Yadong Huang, MD, PhD
Professor
Neurology
School of Medicine
Education & Training
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- Clinical Fellowship University of California, San Francisco
Grants and Projects
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- Decoding the Multifactorial Etiology of Neural Network Dysfunction in Alzheimer's Disease, NIH, 2021-2026
- Neuronal ApoE Drives Selective Neurodegeneration in Alzheimer's Disease, NIH, 2021-2026
- Study the Protective Roles of ApoE2 in Alzheimer's Disease Using Reprogrammed Isogenic Cells, NIH, 2020-2025
- ApoE Genotype-Directed Drug Repositioning and Combination Therapy for Alzheimer's Disease, NIH, 2017-2022
- Study ApoE4's Effects on Hippocampal Network Activity in Alzheimer's Disease, NIH, 2017-2022
- Modeling Alzheimer?s disease using directly reprogrammed isogenic neural cells, NIH, 2017-2022
- Roles of ApoE4 in Brain Aging and Alzheimer's Disease, NIH, 2017-2022
- Apolipoprotein E in Alzheimer's Disease: Molecular Mechanism, NIH, 2015-2020
- Studying Alzheimer's Disease Using Human iPS Cells, NIH, 2014-2019
- Optogenetic Study of ApoE4-Related Alzheimers Disease, NIH, 2014-2019
- New Approaches to Dementia Heterogeneity, NIH, 2004-2019
- Frontotemporal Dementia Induced Pluripotent Stem Cell Consortium, NIH, 2013-2017
- Proteinopathies of the Aging Central Nervous System, NIH, 2003-2013
- Apoe Expression Level Modulates Vldl Metabolism, NIH, 2000-2005
- Regulation of Apolipoprotein Synthesis, NIH, 1986-2005
Publications (97)
Top publication keywords:
NeuronsAlzheimer DiseaseGABAergic NeuronsAstrocytesMaze LearningApolipoprotein E4Memory DisordersApolipoprotein E3InterneuronsCellular ReprogrammingHippocampusDentate GyrusDendritic SpinesApolipoproteins Etau Proteins
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Apolipoprotein E and Alzheimer's Disease: Findings, Hypotheses, and Potential Mechanisms.
Annual review of pathology 2021 Koutsodendris N, Nelson MR, Rao A, Huang Y -
Early Hippocampal Sharp-Wave Ripple Deficits Predict Later Learning and Memory Impairments in an Alzheimer's Disease Mouse Model.
Cell reports 2019 Jones EA, Gillespie AK, Yoon SY, Frank LM, Huang Y -
An Alzheimer's-disease-protective APOE mutation.
Nature medicine 2019 Zalocusky KA, Nelson MR, Huang Y -
Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer's disease.
Molecular neurodegeneration 2019 Najm R, Jones EA, Huang Y -
Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector.
Nature medicine 2018 Wang C, Najm R, Xu Q, Jeong DE, Walker D, Balestra ME, Yoon SY, Yuan H, Li G, Miller ZA, Miller BL, Malloy MJ, Huang Y
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Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case-control study.
PLoS medicine 2017 Steele NZ, Carr JS, Bonham LW, Geier EG, Damotte V, Miller ZA, Desikan RS, Boehme KL, Mukherjee S, Crane PK, Kauwe JS, Kramer JH, Miller BL, Coppola G, Hollenbach JA, Huang Y, Yokoyama JS -
Approaching Alzheimer's disease from a network level.
Oncotarget 2017 Gillespie AK, Jones EA, Huang Y -
Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability.
Stem cell reports 2016 Silva MC, Cheng C, Mair W, Almeida S, Fong H, Biswas MHU, Zhang Z, Huang Y, Temple S, Coppola G, Geschwind DH, Karydas A, Miller BL, Kosik KS, Gao FB, Steen JA, Haggarty SJ -
Apolipoprotein E4 Causes Age-Dependent Disruption of Slow Gamma Oscillations during Hippocampal Sharp-Wave Ripples.
Neuron 2016 Gillespie AK, Jones EA, Lin YH, Karlsson MP, Kay K, Yoon SY, Tong LM, Nova P, Carr JS, Frank LM, Huang Y -
Pharmacological Reprogramming of Fibroblasts into Neural Stem Cells by Signaling-Directed Transcriptional Activation.
