Jenny Fang, MD, MS
Specialist
Dermatology
School of Medicine

Publications (42)

Top publication keywords:
Mesenchymal Stem Cell TransplantationReceptors, LipoxinAcute Lung InjuryPulmonary AlveoliLipoxinsPneumonia, PneumococcalEpitheliumPermeabilityLung InjuryReceptors, Formyl PeptideAlveolar Epithelial CellsBody FluidsAngiopoietin-1LipopolysaccharidesExtravascular Lung Water

• Biological Effects of Corticosteroids on Pneumococcal Pneumonia in Mice and Humans.
  Research square 2024 Taenaka H, Wick KD, Sarma A, Matsumoto S, Ghale R, Fang X, Maishan M, Gotts JE, Langelier CR, Calfee CS, Matthay MA
• Aerosolized nicotine from e-cigarettes alters gene expression, increases lung protein permeability, and impairs viral clearance in murine influenza infection.
  Frontiers in immunology 2023 Maishan M, Sarma A, Chun LF, Caldera S, Fang X, Abbott J, Christenson SA, Langelier CR, Calfee CS, Gotts JE, Matthay MA
• Impact of e-cigarette aerosol on primary human alveolar epithelial type 2 cells.
  American journal of physiology. Lung cellular and molecular physiology 2022 Wick KD, Fang X, Maishan M, Matsumoto S, Spottiswoode N, Sarma A, Simoneau C, Khakoo M, Langelier C, Calfee CS, Gotts JE, Matthay MA
• Aerosolized vitamin E acetate causes oxidative injury in mice and in alveolar macrophages.
  American journal of physiology. Lung cellular and molecular physiology 2022 Matsumoto S, Traber MG, Leonard SW, Choi J, Fang X, Maishan M, Wick KD, Jones KD, Calfee CS, Gotts JE, Matthay MA
• Functional Transcriptomic Studies of Immune Responses and Endotoxin Tolerance in Early Human Sepsis.
  Shock (Augusta, Ga.) 2022 Leligdowicz A, Kamm J, Kalantar K, Jauregui A, Vessel K, Caldera S, Serpa PH, Abbott J, Fang X, Tian X, Prakash A, Kangelaris KN, Liu KD, Calfee CS, Langelier C, Matthay MA

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• Abstract 11496: Increased Pulmonary Microvascular Endothelial Permeability by E-Cigarette Aerosol: The Pathway from Lung to Peripheral Blood Vessels.
  Circulation 2021 Leila Mohammadi, Daniel D Han, Xiaohui Fang, Fengyun Xu, Ronak Derakhshandeh, Judith Hellman, Jeffrey Gotts, Matthew L Springer
• Delayed angiopoietin-2 blockade reduces influenza-induced lung injury and improves survival in mice.
  Physiological reports 2021 Gotts JE, Maishan M, Chun L, Fang X, Han CY, Chiueh V, Khakoo AY, Lee T, Stolina M, Matthay MA
• Inhibition of the lipoxin A4 and resolvin D1 receptor impairs host response to acute lung injury caused by pneumococcal pneumonia in mice.
  American journal of physiology. Lung cellular and molecular physiology 2021 Siegel ER, Croze RH, Fang X, Matthay MA, Gotts JE
• A neutrophil subset defined by intracellular olfactomedin 4 is associated with mortality in sepsis.
  American journal of physiology. Lung cellular and molecular physiology 2020 Kangelaris KN, Clemens R, Fang X, Jauregui A, Liu T, Vessel K, Deiss T, Sinha P, Leligdowicz A, Liu KD, Zhuo H, Alder MN, Wong HR, Calfee CS, Lowell C, Matthay MA
• Proinflammatory cytokines and ARDS pulmonary edema fluid induce CD40 on human mesenchymal stromal cells-A potential mechanism for immune modulation.
  PloS one 2020 Wilfong EM, Croze R, Fang X, Schwede M, Niemi E, López GY, Lee JW, Nakamura MC, Matthay MA
• Clinically relevant model of pneumococcal pneumonia, ARDS, and nonpulmonary organ dysfunction in mice.
  American journal of physiology. Lung cellular and molecular physiology 2019 Gotts JE, Bernard O, Chun L, Croze RH, Ross JT, Nesseler N, Wu X, Abbott J, Fang X, Calfee CS, Matthay MA
• Effects of bone marrow-derived mesenchymal stromal cells on gene expression in human alveolar type II cells exposed to TNF-α, IL-1β, and IFN-γ.
