF, Singh M, Laszik Z, Adey DB, Rajalingam R
• Rationale and design of the Kidney Precision Medicine Project.
  Kidney international 2021 de Boer IH, Alpers CE, Azeloglu EU, Balis UGJ, Barasch JM, Barisoni L, Blank KN, Bomback AS, Brown K, Dagher PC, Dighe AL, Eadon MT, El-Achkar TM, Gaut JP, Hacohen N, He Y, Hodgin JB, Jain S, Kellum …

Show all (73 more) Hide

• Loss of fidelity in scanned digital images compared to glass slides of brain tumors resected using cavitron ultrasonic surgical aspirator.
  Brain pathology (Zurich, Switzerland) 2021 Cadwell CR, Bowman S, Laszik ZG, Pekmezci M
• Interleukin-6 blockade with tocilizumab increases Tregs and reduces T effector cytokines in renal graft inflammation: A randomized controlled trial.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2021 Chandran S, Leung J, Hu C, Laszik ZG, Tang Q, Vincenti FG
• A multimodal and integrated approach to interrogate human kidney biopsies with rigor and reproducibility: guidelines from the Kidney Precision Medicine Project.
  Physiological genomics 2020 El-Achkar TM, Eadon MT, Menon R, Lake BB, Sigdel TK, Alexandrov T, Parikh S, Zhang G, Dobi D, Dunn KW, Otto EA, Anderton CR, Carson JM, Luo J, Park C, Hamidi H, Zhou J, Hoover P, Schroeder A, Joanes M…
• The impact of belatacept on the phenotypic heterogeneity of renal T cell-mediated alloimmune response: The critical role of maintenance treatment and inflammatory load.
  Clinical transplantation 2020 Dobi D, Vincenti F, Chandran S, Greenland JR, Bowman C, Chen A, Junger H, Laszik ZG
• Progression of proliferative glomerulonephritis with monoclonal IgG deposits in pediatric patients.
  Pediatric nephrology (Berlin, Germany) 2020 Miller P, Xiao AY, Kung VL, Sibley RK, Higgins JP, Kambham N, Charu V, Lenihan C, Uber AM, Talley EM, Arora N, Walavalkar V, Laszik ZG, Nast CC, Troxell ML
• Novel In Situ Hybridization and Multiplex Immunofluorescence Technology Combined With Whole-slide Digital Image Analysis in Kidney Transplantation.
  The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2020 Junger H, Dobi D, Chen A, Lee L, Vasquez JJ, Tang Q, Laszik ZG
• Rapid Improvement in Gemcitabine-associated Thrombotic Microangiopathy After a Single Dose of Eculizumab: Case Report and Review of the Literature.
  Anticancer research 2020 Burns ST, Damon L, Akagi N, Laszik Z, Ko AH
• A Virtual Crossmatch-based Strategy Facilitates Sharing of Deceased Donor Kidneys for Highly Sensitized Recipients.
  Transplantation 2020 Roll GR, Webber AB, Gae DH, Laszik Z, Tavakol M, Mayen L, Cunniffe K, Syed S, Hirose R, Freise C, Feng S, Roberts JP, Ascher NL, Stock PG, Rajalingam R
• Further Evidence That the Soluble Urokinase Plasminogen Activator Receptor Does Not Directly Injure Mice or Human Podocytes.
  Transplantation 2020 Harel E, Shoji J, Abraham V, Miller L, Laszik ZG, King A, Dobi D, Szabo G, Hann B, Sarwal MM, Craik CS, Vincenti F
• Clinicopathologic overlap of psoriasis, eczema, and psoriasiform dermatoses: A retrospective study of T helper type 2 and 17 subsets, interleukin 36, and β-defensin 2 in spongiotic psoriasiform dermatitis, sebopsoriasis, and tumor necrosis factor α inhibitor-associated dermatitis.
  Journal of the American Academy of Dermatology 2019 Cohen JN, Bowman S, Laszik ZG, North JP
• Assessment of 19 Genes and Validation of CRM Gene Panel for Quantitative Transcriptional Analysis of Molecular Rejection and Inflammation in Archival Kidney Transplant Biopsies.
  Frontiers in medicine 2019 Sigdel T, Nguyen M, Liberto J, Dobi D, Junger H, Vincenti F, Laszik Z, Sarwal MM
• CD32-RNA Co-localizes with HIV-RNA in CD3+ Cells Found within Gut Tissues from Viremic and ART-Suppressed Individuals.
  Pathogens & immunity 2019 Vásquez JJ, Aguilar-Rodriguez BL, Rodriguez L, Hogan LE, Somsouk M, McCune JM, Deeks SG, Laszik ZG, Hunt PW, Henrich TJ
• Gene signatures common to allograft rejection are associated with lymphocytic bronchitis.
