Yvonne Kapila, DDS, PhD
Professor
Orofacial Sciences
School of Dentistry

Awards

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• R Earl Robinson Distinguished Professor of Periodontology, UCSF

Grants and Projects

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• Oral Treponema Surface Proteins: Host Cell Interactions, NIH, 2015-2021
• Biomarkers of Aggressive Oral Cancer, NIH, 2013-2016
• Fibronectin Regulation of Anoikis, NIH, 2001-2012
• Apoptosis Regulated by Fibronectin Signaling Pathways, NIH, 2000-2011
• Fibronectin Regulation of Carcinoma Apoptosis, NIH, 2004-2010
• Fibronectin Interactions with Periodontal Ligament Cells, NIH, 1993-1998

Publications (139)

Top publication keywords:
BacteriocinsMicrobiotaNisinAnoikisPeriodontal LigamentCarcinoma, Squamous CellPeriodontitisChronic PeriodontitisPeriodontal DiseasesGingival RecessionProbioticsAlveolar Bone LossMouth NeoplasmsTreponema denticolaFibronectins

• Nisin lantibiotic prevents NAFLD liver steatosis and mitochondrial oxidative stress following periodontal disease by abrogating oral, gut and liver dysbiosis.
  NPJ biofilms and microbiomes 2024 Kuraji R, Ye C, Zhao C, Gao L, Martinez A, Miyashita Y, Radaic A, Kamarajan P, Le C, Zhan L, Range H, Sunohara M, Numabe Y, Kapila YL
• Biological biomarkers of oral cancer.
  Periodontology 2000 2023 Radaic A, Kamarajan P, Cho A, Wang S, Hung GC, Najarzadegan F, Wong DT, Ton-That H, Wang CY, Kapila YL
• Geroscience: Aging and Oral Health Research.
  Advances in dental research 2023 Weintraub JA, Kaeberlein M, Perissinotto C, Atchison KA, Chen X, D'Souza RN, Feine JS, Ghezzi EM, Kirkwood KL, Ryder M, Slashcheva LD, Touger-Decker R, Wu B, Kapila Y
• Nisin a probiotic bacteriocin mitigates brain microbiome dysbiosis and Alzheimer's disease-like neuroinflammation triggered by periodontal disease.
  Journal of neuroinflammation 2023 Zhao C, Kuraji R, Ye C, Gao L, Radaic A, Kamarajan P, Taketani Y, Kapila YL
• Specific Oral Microbial Differences in Proteobacteria and Bacteroidetes Are Associated with Distinct Sites When Moving from Healthy Mucosa to Oral Dysplasia-A Microbiome and Gene Profiling Study and Focused Review.
  Microorganisms 2023 Radaic A, Shamir ER, Jones K, Villa A, Garud NR, Tward AD, Kamarajan P, Kapila YL

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• EVIDENCE SUPPORTS SHORT-TERM CLINICAL BENEFITS OF ADJUNCTIVE ORAL PROBIOTICS FOLLOWING SCALING AND ROOT PLANING TREATMENT.
  The journal of evidence-based dental practice 2023 Wu YH, Wang CW, Kapila Y
• Reparative Dentin Formation Following Dental Pulp Capping is Mediated by TNFR1 In Vivo.
  Journal of endodontics 2023 Almeida-Junior LA, Araujo LDC, Lamarque GCC, Arnez MFM, Kapila YL, Silva LABD, Paula-Silva FWG
• Periodontal treatment and microbiome-targeted therapy in management of periodontitis-related nonalcoholic fatty liver disease with oral and gut dysbiosis.
  World journal of gastroenterology 2023 Kuraji R, Shiba T, Dong TS, Numabe Y, Kapila YL
• Stimulation of Human Periodontal Ligament Fibroblasts Using Purified Dentilisin Extracted from Treponema denticola.
  Bio-protocol 2022 Ganther S, Fenno CJ, Kapila YL
• Association between oral health markers and decline in muscle strength and physical performance in later life: longitudinal analyses of two prospective cohorts from the UK and the USA.
  The lancet. Healthy longevity 2022 Kimble R, McLellan G, Lennon LT, Papacosta AO, Weyant RJ, Kapila Y, Mathers JC, Wannamathee SG, Whincup PH, Ramsay SE
• Use of the Probiotic Bifidobacterium animalis subsp. lactis HN019 in Oral Diseases.
