Yoshikazu Uchida, PhD
Full Professional Researcher
Dermatology
School of Medicine

Education & Training

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• Postdoctoral Studies Graduate Division University of California, San Francisco

Publications (80)

Top publication keywords:
CathelicidinsCeramidesLipid MetabolismMatrix Metalloproteinase 1Aryl Hydrocarbon Receptor Nuclear TranslocatorSphingosineKeratinocytesEpidermisSkin AgingPhosphotransferases (Alcohol Group Acceptor)Skin DiseasesSkinLysophospholipidsAntimicrobial Cationic PeptidesEndoplasmic Reticulum Stress

• Barrier Abnormalities in Type 1 Diabetes Mellitus: The Roles of Inflammation and Ceramide Metabolism.
  The Journal of investigative dermatology 2023 Shin KO, Kim B, Choi Y, Bae YJ, Park JH, Park SH, Hwang JT, Choi EH, Uchida Y, Park K
• Modulation of Aryl Hydrocarbon Receptor Can Be a Strategy to Improve Epidermal Barrier Function by Increasing Glucosylceramide Synthesis.
  The Journal of investigative dermatology 2023 Park K, Uchida Y
• The Epidermal Environment's Influence on the Dermal Environment in Response to External Stress.
  Skin pharmacology and physiology 2023 Yoshida M, Shin KO, Muraoka S, Choi Y, Park JH, Park SH, Hwang JT, Park K, Uchida Y
• Exogenous Ceramide Serves as a Precursor to Endogenous Ceramide Synthesis and as a Modulator of Keratinocyte Differentiation.
  Cells 2022 Shin KO, Mihara H, Ishida K, Uchida Y, Park K
• Euphorbia supina Extracts Block NADPH Oxidase-Mediated, Ceramide-Induced Apoptosis Initiated by Diesel Particulate Matter.
  Pharmaceuticals (Basel, Switzerland) 2022 Shin KO, Kim S, Kim B, Park HY, Jung E, Kim G, Kim D, Cho HE, Uchida Y, Park K

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• Diesel Particulate Extract Accelerates Premature Skin Aging in Human Fibroblasts via Ceramide-1-Phosphate-Mediated Signaling Pathway.
  International journal of molecular sciences 2022 Shin KO, Uchida Y, Park K
• N-Palmitoyl Serinol Stimulates Ceramide Production through a CB1-Dependent Mechanism in In Vitro Model of Skin Inflammation.
  International journal of molecular sciences 2021 Shin KO, Kim S, Park BD, Uchida Y, Park K
• Ceramides in Skin Health and Disease: An Update.
  American journal of clinical dermatology 2021 Uchida Y, Park K
• Phenotypic overlap between atopic dermatitis and autism.
  BMC neuroscience 2021 Shin KO, Crumrine DA, Kim S, Lee Y, Kim B, Abuabara K, Park C, Uchida Y, Wakefield JS, Meyer JM, Jeong S, Park BD, Park K, Elias PM
• [Pathogenic and Compensatory Mechanisms in Epidermis of Sphingomyelin Synthase 2-Deficient Mice].
  Skin pharmacology and physiology 2021 Sakai S, Makino A, Nishi A, Ichikawa T, Yamashita T, Taniguchi M, Tokudome Y, Hirabayashi Y, Akiyama M, Crumrine D, Uchida Y, Elias PM, Tsuchida T, Hamanaka S
• Cathelicidin-Related Antimicrobial Peptide Regulates CD73 Expression in Mouse Th17 Cells via p38.
  Cells 2020 Lee J, Shin KO, Kim Y, Cho J, Lim HW, Yoon SI, Lee GS, Ko HJ, Kim PH, Uchida Y, Park K, Kang SG
• A Method to Investigate the Epidermal Permeability Barrier In Vitro.
  Methods in molecular biology (Clifton, N.J.) 2020 Uchida Y, Celli A
• PPAR-γ signalling as a key mediator of human hair follicle physiology and pathology.
