Zhonghui Guan, MD
Professor
Anesthesia
School of Medicine

In his research, Guan focuses on better understanding the regulation of gene expression in chronic pain. Gene expression regulation is essentially cell processes that control synthesis of proteins or other products that play a role in body functions.

Guan earned his medical degree at Peking Union Medical College in Beijing. He completed an anesthesia residency at Massachusetts General Hospital, followed by a pain management fellowship at UCSF.

Guan is a member of numerous professional organizations, including the American Society of Anesthesiologists, California Society of Anesthesiologists and Society for Neuroscience.

• A Procedure for Mouse Dorsal Root Ganglion Cryosectioning.
  Journal of visualized experiments : JoVE 2023 He L, Zhao W, Zhang L, Ilango M, Zhao N, Yang L, Guan Z
• Discharge Opioid Over- and Underprescription to Patients after General Surgery: A Retrospective Cohort Study.
  Journal of the American College of Surgeons 2023 Guan LS, Langnas E, Bongiovanni T, Campbell LJ, Wick EC, Guan Z
• Racial Differences in Postoperative Opioid Prescribing Practices in Spine Surgical Patients.
  Neurosurgery 2022 Letchuman V, He L, Mummaneni PV, Agarwal N, Campbell LJ, Shabani S, Chan AK, Abrecht CR, Miller C, Sankaran S, Rambachan A, Croci R, Berven SH, Chou D, Holly LT, Guan Z
• The Role of Neuro-Immune Interactions in Chronic Pain: Implications for Clinical Practice.
  Journal of pain research 2022 Su PP, Zhang L, He L, Zhao N, Guan Z
• Opioid prescribing practices at hospital discharge for surgical patients before and after the Centers for Disease Control and Prevention's 2016 opioid prescribing guideline.
  BMC anesthesiology 2022 Langnas E, Bishara A, Croci R, Rodriguez-Monguio R, Wick EC, Chen CL, Guan Z
• Neuroanatomical Basis for the Orexinergic Modulation of Anesthesia Arousal and Pain Control.
  Frontiers in cellular neuroscience 2022 Xiang X, Chen Y, Li KX, Fang J, Bickler PE, Guan Z, Zhou W
• Identification of Foramen Ovale With H-Figure Fluoroscopic Landmark Improves Treatment Outcomes in Idiopathic Trigeminal Neuralgia.
  Anesthesia and analgesia 2022 He LL, Zhao WX, Paul Su PY, Sun QR, Guo GL, Yue JN, Ni JX, Yang LQ, Guan Z
• Distinct phases of adult microglia proliferation: a Myc-mediated early phase and a Tnfaip3-mediated late phase.
  Cell discovery 2022 Tan W, Su PP, Leff J, Gao X, Chen J, Guan AK, Kalyanasundaram G, Ma A, Guan Z
• Modified Spared Nerve Injury Surgery Model of Neuropathic Pain in Mice.
  Journal of visualized experiments : JoVE 2022 He L, Zhao W, Zhang L, Ilango M, Zhao N, Yang L, Guan Z
• Function of Oncogene Mycn in Adult Neurogenesis and Oligodendrogenesis.
  Molecular neurobiology 2021 Chen J, Guan Z
• Novel method of locating the foramen ovale: a stable chair with solid legs.
  Regional anesthesia and pain medicine 2021 He L, Guan Z
• Perioperative Use of Gabapentinoids: Comment.
  Anesthesiology 2021 Su PP, Guan Z
• Contribution of colony-stimulating factor 1 to neuropathic pain.
  Pain reports 2021 Yu X, Basbaum A, Guan Z
• Ion Channels in Anesthesia.
  Advances in experimental medicine and biology 2021 Zhou W, Guan Z
• Novel fluoroscopic landmark to significantly facilitate the visualization of foramen ovale in treating idiopathic trigeminal neuralgia.
  Regional anesthesia and pain medicine 2020 He L, Zhao W, Su PP, Guo G, Yue J, Ni J, Yang L, Guan Z
• Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain.
  Nature communications 2020 Yu X, Liu H, Hamel KA, Morvan MG, Yu S, Leff J, Guan Z, Braz JM, Basbaum AI
• Rapid Isolation of Dorsal Root Ganglion Macrophages.
  Journal of visualized experiments : JoVE 2019 Yu X, Leff J, Guan Z
• Case Report and Literature Review: Interventional Management of Erythromelalgia.
  Translational perioperative and pain medicine 2019 Chinn G, Guan Z
• Spinal Cord Stimulation for Failed Back Surgery Syndrome -- Patient Selection Considerations.
  Translational perioperative and pain medicine 2019 Palmer N, Guan Z, Chai NC
• Anesthetic management of radical nephrectomy in patients with renal cell carcinoma involving renal vein or inferior vena cava.
  Tumori 2019 Chen K, Wang J, Dai J, Luo A, Tian Y, Guan Z, Wang X
• Transcription factor Sp4 is required for hyperalgesic state persistence.
  PloS one 2019 Sheehan K, Lee J, Chong J, Zavala K, Sharma M, Philipsen S, Maruyama T, Xu Z, Guan Z, Eilers H, Kawamata T, Schumacher M
• Activation of orexin system facilitates anesthesia emergence and pain control.
  Proceedings of the National Academy of Sciences of the United States of America 2018 Zhou W, Cheung K, Kyu S, Wang L, Guan Z, Kurien PA, Bickler PE, Jan LY
• Contemporary views on inflammatory pain mechanisms: TRPing over innate and microglial pathways.
  F1000Research 2016 Guan Z, Hellman J, Schumacher M
• Transplant-mediated enhancement of spinal cord GABAergic inhibition reverses paclitaxel-induced mechanical and heat hypersensitivity.
  Pain 2015 Bráz JM, Wang X, Guan Z, Rubenstein JL, Basbaum AI
• Primary afferent and spinal cord expression of gastrin-releasing peptide: message, protein, and antibody concerns.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Solorzano C, Villafuerte D, Meda K, Cevikbas F, Bráz J, Sharif-Naeini R, Juarez-Salinas D, Llewellyn-Smith IJ, Guan Z, Basbaum AI
• Misalignment of disposable pulse oximeter probes results in false saturation readings that influence anesthetic management.
  Anesthesia and analgesia 2009 Guan Z, Baker K, Sandberg WS
• The mushroom body defect gene product is an essential component of the meiosis II spindle apparatus in Drosophila oocytes.
  Genetics 2006 Yu JX, Guan Z, Nash HA
• CREB-binding protein controls response to cocaine by acetylating histones at the fosB promoter in the mouse striatum.
  Proceedings of the National Academy of Sciences of the United States of America 2005 Levine AA, Guan Z, Barco A, Xu S, Kandel ER, Schwartz JH
• p38 MAP kinase mediates both short-term and long-term synaptic depression in aplysia.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2003 Guan Z, Kim JH, Lomvardas S, Holick K, Xu S, Kandel ER, Schwartz JH
• Mushroom body defect, a gene involved in the control of neuroblast proliferation in Drosophila, encodes a coiled-coil protein.
  Proceedings of the National Academy of Sciences of the United States of America 2000 Guan Z, Prado A, Melzig J, Heisenberg M, Nash HA, Raabe T
• A new assay for the genetic study of general anesthesia in Drosophila melanogaster: use in analysis of mutations in the X-chromosomal 12E region.
  Journal of neurogenetics 2000 Guan Z, Scott RL, Nash HA