  International journal of molecular sciences 2022 Araujo LDC, Furlaneto FAC, da Silva LAB, Kapila YL
• Nisin and Nisin Probiotic Disrupt Oral Pathogenic Biofilms and Restore Their Microbiome Composition towards Healthy Control Levels in a Peri-Implantitis Setting.
  Microorganisms 2022 Radaic A, Brody H, Contreras F, Hajfathalian M, Lucido L, Kamarajan P, Kapila YL
• Nisin probiotic prevents inflammatory bone loss while promoting reparative proliferation and a healthy microbiome.
  NPJ biofilms and microbiomes 2022 Gao L, Kuraji R, Zhang MJ, Martinez A, Radaic A, Kamarajan P, Le C, Zhan L, Ye C, Rangé H, Sailani MR, Kapila YL
• Cellular Mechanisms of Inflammaging and Periodontal Disease.
  Frontiers in dental medicine 2022 Clark D, Radaic A, Kapila Y
• Incision-free, coronally advanced flap with subepithelial connective tissue graft placed by the molar or canine access (MOCA) technique: 13 case series.
  Clinical advances in periodontics 2022 Kashani H, Vora MV, Kuraji R, Fathi-Kelly H, Nguyen T, Tamraz B, Tran C, Kapila YL
• Solid Lipid Nanoparticles Loaded with Nisin (SLN-Nisin) are More Effective Than Free Nisin as Antimicrobial, Antibiofilm, and Anticancer Agents.
  Journal of biomedical nanotechnology 2022 Radaic A, Malone E, Kamarajan P, Kapila YL
• Periodontal Disease: The Good, The Bad, and The Unknown.
  Frontiers in cellular and infection microbiology 2021 Sedghi LM, Bacino M, Kapila YL
• Functional Adaptation of LPS-affected Dentoalveolar Fibrous Joints in Rats.
  Journal of periodontal research 2021 Wang B, Ustriyana P, Tam CS, Lin JD, Srirangapatanam S, Kapila Y, Ryder MI, Webb S, Seo Y, Ho SP
• A commentary on strategic extraction.
  Journal of periodontology 2021 Kao RT, Lin GH, Kapila Y, Sadowsky S, Curtis DA
• Clinical study showing a lower abundance of Neisseria in the oral microbiome aligns with low birth weight pregnancy outcomes.
  Clinical oral investigations 2021 Ye C, You M, Huang P, Xia Z, Radaic A, Tang J, Wu W, Wu Y, Kapila Y
• Association between metabolic syndrome and periodontitis: The role of lipids, inflammatory cytokines, altered host response, and the microbiome.
  Periodontology 2000 2021 Pirih FQ, Monajemzadeh S, Singh N, Sinacola RS, Shin JM, Chen T, Fenno JC, Kamarajan P, Rickard AH, Travan S, Paster BJ, Kapila Y
• Dental informed consent challenges and considerations for cognitively impaired patients.
  Periodontology 2000 2021 Alsaleh A, Kapila A, Shahriar I, Kapila YL
• Eating disorders through the periodontal lens.
  Periodontology 2000 2021 Rangé H, Colon P, Godart N, Kapila Y, Bouchard P
• Oral health's inextricable connection to systemic health: Special populations bring to bear multimodal relationships and factors connecting periodontal disease to systemic diseases and conditions.
  Periodontology 2000 2021 Kapila YL
• Oral microbiome shifts during pregnancy and adverse pregnancy outcomes: Hormonal and Immunologic changes at play.
  Periodontology 2000 2021 Ye C, Kapila Y
• Paradigm shift in the pathogenesis and treatment of oral cancer and other cancers focused on the oralome and antimicrobial-based therapeutics.
  Periodontology 2000 2021 Radaic A, Ganther S, Kamarajan P, Grandis J, Yom SS, Kapila YL
• Periodontal disease-related nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: An emerging concept of oral-liver axis.
  Periodontology 2000 2021 Kuraji R, Sekino S, Kapila Y, Numabe Y
• Probiotics for periodontal health-Current molecular findings.
  Periodontology 2000 2021 Nguyen T, Brody H, Radaic A, Kapila Y
• The human oral virome: Shedding light on the dark matter.
  Periodontology 2000 2021 Martínez A, Kuraji R, Kapila YL
• The oral microbiome: Role of key organisms and complex networks in oral health and disease.
