Zachary Nevin, PhD
Scientist
Business Service Ctr
Chancellor/EVC/FAS

Education & Training

Show all (2) Hide

• PhD Genetics and Genome Sciences Case Western Reserve University School of Medicine 2018
• BS Biological Sciences Stanford University 2009

Interests

Show all (12) Hide

• Leukodystrophies
• Neuropathies
• Genome Engineering
• ALS
• Neurons
• Charcot-Marie-Tooth
• Pelizaeus-Merzbacher Disease
• Neurogenetic Disease
• Schwann Cells
• Induced Pluripotent Stem Cells
• CRISPR
• Genetics

Websites

Show all (1) Hide

• Conklin Lab (labs.gladstone.org)

Publications (8)

Top publication keywords:
ClobetasolPluripotent Stem CellsMiconazoleMyelin Proteolipid ProteinSterolsOligodendrogliaEndoplasmic Reticulum StressDiseaseInduced Pluripotent Stem CellsRemyelinationMyelin SheathOligodendrocyte Precursor CellsPelizaeus-Merzbacher DiseaseSpheroids, CellularCell Communication

• A reference human induced pluripotent stem cell line for large-scale collaborative studies.
  Cell stem cell 2022 Pantazis CB, Yang A, Lara E, McDonough JA, Blauwendraat C, Peng L, Oguro H, Kanaujiya J, Zou J, Sebesta D, Pratt G, Cross E, Blockwick J, Buxton P, Kinner-Bibeau L, Medura C, Tompkins C, Hughes S, …
• Suppression of proteolipid protein rescues Pelizaeus-Merzbacher disease.
  Nature 2020 Elitt MS, Barbar L, Shick HE, Powers BE, Maeno-Hikichi Y, Madhavan M, Allan KC, Nawash BS, Gevorgyan AS, Hung S, Nevin ZS, Olsen HE, Hitomi M, Schlatzer DM, Zhao HT, Swayze A, LePage DF, Jiang W, …
• Cell Type-Specific Intralocus Interactions Reveal Oligodendrocyte Mechanisms in MS.
  Cell 2020 Factor DC, Barbeau AM, Allan KC, Hu LR, Madhavan M, Hoang AT, Hazel KEA, Hall PA, Nisraiyya S, Najm FJ, Miller TE, Nevin ZS, Karl RT, Lima BR, Song Y, Sibert AG, Dhillon GK, Volsko C, Bartels CF, …
• Chemical Screening Identifies Enhancers of Mutant Oligodendrocyte Survival and Unmasks a Distinct Pathological Phase in Pelizaeus-Merzbacher Disease.
  Stem cell reports 2018 Elitt MS, Shick HE, Madhavan M, Allan KC, Clayton BLL, Weng C, Miller TE, Factor DC, Barbar L, Nawash BS, Nevin ZS, Lager AM, Li Y, Jin F, Adams DJ, Tesar PJ
• Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination.
  Nature 2018 Hubler Z, Allimuthu D, Bederman I, Elitt MS, Madhavan M, Allan KC, Shick HE, Garrison E, T Karl M, Factor DC, Nevin ZS, Sax JL, Thompson MA, Fedorov Y, Jin J, Wilson WK, Giera M, Bracher F, Miller RH,…
• Induction of myelinating oligodendrocytes in human cortical spheroids.
  Nature methods 2018 Madhavan M, Nevin ZS, Shick HE, Garrison E, Clarkson-Paredes C, Karl M, Clayton BLL, Factor DC, Allan KC, Barbar L, Jain T, Douvaras P, Fossati V, Miller RH, Tesar PJ
• Modeling the Mutational and Phenotypic Landscapes of Pelizaeus-Merzbacher Disease with Human iPSC-Derived Oligodendrocytes.
  American journal of human genetics 2017 Nevin ZS, Factor DC, Karl RT, Douvaras P, Laukka J, Windrem MS, Goldman SA, Fossati V, Hobson GM, Tesar PJ
• Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo.
  Nature 2015 Najm FJ, Madhavan M, Zaremba A, Shick E, Karl RT, Factor DC, Miller TE, Nevin ZS, Kantor C, Sargent A, Quick KL, Schlatzer DM, Tang H, Papoian R, Brimacombe KR, Shen M, Boxer MB, Jadhav A, Robinson AP…