Yeyi Zhu, PhD
Associate Professor
Epidemiology & Biostatistics
School of Medicine

yeyi.zhu@ucsf.edu

Dr. Zhu’s research has been focusing on the developmental origins of cardiometabolic disease. She has sought to develop an interdisciplinary research portfolio focusing on disease etiology and prevention strategies to inform upstream prevention and interrupt the vicious intergenerational cycle of obesity, diabetes, and related comorbidities across the lifespan.

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Dr. Zhu has conducted NIH-funded research to examine the intergenerational associations of maternal hyperglycemia and environmental exposures (diet, nutrition, and endocrine disrupter chemicals) during pregnancy in relation to metabolic impairments at birth, during childhood, and in later life among women and their offspring.

Dr. Zhu’s current work also capitalizes on rich resources of real-world clinical data available at Kaiser Permanente Northern California (KPNC) to advance research on strategies for upstream prevention and disparities reduction in cardiometabolic disorders among women and children. She applies machine learning methods to develop models to predict pregnancy complications (e.g., gestational diabetes [GDM]) and treatment modalities in order to inform risk-based models of care in real-world health care settings (K12HD052163). Leveraging resources from the telemedicine program serving all women with GDM at KPNC, Dr. Zhu developed a cohort of ~30,000 individuals with GDM and identified glycemic control trajectories and examined their associations with risk of perinatal complications and childhood obesity (NIDDK P30DK092924 Pilot Program; PI: Zhu). Dr. Zhu has also been investigating the mechanisms by which the in-utero environment may infer risk of fetal growth extremes and childhood obesity (NIDDK K01DK120807; PI: Zhu). Findings may inform the ability of using metabolomics in improving objective dietary assessment and advancing the field of precision nutrition. In addition, in a population-based cohort study of ~0.5 million diverse women at KPNC, Dr. Zhu's team is examining the associations of blood pressure categories and trajectories in pregnancy with risks of perinatal and postpartum complications, and the joint impact of obesity and diabetes (R01HL157666; PI: Zhu).

Awards

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  • American Diabetes Association Pregnancy & Reproductive Health Top 25 Papers of 2022, American Diabetes Association, 2022
  • American Diabetes Association Presidents' Select Abstract, American Diabetes Association, 2021
  • President for Students and Postdocs Early Career Committee, Society for Epidemiologic Research, 2018-2019
  • EPI/lifestyle Early Investigator Travel Award, American Heart/Stroke Association, 2016
  • NIH Fellows Award for Research Excellence, National Institutes of Health, 2016
  • Society for Pediatric and Perinatal Epidemiologic Research Travel Award, Society for Pediatric and Perinatal Epidemiologic Research, 2016
  • The Epidemiology Congress of the Americas Russell Kirby Travel Scholarship, The Epidemiology Congress of the Americas, 2016
  • Publications Management Committee, American Society for Nutrition, 2015-2018
  • NIH Fellows Award for Research Excellence, National Institutes of Health, 2015
  • Intramural Research Training Award, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 2014-2016
  • Graduate School Recruitment Fellowship, The University of Texas at Austin, 2008-2009

Education & Training

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  • Postdoctoral fellowship Reproductive and Perinatal Epidemiology Eunice Kennedy Shriver National Institute of Child Health and Human Development 06/2016
  • PhD Nutritional Epidemiology The University of Texas at Austin 05/2014
  • MS Statistics The University of Texas at Austin 08/2012
  • BS Biological Sciences Fudan University 07/2008

Interests

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  • Developmental origins of cardiometabolic disease
  • Fetal growth
  • Prenatal exposure to environmental hazards
  • Clinical predictives
  • Metabolomics
  • Nutrition in critical windows of development
  • Diabetes and obesity

Grants and Projects

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Publications (118)

Top publication keywords:
Birth WeightBody Mass IndexTriclosanLife StyleFatty Acids, Omega-3Breast FeedingBlood GlucosePregnancyDiabetes, GestationalPremature BirthFetal MacrosomiaPrenatal Nutritional Physiological PhenomenaMaternal Nutritional Physiological PhenomenaPediatric ObesityPhospholipids

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