Yiwey Shieh, MD
Affiliate
Surgery
School of Medicine

His current work uses clinical risk factors, breast density, and genetic variants to refine individualized risk assessment, especially as it pertains to disease biology. As a clinician-investigator, he is particularly interested in how such tools can be used to improve clinical decision-making.

• Abstract PR008: Development and testing of a polygenic risk score for breast cancer. Aggressiveness.
  Cancer Prevention Research 2023 Yiwey Shieh, Jacquelyn Roger, Christina Yau, Denise Wolf, Gillian Hirst, Lamorna Swigart, Scott Huntsman, Donglei Hu, Jovia Nierenberg, Pooja Middha, Rachel Heise, Linda Kachuri, Qianqian Zhu, Song …
• Abstract 5883: Development and testing of a polygenic risk score for proliferative breast cancers.
  Cancer Research 2022 Yiwey Shieh, Jacquelyn Roger, Scott Huntsman, Donglei Hu, Jovia L. Nierenberg, Pooja Middha Kapoor, Christina Yau, Gillian Hirst, Laura van 't Veer, Laura Esserman
• PDIA4, a novel ER stress chaperone, modulates adiponectin expression and inflammation in adipose tissue.
  BioFactors (Oxford, England) 2022 Su SC, Chien CY, Chen YC, Chiang CF, Lin FH, Kuo FC, Huang CL, Li PF, Liu JS, Lu CH, Ho LJ, Hsieh CH, Hung YJ, Shieh YS, Lee CH
• Abstract P5-19-01: The impact of streamlined processes and patient-directed messaging to improve enrollment in a remote, pragmatic clinical trial.
  Cancer Research 2022 Patricia Choy, Tomiyuri Lewis, Stephanie Flores, Leah Sabacan, Halle Thannickal, Steffanie Goodman, Yiwey Shieh, Lisa Madlensky, Jeffrey A. Tice, Elad Ziv, Martin Eklund, Amie Blanco, Barry Tong, …
• Abstract P5-19-04: The WISDOM study: Reducing sequential steps and implementing parallel workflows in pragmatic trials.
  Cancer Research 2022 Tomiyuri Lewis, Stephanie Flores, Leah Sabacan, Patricia Choy, Halle Thannickal, Yiwey Shieh, Jeffrey Tice, Elad Ziv, Lisa Madlensky, Martin Eklund, Christina Yau, Amie Blanco, Barry Tong, Deborah …
• Abstract PO-164: Pathogenic variants in breast cancer risk genes in Latinas.
  Cancer Epidemiology Biomarkers & Prevention 2022 Jovia L Nierenberg, Aaron Adamson, Yuan C. Ding, Yiwey Shieh, Donglei Hu, Scott Huntsman, Esther M. John, Gabriela Torres-Mejia, Christopher A. Haiman, Lawrence H. Kushi, Charite N. Ricker, Linda …
• A case-case analysis of women with breast cancer: predictors of interval vs screen-detected cancer.
  Breast cancer research and treatment 2021 Dreher N, Matthys M, Hadeler E, Shieh Y, Acerbi I, McAuley FM, Melisko M, Eklund M, Tice JA, Esserman LJ, Veer LJV
• The WISDOM study: a new approach to screening can and should be tested.
  Breast cancer research and treatment 2021 Esserman L, Eklund M, Veer LV, Shieh Y, Tice J, Ziv E, Blanco A, Kaplan C, Hiatt R, Fiscalini AS, Yau C, Scheuner M, Naeim A, Wenger N, Lee V, Heditsian D, Brain S, Parker BA, LaCroix AZ, Madlensky L,…
• Elevated risk thresholds predict endocrine risk-reducing medication use in the Athena screening registry.
  NPJ breast cancer 2021 Huilgol YS, Keane H, Shieh Y, Hiatt RA, Tice JA, Madlensky L, Sabacan L, Fiscalini AS, Ziv E, Acerbi I, Che M, Anton-Culver H, Borowsky AD, Hunt S, Naeim A, Parker BA, van 't Veer LJ, Athena Breast …
• Development and pilot of an online, personalized risk assessment tool for a breast cancer precision medicine trial.