  Experimental dermatology 2019 Ramot Y, Bertolini M, Boboljova M, Uchida Y, Paus R
• Tissue microenvironment initiates an immune response to structural components of Staphylococcus aureus.
  Experimental dermatology 2019 Mainzer C, Packard T, Bordes S, Closs B, Greene WC, Elias PM, Uchida Y
• Insights into the role of endoplasmic reticulum stress in skin function and associated diseases.
  The FEBS journal 2019 Park K, Lee SE, Shin KO, Uchida Y
• Mutations in Recessive Congenital Ichthyoses Illuminate the Origin and Functions of the Corneocyte Lipid Envelope.
  The Journal of investigative dermatology 2018 Crumrine D, Khnykin D, Krieg P, Man MQ, Celli A, Mauro TM, Wakefield JS, Menon G, Mauldin E, Miner JH, Lin MH, Brash AR, Sprecher E, Radner FPW, Choate K, Roop D, Uchida Y, Gruber R, Schmuth M, Elias …
• Both Sphingosine Kinase 1 and 2 Coordinately Regulate Cathelicidin Antimicrobial Peptide Production during Keratinocyte Differentiation.
  The Journal of investigative dermatology 2018 Shin KO, Kim KP, Cho Y, Kang MK, Kang YH, Lee YM, Ikushiro H, Yokota M, Yano T, Choe SJ, Choi EH, Lim CJ, Park K, Holleran WM, Park K, Uchida Y
• Ginsenoside Rb1 Enhances Keratinocyte Migration by a Sphingosine-1-Phosphate-Dependent Mechanism.
  Journal of medicinal food 2018 Shin KO, Choe SJ, Uchida Y, Kim I, Jeong Y, Park K
• Naturally Occurring Hair Growth Peptide: Water-Soluble Chicken Egg Yolk Peptides Stimulate Hair Growth Through Induction of Vascular Endothelial Growth Factor Production.
  Journal of medicinal food 2018 Nakamura T, Yamamura H, Park K, Pereira C, Uchida Y, Horie N, Kim M, Itami S
• Cellular and Metabolic Basis for the Ichthyotic Phenotype in NIPAL4 (Ichthyin)-Deficient Canines.
  The American journal of pathology 2018 Mauldin EA, Crumrine D, Casal ML, Jeong S, Opálka L, Vavrova K, Uchida Y, Park K, Craiglow B, Choate KA, Shin KO, Lee YM, Grove GL, Wakefield JS, Khnykin D, Elias PM
• Topical 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition Corrects Cutaneous Features of Systemic Glucocorticoid Excess in Female Mice.
  Endocrinology 2018 Tiganescu A, Hupe M, Uchida Y, Mauro T, Elias PM, Holleran WM
• Aquatide Activation of SIRT1 Reduces Cellular Senescence through a SIRT1-FOXO1-Autophagy Axis.
  Biomolecules & therapeutics 2017 Lim CJ, Lee YM, Kang SG, Lim HW, Shin KO, Jeong SK, Huh YH, Choi S, Kor M, Seo HS, Park BD, Park K, Ahn JK, Uchida Y, Park K
• Brief Report: Interleukin-17A-Dependent Asymmetric Stem Cell Divisions Are Increased in Human Psoriasis: A Mechanism Underlying Benign Hyperproliferation.
  Stem cells (Dayton, Ohio) 2017 Charruyer A, Fong S, Vitcov GG, Sklar S, Tabernik L, Taneja M, Caputo M, Soeung C, Yue L, Uchida Y, Arron ST, Horton KM, Foster RD, Sano S, North JP, Ghadially R
• [Roles of ceramide and its metabolites in cutaneous tissues].
  Seikagaku. The Journal of Japanese Biochemical Society 2017 Uchida Y
• ER stress stimulates production of the key antimicrobial peptide, cathelicidin, by forming a previously unidentified intracellular S1P signaling complex.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Park K, Ikushiro H, Seo HS, Shin KO, Kim YI, Kim JY, Lee YM, Yano T, Holleran WM, Elias P, Uchida Y
• Sphingosine kinase 1 activation enhances epidermal innate immunity through sphingosine-1-phosphate stimulation of cathelicidin production.
