Yutaka Hashimoto
Visitor
Campus Life Services
Chancellor/EVC/FAS

Education & Training

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• JSPS Fellow/ Marie Curie Foundation Fellow Gastrointestinal Cancer Bellvitge Biomedical Institute/ Catalonia Cancer Center 05/2015
• Postdoctoral Fellow/JSPS Fellow Gastrointestinal Cancer Tokyo Medical & Dental Univ. 05/2012
• PhD Gastrointestinal Cancer Tokyo Medical & Dental Univ. 03/2011
• PharmD Gastrointestinal Cancer Tokyo University of Pharmacology & Life Science 03/2006
• Postdoctoral Fellow Urological Cancer UCSF

Publications (37)

Top publication keywords:
Geriatric AssessmentDNA MethylationDeliriumRNA, Long NoncodingN-AcetylglucosaminyltransferasesProstateMAP Kinase Signaling SystemProstatic NeoplasmsCytomegalovirusMicroRNAsCadmiumCatechol O-MethyltransferaseBiomarkers, TumorGolgi ApparatusGene Expression Regulation, Neoplastic

• Cross-Species Comparison between Mouse Kidney Multi-Omics and Human Genome-Wide Association Studies Highlights Molecular Features Associated with Oxalate Nephropathy.
  Kidney360 2026 Chaya R, Taguchi K, Hashimoto Y, Shirai Y, Edahiro R, Sasa N, Yamamoto K, Tomofuji Y, Namba S, Sonehara K, Unno R, Hamamoto S, Okada A, Muroski J, Kato Y, Cristea IM, Okada Y, Yasui T
• Light- and chemical-induced ciliary signaling governs dorsal/ventral regionalization of human telencephalic organoids.
  Nature communications 2026 Shimada IS, Goto A, Hashimoto Y, Inoue H, Sugawara T, Doura T, Fujita T, Iwata T, Shimmoto R, Takase H, Itoh M, Kiyonaka S, Kato Y
• Mechanism of Delirium Risk Prediction Using the Noise Pareidolia Test.
  Geriatrics & gerontology international 2026 Hashimoto Y, Takada S, Ebihara S
• Predicting Delirium Risk in Older Adults Requiring Emergency Hospitalization: Clinical Utility of the Noise Pareidolia Test.
  Geriatrics & gerontology international 2025 Hashimoto Y, Takada S, Ebihara S
• Temporal and Sex-Dependent N-Glycosylation Dynamics in Rat Serum.
  International journal of molecular sciences 2025 Yagi H, Kondo S, Murakami R, Yogo R, Yanaka S, Umezawa F, Yagi-Utsumi M, Fujita A, Okina M, Hashimoto Y, Hotta Y, Kato Y, Nakajima K, Furukawa JI, Kato K

