Yue Leng, PhD
Associate Professor
Psychiatry
School of Medicine

Dr. Leng is also interested in developing behavioral sleep intervention programs in patients with mild cognitive impairment, with the ultimate goal of decreasing risk of Alzheimer’s onset or progression.

• Harnessing Brain Pathology for Dementia Prevention.
  JAMA neurology 2024 Leng Y, Yaffe K
• Association Between Sleep Quantity and Quality in Early Adulthood With Cognitive Function in Midlife.
  Neurology 2024 Leng Y, Knutson K, Carnethon MR, Yaffe K
• Causal Associations of Sleep Apnea with Alzheimer's Disease and Cardiovascular Disease: a Bidirectional Mendelian Randomization Analysis.
  medRxiv : the preprint server for health sciences 2023 Cavaillès C, Andrews SJ, Leng Y, Chatterjee A, Daghlas I, Yaffe K
• Snoring and risk of dementia: a prospective cohort and Mendelian randomization study.
  medRxiv : the preprint server for health sciences 2023 Gao Y, Andrews S, Brenowitz W, Raji CA, Yaffe K, Leng Y
• Associations of 24-Hour Light Exposure and Activity Patterns and Risk of Cognitive Impairment and Decline in Older Men: The MrOS Sleep Study.
  The journals of gerontology. Series A, Biological sciences and medical sciences 2023 Blackwell TL, Figueiro MG, Tranah GJ, Zeitzer JM, Yaffe K, Ancoli-Israel S, Kado DM, Ensrud KE, Lane NE, Leng Y, Stone KL, Osteoporotic Fractures in Men (MrOS) Study Group
• Sleep Architecture, Obstructive Sleep Apnea, and Cognitive Function in Adults.
  JAMA network open 2023 Pase MP, Harrison S, Misialek JR, Kline CE, Cavuoto M, Baril AA, Yiallourou S, Bisson A, Himali D, Leng Y, Yang Q, Seshadri S, Beiser A, Gottesman RF, Redline S, Lopez O, Lutsey PL, Yaffe K, Stone KL,…
• Lung function and risk of incident dementia: A prospective cohort study of 431,834 individuals.
  Brain, behavior, and immunity 2023 Ma YH, Shen LX, Li YZ, Leng Y, Yang L, Chen SD, He XY, Zhang YR, Chen RJ, Feng JF, Tan L, Dong Q, Suckling J, David Smith A, Cheng W, Yu JT
• Multidimensional Sleep Health and Long-Term Cognitive Decline in Community-Dwelling Older Men.
  Journal of Alzheimer's disease : JAD 2023 Cavaillès C, Yaffe K, Blackwell T, Buysse D, Stone K, Leng Y
• Race Differences in the Association Between Sleep Medication Use and Risk of Dementia.
  Journal of Alzheimer's disease : JAD 2023 Leng Y, Stone KL, Yaffe K
• Cognitive and Functional Trajectories in Older Adults With Prediagnostic Parkinson Disease.
  Neurology 2022 Bock MA, Vittinghoff E, Bahorik AL, Leng Y, Fink H, Yaffe K
• Age differences in the association between sleep and Alzheimer's disease biomarkers in the EPAD cohort.
  Alzheimer's & dementia (Amsterdam, Netherlands) 2022 Naismith SL, Leng Y, Palmer JR, Lucey BP
• Depression, Depression Treatments, and Risk of Incident Dementia: A Prospective Cohort Study of 354,313 Participants.
  Biological psychiatry 2022 Yang L, Deng YT, Leng Y, Ou YN, Li YZ, Chen SD, He XY, Wu BS, Huang SY, Zhang YR, Kuo K, Feng W, Dong Q, Feng JF, Suckling J, Smith AD, Li F, Cheng W, Yu JT
• Editorial: Current Concept and Translational Study in ALS-FTD Spectrum: From Genetics, Neuroinflammation to Neurodegeneration.
  Frontiers in molecular neuroscience 2022 Guo W, Zou ZY, Leng Y, Shen DD, Chen S
• Trans-ethnic Mendelian-randomization study reveals causal relationships between cardiometabolic factors and chronic kidney disease.
  International journal of epidemiology 2021 Zheng J, Zhang Y, Rasheed H, Walker V, Sugawara Y, Li J, Leng Y, Elsworth B, Wootton RE, Fang S, Yang Q, Burgess S, Haycock PC, Borges MC, Cho Y, Carnegie R, Howell A, Robinson J, Thomas LF, Brumpton …
• Public Willingness and Determinants of COVID-19 Vaccination at the Initial Stage of Mass Vaccination in China.