Cell stem cell 2016 Zhang M, Lin YH, Sun YJ, Zhu S, Zheng J, Liu K, Cao N, Li K, Huang Y, Ding S -
Enhancing GABA Signaling during Middle Adulthood Prevents Age-Dependent GABAergic Interneuron Decline and Learning and Memory Deficits in ApoE4 Mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Tong LM, Yoon SY, Andrews-Zwilling Y, Yang A, Lin V, Lei H, Huang Y -
Direct Reprogramming of RESTing Astrocytes.
Cell stem cell 2015 Wang C, Fong H, Huang Y -
Stem cell therapy for Alzheimer's disease and related disorders: current status and future perspectives.
Experimental & molecular medicine 2015 Tong LM, Fong H, Huang Y -
Apolipoprotein E4 produced in GABAergic interneurons causes learning and memory deficits in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Knoferle J, Yoon SY, Walker D, Leung L, Gillespie AK, Tong LM, Bien-Ly N, Huang Y -
Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases.
Neurobiology of disease 2014 Huang Y, Mahley RW -
Inhibitory interneuron progenitor transplantation restores normal learning and memory in ApoE4 knock-in mice without or with Aβ accumulation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Tong LM, Djukic B, Arnold C, Gillespie AK, Yoon SY, Wang MM, Zhang O, Knoferle J, Rubenstein JL, Alvarez-Buylla A, Huang Y -
Genetic correction of tauopathy phenotypes in neurons derived from human induced pluripotent stem cells.
Stem cell reports 2013 Fong H, Wang C, Knoferle J, Walker D, Balestra ME, Tong LM, Leung L, Ring KL, Seeley WW, Karydas A, Kshirsagar MA, Boxer AL, Kosik KS, Miller BL, Huang Y -
Greater medial temporal hypometabolism and lower cortical amyloid burden in ApoE4-positive AD patients.
Journal of neurology, neurosurgery, and psychiatry 2013 Lehmann M, Ghosh PM, Madison C, Karydas A, Coppola G, O'Neil JP, Huang Y, Miller BL, Jagust WJ, Rabinovici GD -
Cellular source-specific effects of apolipoprotein (apo) E4 on dendrite arborization and dendritic spine development.
PloS one 2013 Jain S, Yoon SY, Leung L, Knoferle J, Huang Y -
Apolipoprotein E4 causes age- and sex-dependent impairments of hilar GABAergic interneurons and learning and memory deficits in mice.
PloS one 2012 Leung L, Andrews-Zwilling Y, Yoon SY, Jain S, Ring K, Dai J, Wang MM, Tong L, Walker D, Huang Y -
Apolipoprotein e sets the stage: response to injury triggers neuropathology.
Neuron 2012 Mahley RW, Huang Y -
Small-molecule structure correctors target abnormal protein structure and function: structure corrector rescue of apolipoprotein E4-associated neuropathology.
Journal of medicinal chemistry 2012 Mahley RW, Huang Y -
Arf4 determines dentate gyrus-mediated pattern separation by regulating dendritic spine development.
PloS one 2012 Jain S, Yoon SY, Zhu L, Brodbeck J, Dai J, Walker D, Huang Y -
Arf4 determines dentate gyrus-mediated pattern separation by regulating dendritic spine development. PLoS One
Arf4 determines dentate gyrus-mediated pattern separation by regulating dendritic spine development. PLoS One. 2012 Jain S, Yoon SY, Zhu L, Brodbeck J, Dai J, Walker D, Huang Y -
Hilar GABAergic interneuron activity controls spatial learning and memory retrieval.
PloS one 2012 Andrews-Zwilling Y, Gillespie AK, Kravitz AV, Nelson AB, Devidze N, Lo I, Yoon SY, Bien-Ly N, Ring K, Zwilling D, Potter GB, Rubenstein JL, Kreitzer AC, Huang Y -
Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor.