  NPJ breast cancer 2021 Keane H, Huilgol YS, Shieh Y, Tice JA, Belkora J, Sepucha K, Shibley WP, Wang T, Che M, Goodman D, Ozanne E, Fiscalini AS, Esserman LJ
• Abstract OT-21-01: Personalized breast cancer screening in a population-based study: Women informed to screen depending on measures of risk (WISDOM).
  Cancer Research 2021 Irene Acerbi, Allison Stover Fiscalini, Mandy Che, Yiwey Shieh, Lisa Madlensky, Jeffrey Tice, Elad Ziv, Martin Eklund, Amie Blanco, Barry Tong, Deborah Goodman, Lamees Nassereddine, Nancy Anderson, …
• Medications for Primary Prevention of Breast Cancer.
  JAMA 2020 Shieh Y, Tice JA
• A Polygenic Risk Score for Breast Cancer in US Latinas and Latin American Women.
  Journal of the National Cancer Institute 2020 Shieh Y, Fejerman L, Lott PC, Marker K, Sawyer SD, Hu D, Huntsman S, Torres J, Echeverry M, Bohórquez ME, Martínez-Chéquer JC, Polanco-Echeverry G, Estrada-Flórez AP, COLUMBUS Consortium, Haiman CA, …
• Interval breast cancers - insights into a complex phenotype.
  Nature reviews. Clinical oncology 2020 Shieh Y, Ziv E, Kerlikowske K
• Abstract P2-10-05: A breast cancer multi-racial/ethnic polygenic risk score for improved personalized breast cancer screening.
  Cancer Research 2020 Sarah Theiner, Donglei Hu, Scott Huntsman, Yiwey Shieh, Laura Fejerman, Irene Acerbi, Sarah D Sawyer, Paige Kendall, Wei Zheng, Dezheng Huo, Olufunmilayo I Olopade, Christopher Haiman, Karla …
• Abstract P5-08-01: Breast cancer risk thresholds as a predictor of chemoprevention uptake in the Athena Breast Health Network.
  Cancer Research 2020 Yash S Huilgol, Holly Keane, Yiwey Shieh, Jeffrey Tice, Elad Ziv, Lisa Madlensky, Leah Sabacan, Irene Acerbi, Mandy Che, Allison Stover Fiscalini, Hoda Anton-Culver, Alexander D Borowsky, Sharon Hunt,…
• Abstract P5-08-23: Personalized, prevention decision aid developed for breast cancer risk-reducing discussions and interventions in the WISDOM study.
  Cancer Research 2020 Holly Keane, Yash Huilgol, W. Patrick Shibley, Yiwey Shieh, Deborah Goodman, Jeff Tice, Jeff Belkora, Karen Sepucha, Elissa Ozzane, Allison Fiscalini, Laura Esserman
• Abstract 2419: A polygenic risk score predicts breast cancer risk in Latinas.
  Epidemiology 2019 Yiwey Shieh, Laura Fejerman, Sarah D. Sawyer, Donglei Hu, Scott Huntsman, Esther M. John, Lawrence H. Kushi, Gabriela Torres-Mejia, Jeffrey N. Weitzel, Christopher A. Haiman, Elad Ziv, Susan L. …
• Abstract 3361: A prescription for new trial designs for drug development focused on the neoadjuvant setting: Save lives, resources, and time.
  Regulatory Science and Policy 2019 Andreas Karlsson, Yiwey Shieh, Andre Dempsey, Christina Yau, Angela Dmichele, Doug Yes, Laura van't Veer, Nola Hylton, Martin Eklund, Laura Esserman
• Body mass index, mammographic density, and breast cancer risk by estrogen receptor subtype.
  Breast cancer research : BCR 2019 Shieh Y, Scott CG, Jensen MR, Norman AD, Bertrand KA, Pankratz VS, Brandt KR, Visscher DW, Shepherd JA, Tamimi RM, Vachon CM, Kerlikowske K
• A response to "Personalised medicine and population health: breast and ovarian cancer".