  Vaccines 2021 Zhao YM, Liu L, Sun J, Yan W, Yuan K, Zheng YB, Lu ZA, Liu L, Ni SY, Su SZ, Zhu XM, Zeng N, Gong YM, Wu P, Ran MS, Leng Y, Shi J, Shi L, Lu L, Bao YP
• Predicting incident dementia and mild cognitive impairment in older women with nonparametric analysis of circadian activity rhythms in the Study of Osteoporotic Fractures.
  Sleep 2021 Posner AB, Tranah GJ, Blackwell T, Yaffe K, Ancoli-Israel S, Redline S, Leng Y, Zeitzer JM, Chen DM, Webber KR, Stone KL
• Peripheral Clock System Abnormalities in Patients With Parkinson's Disease.
  Frontiers in aging neuroscience 2021 Li T, Cheng C, Jia C, Leng Y, Qian J, Yu H, Liu Y, Wang N, Yang Y, Al-Nusaif M, Le W
• Current Alzheimer disease research highlights: evidence for novel risk factors.
  Chinese medical journal 2021 Brenowitz WD, Xiang Y, McEvoy CT, Yang C, Yaffe K, Le WD, Leng Y
• Association between contact with a general practitioner and depressive symptoms during the COVID-19 pandemic and lockdown: a large community-based study in Hangzhou, China.
  BMJ open 2021 Yang F, Lin W, Frost E, Min Y, Xu X, Wang X, Li W, Leng Y, Zhao X, He W, Hsing AW, Zhu S
• Sleep Timing and Risk of Dementia Among the Chinese Elderly in an Urban Community: The Shanghai Aging Study.
  Frontiers in neurology 2021 Li X, Ding D, Zhao Q, Wu W, Xiao Z, Luo J, Yaffe K, Leng Y
• Grandparental care and sleep disturbances in preschool children: a population-based prospective cohort study.
  Sleep medicine 2021 Li W, Wang G, Yu Z, Ip P, Leng Y, Zhang Y, Zhao J, Zhang J, Jiang Y, Deng Y, Wu Y, Meng M, Zhu Q, Jiang F
• Pharmacological and non-pharmacological interventions to enhance sleep in mild cognitive impairment and mild Alzheimer's disease: A systematic review.
  Journal of sleep research 2020 Blackman J, Swirski M, Clynes J, Harding S, Leng Y, Coulthard E
• Sleep Duration and Cognitive Aging-Beyond a U-Shaped Association.
  JAMA network open 2020 Leng Y, Yaffe K
• Corrigendum to: Sleep duration over 28 years, cognition, gray matter volume, and white matter microstructure: a prospective cohort study.
  Sleep 2020 Zitser J, Anatürk M, Zsoldos E, Mahmood A, Filippini N, Suri S, Leng Y, Yaffe K, Singh-Manoux A, Kivimaki M, Ebmeier K, Sexton C
• Sleep duration over 28 years, cognition, gray matter volume, and white matter microstructure: a prospective cohort study.
  Sleep 2020 Zitser J, Anatürk M, Zsoldos E, Mahmood A, Filippini N, Suri S, Leng Y, Yaffe K, Singh-Manoux A, Kivimaki M, Ebmeier K, Sexton C
• Multidimensional Sleep and Mortality in Older Adults: A Machine-Learning Comparison With Other Risk Factors.
  The journals of gerontology. Series A, Biological sciences and medical sciences 2019 Wallace ML, Buysse DJ, Redline S, Stone KL, Ensrud K, Leng Y, Ancoli-Israel S, Hall MH
• To nap or not to nap: more questions than answers.
  Heart (British Cardiac Society) 2019 Leng Y, Yaffe K
• Association between earthquake experience and depression 37 years after the Tangshan earthquake: a cross-sectional study.
  BMJ open 2019 Gao X, Leng Y, Guo Y, Yang J, Cui Q, Geng B, Hu H, Zhou Y
• Cross-cultural disparities of subjective sleep parameters and their age-related trends over the first three years of human life: A systematic review and meta-analysis.
  Sleep medicine reviews 2019 Lin QM, Spruyt K, Leng Y, Jiang YR, Wang GH, Dong SM, Mei H, Jiang F
• Connections Between Insomnia and Cognitive Aging.