  Periodontology 2000 2021 Sedghi L, DiMassa V, Harrington A, Lynch SV, Kapila YL
• The psychobiological links between chronic stress-related diseases, periodontal/peri-implant diseases, and wound healing.
  Periodontology 2000 2021 Decker AM, Kapila YL, Wang HL
• Treatment planning considerations in the older adult with periodontal disease.
  Periodontology 2000 2021 Curtis DA, Lin GH, Rajendran Y, Gessese T, Suryadevara J, Kapila YL
• Connective Tissue Graft with or without Enamel Matrix Derivative for Treating Gingival Recession Defects: A Systematic Review and Meta-Analysis.
  The journal of evidence-based dental practice 2021 Dubey P, Narasimhan M, Sehgal NK, Yanni P, Kim JW, Kapila YL, Lin GH
• Survival Versus Success.
  Journal of the American Dental Association (1939) 2021 Curtis DA, Sadowsky SJ, Daubert DM, Kapila Y
• Phosphatidylserine-Gold Nanoparticles (PS-AuNP) Induce Prostate and Breast Cancer Cell Apoptosis.
  Pharmaceutics 2021 Radaic A, Joo NE, Jeong SH, Yoo SI, Kotov N, Kapila YL
• Treponema denticola dentilisin triggered TLR2/MyD88 activation upregulates a tissue destructive program involving MMPs via Sp1 in human oral cells.
  PLoS pathogens 2021 Ganther S, Radaic A, Malone E, Kamarajan P, Chang NN, Tafolla C, Zhan L, Fenno JC, Kapila YL
• Treponema denticola-Induced RASA4 Upregulation Mediates Cytoskeletal Dysfunction and MMP-2 Activity in Periodontal Fibroblasts.
  Frontiers in cellular and infection microbiology 2021 Malone ET, Ganther S, Mena N, Radaic A, Shariati K, Kindberg A, Tafolla C, Kamarajan P, Fenno JC, Zhan L, Kapila YL
• Therapeutic Prognosis System for Root Coverage Procedures.
  The International journal of periodontics & restorative dentistry 2021 Nguyen T, Lee KJ, Chen JL, Xenoudi P, Kapila YL, Kao RT, Lin GH
• The Contribution of Macrophages in Old Mice to Periodontal Disease.
  Journal of dental research 2021 Clark D, Halpern B, Miclau T, Nakamura M, Kapila Y, Marcucio R
• The oralome and its dysbiosis: New insights into oral microbiome-host interactions.
  Computational and structural biotechnology journal 2021 Radaic A, Kapila YL
• Poor Oral Health and Inflammatory, Hemostatic, and Cardiac Biomarkers in Older Age: Results From Two Studies in the UK and USA.
  The journals of gerontology. Series A, Biological sciences and medical sciences 2021 Kotronia E, Wannamethee SG, Papacosta AO, Whincup PH, Lennon LT, Visser M, Kapila YL, Weyant RJ, Ramsay SE
• Periodontal inflammation triggers a site-specific and wide radius of calcium metabolic effects on alveolar bone.
  Journal of periodontal research 2020 Kuraji R, Wu YH, Hashimoto S, Miyashita Y, Mishiro S, Ito H, Kamarajan P, Kapila Y, Numabe Y
• Analyzing the predictability of the Kwok and Caton periodontal prognosis system: A retrospective study.
  Journal of periodontology 2020 Nguyen L, Krish G, Alsaleh A, Mailoa J, Kapila Y, Kao RT, Lin GH
• Periodontal pathogens promote cancer aggressivity via TLR/MyD88 triggered activation of Integrin/FAK signaling that is therapeutically reversible by a probiotic bacteriocin.
  PLoS pathogens 2020 Kamarajan P, Ateia I, Shin JM, Fenno JC, Le C, Zhan L, Chang A, Darveau R, Kapila YL
• Unculturable and culturable periodontal-related bacteria are associated with periodontal inflammation during pregnancy and with preterm low birth weight delivery.
  Scientific reports 2020 Ye C, Xia Z, Tang J, Khemwong T, Kapila Y, Kuraji R, Huang P, Wu Y, Kobayashi H
• Modulation of pathogenic oral biofilms towards health with nisin probiotic.
  Journal of oral microbiology 2020 Radaic A, Ye C, Parks B, Gao L, Kuraji R, Malone E, Kamarajan P, Zhan L, Kapila YL
• Rebuilding the Interproximal Papilla: Description of "Tube" Technique and Two Case Reports.