  Clinical transplantation 2019 Greenland JR, Wang P, Brotman JJ, Ahuja R, Chong TA, Kleinhenz ME, Leard LE, Golden JA, Hays SR, Kukreja J, Singer JP, Rajalingam R, Jones K, Laszik ZG, Trivedi NN, Greenland NY, Blanc PD
• Expression of programmed cell death ligand 1 and programmed cell death 1 in cutaneous warts.
  Journal of the American Academy of Dermatology 2019 Yu WY, Berger TG, North JP, Laszik Z, Cohen JN
• Identifying a potential biomarker for primary focal segmental glomerulosclerosis and its association with recurrence after transplantation.
  Clinical transplantation 2019 Harel E, Shoji J, Abraham V, Miller L, Laszik Z, Thurison T, King A, Olshen A, Leung J, Szabo G, Hann B, Høyer-Hansen G, Craik CS, Vincenti F
• Severe Renal Allograft Rejection Resulting from Lenalidomide Therapy for Multiple Myeloma: Case Report.
  Transplantation proceedings 2018 Walavalkar V, Adey DB, Laszik ZG, Jen KY
• Elucidating the Burden of HIV in Tissues Using Multiplexed Immunofluorescence and In Situ Hybridization: Methods for the Single-Cell Phenotypic Characterization of Cells Harboring HIV In Situ.
  The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2018 Vasquez JJ, Hussien R, Aguilar-Rodriguez B, Junger H, Dobi D, Henrich TJ, Thanh C, Gibson E, Hogan LE, McCune J, Hunt PW, Stoddart CA, Laszik ZG
• Targeted Transcriptional Profiling of Kidney Transplant Biopsies.
  Kidney international reports 2018 Sigdel TK, Nguyen M, Dobi D, Hsieh SC, Liberto JM, Vincenti F, Sarwal MM, Laszik Z
• In Situ Hybridization and Double Immunohistochemistry for the Detection of VEGF-A mRNA and CD34/Collagen IV Proteins in Renal Transplant Biopsies.
  Methods in molecular biology (Clifton, N.J.) 2018 Dobi D, Laszik ZG
• Polyclonal Regulatory T Cell Therapy for Control of Inflammation in Kidney Transplants.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2017 Chandran S, Tang Q, Sarwal M, Laszik ZG, Putnam AL, Lee K, Leung J, Nguyen V, Sigdel T, Tavares EC, Yang JYC, Hellerstein M, Fitch M, Bluestone JA, Vincenti F
• Intravoxel incoherent motion analysis of renal allograft diffusion with clinical and histopathological correlation in pediatric kidney transplant patients: A preliminary cross-sectional observational study.
  Pediatric transplantation 2017 Poynton CB, Lee MM, Li Y, Laszik Z, Worters PW, Mackenzie JD, Courtier J
• Pilot Study of Renal Diffusion Tensor Imaging as a Correlate to Histopathology in Pediatric Renal Allografts.
  AJR. American journal of roentgenology 2017 Li Y, Lee MM, Worters PW, MacKenzie JD, Laszik Z, Courtier JL
• Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin.
  Cell host & microbe 2017 Scharschmidt TC, Vasquez KS, Pauli ML, Leitner EG, Chu K, Truong HA, Lowe MM, Sanchez Rodriguez R, Ali N, Laszik ZG, Sonnenburg JL, Millar SE, Rosenblum MD
• Mycobacterium bovis Enterocolitis in an Immunocompromised Host.
  Journal of pediatric gastroenterology and nutrition 2016 Winger BA, Foy E, Sud SR, MacKenzie JD, Pua HH, Lau AH, Heyman MB, Laszik Z, Tureen J
• Morphologic Features and Clinical Impact of Arteritis Concurrent with Transplant Glomerulopathy.
  Pathology oncology research : POR 2015 Dobi D, Bodó Z, Kemény É, Boda K, Szenohradszky P, Szederkényi E, Laszik ZG, Iványi B
• Monoclonal light chain deposits within the stomach manifesting as immunotactoid gastropathy.
  Ultrastructural pathology 2014 Jen KY, Fix OK, Foster EN, Laszik ZG, Ferrell LD
• Recurrent HIV-associated immune complex glomerulonephritis with lupus-like features after kidney transplantation.
  American journal of kidney diseases : the official journal of the National Kidney Foundation 2013 Chandran S, Jen KY, Laszik ZG
• A study of interobserver reproducibility of morphologic lesions of focal segmental glomerulosclerosis.
  Virchows Archiv : an international journal of pathology 2012 Meehan SM, Chang A, Gibson IW, Kim L, Kambham N, Laszik Z
• Reliability of whole slide images as a diagnostic modality for renal allograft biopsies.