  Physiological reports 2018 Schwede M, Wilfong EM, Zemans RL, Lee PJ, Dos Santos C, Fang X, Matthay MA
• Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice.
  American journal of physiology. Lung cellular and molecular physiology 2018 Gotts JE, Chun L, Abbott J, Fang X, Takasaka N, Nishimura SL, Springer ML, Schick SF, Calfee CS, Matthay MA
• Measurement of Protein Permeability and Fluid Transport of Human Alveolar Epithelial Type II Cells Under Pathological Conditions.
  Methods in molecular biology (Clifton, N.J.) 2018 Fang X, Matthay MA
• Cigarette Smoke Exposure Worsens Endotoxin-Induced Lung Injury and Pulmonary Edema in Mice.
  Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2017 Gotts JE, Abbott J, Fang X, Yanagisawa H, Takasaka N, Nishimura SL, Calfee CS, Matthay MA
• Human Mesenchymal Stem (Stromal) Cells Promote the Resolution of Acute Lung Injury in Part through Lipoxin A4.
  Journal of immunology (Baltimore, Md. : 1950) 2015 Fang X, Abbott J, Cheng L, Colby JK, Lee JW, Levy BD, Matthay MA
• Unexpected Role for Adaptive αβTh17 Cells in Acute Respiratory Distress Syndrome.
  Journal of immunology (Baltimore, Md. : 1950) 2015 Li JT, Melton AC, Su G, Hamm DE, LaFemina M, Howard J, Fang X, Bhat S, Huynh KM, O'Kane CM, Ingram RJ, Muir RR, McAuley DF, Matthay MA, Sheppard D
• Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial.
  The Lancet. Respiratory medicine 2014 Wilson JG, Liu KD, Zhuo H, Caballero L, McMillan M, Fang X, Cosgrove K, Vojnik R, Calfee CS, Lee JW, Rogers AJ, Levitt J, Wiener-Kronish J, Bajwa EK, Leavitt A, McKenna D, Thompson BT, Matthay MA
• Design and implementation of the START (STem cells for ARDS Treatment) trial, a phase 1/2 trial of human mesenchymal stem/stromal cells for the treatment of moderate-severe acute respiratory distress syndrome.
  Annals of intensive care 2014 Liu KD, Wilson JG, Zhuo H, Caballero L, McMillan ML, Fang X, Cosgrove K, Calfee CS, Lee JW, Kangelaris KN, Gotts JE, Rogers AJ, Levitt JE, Wiener-Kronish JP, Delucchi KL, Leavitt AD, McKenna DH, …
• Multipotent stromal stem cells from human placenta demonstrate high therapeutic potential.
  Stem cells translational medicine 2012 Nazarov I, Lee JW, Soupene E, Etemad S, Knapik D, Green W, Bashkirova E, Fang X, Matthay MA, Kuypers FA, Serikov VB
• Concise review: Mesenchymal stem cells for acute lung injury: role of paracrine soluble factors.
  Stem cells (Dayton, Ohio) 2011 Lee JW, Fang X, Krasnodembskaya A, Howard JP, Matthay MA
• Alveolar epithelial cells express mesenchymal proteins in patients with idiopathic pulmonary fibrosis.
  American journal of physiology. Lung cellular and molecular physiology 2011 Marmai C, Sutherland RE, Kim KK, Dolganov GM, Fang X, Kim SS, Jiang S, Golden JA, Hoopes CW, Matthay MA, Chapman HA, Wolters PJ
• Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37.
  Stem cells (Dayton, Ohio) 2010 Krasnodembskaya A, Song Y, Fang X, Gupta N, Serikov V, Lee JW, Matthay MA
• Allogeneic human mesenchymal stem cells restore epithelial protein permeability in cultured human alveolar type II cells by secretion of angiopoietin-1.
  The Journal of biological chemistry 2010 Fang X, Neyrinck AP, Matthay MA, Lee JW
• Regulated gene expression in cultured type II cells of adult human lung.
  American journal of physiology. Lung cellular and molecular physiology 2010 Ballard PL, Lee JW, Fang X, Chapin C, Allen L, Segal MR, Fischer H, Illek B, Gonzales LW, Kolla V, Matthay MA
• HMGB1 accelerates alveolar epithelial repair via an IL-1ß-dependent activation of TGF-ß1 by the avß6 integrin.
