Yu Zhou, PhD
Associate Professor
Anesthesia
School of Medicine

Websites

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• Profile at UCSF Cancer Center (cancer.ucsf.edu)

Grants and Projects

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• The antibody technology research center: renewable antibodies to biomedical relevant antigens, NIH/NCI, 2014-2019
• Internalizing and cross-reactive human mAbs to tumor associate antigen, ImmunoGen, Inc., 2018-2019
• Cross reactive human mAbs to tumor associated antigens, Merrimack Pharmaceuticals, Inc., 2016-2018

Publications (22)

Top publication keywords:
Antibody SpecificityProtein EngineeringAntibodies, MonoclonalSingle-Chain AntibodiesAntibodies, ViralHigh-Throughput Screening AssaysEndocytosisImmunoglobulin FragmentsAntibodiesAntigens, NeoplasmAntibody AffinityPeptide LibraryErbB ReceptorsBacteriophagesAntibodies, Neoplasm

• Antibody-mediated targeting of TNFR2 activates CD8+ T cells in mice and promotes antitumor immunity.
  Science translational medicine 2019 Tam EM, Fulton RB, Sampson JF, Muda M, Camblin A, Richards J, Koshkaryev A, Tang J, Kurella V, Jiao Y, Xu L, Zhang K, Kohli N, Luus L, Hutto E, Kumar S, Lulo J, Paragas V, Wong C, Suchy J, Grabow S, …
• Antitumour activity and tolerability of an EphA2-targeted nanotherapeutic in multiple mouse models.
  Nature biomedical engineering 2019 Kamoun WS, Kirpotin DB, Huang ZR, Tipparaju SK, Noble CO, Hayes ME, Luus L, Koshkaryev A, Kim J, Olivier K, Kornaga T, Oyama S, Askoxylakis V, Pien C, Kuesters G, Dumont N, Lugovskoy AA, Schihl SA, …
• Discovery of internalizing antibodies to basal breast cancer cells.
  Protein engineering, design & selection : PEDS 2018 Zhou Y, Zou H, Yau C, Zhao L, Hall SC, Drummond DC, Farr-Jones S, Park JW, Benz CC, Marks JD
• Neutralization of KIT Oncogenic Signaling in Leukemia with Antibodies Targeting KIT Membrane Proximal Domain 5.
  Molecular cancer therapeutics 2015 Le Gall M, Crépin R, Neiveyans M, Auclair C, Fan Y, Zhou Y, Marks JD, Pèlegrin A, Poul MA
• Immunosuppressive human anti-CD83 monoclonal antibody depletion of activated dendritic cells in transplantation.
  Leukemia 2015 Seldon TA, Pryor R, Palkova A, Jones ML, Verma ND, Findova M, Braet K, Sheng Y, Fan Y, Zhou EY, Marks JD, Munro T, Mahler SM, Barnard RT, Fromm PD, Silveira PA, Elgundi Z, Ju X, Clark GJ, Bradstock KF…

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• A fully human scFv phage display library for rapid antibody fragment reformatting.
  Protein engineering, design & selection : PEDS 2015 Li K, Zettlitz KA, Lipianskaya J, Zhou Y, Marks JD, Mallick P, Reiter RE, Wu AM
• High throughput identification of monoclonal antibodies to membrane bound and secreted proteins using yeast and phage display.
  PloS one 2014 Zhao L, Qu L, Zhou J, Sun Z, Zou H, Chen YY, Marks JD, Zhou Y
• Anti-MET immunoPET for non-small cell lung cancer using novel fully human antibody fragments.
  Molecular cancer therapeutics 2014 Li K, Tavaré R, Zettlitz KA, Mumenthaler SM, Mallick P, Zhou Y, Marks JD, Wu AM
• Identifying blood-brain-barrier selective single-chain antibody fragments.
  Biotechnology journal 2014 Jones AR, Stutz CC, Zhou Y, Marks JD, Shusta EV
• N-Terminal labeling of filamentous phage to create cancer marker imaging agents.
  ACS nano 2012 Carrico ZM, Farkas ME, Zhou Y, Hsiao SC, Marks JD, Chokhawala H, Clark DS, Francis MB
• Selection and characterization of cell binding and internalizing phage antibodies.
  Archives of biochemistry and biophysics 2012 Zhou Y, Zhao L, Marks JD
• Impact of intrinsic affinity on functional binding and biological activity of EGFR antibodies.
  Molecular cancer therapeutics 2012 Zhou Y, Goenaga AL, Harms BD, Zou H, Lou J, Conrad F, Adams GP, Schoeberl B, Nielsen UB, Marks JD
• Building and characterizing antibody-targeted lipidic nanotherapeutics.
  Methods in enzymology 2012 Kirpotin DB, Noble CO, Hayes ME, Huang Z, Kornaga T, Zhou Y, Nielsen UB, Marks JD, Drummond DC
• Discovery of internalizing antibodies to tumor antigens from phage libraries.
  Methods in enzymology 2012 Zhou Y, Marks JD
• Internalizing cancer antibodies from phage libraries selected on tumor cells and yeast-displayed tumor antigens.
  Journal of molecular biology 2010 Zhou Y, Zou H, Zhang S, Marks JD
• TSG101 exposure on the surface of HIV-1 infected cells: implications for monoclonal antibody therapy for HIV/AIDS.
  American journal of translational research 2010 Diaz L, Mao H, Zhou Y, Kohli M, Cassella J, Santos D, Fesseha Z, Weng K, Chen H, Bamba D, Marks JD, Goldblatt M, Kinch M
• An affinity matured minibody for PET imaging of prostate stem cell antigen (PSCA)-expressing tumors.
  European journal of nuclear medicine and molecular imaging 2010 Lepin EJ, Leyton JV, Zhou Y, Olafsen T, Salazar FB, McCabe KE, Hahm S, Marks JD, Reiter RE, Wu AM
• Identification of target and function specific antibodies for effective drug delivery.
  Methods in molecular biology (Clifton, N.J.) 2009 Zhou Y, Marks JD
• Development of human single-chain antibodies against SARS-associated coronavirus.
  Intervirology 2008 Leung KM, Feng DX, Lou J, Zhou Y, Fung KP, Waye MM, Tsui SK, Chan PK, Marks JD, Pang SF, Kan YW
• Identification and characterization of tumor antigens by using antibody phage display and intrabody strategies.
  Molecular immunology 2007 Goenaga AL, Zhou Y, Legay C, Bougherara H, Huang L, Liu B, Drummond DC, Kirpotin DB, Auclair C, Marks JD, Poul MA
• Impact of single-chain Fv antibody fragment affinity on nanoparticle targeting of epidermal growth factor receptor-expressing tumor cells.
  Journal of molecular biology 2007 Zhou Y, Drummond DC, Zou H, Hayes ME, Adams GP, Kirpotin DB, Marks JD
• Isolation of scFvs to in vitro produced extracellular domains of EGFR family members.
  Cancer biotherapy & radiopharmaceuticals 2005 Horak E, Heitner T, Robinson MK, Simmons HH, Garrison J, Russeva M, Furmanova P, Lou J, Zhou Y, Yuan QA, Weiner LM, Adams GP, Marks JD