  Journal of dermatological science 2015 Jeong SK, Kim YI, Shin KO, Kim BW, Lee SH, Jeon JE, Kim HJ, Lee YM, Mauro TM, Elias PM, Uchida Y, Park K
• UVB induces epidermal 11β-hydroxysteroid dehydrogenase type 1 activity in vivo.
  Experimental dermatology 2015 Tiganescu A, Hupe M, Jiang YJ, Celli A, Uchida Y, Mauro TM, Bikle DD, Elias PM, Holleran WM
• Lowered humidity produces human epidermal equivalents with enhanced barrier properties.
  Tissue engineering. Part C, Methods 2015 Sun R, Celli A, Crumrine D, Hupe M, Adame LC, Pennypacker SD, Park K, Uchida Y, Feingold KR, Elias PM, Ilic D, Mauro TM
• An endoplasmic reticulum stress-initiated sphingolipid metabolite, ceramide-1-phosphate, regulates epithelial innate immunity by stimulating β-defensin production.
  Molecular and cellular biology 2014 Kim YI, Park K, Kim JY, Seo HS, Shin KO, Lee YM, Holleran WM, Elias PM, Uchida Y
• The dietary ingredient, genistein, stimulates cathelicidin antimicrobial peptide expression through a novel S1P-dependent mechanism.
  The Journal of nutritional biochemistry 2014 Park K, Kim YI, Shin KO, Seo HS, Kim JY, Mann T, Oda Y, Lee YM, Holleran WM, Elias PM, Uchida Y
• Increased glucocorticoid activation during mouse skin wound healing.
  The Journal of endocrinology 2014 Tiganescu A, Hupe M, Uchida Y, Mauro T, Elias PM, Holleran WM
• Increased OPG/RANKL ratio in the conditioned medium of soybean-treated osteoblasts suppresses RANKL-induced osteoclast differentiation.
  International journal of molecular medicine 2013 Park K, Ju WC, Yeo JH, Kim JY, Seo HS, Uchida Y, Cho Y
• Formation and functions of the corneocyte lipid envelope (CLE).
  Biochimica et biophysica acta 2013 Elias PM, Gruber R, Crumrine D, Menon G, Williams ML, Wakefield JS, Holleran WM, Uchida Y
• Ceramide signaling in mammalian epidermis.
  Biochimica et biophysica acta 2013 Uchida Y
• Altered sphingoid base profiles predict compromised membrane structure and permeability in atopic dermatitis.
  Journal of dermatological science 2013 Loiseau N, Obata Y, Moradian S, Sano H, Yoshino S, Aburai K, Takayama K, Sakamoto K, Holleran WM, Elias PM, Uchida Y
• Local blockade of glucocorticoid activation reverses stress- and glucocorticoid-induced delays in cutaneous wound healing.
  Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2013 Youm JK, Park K, Uchida Y, Chan A, Mauro TM, Holleran WM, Elias PM
• Resveratrol stimulates sphingosine-1-phosphate signaling of cathelicidin production.
  The Journal of investigative dermatology 2013 Park K, Elias PM, Hupe M, Borkowski AW, Gallo RL, Shin KO, Lee YM, Holleran WM, Uchida Y
• Activation of TLR3 in keratinocytes increases expression of genes involved in formation of the epidermis, lipid accumulation, and epidermal organelles.
  The Journal of investigative dermatology 2013 Borkowski AW, Park K, Uchida Y, Gallo RL
• Ceramides stimulate caspase-14 expression in human keratinocytes.
  Experimental dermatology 2013 Jiang YJ, Kim P, Uchida Y, Elias PM, Bikle DD, Grunfeld C, Feingold KR
• A novel role of a lipid species, sphingosine-1-phosphate, in epithelial innate immunity.
