Yoshinori Kohwi, PhD
Professor
Orofacial Sciences
School of Dentistry

Publications (44)

Top publication keywords:
Nucleic Acid ConformationDNA, SuperhelicalDNAThymocytesMatrix Attachment Region Binding ProteinsRepetitive Sequences, Nucleic AcidAcetaldehydeDNA-Binding ProteinsChromatin Assembly and DisassemblyPolydeoxyribonucleotidesDendritic SpinesGene Expression Regulation, DevelopmentalChromatinPlasmidsGenes, Immediate-Early

• The therapeutically actionable long non-coding RNA 'T-RECS' is essential to cancer cells' survival in NRAS/MAPK-driven melanoma.
  Molecular cancer 2024 Feichtenschlager V, Chen L, Zheng YJ, Ho W, Sanlorenzo M, Vujic I, Fewings E, Lee A, Chen C, Callanan C, Lin K, Qu T, Hohlova D, Vujic M, Hwang Y, Lai K, Chen S, Nguyen T, Muñoz DP, Kohwi Y, Posch C, …
• The therapeutically actionable long non-coding RNA 'T-RECS' is essential to cancer cells' survival in NRAS/MAPK-driven melanoma.
  Research square 2023 Feichtenschlager V, Chen L, Zheng YJ, Ho W, Sanlorenzo M, Vujic I, Fewings E, Lee A, Chen C, Callanan C, Lin K, Qu T, Hohlova D, Vujic M, Hwang Y, Lai K, Chen S, Nguyen T, Muñoz DP, Kohwi Y, Posch C, …
• Chromatin organizer SATB1 controls the cell identity of CD4+ CD8+ double-positive thymocytes by regulating the activity of super-enhancers.
  Nature communications 2022 Feng D, Chen Y, Dai R, Bian S, Xue W, Zhu Y, Li Z, Yang Y, Zhang Y, Zhang J, Bai J, Qin L, Kohwi Y, Shi W, Kohwi-Shigematsu T, Ma J, Liao S, Hao B
• SATB1 establishes ameloblast cell polarity and regulates directional amelogenin secretion for enamel formation.
  BMC biology 2019 Zhang Y, Zheng L, Le M, Nakano Y, Chan B, Huang Y, Torbaty PM, Kohwi Y, Marcucio R, Habelitz S, Den Besten PK, Kohwi-Shigematsu T
• Essential Roles of SATB1 in Specifying T Lymphocyte Subsets.
  Cell reports 2017 Kakugawa K, Kojo S, Tanaka H, Seo W, Endo TA, Kitagawa Y, Muroi S, Tenno M, Yasmin N, Kohwi Y, Sakaguchi S, Kowhi-Shigematsu T, Taniuchi I

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• Satb2 Is Required for the Development of a Spinal Exteroceptive Microcircuit that Modulates Limb Position.
  Neuron 2016 Hilde KL, Levine AJ, Hinckley CA, Hayashi M, Montgomery JM, Gullo M, Driscoll SP, Grosschedl R, Kohwi Y, Kohwi-Shigematsu T, Pfaff SL
• An anti-silencer- and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development.
  The Journal of experimental medicine 2015 Hao B, Naik AK, Watanabe A, Tanaka H, Chen L, Richards HW, Kondo M, Taniuchi I, Kohwi Y, Kohwi-Shigematsu T, Krangel MS
• Required enhancer-matrin-3 network interactions for a homeodomain transcription program.
  Nature 2014 Skowronska-Krawczyk D, Ma Q, Schwartz M, Scully K, Li W, Liu Z, Taylor H, Tollkuhn J, Ohgi KA, Notani D, Kohwi Y, Kohwi-Shigematsu T, Rosenfeld MG
• ATM suppresses SATB1-induced malignant progression in breast epithelial cells.