  Human genetics 2019 Antoniou A, Anton-Culver H, Borowsky A, Broeders M, Brooks J, Chiarelli A, Chiquette J, Cuzick J, Delaloge S, Devilee P, Dorval M, Easton D, Eisen A, Eklund M, Eloy L, Esserman L, Garcia-Closas M, …
• A breast cancer risk model as a predictor of interval cancer rate and tumor characteristics.
  Journal of Clinical Oncology 2018 Nickolas Dreher, Irene Acerbi, Edward Kenji Hadeler, Yiwey Shieh, Michelle E. Melisko, Athena Investigators and Advocates, Laura Esserman, Laura van 't Veer
• Abstract P3-09-02: Risk stratification using clinical risk factors and genetic variants in a personalized screening trial.
  Poster Session Abstracts 2018 Y Shieh, E Ziv, M Eklund, L Sabacan, R Firouzian, L Madlensky, H Anton-Culver, A Borowsky, A LaCroix, A Naeim, B Parker, L van't Veer, L Esserman, J Tice
• The WISDOM Study: breaking the deadlock in the breast cancer screening debate.
  NPJ breast cancer 2017 Esserman LJ, WISDOM Study and Athena Investigators
• Joint relative risks for estrogen receptor-positive breast cancer from a clinical model, polygenic risk score, and sex hormones.
  Breast cancer research and treatment 2017 Shieh Y, Hu D, Ma L, Huntsman S, Gard CC, Leung JWT, Tice JA, Ziv E, Kerlikowske K, Cummings SR
• Low-Dose CT Scan for Lung Cancer Screening: Clinical and Coding Considerations.
  Chest 2017 Shieh Y, Bohnenkamp M
• Abstract P5-09-05: A model with polygenic risk score and mammographic density predicts interval cancers.
  Poster Session Abstracts 2017 Y Shieh, D Hu, S Huntsman, L Ma, CC Gard, JWT Leung, JA Tice, SR Cummings, K Kerlikowske, E Ziv
• Breast Cancer Screening in the Precision Medicine Era: Risk-Based Screening in a Population-Based Trial.
  Journal of the National Cancer Institute 2017 Shieh Y, Eklund M, Madlensky L, Sawyer SD, Thompson CK, Stover Fiscalini A, Ziv E, Van't Veer LJ, Esserman LJ, Tice JA, Athena Breast Health Network Investigators
• Breast cancer risk prediction using a clinical risk model and polygenic risk score.
  Breast cancer research and treatment 2016 Shieh Y, Hu D, Ma L, Huntsman S, Gard CC, Leung JW, Tice JA, Vachon CM, Cummings SR, Kerlikowske K, Ziv E
• Population-based screening for cancer: hope and hype.
  Nature reviews. Clinical oncology 2016 Shieh Y, Eklund M, Sawaya GF, Black WC, Kramer BS, Esserman LJ
• Detection of ductal carcinoma in situ and subsequent interval cancers.
  BMJ (Clinical research ed.) 2016 Shieh Y, Eklund M, Esserman L
• Impact of mammographic screening on the detection of good and poor prognosis breast cancers.
  Breast cancer research and treatment 2011 Esserman LJ, Shieh Y, Rutgers EJ, Knauer M, Retèl VP, Mook S, Glas AM, Moore DH, Linn S, van Leeuwen FE, van 't Veer LJ
• Characterizing the impact of 25 years of DCIS treatment.
  Breast cancer research and treatment 2011 Ozanne EM, Shieh Y, Barnes J, Bouzan C, Hwang ES, Esserman LJ
• Effect of screening on the detection of good and poor prognosis breast cancers.
  Journal of Clinical Oncology 2010 Y. Shieh, L. Esserman, E. J. Rutgers, M. Knauer, V. Retel, S. Mook, A. Glas, S. C. Linn, F. E. van Leeuwen, L. van't Veer
• Rethinking screening for breast cancer and prostate cancer.
  JAMA 2009 Esserman L, Shieh Y, Thompson I
• A role for biomarkers in the screening and diagnosis of breast cancer in younger women.
  Expert review of molecular diagnostics 2007 Esserman LJ, Shieh Y, Park JW, Ozanne EM