  Clinical advances in periodontics 2020 Kashani H, Vora MV, Kuraji R, Brody H, Kapila YL
• Oxidative stress, neutrophil elastase and IGFBP7 levels in patients with oropharyngeal cancer and chronic periodontitis.
  Oral diseases 2020 Aral CA, Ölçer SN, Aral K, Kapila Y
• Innovative application of nested PCR for detection of Porphyromonas gingivalis in human highly calcified atherothrombotic plaques.
  Journal of oral microbiology 2020 Brun A, Rangé H, Prouvost B, Mazighi M, Kapila Y, Bouchard P, Michel JB
• Temporal and dynamic changes in gingival blood flow during progression of ligature-induced periodontitis.
  Oral diseases 2020 Kuraji R, Wu YH, Hashimoto S, Mishiro S, Maeda Y, Miyashita Y, Ito H, Miwa Y, Sunohara M, Kapila Y, Numabe Y
• Polymicrobial periodontal disease triggers a wide radius of effect and unique virome.
  NPJ biofilms and microbiomes 2020 Gao L, Kang M, Zhang MJ, Reza Sailani M, Kuraji R, Martinez A, Ye C, Kamarajan P, Le C, Zhan L, Rangé H, Ho SP, Kapila YL
• Bacterial anti-microbial peptides and nano-sized drug delivery systems: The state of the art toward improved bacteriocins.
  Journal of controlled release : official journal of the Controlled Release Society 2020 Radaic A, de Jesus MB, Kapila YL
• Host-microbe interactions: Profiles in the transcriptome, the proteome, and the metabolome.
  Periodontology 2000 2020 Nguyen T, Sedghi L, Ganther S, Malone E, Kamarajan P, Kapila YL
• Probiotics, including nisin-based probiotics, improve clinical and microbial outcomes relevant to oral and systemic diseases.
  Periodontology 2000 2020 Nguyen T, Brody H, Lin GH, Rangé H, Kuraji R, Ye C, Kamarajan P, Radaic A, Gao L, Kapila Y
• Inflammasomes and their regulation in periodontal disease: A review.
  Journal of periodontal research 2020 Aral K, Milward MR, Kapila Y, Berdeli A, Cooper PR
• High serum ferritin levels are associated with a reduced periodontium in women with anorexia nervosa.
  Eating and weight disorders : EWD 2019 Boillot A, Ringuenet D, Kapila Y, Pallier A, Colon P, Bouchard P, Rangé H
• The significance of surgically modifying soft tissue phenotype around fixed dental prostheses: An American Academy of Periodontology best evidence review.
  Journal of periodontology 2019 Lin GH, Curtis DA, Kapila Y, Velasquez D, Kan JYK, Tahir P, Avila-Ortiz G, Kao RT
• Differential expression of inflammasome regulatory transcripts in periodontal disease.
  Journal of periodontology 2019 Aral K, Berdeli E, Cooper PR, Milward MR, Kapila Y, Karadede Ünal B, Aral CA, Berdeli A
• Antibiotic prescribing practices in periodontal surgeries with and without bone grafting.
  Journal of periodontology 2019 Hai JH, Lee C, Kapila YL, Chaffee BW, Armitage GC
• Patient-Centered Risk Assessment in Implant Treatment Planning.
  The International journal of oral & maxillofacial implants 2019 Curtis DA, Lin GH, Fishman A, Sadowsky SJ, Daubert DM, Kapila Y, Sharma AB, Conte GJ, Yonemura CY, Marinello CP, Kao R
• Six-month clinical outcomes of non-surgical periodontal treatment with antibiotics on apoptosis markers in aggressive periodontitis.
  Oral diseases 2019 Aral K, Aral CA, Kapila Y
• The role of caspase-8, caspase-9, and apoptosis inducing factor in periodontal disease.
  Journal of periodontology 2018 Aral K, Aral CA, Kapila Y
• Applications of sensory and physiological measurement in oral-facial dental pain.
  Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry 2018 Dabiri D, Harper DE, Kapila Y, Kruger GH, Clauw DJ, Harte S
• Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
  Journal of clinical periodontology 2018 Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, …
• Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
  Journal of periodontology 2018 Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, …
• Effect of membrane exposure on guided bone regeneration: A systematic review and meta-analysis.