  Molecular and cellular biology 2012 Park K, Elias PM, Shin KO, Lee YM, Hupe M, Borkowski AW, Gallo RL, Saba J, Holleran WM, Uchida Y
• Imaging mass spectrometry visualizes ceramides and the pathogenesis of dorfman-chanarin syndrome due to ceramide metabolic abnormality in the skin.
  PloS one 2012 Goto-Inoue N, Hayasaka T, Zaima N, Nakajima K, Holleran WM, Sano S, Uchida Y, Setou M
• Cannabinoid receptors 1 and 2 oppositely regulate epidermal permeability barrier status and differentiation.
  Experimental dermatology 2012 Roelandt T, Heughebaert C, Bredif S, Giddelo C, Baudouin C, Msika P, Roseeuw D, Uchida Y, Elias PM, Hachem JP
• Cellular changes that accompany shedding of human corneocytes.
  The Journal of investigative dermatology 2012 Lin TK, Crumrine D, Ackerman LD, Santiago JL, Roelandt T, Uchida Y, Hupe M, Fabriàs G, Abad JL, Rice RH, Elias PM
• GPHR-dependent functions of the Golgi apparatus are essential for the formation of lamellar granules and the skin barrier.
  The Journal of investigative dermatology 2012 Tarutani M, Nakajima K, Uchida Y, Takaishi M, Goto-Inoue N, Ikawa M, Setou M, Kinoshita T, Elias PM, Sano S, Maeda Y
• SERCA2-controlled Ca²+-dependent keratinocyte adhesion and differentiation is mediated via the sphingolipid pathway: a therapeutic target for Darier's disease.
  The Journal of investigative dermatology 2012 Celli A, Mackenzie DS, Zhai Y, Tu CL, Bikle DD, Holleran WM, Uchida Y, Mauro TM
• Regulation of cathelicidin antimicrobial peptide expression by an endoplasmic reticulum (ER) stress signaling, vitamin D receptor-independent pathway.
  The Journal of biological chemistry 2011 Park K, Elias PM, Oda Y, Mackenzie D, Mauro T, Holleran WM, Uchida Y
• Altered lipid profiles in the stratum corneum of Sjögren-Larsson syndrome.
  Journal of dermatological science 2011 Nakajima K, Sano S, Uchida Y, Akiyama M, Morita Y, Shimizu H
• The role of fatty acid elongation in epidermal structure and function.
  Dermato-endocrinology 2011 Uchida Y
• A murine model of isolated cardiac steatosis leads to cardiomyopathy.
  Hypertension (Dallas, Tex. : 1979) 2011 Glenn DJ, Wang F, Nishimoto M, Cruz MC, Uchida Y, Holleran WM, Zhang Y, Yeghiazarians Y, Gardner DG
• Physicochemical analysis of liposome membranes consisting of model lipids in the stratum corneum.
  Journal of oleo science 2011 Aburai K, Yoshino S, Sakai K, Sakai H, Abe M, Loiseau N, Holleran W, Uchida Y, Sakamoto K
• Hydrolytic pathway protects against ceramide-induced apoptosis in keratinocytes exposed to UVB.
  The Journal of investigative dermatology 2010 Uchida Y, Houben E, Park K, Douangpanya S, Lee YM, Wu BX, Hannun YA, Radin NS, Elias PM, Holleran WM
• Neutral lipid storage leads to acylceramide deficiency, likely contributing to the pathogenesis of Dorfman-Chanarin syndrome.
  The Journal of investigative dermatology 2010 Uchida Y, Cho Y, Moradian S, Kim J, Nakajima K, Crumrine D, Park K, Ujihara M, Akiyama M, Shimizu H, Holleran WM, Sano S, Elias PM
• Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing.
  The Journal of clinical investigation 2010 Bonnart C, Deraison C, Lacroix M, Uchida Y, Besson C, Robin A, Briot A, Gonthier M, Lamant L, Dubus P, Monsarrat B, Hovnanian A
• Epidermal triglyceride levels are correlated with severity of ichthyosis in Dorfman-Chanarin syndrome.
