Zeinab Kosibaty, PhD
Assistant Researcher
Medicine
School of Medicine

Awards

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• HDFCCC Sarcoma Research Award, UCSF Helen Diller Family Comprehensive Cancer Center, 2025

Education & Training

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• Postdoctoral Fellow Mechanism of drug resistance in lung adenocarcinoma Karolinska Institutet 2022
• PhD Medical Sciences University of Tsukuba 2020
• MSc Medical Sciences University of Tsukuba 2016
• BSc Medical Sciences University of Tsukuba 2014

Publications (9)

Top publication keywords:
Cyclin EProto-Oncogene ProteinsFocal Adhesion Protein-Tyrosine KinasesFocal AdhesionsOncogene ProteinsExtracellular MatrixGuanine Nucleotide-Releasing Factor 2DNA RepairCytoplasmLung NeoplasmsProtein-Tyrosine KinasesCell Line, TumorOncogene Proteins, FusionDNA ReplicationHomeodomain Proteins

• The CIC::DUX4 oncoprotein maintains DNA integrity through direct regulation of the catalytic subunit of DNA polymerase epsilon (POLE).
  Oncogene 2025 Kosibaty Z, Luck C, Okimoto RA
• Targeting DNA repair mechanisms to overcome CIC::DUX4 undifferentiated sarcomas
  2025 Kosibaty Z; Luck C; Okimoto R, Cancer Res (2025) 85 (8_Supplement_1): 2923.
• What is the role of membrane-located epithelial cell transforming sequence 2 at the interphase of lung adenocarcinoma cells?
  Pathology international 2023 Murata Y, Yoshida A, Minami Y, Kosibaty Z, Matsubara D, Noguchi M
• Mapping chromatin state and transcriptional response in CIC-DUX4 undifferentiated round cell sarcoma.
  bioRxiv : the preprint server for biology 2023 Thomas NJ, Luck C, Shlimon N, Ponce RK, Kosibaty Z, Okimoto RA
• Plasma RNA profiling unveils transcriptional signatures associated with resistance to osimertinib in EGFR T790M positive non-small cell lung cancer patients.
  Translational lung cancer research 2022 Alexeyenko A, Brustugun OT, Eide IJZ, Gencheva R, Kosibaty Z, Lai Y, de Petris L, Tsakonas G, Grundberg O, Franzen B, Viktorsson K, Lewensohn R, Hydbring P, Ekman S

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• Ras-Related Protein Rab-32 and Thrombospondin 1 Confer Resistance to the EGFR Tyrosine Kinase Inhibitor Osimertinib by Activating Focal Adhesion Kinase in Non-Small Cell Lung Cancer.
  Cancers 2022 Kosibaty Z, Brustugun OT, Zwicky Eide IJ, Tsakonas G, Grundberg O, De Petris L, McGowan M, Hydbring P, Ekman S
• High expression of Ras-specific guanine nucleotide-releasing factor 2 (RasGRF2) in lung adenocarcinoma is associated with tumor invasion and poor prognosis.
  Pathology international 2021 Nakagawa T, Kim Y, Kano J, Murata Y, Kosibaty Z, Noguchi M, Sakamoto N
• ECT2 promotes lung adenocarcinoma progression through extracellular matrix dynamics and focal adhesion signaling.
  Cancer science 2020 Kosibaty Z, Murata Y, Minami Y, Noguchi M, Sakamoto N
• Cytoplasmic expression of epithelial cell transforming sequence 2 in lung adenocarcinoma and its implications for malignant progression.
  Laboratory investigation; a journal of technical methods and pathology 2018 Kosibaty Z, Murata Y, Minami Y, Dai T, Kano J, Matsuoka R, Nakano N, Noguchi M