  Clinical oral implants research 2018 Garcia J, Dodge A, Luepke P, Wang HL, Kapila Y, Lin GH
• Treponema denticola increases MMP-2 expression and activation in the periodontium via reversible DNA and histone modifications.
  Cellular microbiology 2018 Ateia IM, Sutthiboonyapan P, Kamarajan P, Jin T, Godovikova V, Kapila YL, Fenno JC
• Increased Variance in Oral and Gastric Microbiome Correlates With Esophagectomy Anastomotic Leak.
  The Annals of thoracic surgery 2018 Reddy RM, Weir WB, Barnett S, Heiden BT, Orringer MB, Lin J, Chang AC, Carrott PW, Lynch WR, Beer DG, Fenno JC, Kapila Y
• Parameters to Define Peri-Implantitis: A Review and a Proposed Multi-Domain Scale.
  The Journal of oral implantology 2017 Lin GH, Kapila Y, Wang HL
• Microbial Communities Associated with Primary and Metastatic Head and Neck Squamous Cell Carcinoma - A High Fusobacterial and Low Streptococcal Signature.
  Scientific reports 2017 Shin JM, Luo T, Kamarajan P, Fenno JC, Rickard AH, Kapila YL
• High-purity Nisin Alone or in Combination with Sodium Hypochlorite Is Effective against Planktonic and Biofilm Populations of Enterococcus faecalis.
  Journal of endodontics 2017 Kajwadkar R, Shin JM, Lin GH, Fenno JC, Rickard AH, Kapila YL
• Head and Neck Squamous Cell Carcinoma Metabolism Draws on Glutaminolysis, and Stemness Is Specifically Regulated by Glutaminolysis via Aldehyde Dehydrogenase.
  Journal of proteome research 2017 Kamarajan P, Rajendiran TM, Kinchen J, Bermúdez M, Danciu T, Kapila YL
• Dental implants and grafting success remain high despite large variations in maxillary sinus mucosal thickening.
  International journal of implant dentistry 2017 Maska B, Lin GH, Othman A, Behdin S, Travan S, Benavides E, Kapila Y
• Metabolomics of Head and Neck Cancer: A Mini-Review.
  Frontiers in physiology 2016 Shin JM, Kamarajan P, Fenno JC, Rickard AH, Kapila YL
• The Role of Apoptotic Factors in Assessing Progression of Periodontal Disease.
  International journal of dentistry and oral science 2016 Dabiri D, Halubai S, Layher M, Klausner C, Makhoul H, Lin GH, Eckert G, Abuhussein H, Kamarajan P, Kapila Y
• Incidental Findings From Cone-Beam Computed Tomography During Implant Therapy.
  Clinical advances in periodontics 2016 Maska B, Othman A, Behdin S, Benavides E, Kapila Y
• Community-based assessment and intervention for early childhood caries in rural El Salvador.
  International dental journal 2016 Dabiri D, Fontana M, Kapila Y, Eckert G, Sokal-Gutierrez K
• Biomedical applications of nisin.
  Journal of applied microbiology 2016 Shin JM, Gwak JW, Kamarajan P, Fenno JC, Rickard AH, Kapila YL
• Oral Health Status of Adults in Rural Meru, Kenya
  Oral Health Dent Manag 2016 Crouch, SDzingle, JTyus, JKapila, SEber, RNdege, PKKapila, Y
• A Novel Sirtuin-3 Inhibitor, LC-0296, Inhibits Cell Survival and Proliferation, and Promotes Apoptosis of Head and Neck Cancer Cells.
  Anticancer research 2016 Alhazzazi TY, Kamarajan P, Xu Y, Ai T, Chen L, Verdin E, Kapila YL
• A Modified Shuttle Plasmid Facilitates Expression of a Flavin Mononucleotide-Based Fluorescent Protein in Treponema denticola ATCC 35405.
  Applied and environmental microbiology 2015 Godovikova V, Goetting-Minesky MP, Shin JM, Kapila YL, Rickard AH, Fenno JC
• Nisin ZP, a Bacteriocin and Food Preservative, Inhibits Head and Neck Cancer Tumorigenesis and Prolongs Survival.
  PloS one 2015 Kamarajan P, Hayami T, Matte B, Liu Y, Danciu T, Ramamoorthy A, Worden F, Kapila S, Kapila Y
• To Brazil and Back: An International Dental Student Exchange Program.