Cell stem cell 2012 Ring KL, Tong LM, Balestra ME, Javier R, Andrews-Zwilling Y, Li G, Walker D, Zhang WR, Kreitzer AC, Huang Y -
ApoE and TDP-43 neuropathology in two siblings with familial FTLD-motor neuron disease.
Neurocase 2012 Vossel KA, Bien-Ly N, Bernardo A, Rascovsky K, Karydas A, Rabinovici GD, Sidhu M, Huang EJ, Miller BL, Huang Y, Seeley WW -
Reducing human apolipoprotein E levels attenuates age-dependent Aβ accumulation in mutant human amyloid precursor protein transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Bien-Ly N, Gillespie AK, Walker D, Yoon SY, Huang Y -
Alzheimer mechanisms and therapeutic strategies.
Cell 2012 Huang Y, Mucke L -
Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons.
The Journal of biological chemistry 2011 Chen HK, Liu Z, Meyer-Franke A, Brodbeck J, Miranda RD, McGuire JG, Pleiss MA, Ji ZS, Balestra ME, Walker DW, Xu Q, Jeong DE, Budamagunta MS, Voss JC, Freedman SB, Weisgraber KH, Huang Y, Mahley RW -
Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: lessons from ApoE mouse models.
Biochemical Society transactions 2011 Huang Y -
Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration.
Cell 2011 Zwilling D, Huang SY, Sathyasaikumar KV, Notarangelo FM, Guidetti P, Wu HQ, Lee J, Truong J, Andrews-Zwilling Y, Hsieh EW, Louie JY, Wu T, Scearce-Levie K, Patrick C, Adame A, Giorgini F, Moussaoui S,… -
Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors.
The Journal of biological chemistry 2011 Brodbeck J, McGuire J, Liu Z, Meyer-Franke A, Balestra ME, Jeong DE, Pleiss M, McComas C, Hess F, Witter D, Peterson S, Childers M, Goulet M, Liverton N, Hargreaves R, Freedman S, Weisgraber KH, … -
C-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid-beta (Abeta) and acts in concert with Abeta to elicit neuronal and behavioral deficits in mice.
Proceedings of the National Academy of Sciences of the United States of America 2011 Bien-Ly N, Andrews-Zwilling Y, Xu Q, Bernardo A, Wang C, Huang Y -
Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease.
The Journal of biological chemistry 2010 Chen HK, Ji ZS, Dodson SE, Miranda RD, Rosenblum CI, Reynolds IJ, Freedman SB, Weisgraber KH, Huang Y, Mahley RW -
Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Andrews-Zwilling Y, Bien-Ly N, Xu Q, Li G, Bernardo A, Yoon SY, Zwilling D, Yan TX, Chen L, Huang Y -
Mechanisms linking apolipoprotein E isoforms with cardiovascular and neurological diseases.
Current opinion in lipidology 2010 Huang Y -
Cellular source of apolipoprotein E4 determines neuronal susceptibility to excitotoxic injury in transgenic mice.
The American journal of pathology 2010 Buttini M, Masliah E, Yu GQ, Palop JJ, Chang S, Bernardo A, Lin C, Wyss-Coray T, Huang Y, Mucke L -
Abeta-independent roles of apolipoprotein E4 in the pathogenesis of Alzheimer's disease.
Trends in molecular medicine 2010 Huang Y -
GABAergic interneuron dysfunction impairs hippocampal neurogenesis in adult apolipoprotein E4 knockin mice.
Cell stem cell 2009 Li G, Bien-Ly N, Andrews-Zwilling Y, Xu Q, Bernardo A, Ring K, Halabisky B, Deng C, Mahley RW, Huang Y -
Bioactive TGF-beta can associate with lipoproteins and is enriched in those containing apolipoprotein E3.
Journal of neurochemistry 2009 Tesseur I, Zhang H, Brecht W, Corn J, Gong JS, Yanagisawa K, Michikawa M, Weisgraber K, Huang Y, Wyss-Coray T -
Alzheimer disease: multiple causes, multiple effects of apolipoprotein E4, and multiple therapeutic approaches.
Annals of neurology 2009 Mahley RW, Huang Y -
Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS.
Journal of lipid research 2008 Mahley RW, Weisgraber KH, Huang Y -
Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression.