  PloS one 2012 Ordinario E, Han HJ, Furuta S, Heiser LM, Jakkula LR, Rodier F, Spellman PT, Campisi J, Gray JW, Bissell MJ, Kohwi Y, Kohwi-Shigematsu T
• A network of genetic repression and derepression specifies projection fates in the developing neocortex.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Srinivasan K, Leone DP, Bateson RK, Dobreva G, Kohwi Y, Kohwi-Shigematsu T, Grosschedl R, McConnell SK
• SATB1-mediated functional packaging of chromatin into loops.
  Methods (San Diego, Calif.) 2012 Kohwi-Shigematsu T, Kohwi Y, Takahashi K, Richards HW, Ayers SD, Han HJ, Cai S
• Genome organizing function of SATB1 in tumor progression.
  Seminars in cancer biology 2012 Kohwi-Shigematsu T, Poterlowicz K, Ordinario E, Han HJ, Botchkarev VA, Kohwi Y
• Satb1 ablation alters temporal expression of immediate early genes and reduces dendritic spine density during postnatal brain development.
  Molecular and cellular biology 2011 Balamotis MA, Tamberg N, Woo YJ, Li J, Davy B, Kohwi-Shigematsu T, Kohwi Y
• p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis.
  The Journal of cell biology 2011 Fessing MY, Mardaryev AN, Gdula MR, Sharov AA, Sharova TY, Rapisarda V, Gordon KB, Smorodchenko AD, Poterlowicz K, Ferone G, Kohwi Y, Missero C, Kohwi-Shigematsu T, Botchkarev VA
• Re: The role of SATB1 in breast cancer pathogenesis.
  Journal of the National Cancer Institute 2010 Kohwi-Shigematsu T, Han HJ, Russo J, Kohwi Y
• New advances in breast cancer metastasis.
  Women's health (London, England) 2008 Russo J, Han HJ, Kohwi Y, Kohwi-Shigematsu T
• SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis.
  Nature 2008 Han HJ, Russo J, Kohwi Y, Kohwi-Shigematsu T
• Identification of (CAG)(n) and (CGG)(n) repeat-binding proteins, CAGERs expressed in mature neurons of the mouse brain.
  Experimental cell research 1999 Yano H, Wang BE, Ahmad I, Zhang J, Abo T, Nakayama J, Krempen K, Kohwi Y
• Molecular characterization of a common fragile site (FRA7H) on human chromosome 7 by the cloning of a simian virus 40 integration site.
  Proceedings of the National Academy of Sciences of the United States of America 1998 Mishmar D, Rahat A, Scherer SW, Nyakatura G, Hinzmann B, Kohwi Y, Mandel-Gutfroind Y, Lee JR, Drescher B, Sas DE, Margalit H, Platzer M, Weiss A, Tsui LC, Rosenthal A, Kerem B
• Identification of base-unpairing region-binding proteins and characterization of their in vivo binding sequences.
  Methods in cell biology 1998 Kohwi-Shigematsu T, deBelle I, Dickinson LA, Galande S, Kohwi Y
• A matrix attachment region (MAR)-binding activity due to a p114 kilodalton protein is found only in human breast carcinomas and not in normal and benign breast disease tissues.
  Cancer research 1996 Yanagisawa J, Ando J, Nakayama J, Kohwi Y, Kohwi-Shigematsu T
• [Biological significance of nuclear matrix attachment regions (MAR) and tissue specific MAR-DNA binding proteins].
  Seikagaku. The Journal of Japanese Biochemical Society 1995 Kohwi Y, Kohwi-Shigematsu T
• Single-stranded DNA binding proteins isolated from mouse brain recognize specific trinucleotide repeat sequences in vitro.
  Nucleic acids research 1995 Yano-Yanagisawa H, Li Y, Wang H, Kohwi Y
• A novel DNA-binding motif in the nuclear matrix attachment DNA-binding protein SATB1.
  Molecular and cellular biology 1994 Nakagomi K, Kohwi Y, Dickinson LA, Kohwi-Shigematsu T
• The non-B-DNA structure of d(CA/TG)n differs from that of Z-DNA.