  The Journal of the Michigan Dental Association 2015 Crouch S, Farkash J, Branch A, Vasconcellos L, Veronesi G, Kapila YL
• Antimicrobial nisin acts against saliva derived multi-species biofilms without cytotoxicity to human oral cells.
  Frontiers in microbiology 2015 Shin JM, Ateia I, Paulus JR, Liu H, Fenno JC, Rickard AH, Kapila YL
• Oral health status of children in rural schools in Kithoka, Kenya
  Oral Health and Dental Management 2014 Fujawa, DTyus, JCooper, JDzingle, JKapila, SEber, RGonzalez-Cabezas, CNdege, PKPeck, MPeck, SKapila, Y
• Shedding of NG2 by MMP-13 attenuates anoikis.
  DNA and cell biology 2014 Joo NE, Miao D, Bermúdez M, Stallcup WB, Kapila YL
• Treponema denticola upregulates MMP-2 activation in periodontal ligament cells: interplay between epigenetics and periodontal infection.
  Archives of oral biology 2014 Miao D, Godovikova V, Qian X, Seshadrinathan S, Kapila YL, Fenno JC
• The student perspective: international exchange programs.
  The Journal of the Michigan Dental Association 2014 Lesch A, Pisano J, Kapila YL
• Implant success remains high despite grafting voids in the maxillary sinus.
  Clinical oral implants research 2014 Tsai CY, Garaicoa-Pazmino C, Mori K, Benavides E, Kaigler D, Kapila Y
• The role of factors associated with apoptosis in assessing periodontal disease status.
  Journal of periodontology 2013 Abuhussein H, Bashutski JD, Dabiri D, Halubai S, Layher M, Klausner C, Makhoul H, Kapila Y
• ADAM17-mediated CD44 cleavage promotes orasphere formation or stemness and tumorigenesis in HNSCC.
  Cancer medicine 2013 Kamarajan P, Shin JM, Qian X, Matte B, Zhu JY, Kapila YL
• Sirtuin-3 (SIRT3) and the Hallmarks of Cancer.
  Genes & cancer 2013 Alhazzazi TY, Kamarajan P, Verdin E, Kapila YL
• Apoptotic activity of gingival crevicular fluid from localized aggressive periodontitis.
  Journal of the International Academy of Periodontology 2013 Makhoul H, Bashutski J, Halubai S, Dabiri D, Benavides E, Kapila YL
• Nisin, an apoptogenic bacteriocin and food preservative, attenuates HNSCC tumorigenesis via CHAC1.
  Cancer medicine 2012 Joo NE, Ritchie K, Kamarajan P, Miao D, Kapila YL
• Delineating metabolic signatures of head and neck squamous cell carcinoma: phospholipase A2, a potential therapeutic target.
  The international journal of biochemistry & cell biology 2012 Tripathi P, Kamarajan P, Somashekar BS, MacKinnon N, Chinnaiyan AM, Kapila YL, Rajendiran TM, Ramamoorthy A
• Receptor-interacting protein (RIP) and Sirtuin-3 (SIRT3) are on opposite sides of anoikis and tumorigenesis.
  Cancer 2012 Kamarajan P, Alhazzazi TY, Danciu T, D'silva NJ, Verdin E, Kapila YL
• Magic angle spinning NMR-based metabolic profiling of head and neck squamous cell carcinoma tissues.
  Journal of proteome research 2011 Somashekar BS, Kamarajan P, Danciu T, Kapila YL, Chinnaiyan AM, Rajendiran TM, Ramamoorthy A
• SIRT3 and cancer: tumor promoter or suppressor?
  Biochimica et biophysica acta 2011 Alhazzazi TY, Kamarajan P, Verdin E, Kapila YL
• Divergent upstream osteogenic events contribute to the differential modulation of MG63 cell osteoblast differentiation by MMP-1 (collagenase-1) and MMP-13 (collagenase-3).
  Matrix biology : journal of the International Society for Matrix Biology 2011 Hayami T, Kapila YL, Kapila S
• Implications of cultured periodontal ligament cells for the clinical and experimental setting: a review.
  Archives of oral biology 2011 Marchesan JT, Scanlon CS, Soehren S, Matsuo M, Kapila YL
• Capturing the regenerative potential of periodontal ligament fibroblasts.