  Human pathology 2012 Jen KY, Olson JL, Brodsky S, Zhou XJ, Nadasdy T, Laszik ZG
• C4d/CD34 double-immunofluorescence staining of renal allograft biopsies for assessing peritubular capillary C4d positivity.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2011 Jen KY, Nguyen TB, Vincenti FG, Laszik ZG
• Cytomegalovirus in the transplanted kidney: a report of two cases and review of prophylaxis.
  NDT plus 2011 Anand S, Yabu JM, Melcher ML, Kambham N, Laszik Z, Tan JC
• Kidney microvasculature in health and disease.
  Contributions to nephrology 2011 Jen KY, Haragsim L, Laszik ZG
• Tamm-horsfall protein protects against urinary tract infection by proteus mirabilis.
  The Journal of urology 2009 Raffi HS, Bates JM, Laszik Z, Kumar S
• Tamm-Horsfall protein knockout mice have increased stress induced micturition.
  Neurourology and urodynamics 2009 Raffi H, Bates J, Kumar S, Laszik Z, Buffington CA
• The effect of costimulatory and interleukin 2 receptor blockade on regulatory T cells in renal transplantation.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2008 Bluestone JA, Liu W, Yabu JM, Laszik ZG, Putnam A, Belingheri M, Gross DM, Townsend RM, Vincenti F
• Human tumor antigens Tn and sialyl Tn arise from mutations in Cosmc.
  Cancer research 2008 Ju T, Lanneau GS, Gautam T, Wang Y, Xia B, Stowell SR, Willard MT, Wang W, Xia JY, Zuna RE, Laszik Z, Benbrook DM, Hanigan MH, Cummings RD
• Thrombotic microangiopathy after allogeneic hematopoietic stem cell transplantation: an autopsy study.
  Transplantation 2008 Siami K, Kojouri K, Swisher KK, Selby GB, George JN, Laszik ZG
• Infective endocarditis of a papillary fibroelastoma on Chiari network of right atrium: a case report.
  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 2007 Latif F, Peyton M, Laszik Z, Sivaram CA
• HIV-associated nephropathy.
  Advances in chronic kidney disease 2006 Khan S, Haragsim L, Laszik ZG
• A 67-year-old woman with chronic proteinuria. Focal segmental and global glomerulosclerosis with light microscopic and ultrastructural features consistent with Fabry disease.
  Archives of pathology & laboratory medicine 2006 Osunkoya AO, Agte SD, Laszik Z
• Tamm-Horsfall protein knockout mice do not develop medullary cystic kidney disease.
  Kidney international 2006 Raffi H, Bates JM, Laszik Z, Kumar S
• Chronic allograft nephropathy.
  Advances in chronic kidney disease 2006 Baluja P, Haragsim L, Laszik Z
• Mesothelin is overexpressed in pancreaticobiliary adenocarcinomas but not in normal pancreas and chronic pancreatitis.
  American journal of clinical pathology 2005 Hassan R, Laszik ZG, Lerner M, Raffeld M, Postier R, Brackett D
• Tamm-Horsfall protein acts as a general host-defense factor against bacterial cystitis.
  American journal of nephrology 2005 Raffi HS, Bates JM, Laszik Z, Kumar S
• The protein C system in placental massive perivillous fibrin deposition.
  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2004 Svensson AM, Waters BL, Laszik ZG, Simmons-Arnold L, Goodwin A, Beatty BG, Bovill EG
• Laser-assisted microdissection of the kidney: fundamentals and applications.
  Journal of molecular histology 2004 Blakey GL, Laszik ZG
• Tamm-Horsfall protein knockout mice are more prone to urinary tract infection: rapid communication.
  Kidney international 2004 Bates JM, Raffi HM, Prasadan K, Mascarenhas R, Laszik Z, Maeda N, Hultgren SJ, Kumar S
• Searching for a valid animal model of hemolytic uremic syndrome.
  American journal of clinical pathology 2002 Laszik ZG, Blakey GL
• Nitric oxide synthase expression in hypertension induced by inhibition of glutathione synthase.
  The Journal of pharmacology and experimental therapeutics 2002 Zhou XJ, Vaziri ND, Wang XQ, Silva FG, Laszik Z
• Down-regulation of endothelial expression of endothelial cell protein C receptor and thrombomodulin in coronary atherosclerosis.
  The American journal of pathology 2001 Laszik ZG, Zhou XJ, Ferrell GL, Silva FG, Esmon CT
• Outcome of renal transplantation in fibrillary glomerulonephritis.
  Clinical nephrology 2001 Samaniego M, Nadasdy GM, Laszik Z, Nadasdy T
• Association of renal injury with increased oxygen free radical activity and altered nitric oxide metabolism in chronic experimental hemosiderosis.
