Yihua Zhu, PhD
Specialist
Radiology
School of Medicine

His work focuses on advanced image processing and analysis techniques, specifically in high-resolution peripheral quantitative computed tomography (HR-pQCT), dual-energy X-ray absorptiometry (DXA), and magnetic resonance imaging (MRI) for bone quality assessment.

Yihua earned his Ph.D. from UCSF in May 2024, where he specialized in optical imaging applications in dentistry. His doctoral research included developing a pioneering dual-wavelength short-wave infrared (SWIR) intraoral camera for early caries detection, featured in multiple NIH-funded clinical studies. Additionally, he explored optical coherence tomography (OCT) for monitoring remineralization in dental lesions and applied machine learning to enhance fluorescence-guided intraoperative therapy.

• Monitoring lesion activity on primary teeth with CP-OCT and SWIR reflectance imaging.
  Lasers in surgery and medicine 2023 Zhu Y, Kim J, Lin B, Fried D
• Active Surveillance of Root Caries in Vivo with CP-OCT.
  Diagnostics (Basel, Switzerland) 2023 Zhu Y, Kim M, Curtis D, Wang J, Le O, Fried D
• Assessment of the activity of secondary caries lesions with short-wavelength infrared, thermal, and optical coherence tomographic imaging.
  Journal of biomedical optics 2023 Chang NN, Dillas T, Zhu Y, Fried D
• Evaluating interproximal and occlusal lesion severity with a dual SWIR transillumination/reflectance probe.
  Proceedings of SPIE--the International Society for Optical Engineering 2022 Zhu Y, Fried D
• Measurement of the Depth of Lesions on Proximal Surfaces with SWIR Multispectral Transillumination and Reflectance Imaging.
  Diagnostics (Basel, Switzerland) 2022 Zhu Y, Fried D
• Compact in vivo handheld dual SWIR transillumination/reflectance imaging system for the detection of proximal and occlusal lesions.
  Proceedings of SPIE--the International Society for Optical Engineering 2021 Zhu Y, Simon J, Ng C, Fried D
• Dual short wavelength infrared transillumination/reflectance mode imaging for caries detection.
  Journal of biomedical optics 2021 Zhu Y, Abdelaziz M, Simon J, Le O, Fried D
• A SWIR imaging handpiece for the clinical assessment of lesion activity via dehydration. Preclinical Assessment.
  Proceedings of SPIE--the International Society for Optical Engineering 2020 Fried WA, Zhu Y, Yang V, Chang NY, Fried D
• A dual handheld SWIR transillumination/reflectance probe for imaging lesions on tooth occlusal and proximal surfaces.
  Proceedings of SPIE--the International Society for Optical Engineering 2020 Zhu Y, Chang NY, Fried WA, Yang V, Fried D
• SWIR, Thermal and CP-OCT imaging probes for the in vivo assessment of the activity of root caries lesions.
  Proceedings of SPIE--the International Society for Optical Engineering 2020 Chang NY, Zhu Y, Curtis D, Le O, Yang V, Fried WA, Simon JC, Banan P, Darling CL, Fried D
• Cherenkov imaging for total skin electron therapy (TSET).
  Medical physics 2019 Xie Y, Petroccia H, Maity A, Miao T, Zhu Y, Bruza P, Pogue BW, Plastaras JP, Dong L, Zhu TC
• Validation of tissue optical properties measurement using diffuse reflectance spectroscopy (DRS).
  Proceedings of SPIE--the International Society for Optical Engineering 2019 Ong YH, Zhu Y, Zhu TC