  Neuroscience bulletin 2019 Sexton CE, Sykara K, Karageorgiou E, Zitser J, Rosa T, Yaffe K, Leng Y
• Interventions involving a major dietary component improve cognitive function in cognitively healthy adults: a systematic review and meta-analysis.
  Nutrition research (New York, N.Y.) 2019 McEvoy CT, Leng Y, Peeters GM, Kaup AR, Allen IE, Yaffe K
• Gender differences in the relationship between alcohol consumption and insomnia in the northern Chinese population.
  PloS one 2018 Guo Y, Hu H, Liu Y, Leng Y, Gao X, Cui Q, Chen J, Geng B, Zhou Y
• Mortality risk of loneliness in the oldest old over a 10-year follow-up.
  Aging & mental health 2018 Wang H, Leng Y, Zhao E, Fleming J, Brayne C, CC75C Study Collaboration
• Excessive daytime sleepiness, objective napping and 11-year risk of Parkinson's disease in older men.
  International journal of epidemiology 2018 Leng Y, Goldman SM, Cawthon PM, Stone KL, Ancoli-Israel S, Yaffe K
• Antidepressant Use and Cognitive Outcomes in Very Old Women.
  The journals of gerontology. Series A, Biological sciences and medical sciences 2018 Leng Y, Diem SJ, Stone KL, Yaffe K
• Intracranial Aneurysm Wall Enhancement Associated with Aneurysm Rupture: A Systematic Review and Meta-analysis.
  Academic radiology 2018 Wang X, Zhu C, Leng Y, Degnan AJ, Lu J
• Corrigendum to: "Who Take Naps? Self-Reported and Objectively Measured Napping in Very Old Women".
  The journals of gerontology. Series A, Biological sciences and medical sciences 2018 Leng Y, Stone K, Ancoli-Israel S, Covinsky K, Yaffe K
• Who Take Naps? Self-Reported and Objectively Measured Napping in Very Old Women.
  The journals of gerontology. Series A, Biological sciences and medical sciences 2018 Leng Y, Stone K, Ancoli-Israel S, Covinsky K, Yaffe K
• How are age-related differences in sleep quality associated with health outcomes? An epidemiological investigation in a UK cohort of 2406 adults.
  BMJ open 2017 Gadie A, Shafto M, Leng Y, Kievit RA, Cam-CAN
• Periodic Limb Movements in Sleep are Associated with Greater Cognitive Decline in Older Men without Dementia.
  Sleep 2016 Leng Y, Blackwell T, Stone KL, Hoang TD, Redline S, Yaffe K
• A population study of the association between sleep disturbance and suicidal behaviour in people with mental illness.
  Journal of psychiatric research 2016 Stubbs B, Wu YT, Prina AM, Leng Y, Cosco TD
• Daytime napping and increased risk of incident respiratory diseases: symptom, marker, or risk factor?
  Sleep medicine 2016 Leng Y, Wainwright NW, Cappuccio FP, Surtees PG, Hayat S, Luben R, Brayne C, Khaw KT
• Daytime napping, sleep duration and increased 8-year risk of type 2 diabetes in a British population.
  Nutrition, metabolism, and cardiovascular diseases : NMCD 2016 Leng Y, Cappuccio FP, Surtees PG, Luben R, Brayne C, Khaw KT
• Daytime napping, sleep duration and serum C reactive protein: a population-based cohort study.
  BMJ open 2014 Leng Y, Ahmadi-Abhari S, Wainwright NW, Cappuccio FP, Surtees PG, Luben R, Brayne C, Khaw KT
• Self-reported sleep patterns in a British population cohort.
  Sleep medicine 2014 Leng Y, Wainwright NW, Cappuccio FP, Surtees PG, Luben R, Wareham N, Brayne C, Khaw KT
• Epidemiology of esophageal cancer in Yanting - regional report of a national screening programme in China.
  Asian Pacific journal of cancer prevention : APJCP 2013 Wang X, Fan JC, Wang AR, Leng Y, Li J, Bao Y, Wang Y, Yang QF, Ren Y
• The association between social stress and global cognitive function in a population-based study: the European Prospective Investigation into Cancer (EPIC)-Norfolk study.
  Psychological medicine 2012 Leng Y, Wainwright NW, Hayat S, Stephan BC, Matthews FE, Luben R, Surtees PG, Khaw KT, Brayne C
• Cervical cancer in Indigenous women: The case of Australia.
  Maturitas 2011 Shannon GD, Franco OH, Powles J, Leng Y, Pashayan N