  Laboratory investigation; a journal of technical methods and pathology 2000 Zhou XJ, Laszik Z, Wang XQ, Silva FG, Vaziri ND
• Down-regulation of renal endothelial nitric oxide synthase expression in experimental glomerular thrombotic microangiopathy.
  Laboratory investigation; a journal of technical methods and pathology 2000 Zhou XJ, Laszik Z, Ni Z, Wang XQ, Brackett DJ, Lerner MR, Silva FG, Vaziri ND
• The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis.
  Blood 2000 Taylor FB, Stearns-Kurosawa DJ, Kurosawa S, Ferrell G, Chang AC, Laszik Z, Kosanke S, Peer G, Esmon CT
• Divergent inducible expression of P-selectin and E-selectin in mice and primates.
  Blood 1999 Yao L, Setiadi H, Xia L, Laszik Z, Taylor FB, McEver RP
• MDC-L, a novel metalloprotease disintegrin cysteine-rich protein family member expressed by human lymphocytes.
  The Journal of biological chemistry 1999 Roberts CM, Tani PH, Bridges LC, Laszik Z, Bowditch RD
• Endothelial protein C receptor.
  Thrombosis and haemostasis 1999 Esmon CT, Xu J, Gu JM, Qu D, Laszik Z, Ferrell G, Stearns-Kurosawa DJ, Kurosawa S, Taylor FB, Esmon NL
• Cell proliferation in the developing human kidney.
  Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society 1998 Nadasdy T, Lajoie G, Laszik Z, Blick KE, Molnar-Nadasdy G, Silva FG
• Human protein C receptor is present primarily on endothelium of large blood vessels: implications for the control of the protein C pathway.
  Circulation 1997 Laszik Z, Mitro A, Taylor FB, Ferrell G, Esmon CT
• Tissue factor expression in mesothelial cells: induction both in vivo and in vitro.
  American journal of respiratory cell and molecular biology 1997 Bottles KD, Laszik Z, Morrissey JH, Kinasewitz GT
• The protein C pathway: new insights.
  Thrombosis and haemostasis 1997 Esmon CT, Ding W, Yasuhiro K, Gu JM, Ferrell G, Regan LM, Stearns-Kurosawa DJ, Kurosawa S, Mather T, Laszik Z, Esmon NL
• Mast cells in acute cellular rejection of human renal allografts.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1996 Lajoie G, Nadasdy T, Laszik Z, Blick KE, Silva FG
• P-selectin glycoprotein ligand-1 is broadly expressed in cells of myeloid, lymphoid, and dendritic lineage and in some nonhematopoietic cells.
  Blood 1996 Laszik Z, Jansen PJ, Cummings RD, Tedder TF, McEver RP, Moore KL
• Human acute tubular necrosis: a lectin and immunohistochemical study.
  Human pathology 1995 Nadasdy T, Laszik Z, Blick KE, Johnson DL, Burst-Singer K, Nast C, Cohen AH, Ormos J, Silva FG
• Proliferative activity of cyst epithelium in human renal cystic diseases.
  Journal of the American Society of Nephrology : JASN 1995 Nadasdy T, Laszik Z, Lajoie G, Blick KE, Wheeler DE, Silva FG
• The renal-cardiac connection: renal parenchymal alterations in patients with heart disease.
  Seminars in nephrology 1994 Lajoie G, Laszik Z, Nadasdy T, Silva FG
• Renal interleukin-1 expression during endotoxemia and gram-negative septicemia in conscious rats.
  Circulatory shock 1994 Laszik Z, Nadasdy T, Johnson LD, Lerner MR, Brackett D, Silva FG
• Lack of suppressed renal thrombomodulin expression in a septic rat model with glomerular thrombotic microangiopathy.
  Laboratory investigation; a journal of technical methods and pathology 1994 Laszik Z, Carson CW, Nadasdy T, Johnson LD, Lerner MR, Brackett DJ, Esmon CT, Silva FG
• Proliferative activity of intrinsic cell populations in the normal human kidney.
  Journal of the American Society of Nephrology : JASN 1994 Nadasdy T, Laszik Z, Blick KE, Johnson LD, Silva FG
• Absence of association between cytomegalovirus infection and obliterative transplant arteriopathy in renal allograft rejection.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1994 Nadasdy T, Smith J, Laszik Z, Waner JL, Johnson LD, Silva FG
• Tubular atrophy in the end-stage kidney: a lectin and immunohistochemical study.
  Human pathology 1994 Nadasdy T, Laszik Z, Blick KE, Johnson DL, Silva FG
• Immunohistochemical and lectin dissection of the human nephron in health and disease.
  Archives of pathology & laboratory medicine 1993 Silva FG, Nadasdy T, Laszik Z
• The role of the complement system in the pathogenesis of multiple organ failure in shock.
  Progress in clinical and biological research 1989 Zimmermann T, Laszik Z, Nagy S, Kaszaki J, Joo F