  Journal of dermatological science 2009 Ujihara M, Nakajima K, Yamamoto M, Teraishi M, Uchida Y, Akiyama M, Shimizu H, Sano S
• Murine atopic dermatitis responds to peroxisome proliferator-activated receptors alpha and beta/delta (but not gamma) and liver X receptor activators.
  The Journal of allergy and clinical immunology 2009 Hatano Y, Man MQ, Uchida Y, Crumrine D, Mauro TM, Feingold KR, Elias PM, Holleran WM
• Ceramide stimulates ABCA12 expression via peroxisome proliferator-activated receptor {delta} in human keratinocytes.
  The Journal of biological chemistry 2009 Jiang YJ, Uchida Y, Lu B, Kim P, Mao C, Akiyama M, Elias PM, Holleran WM, Grunfeld C, Feingold KR
• Maintenance of an acidic stratum corneum prevents emergence of murine atopic dermatitis.
  The Journal of investigative dermatology 2009 Hatano Y, Man MQ, Uchida Y, Crumrine D, Scharschmidt TC, Kim EG, Mauro TM, Feingold KR, Elias PM, Holleran WM
• Vitamin D receptor and coactivators SRC2 and 3 regulate epidermis-specific sphingolipid production and permeability barrier formation.
  The Journal of investigative dermatology 2008 Oda Y, Uchida Y, Moradian S, Crumrine D, Elias PM, Bikle DD
• Epidermal vascular endothelial growth factor production is required for permeability barrier homeostasis, dermal angiogenesis, and the development of epidermal hyperplasia: implications for the pathogenesis of psoriasis.
  The American journal of pathology 2008 Elias PM, Arbiser J, Brown BE, Rossiter H, Man MQ, Cerimele F, Crumrine D, Gunathilake R, Choi EH, Uchida Y, Tschachler E, Feingold KR
• Decreased ceramide transport protein (CERT) function alters sphingomyelin production following UVB irradiation.
  The Journal of biological chemistry 2008 Charruyer A, Bell SM, Kawano M, Douangpanya S, Yen TY, Macher BA, Kumagai K, Hanada K, Holleran WM, Uchida Y
• On the effects of topical synthetic pseudoceramides: comparison of possible keratinocyte toxicities provoked by the pseudoceramides, PC104 and BIO391, and natural ceramides.
  Journal of dermatological science 2008 Uchida Y, Holleran WM, Elias PM
• Omega-O-acylceramide, a lipid essential for mammalian survival.
  Journal of dermatological science 2008 Uchida Y, Holleran WM
• Characterization of a hapten-induced, murine model with multiple features of atopic dermatitis: structural, immunologic, and biochemical changes following single versus multiple oxazolone challenges.
  The Journal of investigative dermatology 2007 Man MQ, Hatano Y, Lee SH, Man M, Chang S, Feingold KR, Leung DY, Holleran W, Uchida Y, Elias PM
• Fatty acid 2-hydroxylase, encoded by FA2H, accounts for differentiation-associated increase in 2-OH ceramides during keratinocyte differentiation.
  The Journal of biological chemistry 2007 Uchida Y, Hama H, Alderson NL, Douangpanya S, Wang Y, Crumrine DA, Elias PM, Holleran WM
• Loss of functional ELOVL4 depletes very long-chain fatty acids (> or =C28) and the unique omega-O-acylceramides in skin leading to neonatal death.
  Human molecular genetics 2007 Vasireddy V, Uchida Y, Salem N, Kim SY, Mandal MN, Reddy GB, Bodepudi R, Alderson NL, Brown JC, Hama H, Dlugosz A, Elias PM, Holleran WM, Ayyagari R
• Epidermal sphingolipids: metabolism, function, and roles in skin disorders.
  FEBS letters 2006 Holleran WM, Takagi Y, Uchida Y
• Serine protease signaling of epidermal permeability barrier homeostasis.
