Xin Duan, PhD
Associate Professor
Ophthalmology
School of Medicine
Awards
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- Kavli Neuroscience Institute Collaborative Award, Kavli Institute for Fundamental Neuroscience, 2020-2021
- Catalyst for a Cure Team Award (CFC3), Glaucoma Research Foundation, 2019-2025
- Klingenstein-Simons Neuroscience Fellowship, The Klingenstein Foundation, 2018-2021
- Whitehall Neuroscience Scholarship, Whitehall Foundation, 2018-2021
- Career Development Award, Research to Prevent Blindness, 2017-2020
- Trailblazer Award in Neuroscience, UCSF Weill Institute of Neuroscience, 2017-2018
- HHMI-LSRF Fellowship, Life Science Research Foundation, 2010-2013
- Young Investigator Award, Johns Hopkins University School of Medicine, 2008
- Graduation with Highest Honor, Tsinghua University, 2002
Education & Training
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- Diversity, Equity and Inclusion Training UCSF 06/2022
- Postdoc Neuroscience Harvard University 12/2016
- Ph.D. Neuroscience Johns Hopkins University 12/2008
- B.S. Biological Sciences Tsinghua University 07/2002
Interests
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- aging in CNS
- axon regeneration
- synapse formation
- retinal ganglion cell
- Cadherins
- spatial transcriptomics
- neural development
- experimental glaucoma
Grants and Projects
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Publications (26)
Top publication keywords:
Optic Nerve InjuriesDendritesRetinal Ganglion CellsRetinal NeuronsOptic Nerve DiseasesRetinaAxonsCadherinsRetinal Bipolar CellsNerve RegenerationSynapsesGlaucomaOsteopontinSuperior ColliculiVisual Pathways
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Live, die, or regenerate? New insights from multi-omic analyses.
Neuron 2022 Tsai NY, Welsbie DS, Duan X -
Trans-Seq maps a selective mammalian retinotectal synapse instructed by Nephronectin.
Nature neuroscience 2022 Tsai NY, Wang F, Toma K, Yin C, Takatoh J, Pai EL, Wu K, Matcham AC, Yin L, Dang EJ, Marciano DK, Rubenstein JL, Wang F, Ullian EM, Duan X -
Cadherin Combinations Recruit Dendrites of Distinct Retinal Neurons to a Shared Interneuronal Scaffold.
Neuron 2018 Duan X, Krishnaswamy A, Laboulaye MA, Liu J, Peng YR, Yamagata M, Toma K, Sanes JR -
Subtype-specific regeneration of retinal ganglion cells following axotomy: effects of osteopontin and mTOR signaling.
Neuron 2015 Duan X, Qiao M, Bei F, Kim IJ, He Z, Sanes JR -
Type II cadherins guide assembly of a direction-selective retinal circuit.
Cell 2014 Duan X, Krishnaswamy A, De la Huerta I, Sanes JR -
Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain.
Cell 2007 Duan X, Chang JH, Ge S, Faulkner RL, Kim JY, Kitabatake Y, Liu XB, Yang CH, Jordan JD, Ma DK, Liu CY, Ganesan S, Cheng HJ, Ming GL, Lu B, Song H
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Cadherin-13 Maintains Retinotectal Synapses via Transneuronal Interactions.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2024 Matcham AC, Toma K, Tsai NY, Sze CJ, Lin PY, Stewart IF, Duan X -
Osteopontin drives retinal ganglion cell resiliency in glaucomatous optic neuropathy.
Cell reports 2023 Zhao M, Toma K, Kinde B, Li L, Patel AK, Wu KY, Lum MR, Tan C, Hooper JE, Kriegstein AR, La Torre A, Liao YJ, Welsbie DS, Hu Y, Han Y, Duan X -
Postsynaptic neuronal activity promotes regeneration of retinal axons.
Cell reports 2023 Varadarajan SG, Wang F, Dhande OS, Le P, Duan X, Huberman AD -
Coordinated cadherin functions sculpt respiratory motor circuit connectivity.
eLife 2022 Vagnozzi AN, Moore MT, Lin M, Brozost EM, Kc R, Agarwal A, Schwarz LA, Duan X, Zampieri N, Landmesser LT, Philippidou P -
Longitudinal in vivo Ca2+ imaging reveals dynamic activity changes of diseased retinal ganglion cells at the single-cell level.
