Yvonne Ou, MD
Professor
Ophthalmology
School of Medicine

Our research program combines imaging and analysis of specific cell and synaptic labels in the retina, rodent models of experimental glaucoma, novel genetic tools in which specific cell types are labeled, and the tools of molecular/cell biology and physiology to address a series of questions that, unanswered, have prevented progress in the field: 1) What are the early steps of compartmentalized neurodegeneration of the ganglion cell in glaucoma? 2) Are there specific ganglion cell types that are more susceptible to intraocular pressure (IOP) elevation? 3) Are there specific inner retinal circuits that are more susceptible to IOP elevation? As a clinician-scientist, I am motivated to advance our field not only by answering these fundamental questions, but also by translating the knowledge gained into improvements in diagnostic and treatment modalities in glaucoma. For example, a detailed understanding of the earliest structural and functional changes that occur in glaucoma will allow us to design treatments that can rescue RGCs, perhaps the most susceptible RGCs, before irreversible cell death occurs. Our long-term goal is to understand the mechanisms underlying ganglion cell degeneration and circuit remodeling in glaucoma in order to improve diagnosis and treatment.

• Selective Laser Trabeculoplasty for the Treatment of Glaucoma: A Report by the American Academy of Ophthalmology.
  Ophthalmology 2023 Takusagawa HL, Hoguet A, Sit AJ, Rosdahl JA, Chopra V, Ou Y, Richter G, Kim SJ, WuDunn D
• The Retinal Ganglion Cell Repopulation, Stem Cell Transplantation, and Optic Nerve Regeneration Consortium.
  Ophthalmology science 2023 Johnson TV, Baranov P, Di Polo A, Fortune B, Gokoffski KK, Goldberg JL, Guido W, Kolodkin AL, Mason CA, Ou Y, Reh TA, Ross AG, Samuels BC, Zack DJ
• Assessment of Remote Training, At-Home Testing, and Test-Retest Variability of a Novel Test for Clustered Virtual Reality Perimetry.
  Ophthalmology. Glaucoma 2023 Chia ZK, Kong AW, Turner ML, Saifee M, Damato BE, Backus BT, Blaha JJ, Schuman JS, Deiner MS, Ou Y
• Anterior Segment Optical Coherence Tomography for Detection of Narrow Angles: A Community-Based Diagnostic Accuracy Study.
  Ophthalmology. Glaucoma 2023 Pradhan S, Sah RK, Bhandari G, Bhandari S, Byanju R, Kandel RP, Thompson IJB, Stevens VM, Aromin KM, Oatts JT, Ou Y, Lietman TM, O'Brien KS, Keenan JD
• Relationship Between Intraocular Pressure and Age: A Population-Based Study in Nepal.
  Journal of glaucoma 2023 Bhandari G, Bhandari S, Byanju R, Pradhan S, Sah RK, Kandel RP, Thompson IJ, Rotchford AP, West SK, Muñoz B, Stevens VM, Oatts JT, Ou Y, Lietman TM, O'Brien KS, Keenan JD
• Large-scale survey of excitatory synapses reveals sublamina-specific and asymmetric synapse disassembly in a neurodegenerative circuit.
  iScience 2023 Soliño M, Yu A, Della Santina L, Ou Y
• From bench to behaviour: The role of lifestyle factors on intraocular pressure, neuroprotection, and disease progression in glaucoma.
  Clinical & experimental ophthalmology 2023 Kumar A, Ou Y
• Corneal Hysteresis for the Diagnosis of Glaucoma and Assessment of Progression Risk: A Report by the American Academy of Ophthalmology.
  Ophthalmology 2022 Sit AJ, Chen TC, Takusagawa HL, Rosdahl JA, Hoguet A, Chopra V, Richter GM, Ou Y, Kim SJ, WuDunn D
• Reply.
  Ophthalmology. Glaucoma 2022 Ou Y, Turner M
• Randomized Trial to Evaluate the Efficacy of the Nanodropper Device for Pupillary Dilation and Cycloplegia in Children.
  Ophthalmology 2022 Hoppe CB, Yonamine S, Kao BW, Turner ML, Ou Y, Han Y, Keenan JD, Oatts JT
• At-Home Glaucoma Monitoring: Is it Ready for Prime Time?
  Ophthalmology. Glaucoma 2022 Turner M, Ou Y
• The Catcher in the Eye: Stem Cells as a Therapeutic for Glaucoma.
  Ophthalmology. Glaucoma 2022 Kong AW, Ou Y
• A Global and Sector-Based Comparison of OCT Angiography and Visual Field Defects in Glaucoma.
  Journal of ophthalmology 2022 Kong AW, Turner ML, Saifee M, Jethi M, Mora M, Ou Y
• Virtual Reality Oculokinetic Perimetry Test Reproducibility and Relationship to Conventional Perimetry and OCT.
  Ophthalmology science 2021 Greenfield JA, Deiner M, Nguyen A, Wollstein G, Damato B, Backus BT, Wu M, Schuman JS, Ou Y
• Individuals with and without normal tension glaucoma exhibit comparable performance on tests of cognitive function.
  International journal of ophthalmology 2021 Cui QN, Green D, Jethi M, Driver T, Porco TC, Kuo J, Lin SC, Stamper RL, Han Y, Chiu CS, Ramanathan S, Ward ME, Possin K, Ou Y
• Single Ophthalmology Program Trends in Resident Surgical and Research Productivity by Gender, Underrepresented Minority Status, and Welcoming a Child.
  Journal of academic ophthalmology (2017) 2021 Kong AW, Schallhorn JM, Ou Y
• Disassembly and rewiring of a mature converging excitatory circuit following injury.
