Xiaowen Zhuang, PhD
Assistant Researcher
Neurology
School of Medicine

Education & Training

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• Neuroscience Texas A&M University 09/2019
• Ph.D. Neuroscience University at Buffalo-SUNY 08/2018
• B.S. Biochemistry and Molecular Biology Liaoning University 09/2011

Interests

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• Parkinson's disease
• Basal Ganglia Circuits
• dopamine signaling
• Auditory Neuroscience
• Impulsive decision-making
• Cognitive Dysfunction

Grants and Projects

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• Circuit Mechanisms of Impulse Control Disorder in Parkinsonism, Parkinson's Foundation, 2021-2023

Publications (7)

Top publication keywords:
Neuronal PlasticityCochlear NucleusDrug-Seeking BehaviorMice, Inbred CBAOptogeneticsCochlear NerveCorpus StriatumNoiseEvoked Potentials, Auditory, Brain StemBrain StemCholinergic NeuronsSynaptic PotentialsAuditory PathwaysPresynaptic TerminalsHearing Loss, Conductive

• Dopamine across timescales and cell types: Relevance for phenotypes in Parkinson's disease progression.
  Experimental neurology 2024 Seiler JL, Zhuang X, Nelson AB, Lerner TN
• Drug reinforcement impairs cognitive flexibility by inhibiting striatal cholinergic neurons.
  Nature communications 2023 Gangal H, Xie X, Huang Z, Cheng Y, Wang X, Lu J, Zhuang X, Essoh A, Huang Y, Chen R, Smith LN, Smith RJ, Wang J
• Striatal μ-opioid receptor activation triggers direct-pathway GABAergic plasticity and induces negative affect.
  Cell reports 2023 Wang W, Xie X, Zhuang X, Huang Y, Tan T, Gangal H, Huang Z, Purvines W, Wang X, Stefanov A, Chen R, Rodriggs L, Chaiprasert A, Yu E, Vierkant V, Hook M, Huang Y, Darcq E, Wang J
• Chronic alcohol drinking persistently suppresses thalamostriatal excitation of cholinergic neurons to impair cognitive flexibility.
  The Journal of clinical investigation 2022 Ma T, Huang Z, Xie X, Cheng Y, Zhuang X, Childs MJ, Gangal H, Wang X, Smith LN, Smith RJ, Zhou Y, Wang J
• Mechanisms and Functional Consequences of Presynaptic Homeostatic Plasticity at Auditory Nerve Synapses.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 Zhuang X, Wong NF, Sun W, Xu-Friedman MA
• Optogenetic control of alcohol-seeking behavior via the dorsomedial striatal circuit.
  Neuropharmacology 2019 Roltsch Hellard E, Binette A, Zhuang X, Lu J, Ma T, Jones B, Williams E, Jayavelu S, Wang J
• Changes in Properties of Auditory Nerve Synapses following Conductive Hearing Loss.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Zhuang X, Sun W, Xu-Friedman MA