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• Aberrant activation of IL-6/JAK/STAT3/FOSL1 signaling induces renal abnormalities in a Xenopus model of Joubert syndrome-related disorders.
  The Journal of biological chemistry 2025 Uuganbayar U, Ninomiya H, Shimada IS, Yamada C, Kanie M, Kawai S, Asai T, Miyoshi-Akiyama T, Itoh M, Hashimoto Y, Kato Y
• The K346T mutant of GnT-III bearing weak in vitro and potent intracellular activity.
  Biochimica et biophysica acta. General subjects 2024 Hashimoto Y, Kawade H, Bao W, Morii S, Nakano M, Nagae M, Murakami R, Tokoro Y, Nakashima M, Cai Z, Isaji T, Gu J, Nakajima K, Kizuka Y
• Noise pareidolia test for predicting delirium in hospitalized older patients with cognitive decline.
  Geriatrics & gerontology international 2022 Hashimoto Y, Kano O, Ebihara S
• Cardiac proteomics reveals sex chromosome-dependent differences between males and females that arise prior to gonad formation.
  Developmental cell 2021 Shi W, Sheng X, Dorr KM, Hutton JE, Emerson JI, Davies HA, Andrade TD, Wasson LK, Greco TM, Hashimoto Y, Federspiel JD, Robbe ZL, Chen X, Arnold AP, Cristea IM, Conlon FL
• Suppressor effect of catechol-O-methyltransferase gene in prostate cancer.
  PloS one 2021 Hashimoto Y, Shiina M, Maekawa S, Kato T, Shahryari V, Kulkarni P, Dasgupta P, Yamamura S, Saini S, Tabatabai ZL, Dahiya R, Tanaka Y
• Role of miR-182/PDCD4 axis in aggressive behavior of prostate cancer in the African Americans.
  BMC cancer 2021 Shiina M, Hashimoto Y, Kulkarni P, Dasgupta P, Shahryari V, Yamamura S, Tanaka Y, Dahiya R
• A lncRNA TCL6-miR-155 Interaction Regulates the Src-Akt-EMT Network to Mediate Kidney Cancer Progression and Metastasis.
  Cancer research 2021 Kulkarni P, Dasgupta P, Hashimoto Y, Shiina M, Shahryari V, Tabatabai ZL, Yamamura S, Tanaka Y, Saini S, Dahiya R, Majid S
• Protrudin-deficient mice manifest depression-like behavior with abnormalities in activity, attention, and cued fear-conditioning.
  Molecular brain 2020 Shirane M, Shoji H, Hashimoto Y, Katagiri H, Kobayashi S, Manabe T, Miyakawa T, Nakayama KI
• Role of the PI3K/Akt pathway in cadmium induced malignant transformation of normal prostate epithelial cells.
  Toxicology and applied pharmacology 2020 Kulkarni P, Dasgupta P, Bhat NS, Hashimoto Y, Saini S, Shahryari V, Yamamura S, Shiina M, Tanaka Y, Dahiya R, Majid S
• LncRNA CDKN2B-AS1/miR-141/cyclin D network regulates tumor progression and metastasis of renal cell carcinoma.
  Cell death & disease 2020 Dasgupta P, Kulkarni P, Majid S, Hashimoto Y, Shiina M, Shahryari V, Bhat NS, Tabatabai L, Yamamura S, Saini S, Tanaka Y, Dahiya R
• Activation of the Erk/MAPK signaling pathway is a driver for cadmium induced prostate cancer.
  Toxicology and applied pharmacology 2020 Dasgupta P, Kulkarni P, Bhat NS, Majid S, Shiina M, Shahryari V, Yamamura S, Tanaka Y, Gupta RK, Dahiya R, Hashimoto Y
• Temporal dynamics of protein complex formation and dissociation during human cytomegalovirus infection.
  Nature communications 2020 Hashimoto Y, Sheng X, Murray-Nerger LA, Cristea IM
• Genistein Represses HOTAIR/Chromatin Remodeling Pathways to Suppress Kidney Cancer.
  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2020 Imai-Sumida M, Dasgupta P, Kulkarni P, Shiina M, Hashimoto Y, Shahryari V, Majid S, Tanaka Y, Dahiya R, Yamamura S
• Upregulation of miR-130b Contributes to Risk of Poor Prognosis and Racial Disparity in African-American Prostate Cancer.
  Cancer prevention research (Philadelphia, Pa.) 2019 Hashimoto Y, Shiina M, Dasgupta P, Kulkarni P, Kato T, Wong RK, Tanaka Y, Shahryari V, Maekawa S, Yamamura S, Saini S, Deng G, Tabatabai ZL, Majid S, Dahiya R
• Influence of lifestyle choices on risks of CYP1B1 polymorphisms for prostate cancer.
  Journal of cellular and molecular medicine 2018 Kato T, Hashimoto Y, Wong RK, Mitsui Y, Maekawa S, Chang I, Shahryari V, Yamamura S, Majid S, Saini S, Tabatabai ZL, Dahiya R, Deguchi T, Tanaka Y
• Elevated miR-182-5p Associates with Renal Cancer Cell Mitotic Arrest through Diminished MALAT-1 Expression.
  Molecular cancer research : MCR 2018 Kulkarni P, Dasgupta P, Bhat NS, Shahryari V, Shiina M, Hashimoto Y, Majid S, Deng G, Saini S, Tabatabai ZL, Yamamura S, Tanaka Y, Dahiya R