  Journal of stem cells & regenerative medicine 2011 Scanlon C, Marchesan J, Soehren S, Matsuo M, Kapila Y
• Anoikis mediators in oral squamous cell carcinoma.
  Oral diseases 2010 Bunek J, Kamarajan P, Kapila YL
• Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer.
  Cancer 2010 Alhazzazi TY, Kamarajan P, Joo N, Huang JY, Verdin E, D'Silva NJ, Kapila YL
• The Treponema denticola chymotrypsin-like protease dentilisin induces matrix metalloproteinase-2-dependent fibronectin fragmentation in periodontal ligament cells.
  Infection and immunity 2010 Miao D, Fenno JC, Timm JC, Joo NE, Kapila YL
• Parathyroid hormone mediates hematopoietic cell expansion through interleukin-6.
  PloS one 2010 Pirih FQ, Michalski MN, Cho SW, Koh AJ, Berry JE, Ghaname E, Kamarajan P, Bonnelye E, Ross CW, Kapila YL, Jurdic P, McCauley LK
• Anoikis triggers Mdm2-dependent p53 degradation.
  Molecular and cellular biochemistry 2010 Ghosh A, Chen TC, Kapila YL
• The CS1 segment of fibronectin is involved in human OSCC pathogenesis by mediating OSCC cell spreading, migration, and invasion.
  BMC cancer 2010 Kamarajan P, Garcia-Pardo A, D'Silva NJ, Kapila YL
• Calcium hydroxide promotes cementogenesis and induces cementoblastic differentiation of mesenchymal periodontal ligament cells in a CEMP1- and ERK-dependent manner.
  Calcified tissue international 2010 Paula-Silva FW, Ghosh A, Arzate H, Kapila S, da Silva LA, Kapila YL
• Proapoptotic fibronectin fragment induces the degradation of ubiquitinated p53 via proteasomes in periodontal ligament cells.
  Journal of periodontal research 2010 Ghosh A, Joo NE, Chen TC, Kapila YL
• Matrix metalloproteinase expression in teeth with apical periodontitis is differentially modulated by the modality of root canal treatment.
  Journal of endodontics 2010 Paula-Silva FW, da Silva LA, Kapila YL
• Disease-associated extracellular matrix suppresses osteoblastic differentiation of human periodontal ligament cells via MMP-1.
  Calcified tissue international 2009 Joseph J, Kapila YL, Hayami T, Kapila S
• Receptor-interacting protein shuttles between cell death and survival signaling pathways.
  Molecular biology of the cell 2009 Kamarajan P, Bunek J, Lin Y, Nunez G, Kapila YL
• Comments on atrophic lingual papillae and candidiasis in Sjögren syndrome.
  Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 2009 Daniels TE, Kapila YL
• High matrix metalloproteinase activity is a hallmark of periapical granulomas.
  Journal of endodontics 2009 de Paula-Silva FW, D'Silva NJ, da Silva LA, Kapila YL
• Multiple differentiation capacity of STRO-1+/CD146+ PDL mesenchymal progenitor cells.
  Stem cells and development 2009 Xu J, Wang W, Kapila Y, Lotz J, Kapila S
• TNF-alpha promotes an odontoblastic phenotype in dental pulp cells.
  Journal of dental research 2009 Paula-Silva FW, Ghosh A, Silva LA, Kapila YL
• Porphyromonas gingivalis, gamma interferon, and a proapoptotic fibronectin matrix form a synergistic trio that induces c-Jun N-terminal kinase 1-mediated nitric oxide generation and cell death.
  Infection and immunity 2008 Ghosh A, Park JY, Fenno C, Kapila YL
• MMP-1 (collagenase-1) and MMP-13 (collagenase-3) differentially regulate markers of osteoblastic differentiation in osteogenic cells.
  Matrix biology : journal of the International Society for Matrix Biology 2008 Hayami T, Kapila YL, Kapila S
• NG2, a novel proapoptotic receptor, opposes integrin alpha4 to mediate anoikis through PKCalpha-dependent suppression of FAK phosphorylation.
  Cell death and differentiation 2008 Joo NE, Watanabe T, Chen C, Chekenya M, Stallcup WB, Kapila YL
• An altered fibronectin matrix induces anoikis of human squamous cell carcinoma cells by suppressing integrin alpha v levels and phosphorylation of FAK and ERK.