Proceedings of the National Academy of Sciences of the United States of America 2008 Burt TD, Agan BK, Marconi VC, He W, Kulkarni H, Mold JE, Cavrois M, Huang Y, Mahley RW, Dolan MJ, McCune JM, Ahuja SK -
Intron-3 retention/splicing controls neuronal expression of apolipoprotein E in the CNS.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Xu Q, Walker D, Bernardo A, Brodbeck J, Balestra ME, Huang Y -
Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons.
Proceedings of the National Academy of Sciences of the United States of America 2008 Brodbeck J, Balestra ME, Saunders AM, Roses AD, Mahley RW, Huang Y -
Detrimental effects of apolipoprotein E4: potential therapeutic targets in Alzheimer's disease.
Current Alzheimer research 2007 Mahley RW, Huang Y, Weisgraber KH -
Atherogenic remnant lipoproteins: role for proteoglycans in trapping, transferring, and internalizing.
The Journal of clinical investigation 2007 Mahley RW, Huang Y -
Molecular and cellular mechanisms of apolipoprotein E4 neurotoxicity and potential therapeutic strategies.
Current opinion in drug discovery & development 2006 Huang Y -
Complex disease-associated pharmacogenetics: drug efficacy, drug safety, and confirmation of a pathogenetic hypothesis (Alzheimer's disease).
The pharmacogenomics journal 2006 Roses AD, Saunders AM, Huang Y, Strum J, Weisgraber KH, Mahley RW -
Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 Xu Q, Bernardo A, Walker D, Kanegawa T, Mahley RW, Huang Y -
Putting cholesterol in its place: apoE and reverse cholesterol transport.
The Journal of clinical investigation 2006 Mahley RW, Huang Y, Weisgraber KH -
Commentary on "Perspective on a pathogenesis and treatment of Alzheimer's disease." Apolipoprotein E and the mitochondrial metabolic hypothesis.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2006 Huang Y, Mahley RW -
Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2006 Mahley RW, Weisgraber KH, Huang Y -
Apolipoprotein E and Alzheimer disease.
Neurology 2006 Huang Y -
Apolipoprotein (apo) E4 and Alzheimer's disease: unique conformational and biophysical properties of apoE4 can modulate neuropathology.
Acta neurologica Scandinavica. Supplementum 2006 Mahley RW, Huang Y -
Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target.
Proceedings of the National Academy of Sciences of the United States of America 2005 Ye S, Huang Y, Müllendorff K, Dong L, Giedt G, Meng EC, Cohen FE, Kuntz ID, Weisgraber KH, Mahley RW -
Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity.
Proceedings of the National Academy of Sciences of the United States of America 2005 Chang S, ran Ma T, Miranda RD, Balestra ME, Mahley RW, Huang Y -
Reactivity of apolipoprotein E4 and amyloid beta peptide: lysosomal stability and neurodegeneration.
The Journal of biological chemistry 2005 Ji ZS, Müllendorff K, Cheng IH, Miranda RD, Huang Y, Mahley RW -
Effect of domain interaction on apolipoprotein E levels in mouse brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005 Ramaswamy G, Xu Q, Huang Y, Weisgraber KH -
Apolipoprotein A-V: a potential modulator of plasma triglyceride levels in Turks.
Journal of lipid research 2005 Hodoglugil U, Tanyolaç S, Williamson DW, Huang Y, Mahley RW -
Common polymorphisms of ATP binding cassette transporter A1, including a functional promoter polymorphism, associated with plasma high density lipoprotein cholesterol levels in Turks.
Atherosclerosis 2005 Hodoglugil U, Williamson DW, Huang Y, Mahley RW -
Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc.
The Journal of biological chemistry 2004 Harris FM, Brecht WJ, Xu Q, Mahley RW, Huang Y -
ApoE genotype accounts for the vast majority of AD risk and AD pathology.
Neurobiology of aging 2004 Raber J, Huang Y, Ashford JW -
Apolipoprotein E4 domain interaction occurs in living neuronal cells as determined by fluorescence resonance energy transfer.