  The Journal of investigative dermatology 2006 Hachem JP, Houben E, Crumrine D, Man MQ, Schurer N, Roelandt T, Choi EH, Uchida Y, Brown BE, Feingold KR, Elias PM
• Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis.
  Journal of lipid research 2006 Houben E, Holleran WM, Yaginuma T, Mao C, Obeid LM, Rogiers V, Takagi Y, Elias PM, Uchida Y
• Basis for improved permeability barrier homeostasis induced by PPAR and LXR activators: liposensors stimulate lipid synthesis, lamellar body secretion, and post-secretory lipid processing.
  The Journal of investigative dermatology 2006 Man MQ, Choi EH, Schmuth M, Crumrine D, Uchida Y, Elias PM, Holleran WM, Feingold KR
• Structural changes in epidermal scale and appendages as indicators of defective TGM1 activity.
  Archives of dermatological research 2005 Rice RH, Crumrine D, Uchida Y, Gruber R, Elias PM
• Activation of CYP1A1 gene expression during primary culture of mouse hepatocytes.
  Toxicology 2005 Tamaki H, Sakuma T, Uchida Y, Jaruchotikamol A, Nemoto N
• Sustained serine proteases activity by prolonged increase in pH leads to degradation of lipid processing enzymes and profound alterations of barrier function and stratum corneum integrity.
  The Journal of investigative dermatology 2005 Hachem JP, Man MQ, Crumrine D, Uchida Y, Brown BE, Rogiers V, Roseeuw D, Feingold KR, Elias PM
• A homolog of Drosophila grainy head is essential for epidermal integrity in mice.
  Science (New York, N.Y.) 2005 Ting SB, Caddy J, Hislop N, Wilanowski T, Auden A, Zhao LL, Ellis S, Kaur P, Uchida Y, Holleran WM, Elias PM, Cunningham JM, Jane SM
• Ceramide reduction and transcriptional up-regulation of glucosylceramide synthase through doxorubicin-activated Sp1 in drug-resistant HL-60/ADR cells.
  Cancer research 2004 Uchida Y, Itoh M, Taguchi Y, Yamaoka S, Umehara H, Ichikawa S, Hirabayashi Y, Holleran WM, Okazaki T
• Epidermal-specific defect of GPI anchor in Pig-a null mice results in Harlequin ichthyosis-like features.
  The Journal of investigative dermatology 2004 Hara-Chikuma M, Takeda J, Tarutani M, Uchida Y, Holleran WM, Endo Y, Elias PM, Inoue S
• Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes.
  The Journal of investigative dermatology 2004 Schmuth M, Haqq CM, Cairns WJ, Holder JC, Dorsam S, Chang S, Lau P, Fowler AJ, Chuang G, Moser AH, Brown BE, Mao-Qiang M, Uchida Y, Schoonjans K, Auwerx J, Chambon P, Willson TM, Elias PM, Feingold KR
• Structural and functional consequences of loricrin mutations in human loricrin keratoderma (Vohwinkel syndrome with ichthyosis).
  The Journal of investigative dermatology 2004 Schmuth M, Fluhr JW, Crumrine DC, Uchida Y, Hachem JP, Behne M, Moskowitz DG, Christiano AM, Feingold KR, Elias PM
• De novo ceramide synthesis participates in the ultraviolet B irradiation-induced apoptosis in undifferentiated cultured human keratinocytes.
  The Journal of investigative dermatology 2003 Uchida Y, Nardo AD, Collins V, Elias PM, Holleran WM
• Glucosylceramide synthesis and synthase expression protect against ceramide-induced stress.
  Journal of lipid research 2002 Uchida Y, Murata S, Schmuth M, Behne MJ, Lee JD, Ichikawa S, Elias PM, Hirabayashi Y, Holleran WM
• Basis for the permeability barrier abnormality in lamellar ichthyosis.
  Experimental dermatology 2002 Elias PM, Schmuth M, Uchida Y, Rice RH, Behne M, Crumrine D, Feingold KR, Holleran WM, Pharm D