  Cell reports 2021 Della Santina L, Yu AK, Harris SC, Soliño M, Garcia Ruiz T, Most J, Kuo YM, Dunn FA, Ou Y
• Asymmetric Functional Impairment of ON and OFF Retinal Pathways in Glaucoma.
  Ophthalmology science 2021 Kong AW, Turner ML, Chan H, Stamper RL, Arnold BF, Della Santina L, Ou Y
• Clinical Outcomes of Micropulse Laser Trabeculoplasty Compared to Selective Laser Trabeculoplasty at One Year in Open-Angle Glaucoma.
  Clinical ophthalmology (Auckland, N.Z.) 2021 Sun CQ, Chen TA, Deiner MS, Ou Y
• Probing ON and OFF Retinal Pathways in Glaucoma Using Electroretinography.
  Translational vision science & technology 2020 Kong AW, Della Santina L, Ou Y
• Subconjunctival Injections of Mitomycin C Are Associated with a Lower Incidence of Hypertensive Phase in Eyes with Ahmed Glaucoma Valve.
  Ophthalmology. Glaucoma 2020 Perez CI, Verdaguer S, Khaliliyeh D, Maul EA, Ou Y, Han Y
• Implementing and Monitoring At-Home Virtual Reality Oculo-kinetic Perimetry During COVID-19.
  Ophthalmology 2020 Deiner MS, Damato BE, Ou Y
• Neurotrophic keratitis after micropulse transscleral diode laser cyclophotocoagulation.
  American journal of ophthalmology case reports 2019 Perez CI, Han Y, Rose-Nussbaumer J, Ou Y, Hsia YC
• Partial Cone Loss Triggers Synapse-Specific Remodeling and Spatial Receptive Field Rearrangements in a Mature Retinal Circuit.
  Cell reports 2019 Care RA, Kastner DB, De la Huerta I, Pan S, Khoche A, Della Santina L, Gamlin C, Santo Tomas C, Ngo J, Chen A, Kuo YM, Ou Y, Dunn FA
• Reduced contrast sensitivity among older women is associated with increased risk of cognitive impairment.
  Annals of neurology 2018 Ward ME, Gelfand JM, Lui LY, Ou Y, Green AJ, Stone K, Pedula KL, Cummings SR, Yaffe K
• Biolistic Labeling of Retinal Ganglion Cells.
  Methods in molecular biology (Clifton, N.J.) 2018 Santina LD, Ou Y
• Establishment and Characterization of an Acute Model of Ocular Hypertension by Laser-Induced Occlusion of Episcleral Veins.
  Investigative ophthalmology & visual science 2017 Zhang L, Li G, Shi M, Liu HH, Ge S, Ou Y, Flanagan JG, Chen L
• Surgical Management of Pediatric Glaucoma.
  Developments in ophthalmology 2017 Chang I, Caprioli J, Ou Y
• Genetic dissection of anterior segment dysgenesis caused by a Col4a1 mutation in mouse.
  Disease models & mechanisms 2017 Mao M, Kiss M, Ou Y, Gould DB
• Selective Vulnerability of Specific Retinal Ganglion Cell Types and Synapses after Transient Ocular Hypertension.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Ou Y, Jo RE, Ullian EM, Wong RO, Della Santina L
• Who's lost first? Susceptibility of retinal ganglion cell types in experimental glaucoma.
  Experimental eye research 2016 Della Santina L, Ou Y
• Correlation of Serial Scleral and Corneal Pneumatonometry.
  Ophthalmology 2015 Kuo DS, Ou Y, Jeng BH, Bhisitkul R, Stewart JM, Duncan JL, Han Y
• Expert Review of Ophthalmology
  Towards the development of a human glaucoma disease-in-a-dish model using stem cells 2015 Green DI Ou Y
• Factors that influence intraocular pressure changes after myopic and hyperopic LASIK and photorefractive keratectomy: a large population study.
  Ophthalmology 2014 Schallhorn JM, Schallhorn SC, Ou Y
• Scleral intraocular pressure measurement in cadaver eyes pre- and postkeratoprosthesis implantation.
  Investigative ophthalmology & visual science 2014 Lin CC, Chen A, Jeng BH, Porco TC, Ou Y, Han Y
• Development of a resident training module for systematic optic disc evaluation in glaucoma.
  Journal of glaucoma 2012 Law SK, Tamboli DA, Ou Y, Giaconi JA, Caprioli J
• Glaucoma, Alzheimer disease and other dementia: a longitudinal analysis.
  Ophthalmic epidemiology 2012 Ou Y, Grossman DS, Lee PP, Sloan FA
• Surgical management of pediatric glaucoma.
  Developments in ophthalmology 2012 Ou Y, Caprioli J
• A critical appraisal and comparison of the quality and recommendations of glaucoma clinical practice guidelines.
  Ophthalmology 2011 Ou Y, Goldberg I, Migdal C, Lee PP
• Outcomes of Ahmed glaucoma valve implantation in children with primary congenital glaucoma.
  Archives of ophthalmology (Chicago, Ill. : 1960) 2009 Ou Y, Yu F, Law SK, Coleman AL, Caprioli J
• Transcriptional modification by a CASK-interacting nucleosome assembly protein.
  Neuron 2004 Wang GS, Hong CJ, Yen TY, Huang HY, Ou Y, Huang TN, Jung WG, Kuo TY, Sheng M, Wang TF, Hsueh YP
• The transmembrane domains of ectoapyrase (CD39) affect its enzymatic activity and quaternary structure.
  The Journal of biological chemistry 1998 Wang TF, Ou Y, Guidotti G