The Journal of biological chemistry 2004 Xu Q, Brecht WJ, Weisgraber KH, Mahley RW, Huang Y -
Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004 Brecht WJ, Harris FM, Chang S, Tesseur I, Yu GQ, Xu Q, Dee Fish J, Wyss-Coray T, Buttini M, Mucke L, Mahley RW, Huang Y -
Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease.
Journal of molecular neuroscience : MN 2004 Huang Y, Weisgraber KH, Mucke L, Mahley RW -
Astroglial regulation of apolipoprotein E expression in neuronal cells. Implications for Alzheimer's disease.
The Journal of biological chemistry 2003 Harris FM, Tesseur I, Brecht WJ, Xu Q, Mullendorff K, Chang S, Wyss-Coray T, Mahley RW, Huang Y -
Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 2003 Harris FM, Brecht WJ, Xu Q, Tesseur I, Kekonius L, Wyss-Coray T, Fish JD, Masliah E, Hopkins PC, Scearce-Levie K, Weisgraber KH, Mucke L, Mahley RW, Huang Y -
Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002 Buttini M, Yu GQ, Shockley K, Huang Y, Jones B, Masliah E, Mallory M, Yeo T, Longo FM, Mucke L -
Evidence for differential effects of apoE3 and apoE4 on HDL metabolism.
Journal of lipid research 2002 Hopkins PC, Huang Y, McGuire JG, Pitas RE -
Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells.
The Journal of biological chemistry 2002 Ji ZS, Miranda RD, Newhouse YM, Weisgraber KH, Huang Y, Mahley RW -
Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons.
Proceedings of the National Academy of Sciences of the United States of America 2001 Huang Y, Liu XQ, Wyss-Coray T, Brecht WJ, Sanan DA, Mahley RW -
Endogenous apolipoprotein E modulates cholesterol efflux and cholesteryl ester hydrolysis mediated by high-density lipoprotein-3 and lipid-free apolipoproteins in mouse peritoneal macrophages.
Journal of molecular medicine (Berlin, Germany) 2000 Langer C, Huang Y, Cullen P, Wiesenhütter B, Mahley RW, Assmann G, von Eckardstein A -
Overexpression of apolipoprotein E3 in transgenic rabbits causes combined hyperlipidemia by stimulating hepatic VLDL production and impairing VLDL lipolysis.
Arteriosclerosis, thrombosis, and vascular biology 1999 Huang Y, Ji ZS, Brecht WJ, Rall SC, Taylor JM, Mahley RW -
Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia). Questions, quandaries, and paradoxes.
Journal of lipid research 1999 Mahley RW, Huang Y, Rall SC -
Apolipoprotein E: from atherosclerosis to Alzheimer's disease and beyond.
Current opinion in lipidology 1999 Mahley RW, Huang Y -
Overexpression and accumulation of apolipoprotein E as a cause of hypertriglyceridemia.
The Journal of biological chemistry 1998 Huang Y, Liu XQ, Rall SC, Taylor JM, von Eckardstein A, Assmann G, Mahley RW -
Apolipoprotein E2 reduces the low density lipoprotein level in transgenic mice by impairing lipoprotein lipase-mediated lipolysis of triglyceride-rich lipoproteins.
The Journal of biological chemistry 1998 Huang Y, Liu XQ, Rall SC, Mahley RW -
Increased expression of apolipoprotein E in transgenic rabbits results in reduced levels of very low density lipoproteins and an accumulation of low density lipoproteins in plasma.
The Journal of clinical investigation 1998 Fan J, Ji ZS, Huang Y, de Silva H, Sanan D, Mahley RW, Innerarity TL, Taylor JM -
Lipid-free apolipoprotein (apo) A-I is converted into alpha-migrating high density lipoproteins by lipoprotein-depleted plasma of normolipidemic donors and apo A-I-deficient patients but not of Tangier disease patients.
Atherosclerosis 1998 von Eckardstein A, Huang Y, Kastelein JJ, Geisel J, Real JT, Kuivenhoven JA, Miccoli R, Noseda G, Assmann G -
Genetic factors precipitating type III hyperlipoproteinemia in hypolipidemic transgenic mice expressing human apolipoprotein E2.
