Zhe Chen, MD
Associate Professor
Anesthesia
School of Medicine

Publications (19)

Top publication keywords:
Drosophila ProteinsIntracellular Signaling Peptides and ProteinsDNA Repair EnzymesCullin ProteinsAtaxin-3Proteasome Endopeptidase ComplexF-Box ProteinsCell PolarityCarcinogenesisRNA Splicing FactorsPeptidesCytoskeletal ProteinsSKP Cullin F-Box Protein LigasesVesicular Transport ProteinsMachado-Joseph Disease

• Application of lignin and lignin-based composites in different tissue engineering fields.
  International journal of biological macromolecules 2022 Liu Y, Wang X, Wu Q, Pei W, Teo MJ, Chen ZS, Huang C
• Multifaceted investigation underlies diverse mechanisms contributing to the downregulation of Hedgehog pathway-associated genes INTU and IFT88 in lung adenocarcinoma and uterine corpus endometrial carcinoma.
  Aging 2022 Chan HYE, Chen ZS
• Lignin-carbohydrate complexes suppress SCA3 neurodegeneration via upregulating proteasomal activities.
  International journal of biological macromolecules 2022 Chen ZS, Yan M, Pei W, Yan B, Huang C, Chan HYE
• A peptide inhibitor that rescues polyglutamine-induced synaptic defects and cell death through suppressing RNA and protein toxicities.
  Molecular therapy. Nucleic acids 2022 Peng SI, Leong LI, Sun JK, Chen ZS, Chow HM, Chan HYE
• Insight in the Recent Application of Polyphenols From Biomass.
  Frontiers in bioengineering and biotechnology 2021 Yan B, Chen ZS, Hu Y, Yong Q

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• CAG RNAs induce DNA damage and apoptosis by silencing NUDT16 expression in polyglutamine degeneration.
  Proceedings of the National Academy of Sciences of the United States of America 2021 Peng S, Guo P, Lin X, An Y, Sze KH, Lau MHY, Chen ZS, Wang Q, Li W, Sun JK, Ma SY, Chan TF, Lau KF, Ngo JCK, Kwan KM, Wong CH, Lam SL, Zimmerman SC, Tuccinardi T, Zuo Z, Au-Yeung HY, Chow HM, Chan HYE
• Pan-cancer investigation reveals mechanistic insights of planar cell polarity gene Fuz in carcinogenesis.
  Aging 2021 Chen ZS, Lin X, Chan TF, Chan HYE
• A heterozygous mutation in the CCDC88C gene likely causes early-onset pure hereditary spastic paraplegia: a case report.
  BMC neurology 2021 Yahia A, Chen ZS, Ahmed AE, Emad S, Adil R, Abubaker R, Taha SOMA, Salih MA, Elsayed L, Chan HYE, Stevanin G
• Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
  Autophagy 2021 Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, …
• A fine balance between Prpf19 and Exoc7 in achieving degradation of aggregated protein and suppression of cell death in spinocerebellar ataxia type 3.
  Cell death & disease 2021 Chen ZS, Huang X, Talbot K, Chan HYE
• Isolation and Identification of a Novel Anti-protein Aggregation Activity of Lignin-Carbohydrate Complex From Chionanthus retusus Leaves.
  Frontiers in bioengineering and biotechnology 2020 Pei W, Chen ZS, Chan HYE, Zheng L, Liang C, Huang C
• Transcriptional dysregulation in neurodegenerative diseases: Who tipped the balance of Yin Yang 1 in the brain?
  Neural regeneration research 2019 Chen ZS, Chan HYE
• FipoQ/FBXO33, a Cullin-1-based ubiquitin ligase complex component modulates ubiquitination and solubility of polyglutamine disease protein.
  Journal of neurochemistry 2019 Chen ZS, Wong AKY, Cheng TC, Koon AC, Chan HYE
• A Peptidylic Inhibitor for Neutralizing r(GGGGCC)exp-Associated Neurodegeneration in C9ALS-FTD.
  Molecular therapy. Nucleic acids 2019 Zhang Q, An Y, Chen ZS, Koon AC, Lau KF, Ngo JCK, Chan HYE
• AQAMAN, a bisamidine-based inhibitor of toxic protein inclusions in neurons, ameliorates cytotoxicity in polyglutamine disease models.
  The Journal of biological chemistry 2018 Hong H, Koon AC, Chen ZS, Wei Y, An Y, Li W, Lau MHY, Lau KF, Ngo JCK, Wong CH, Au-Yeung HY, Zimmerman SC, Chan HYE
• Familial ataxia, tremor, and dementia in a polish family with a novel mutation in the CCDC88C gene.
  Movement disorders : official journal of the Movement Disorder Society 2018 Lenska-Mieciek M, Charzewska A, Królicki L, Hoffman-Zacharska D, Chen ZS, Lau KF, Chan HYE, Gambin T, Fiszer U
• Drosophila Exo70 Is Essential for Neurite Extension and Survival under Thermal Stress.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Koon AC, Chen ZS, Peng S, Fung JMS, Zhang X, Lembke KM, Chow HK, Frank CA, Jiang L, Lau KF, Chan HYE
• Planar cell polarity gene Fuz triggers apoptosis in neurodegenerative disease models.
  EMBO reports 2018 Chen ZS, Li L, Peng S, Chen FM, Zhang Q, An Y, Lin X, Li W, Koon AC, Chan TF, Lau KF, Ngo JCK, Wong WT, Kwan KM, Chan HYE
• A peptidylic inhibitor for neutralizing expanded CAG RNA-induced nucleolar stress in polyglutamine diseases.
  RNA (New York, N.Y.) 2018 Zhang Q, Chen ZS, An Y, Liu H, Hou Y, Li W, Lau KF, Koon AC, Ngo JCK, Chan HYE