Proceedings of the National Academy of Sciences of the United States of America 2022 Li L, Feng X, Fang F, Miller DA, Zhang S, Zhuang P, Huang H, Liu P, Liu J, Sredar N, Liu L, Sun Y, Duan X, Goldberg JL, Zhang HF, Hu Y -
Solving neurodegeneration: common mechanisms and strategies for new treatments.
Molecular neurodegeneration 2022 Wareham LK, Liddelow SA, Temple S, Benowitz LI, Di Polo A, Wellington C, Goldberg JL, He Z, Duan X, Bu G, Davis AA, Shekhar K, Torre A, Chan DC, Canto-Soler MV, Flanagan JG, Subramanian P, Rossi S, … -
Oestrogen engages brain MC4R signalling to drive physical activity in female mice.
Nature 2021 Krause WC, Rodriguez R, Gegenhuber B, Matharu N, Rodriguez AN, Padilla-Roger AM, Toma K, Herber CB, Correa SM, Duan X, Ahituv N, Tollkuhn J, Ingraham HA -
Inhibition of GCK-IV kinases dissociates cell death and axon regeneration in CNS neurons.
Proceedings of the National Academy of Sciences of the United States of America 2020 Patel AK, Broyer RM, Lee CD, Lu T, Louie MJ, La Torre A, Al-Ali H, Vu MT, Mitchell KL, Wahlin KJ, Berlinicke CA, Jaskula-Ranga V, Hu Y, Duan X, Vilar S, Bixby JL, Weinreb RN, Lemmon VP, Zack DJ, … -
Molecular mechanisms regulating synaptic specificity and retinal circuit formation.
Wiley interdisciplinary reviews. Developmental biology 2020 Graham HK, Duan X -
Mapping Transgene Insertion Sites Reveals Complex Interactions Between Mouse Transgenes and Neighboring Endogenous Genes.
Frontiers in molecular neuroscience 2018 Laboulaye MA, Duan X, Qiao M, Whitney IE, Sanes JR -
Cadherins Interact With Synaptic Organizers to Promote Synaptic Differentiation.
Frontiers in molecular neuroscience 2018 Yamagata M, Duan X, Sanes JR -
Heterophilic Type II Cadherins Are Required for High-Magnitude Synaptic Potentiation in the Hippocampus.
Neuron 2017 Basu R, Duan X, Taylor MR, Martin EA, Muralidhar S, Wang Y, Gangi-Wellman L, Das SC, Yamagata M, West PJ, Sanes JR, Williams ME -
Diverse Central Projection Patterns of Retinal Ganglion Cells.
Cell reports 2017 Martersteck EM, Hirokawa KE, Evarts M, Bernard A, Duan X, Li Y, Ng L, Oh SW, Ouellette B, Royall JJ, Stoecklin M, Wang Q, Zeng H, Sanes JR, Harris JA -
Sidekick 2 directs formation of a retinal circuit that detects differential motion.
Nature 2015 Krishnaswamy A, Yamagata M, Duan X, Hong YK, Sanes JR -
Interplay between DISC1 and GABA signaling regulates neurogenesis in mice and risk for schizophrenia.
Cell 2012 Kim JY, Liu CY, Zhang F, Duan X, Wen Z, Song J, Feighery E, Lu B, Rujescu D, St Clair D, Christian K, Callicott JH, Weinberger DR, Song H, Ming GL -
Interaction between FEZ1 and DISC1 in regulation of neuronal development and risk for schizophrenia.
Neuron 2011 Kang E, Burdick KE, Kim JY, Duan X, Guo JU, Sailor KA, Jung DE, Ganesan S, Choi S, Pradhan D, Lu B, Avramopoulos D, Christian K, Malhotra AK, Song H, Ming GL -
Aspartate racemase, generating neuronal D-aspartate, regulates adult neurogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2010 Kim PM, Duan X, Huang AS, Liu CY, Ming GL, Song H, Snyder SH -
DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212.
Neuron 2009 Kim JY, Duan X, Liu CY, Jang MH, Guo JU, Pow-anpongkul N, Kang E, Song H, Ming GL -
Development of hippocampal mossy fiber synaptic outputs by new neurons in the adult brain.
Proceedings of the National Academy of Sciences of the United States of America 2008 Faulkner RL, Jang MH, Liu XB, Duan X, Sailor KA, Kim JY, Ge S, Jones EG, Ming GL, Song H, Cheng HJ -
Development of neural stem cell in the adult brain.
Current opinion in neurobiology 2008 Duan X, Kang E, Liu CY, Ming GL, Song H