Arteriosclerosis, thrombosis, and vascular biology 1997 Huang Y, Rall SC, Mahley RW -
Effects of genotype and diet on cholesterol efflux into plasma and lipoproteins of normal, apolipoprotein A-I-, and apolipoprotein E-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology 1997 Huang Y, Zhu Y, Langer C, Raabe M, Wu S, Wiesenhütter B, Seedorf U, Maeda N, Assmann G, von Eckardstein A -
Apolipoprotein E2 transgenic rabbits. Modulation of the type III hyperlipoproteinemic phenotype by estrogen and occurrence of spontaneous atherosclerosis.
The Journal of biological chemistry 1997 Huang Y, Schwendner SW, Rall SC, Sanan DA, Mahley RW -
A natural apolipoprotein A-I variant, apoA-I (L141R)Pisa, interferes with the formation of alpha-high density lipoproteins (HDL) but not with the formation of pre beta 1-HDL and influences efflux of cholesterol into plasma.
Journal of lipid research 1997 Miccoli R, Zhu Y, Daum U, Wessling J, Huang Y, Navalesi R, Assmann G, von Eckardstein A -
Hypolipidemic and hyperlipidemic phenotypes in transgenic mice expressing human apolipoprotein E2.
The Journal of biological chemistry 1996 Huang Y, Schwendner SW, Rall SC, Mahley RW -
High-density lipoprotein cholesterol as a predictor of coronary heart disease risk. The PROCAM experience and pathophysiological implications for reverse cholesterol transport.
Atherosclerosis 1996 Assmann G, Schulte H, von Eckardstein A, Huang Y -
Phospholipid transfer protein mediated conversion of high density lipoproteins generates pre beta 1-HDL.
Biochimica et biophysica acta 1996 von Eckardstein A, Jauhiainen M, Huang Y, Metso J, Langer C, Pussinen P, Wu S, Ehnholm C, Assmann G -
Uptake, transfer, and esterification of cell-derived cholesterol in plasma of patients with familial HDL-deficiency.
Zeitschrift fur Gastroenterologie 1996 von Eckardstein A, Huang Y, Wu S, Assmann G -
Effects of the apolipoprotein E polymorphism on uptake and transfer of cell-derived cholesterol in plasma.
The Journal of clinical investigation 1995 Huang Y, von Eckardstein A, Wu S, Assmann G -
Generation of pre-beta 1-HDL and conversion into alpha-HDL. Evidence for disturbed HDL conversion in Tangier disease.
Arteriosclerosis, thrombosis, and vascular biology 1995 Huang Y, von Eckardstein A, Wu S, Langer C, Assmann G -
Lipoproteins containing apolipoprotein A-IV but not apolipoprotein A-I take up and esterify cell-derived cholesterol in plasma.
Arteriosclerosis, thrombosis, and vascular biology 1995 von Eckardstein A, Huang Y, Wu S, Sarmadi AS, Schwarz S, Steinmetz A, Assmann G -
Cholesterol efflux, cholesterol esterification, and cholesteryl ester transfer by LpA-I and LpA-I/A-II in native plasma.
Arteriosclerosis, thrombosis, and vascular biology 1995 Huang Y, von Eckardstein A, Wu S, Assmann G -
Reverse cholesterol transport in plasma of patients with different forms of familial HDL deficiency.
Arteriosclerosis, thrombosis, and vascular biology 1995 von Eckardstein A, Huang Y, Wu S, Funke H, Noseda G, Assmann G -
Physiological role and clinical relevance of high-density lipoprotein subclasses.
Current opinion in lipidology 1994 von Eckardstein A, Huang Y, Assmann G -
A plasma lipoprotein containing only apolipoprotein E and with gamma mobility on electrophoresis releases cholesterol from cells.
Proceedings of the National Academy of Sciences of the United States of America 1994 Huang Y, von Eckardstein A, Wu S, Maeda N, Assmann G -
Cell-derived unesterified cholesterol cycles between different HDLs and LDL for its effective esterification in plasma.
Arteriosclerosis and thrombosis : a journal of vascular biology 1993 Huang Y, von Eckardstein A, Assmann G