  Apoptosis : an international journal on programmed cell death 2007 Kamarajan P, Kapila YL
• Dexamethasone's enhancement of osteoblastic markers in human periodontal ligament cells is associated with inhibition of collagenase expression.
  Bone 2006 Hayami T, Zhang Q, Kapila Y, Kapila S
• Disease-associated fibronectin matrix fragments trigger anoikis of human primary ligament cells: p53 and c-myc are suppressed.
  Apoptosis : an international journal on programmed cell death 2005 Dai R, Iwama A, Wang S, Kapila YL
• JNK1 and JNK2 oppositely regulate p53 in signaling linked to apoptosis triggered by an altered fibronectin matrix: JNK links FAK and p53.
  The Journal of biological chemistry 2005 Tafolla E, Wang S, Wong B, Leong J, Kapila YL
• Application of laser capture microdissection to phage display peptide library screening.
  Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 2004 Lu H, Jin D, Kapila YL
• Squamous cell carcinoma cell aggregates escape suspension-induced, p53-mediated anoikis: fibronectin and integrin alphav mediate survival signals through focal adhesion kinase.
  The Journal of biological chemistry 2004 Zhang Y, Lu H, Dazin P, Kapila Y
• Functional differences between integrin alpha4 and integrins alpha5/alphav in modulating the motility of human oral squamous carcinoma cells in response to the V region and heparin-binding domain of fibronectin.
  Experimental cell research 2004 Zhang Y, Lu H, Dazin P, Kapila Y
• Specific pro-apoptotic fibronectin fragments modulate proteinase expression in periodontal ligament cells.
  Journal of periodontology 2004 Jee SW, Wang S, Kapila YL
• The effect of high sugar intake on the development of periradicular lesions in rats with type 2 diabetes.
  Journal of dental research 2003 Iwama A, Nishigaki N, Nakamura K, Imaizumi I, Shibata N, Yamasaki M, Nakamura H, Kameyama Y, Kapila Y
• Ascorbic acid induces collagenase-1 in human periodontal ligament cells but not in MC3T3-E1 osteoblast-like cells: potential association between collagenase expression and changes in alkaline phosphatase phenotype.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2003 Shiga M, Kapila YL, Zhang Q, Hayami T, Kapila S
• Specific fibronectin fragments as markers of periodontal disease status.
  Journal of periodontology 2002 Huynh QN, Wang S, Tafolla E, Gansky SA, Kapila S, Armitage GC, Kapila YL
• The heparin-binding domain and V region of fibronectin regulate apoptosis by suppression of p53 and c-myc in human primary cells.
  The Journal of biological chemistry 2001 Kapila YL, Wang S, Dazin P, Tafolla E, Mass MJ
• Three-dimensional structural analysis of fibronectin heparin-binding domain mutations.
  Journal of cellular biochemistry. Supplement 2001 Kapila Y, Doan D, Tafolla E, Fletterick R
• Coordinate induction of collagenase-1, stromelysin-1 and urokinase plasminogen activator (uPA) by the 120-kDa cell-binding fibronectin fragment in fibrocartilaginous cells: uPA contributes to activation of procollagenase-1.
  Matrix biology : journal of the International Society for Matrix Biology 2000 Hu B, Kapila YL, Buddhikot M, Shiga M, Kapila S
• Mutations in the heparin binding domain of fibronectin in cooperation with the V region induce decreases in pp125(FAK) levels plus proteoglycan-mediated apoptosis via caspases.
  The Journal of biological chemistry 1999 Kapila YL, Wang S, Johnson PW
• The response of periodontal ligament cells to fibronectin.
  Journal of periodontology 1998 Kapila YL, Lancero H, Johnson PW
• The high affinity heparin-binding domain and the V region of fibronectin mediate invasion of human oral squamous cell carcinoma cells in vitro.
  The Journal of biological chemistry 1997 Kapila YL, Niu J, Johnson PW
• Cocaine-associated rapid gingival recession and dental erosion. A case report.
  Journal of periodontology 1997 Kapila YL, Kashani H
• Fibronectin and fibronectin fragments modulate the expression of proteinases and proteinase inhibitors in human periodontal ligament cells.
  Matrix biology : journal of the International Society for Matrix Biology 1996 Kapila YL, Kapila S, Johnson PW
• Oral candidiasis in Sjögren's syndrome: prevalence, clinical correlations, and treatment.
  Oral surgery, oral medicine, and oral pathology 1989 Hernandez YL, Daniels TE