  The FASEB Journal 2010 Jeremie Roux, Hidefumi Koh, Xiaohui Fang, Benjamin T Houseman, Kevan M Shokat, Dean Sheppard, Michael A Matthay, Jean-Francois Pittet
• Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung.
  Proceedings of the National Academy of Sciences of the United States of America 2009 Lee JW, Fang X, Gupta N, Serikov V, Matthay MA
• Allogeneic human mesenchymal stem cells for treatment of E. Coli endotoxin-induced acute lung injury in an ex vivo perfused human lung.
  The FASEB Journal 2009 Jae Woo Lee, Naveen Gupta, Xiaohui Fang, James A. Frank, Raphael Briot, Michael A. Matthay
• Claudin-18 May Contribute to the Increase of Protein Permeability in Cultured Human Alveolar Epithelial Type II Cells Exposed to Proinflammatory Cytokines.
  The FASEB Journal 2009 Xiaohui Fang, Jae-Woo Lee, Arne Neyrink, Linda W Gonzales, Philip L Ballard, Michael A Matthay
• Alterations in the proteome of pulmonary alveolar type II cells in the rat after hepatic ischemia-reperfusion.
  Critical care medicine 2008 Hirsch J, Niemann CU, Hansen KC, Choi S, Su X, Frank JA, Fang X, Hirose R, Theodore P, Sapru A, Burlingame AL, Matthay MA
• Angiopoietin-1 reverses protein permeability in an injury model of cultured human alveolar epithelial type II cells.
  The FASEB Journal 2008 Arne Pieter Neyrinck, Jae-Woo Lee, Xiaohui Fang, Naveen Gupta, Michael A Matthay
• Acute lung injury edema fluid decreases net fluid transport across human alveolar epithelial type II cells.
  The Journal of biological chemistry 2007 Lee JW, Fang X, Dolganov G, Fremont RD, Bastarache JA, Ware LB, Matthay MA
• Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and rats.
  American journal of respiratory cell and molecular biology 2007 Su X, Lee JW, Matthay ZA, Mednick G, Uchida T, Fang X, Gupta N, Matthay MA
• Impact of low and high tidal volumes on the rat alveolar epithelial type II cell proteome.
  American journal of respiratory and critical care medicine 2007 Hirsch J, Hansen KC, Sapru A, Frank JA, Chalkley RJ, Fang X, Trinidad JC, Baker P, Burlingame AL, Matthay MA
• Formation of cysts by alveolar type II cells in three-dimensional culture reveals a novel mechanism for epithelial morphogenesis.
  Molecular biology of the cell 2007 Yu W, Fang X, Ewald A, Wong K, Hunt CA, Werb Z, Matthay MA, Mostov K
• Contribution of CFTR to apical-basolateral fluid transport in cultured human alveolar epithelial type II cells.
  American journal of physiology. Lung cellular and molecular physiology 2005 Fang X, Song Y, Hirsch J, Galietta LJ, Pedemonte N, Zemans RL, Dolganov G, Verkman AS, Matthay MA
• Alveolar epithelium: role in lung fluid balance and acute lung injury.
  Proceedings of the American Thoracic Society 2005 Matthay MA, Robriquet L, Fang X
• Direct visual instillation as a method for efficient delivery of fluid into the distal airspaces of anesthetized mice.
  Experimental lung research 2004 Su X, Looney M, Robriquet L, Fang X, Matthay MA
• Clinically relevant concentrations of beta2-adrenergic agonists stimulate maximal cyclic adenosine monophosphate-dependent airspace fluid clearance and decrease pulmonary edema in experimental acid-induced lung injury.
  Critical care medicine 2004 McAuley DF, Frank JA, Fang X, Matthay MA
• Altered proteomic patterns in rat alveolar epithelial type II cells after ventilation with high and low tidal volumes.
  Critical Care 2004 J Hirsch, K Hansen, J Frank, R Chalkley, X Fang, A Burlingame, M Matthay
• Clinically relevant concentrations of beta agonists may stimulate alveolar fluid clearance in acute respiratory distress syndrome.
  Critical Care 2004 G Perkins, D McAuley, J Frank, D Thickett, X Fang, M Matthay
• Clinical Acute Lung Injury and Acute Respiratory Distress Syndrome.
  Current treatment options in cardiovascular medicine 2002 Matthay MA, Uchida T, Fang X