  Proceedings of the National Academy of Sciences of the United States of America 1994 Kladde MP, Kohwi Y, Kohwi-Shigematsu T, Gorski J
• A single trinucleotide, 5'AGC3'/5'GCT3', of the triplet-repeat disease genes confers metal ion-induced non-B DNA structure.
  Nucleic acids research 1993 Kohwi Y, Wang H, Kohwi-Shigematsu T
• Transcription-dependent recombination induced by triple-helix formation.
  Genes & development 1993 Kohwi Y, Panchenko Y
• Structural polymorphism of homopurine-homopyrimidine sequences at neutral pH.
  Journal of molecular biology 1993 Kohwi Y, Kohwi-Shigematsu T
• A tissue-specific MAR/SAR DNA-binding protein with unusual binding site recognition.
  Cell 1992 Dickinson LA, Joh T, Kohwi Y, Kohwi-Shigematsu T
• Intramolecular dG.dG.dC triplex detected in Escherichia coli cells.
  Journal of molecular biology 1992 Kohwi Y, Malkhosyan SR, Kohwi-Shigematsu T
• Biological significance of unwinding capability of nuclear matrix-associating DNAs.
  Science (New York, N.Y.) 1992 Bode J, Kohwi Y, Dickinson L, Joh T, Klehr D, Mielke C, Kohwi-Shigematsu T
• Detection of non-B-DNA structures at specific sites in supercoiled plasmid DNA and chromatin with haloacetaldehyde and diethyl pyrocarbonate.
  Methods in enzymology 1992 Kohwi-Shigematsu T, Kohwi Y
• Altered gene expression correlates with DNA structure.
  Genes & development 1991 Kohwi Y, Kohwi-Shigematsu T
• Detection of triple-helix related structures adopted by poly(dG)-poly(dC) sequences in supercoiled plasmid DNA.
  Nucleic acids research 1991 Kohwi-Shigematsu T, Kohwi Y
• Torsional stress stabilizes extended base unpairing in suppressor sites flanking immunoglobulin heavy chain enhancer.
  Biochemistry 1990 Kohwi-Shigematsu T, Kohwi Y
• Hierarchical binding of DNA fragments derived from scaffold-attached regions: correlation of properties in vitro and function in vivo.
  Biochemistry 1990 Mielke C, Kohwi Y, Kohwi-Shigematsu T, Bode J
• Non-B DNA structure: preferential target for the chemical carcinogen glycidaldehyde.
  Carcinogenesis 1989 Kohwi Y
• Cationic metal-specific structures adopted by the poly(dG) region and the direct repeats in the chicken adult beta A globin gene promoter.
  Nucleic acids research 1989 Kohwi Y
• Magnesium ion-dependent triple-helix structure formed by homopurine-homopyrimidine sequences in supercoiled plasmid DNA.
  Proceedings of the National Academy of Sciences of the United States of America 1988 Kohwi Y, Kohwi-Shigematsu T
• An ultimate chemical carcinogen, N-acetoxy-2-acetylaminofluorene, detects non-B DNA structures that are reactive with chloroacetaldehyde in supercoiled plasmid DNA.
  Carcinogenesis 1988 Kohwi-Shigematsu T, Scribner N, Kohwi Y
• Unusual conformational effect exerted by Z-DNA upon its neighboring sequences.
  Proceedings of the National Academy of Sciences of the United States of America 1987 Kohwi-Shigematsu T, Manes T, Kohwi Y
• Poly(dG)-poly(dC) sequences, under torsional stress, induce an altered DNA conformation upon neighboring DNA sequences.
  Cell 1985 Kohwi-Shigematsu T, Kohwi Y
• Amphipathic lipid-bound protein antigens in mouse bladder carcinomas detected by a monoclonal antibody.
  Biochemistry 1984 Kohwi Y, Hellström I, Hakomori S, Hellström KE
• Antitumor effect of Bifidobacterium infantis in mice.
  Gan 1978 Kohwi Y, Imai K, Tamura Z, Hashimoto Y