Xiangning Jiang, PhD
Associate Professor
Neurology
School of Medicine

Education & Training

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• Postdoctoral Studies Graduate Division University of California, San Francisco

Grants and Projects

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• Regulation of brain cholesterol homeostasis following neonatal hypoxia-ischemia, NIH, 2020-2021
• Phospho-regulation of NMDA receptors in neonatal brain hypoxia-ischemia, NIH, 2014-2020
• Src Family Kinases - Mediated Ischemic Neonatal Brain Injury, NIH, 2009-2012

Publications (23)

Top publication keywords:
CholesterolBrainHypoxia-Ischemia, Brainsrc-Family KinasesHydroxycholesterolsGene Expression Regulation, EnzymologicBrain ChemistryCholesterol 24-HydroxylaseProto-Oncogene Proteins c-fynBrain InjuriesAnimals, NewbornReceptors, NeurotransmitterReceptors, N-Methyl-D-AspartateImmunoprecipitationNeurons

• Hypothermia Treatment After Hypoxia-Ischemia in Glutathione Peroxidase-1 Overexpressing Mice.
  Developmental neuroscience 2023 Sheldon RA, Windsor C, Lu F, Stewart NR, Jiang X, Ferriero DM
• Cholesterol in Brain Development and Perinatal Brain Injury: More than a Building Block.
  Current neuropharmacology 2022 Lu F, Ferriero DM, Jiang X
• Serum 24S-hydroxycholesterol predicts long-term brain structural and functional outcomes after hypoxia-ischemia in neonatal mice.
  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2020 Lu F, Fan S, Romo AR, Xu D, Ferriero DM, Jiang X
• Excitotoxic superoxide production and neuronal death require both ionotropic and non-ionotropic NMDA receptor signaling.
  Scientific reports 2018 Minnella AM, Zhao JX, Jiang X, Jakobsen E, Lu F, Wu L, El-Benna J, Gray JA, Swanson RA
• Upregulation of cholesterol 24-hydroxylase following hypoxia-ischemia in neonatal mouse brain.
  Pediatric research 2018 Lu F, Zhu J, Guo S, Wong BJ, Chehab FF, Ferriero DM, Jiang X

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• Hypoxia-ischemia modifies postsynaptic GluN2B-containing NMDA receptor complexes in the neonatal mouse brain.
  Experimental neurology 2017 Lu F, Shao G, Wang Y, Guan S, Burlingame AL, Liu X, Liang X, Knox R, Ferriero DM, Jiang X
• Cellular and molecular introduction to brain development.
  Neurobiology of disease 2015 Jiang X, Nardelli J
• Isolating astrocytes and neurons sequentially from postnatal murine brains with a magnetic cell separation technique.
  Journal of Biological Methods 2014 Maria Feldmann, Praneeti Pathipati, R Ann Sheldon, Xiangning Jiang, Donna M Ferriero
• NR2B phosphorylation at tyrosine 1472 contributes to brain injury in a rodent model of neonatal hypoxia-ischemia.
  Stroke 2014 Knox R, Brennan-Minnella AM, Lu F, Yang D, Nakazawa T, Yamamoto T, Swanson RA, Ferriero DM, Jiang X
• Hypoxic preconditioning protection is eliminated in HIF-1α knockout mice subjected to neonatal hypoxia-ischemia.
  Pediatric research 2014 Sheldon RA, Lee CL, Jiang X, Knox RN, Ferriero DM
• FoxO4 interacts with the sterol regulatory factor SREBP2 and the hypoxia inducible factor HIF2α at the CYP51 promoter.
  Journal of lipid research 2013 Zhu J, Jiang X, Chehab FF
• Phenotype and secretory responses to oxidative stress in microglia.
  Developmental neuroscience 2013 Pathipati P, Müller S, Jiang X, Ferriero D
• Enhanced NMDA receptor tyrosine phosphorylation and increased brain injury following neonatal hypoxia-ischemia in mice with neuronal Fyn overexpression.
  Neurobiology of disease 2012 Knox R, Zhao C, Miguel-Perez D, Wang S, Yuan J, Ferriero D, Jiang X
• Developmental localization of NMDA receptors, Src and MAP kinases in mouse brain.
  Neuroscience letters 2011 Jiang X, Knox R, Pathipati P, Ferriero D
• Role of vasodilator stimulated phosphoprotein in VEGF induced blood-brain barrier permeability in endothelial cell monolayers.
  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2010 Davis B, Tang J, Zhang L, Mu D, Jiang X, Biran V, Vexler Z, Ferriero DM
• HIF-1 alpha-deficient mice have increased brain injury after neonatal hypoxia-ischemia.
  Developmental neuroscience 2009 Sheldon RA, Osredkar D, Lee CL, Jiang X, Mu D, Ferriero DM
• Exogenous low dose hydrogen peroxide increases hypoxia-inducible factor-1alpha protein expression and induces preconditioning protection against ischemia in primary cortical neurons.
  Neuroscience letters 2008 Chang S, Jiang X, Zhao C, Lee C, Ferriero DM
• Activated Src kinases interact with the N-methyl-D-aspartate receptor after neonatal brain ischemia.
  Annals of neurology 2008 Jiang X, Mu D, Biran V, Faustino J, Chang S, Rincón CM, Sheldon RA, Ferriero DM
• A role for hypoxia-inducible factor-1alpha in desferoxamine neuroprotection.
  Neuroscience letters 2005 Hamrick SE, McQuillen PS, Jiang X, Mu D, Madan A, Ferriero DM
• Differential vulnerability of immature murine neurons to oxygen-glucose deprivation.
  Experimental neurology 2004 Jiang X, Mu D, Manabat C, Koshy AA, Christen S, Täuber MG, Vexler ZS, Ferriero DM
• Manipulation of antioxidant pathways in neonatal murine brain.
  Pediatric research 2004 Sheldon RA, Jiang X, Francisco C, Christen S, Vexler ZS, Täuber MG, Ferriero DM
• Regulation of hypoxia-inducible factor 1alpha and induction of vascular endothelial growth factor in a rat neonatal stroke model.
  Neurobiology of disease 2003 Mu D, Jiang X, Sheldon RA, Fox CK, Hamrick SE, Vexler ZS, Ferriero DM
• Neonatal hypoxia-ischemia differentially upregulates MAGUKs and associated proteins in PSD-93-deficient mouse brain.
  Stroke 2003 Jiang X, Mu D, Sheldon RA, Glidden DV, Ferriero DM