• MicroRNA-203 Inhibits Long Noncoding RNA HOTAIR and Regulates Tumorigenesis through Epithelial-to-mesenchymal Transition Pathway in Renal Cell Carcinoma.
  Molecular cancer therapeutics 2018 Dasgupta P, Kulkarni P, Majid S, Shahryari V, Hashimoto Y, Bhat NS, Shiina M, Deng G, Saini S, Tabatabai ZL, Yamamura S, Tanaka Y, Dahiya R
• Enhancement of transdermal protein delivery by photothermal effect of gold nanorods coated on polysaccharide-based hydrogel.
  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 2017 Haine AT, Koga Y, Hashimoto Y, Higashi T, Motoyama K, Arima H, Niidome T
• A novel microRNA regulator of prostate cancer epithelial-mesenchymal transition.
  Cell death and differentiation 2017 Bucay N, Bhagirath D, Sekhon K, Yang T, Fukuhara S, Majid S, Shahryari V, Tabatabai Z, Greene KL, Hashimoto Y, Shiina M, Yamamura S, Tanaka Y, Deng G, Dahiya R, Saini S
• The role of miR-24 as a race related genetic factor in prostate cancer.
  Oncotarget 2017 Hashimoto Y, Shiina M, Kato T, Yamamura S, Tanaka Y, Majid S, Saini S, Shahryari V, Kulkarni P, Dasgupta P, Mitsui Y, Sumida M, Deng G, Tabatabai L, Kumar D, Dahiya R
• Versican Promotes Tumor Progression, Metastasis and Predicts Poor Prognosis in Renal Carcinoma.
  Molecular cancer research : MCR 2017 Mitsui Y, Shiina H, Kato T, Maekawa S, Hashimoto Y, Shiina M, Imai-Sumida M, Kulkarni P, Dasgupta P, Wong RK, Hiraki M, Arichi N, Fukuhara S, Yamamura S, Majid S, Saini S, Deng G, Dahiya R, Nakajima K…
• Differential expression of miR-34b and androgen receptor pathway regulate prostate cancer aggressiveness between African-Americans and Caucasians.
  Oncotarget 2017 Shiina M, Hashimoto Y, Kato T, Yamamura S, Tanaka Y, Majid S, Saini S, Varahram S, Kulkarni P, Dasgupta P, Mitsui Y, Sumida M, Tabatabai L, Deng G, Kumar D, Dahiya R
• Epigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancer.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Diaz-Lagares A, Crujeiras AB, Lopez-Serra P, Soler M, Setien F, Goyal A, Sandoval J, Hashimoto Y, Martinez-Cardús A, Gomez A, Heyn H, Moutinho C, Espada J, Vidal A, Paúles M, Galán M, Sala N, Akiyama …
• Oncogenic microRNA-4534 regulates PTEN pathway in prostate cancer.
  Oncotarget 2016 Nip H, Dar AA, Saini S, Colden M, Varahram S, Chowdhary H, Yamamura S, Mitsui Y, Tanaka Y, Kato T, Hashimoto Y, Shiina M, Kulkarni P, Dasgupta P, Imai-Sumida M, Tabatabai ZL, Greene K, Deng G, Dahiya …
• Functional role and tobacco smoking effects on methylation of CYP1A1 gene in prostate cancer.
  Oncotarget 2016 Mitsui Y, Chang I, Kato T, Hashimoto Y, Yamamura S, Fukuhara S, Wong DK, Shiina M, Imai-Sumida M, Majid S, Saini S, Shiina H, Nakajima K, Deng G, Dahiya R, Tanaka Y
• DNA methylation patterns as noninvasive biomarkers and targets of epigenetic therapies in colorectal cancer.
  Epigenomics 2016 Hashimoto Y, Zumwalt TJ, Goel A
• A comprehensive DNA methylation profile of epithelial-to-mesenchymal transition.
  Cancer research 2014 Carmona FJ, Davalos V, Vidal E, Gomez A, Heyn H, Hashimoto Y, Vizoso M, Martinez-Cardus A, Sayols S, Ferreira HJ, Sánchez-Mut JV, Morán S, Margelí M, Castella E, Berdasco M, Stefansson OA, Eyfjord JE,…
• MiR-9 downregulates CDX2 expression in gastric cancer cells.
  International journal of cancer 2011 Rotkrua P, Akiyama Y, Hashimoto Y, Otsubo T, Yuasa Y
• MicroRNA-126 inhibits SOX2 expression and contributes to gastric carcinogenesis.
  PloS one 2011 Otsubo T, Akiyama Y, Hashimoto Y, Shimada S, Goto K, Yuasa Y
• miR-212 is downregulated and suppresses methyl-CpG-binding protein MeCP2 in human gastric cancer.
  International journal of cancer 2010 Wada R, Akiyama Y, Hashimoto Y, Fukamachi H, Yuasa Y
• Involvement of epigenetically silenced microRNA-181c in gastric carcinogenesis.
  Carcinogenesis 2010 Hashimoto Y, Akiyama Y, Otsubo T, Shimada S, Yuasa Y
• DNA methylation status is inversely correlated with green tea intake and physical activity in gastric cancer patients.
  International journal of cancer 2009 Yuasa Y, Nagasaki H, Akiyama Y, Hashimoto Y, Takizawa T, Kojima K, Kawano T, Sugihara K, Imai K, Nakachi K