Xander Van Wijk, PhD
Associate Professor
Laboratory Medicine
School of Medicine
Awards
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- Power List, The Pathologist, 2022
- 40 Under Forty, ASCP, 2021
- Academy George Grannis Award for Excellence in Research and Scientific Publication, ADLM, 2020
Education & Training
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- MSc Biomedical Sciences, specialization Clinical and Molecular Sciences Hasselt University
- BSc Molecular Life Sciences Maastricht University
- PhD Medical Sciences, Biochemistry Radboud University Nijmegen
- DABCC Clinical Chemistry University of California
Interests
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- Blood Gas
- Pharmacogenomics
- Laboratory Developed Tests
- Clinical Chemistry
- Cardiac Biomarkers
- Analytical Toxicology
Websites
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- Van Wijk Consulting (vanwijkconsulting.com)
- LinkedIn (linkedin.com)
- Google Scholar (scholar.google.com)
Publications (59)
Top publication keywords:
ImmunoassayHeparitin SulfateReagent Kits, DiagnosticBlood Gas AnalysisFalse Positive ReactionsThrombocytosisHemolysisIcePharmacogeneticsJaundiceSubstance Abuse DetectionL-Lactate DehydrogenaseGlycosaminoglycansTroponin TTroponin I
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Advances in Cardiac Troponin Composition Assays: A Step Closer to the Clinic?
Clinical chemistry 2025 van Wijk XMR, Damen SAJ -
An Introduction to the Complete Blood Count for Clinical Chemists: White Blood Cells.
The journal of applied laboratory medicine 2025 Osa-Andrews B, van Wijk XMR, Herrera Rivera N, Seifert RP, Harris NS, Marin MJ -
FDA's Final Rule on Laboratory-Developed Tests: What Is the Impact on Clinical Pharmacogenomics in the United States?
The journal of applied laboratory medicine 2025 van Wijk XMR, McMillin GA -
An Introduction to the Complete Blood Count for Clinical Chemists: Red Blood Cells.
The journal of applied laboratory medicine 2024 Marin MJ, van Wijk XMR, Boothe PD, Harris NS, Winter WE -
FDA's Final Rule on Laboratory Developed Tests.
Clinical chemistry 2024 van Wijk XMR, Master SR, Genzen JR
Show all (54 more) Hide
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An Introduction to the Complete Blood Count for Clinical Chemists: Platelets.
The journal of applied laboratory medicine 2024 van Wijk XMR, Sanchez Oviol Z, Winter WE, Harris NS, Marin MJ -
Advances in sepsis biomarkers.
Advances in clinical chemistry 2024 Marin MJ, van Wijk XMR, Chambliss AB -
The stability of blood gases and CO-oximetry under slushed ice and room temperature conditions.
Clinical chemistry and laboratory medicine 2023 Zavorsky GS, van Wijk XMR -
Reducing Specimen Rejection Rates Using Concentration-Dependent Hemolysis Rejection Thresholds.
The journal of applied laboratory medicine 2023 Tang NY, Mitchell KR, Groboske SE, Baldwin AD, Lenza M, Yeo KJ, van Wijk XMR -
Implementation of pharmacogenomics into inpatient general medicine.
Pharmacogenetics and genomics 2022 Chen T, O'Donnell PH, Middlestadt M, Ruhnke GW, Danahey K, van Wijk XMR, Choksi A, Knoebel R, Hartman S, Yeo KJ, Friedman PN, Ratain MJ, Nutescu EA, O'Leary KJ, Perera MA, Meltzer DO -
Machine Learning in Healthcare: Mapping a Path to Title 21.
Clinical chemistry 2022 Marin MJ, Van Wijk XMR, Durant TJS -
Stability of Whole Blood Electrolyte Specimens at Room Temperature vs. Slushed Ice Conditions.
The journal of applied laboratory medicine 2022 Zavorsky GS, van Wijk XMR, Gasparyan S, Stollenwerk NS, Brooks RA -
Pilot Findings of Pharmacogenomics in Perioperative Care: Initial Results From the First Phase of the ImPreSS Trial.
Anesthesia and analgesia 2022 Truong TM, Apfelbaum JL, Danahey K, Schierer E, Ludwig J, George D, House L, Karrison T, Shahul S, Anitescu M, Choksi A, Hartman S, Knoebel RW, van Wijk XMR, Yeo KJ, Meltzer DO, Ratain MJ, O'Donnell … -
Clinically actionable genotypes for anticancer prescribing among >1500 patients with pharmacogenomic testing.
Cancer 2022 Reizine NM, Danahey K, Truong TM, George D, House LK, Karrison TG, van Wijk XMR, Yeo KJ, Ratain MJ, O'Donnell PH -
Development of an LC-MS/MS Method for Measurement of Irinotecan and Its Major Metabolites in Plasma: Technical Considerations.
Laboratory medicine 2022 Aoullay Z, Van Wijk XMR, Yanhui M, Meddah B, Lynch KL, Cherrah Y, Wu AHB -
Applicability of Pharmacogenomically Guided Medication Treatment during Hospitalization of At-Risk Minority Patients.
Journal of personalized medicine 2021 Saulsberry L, Danahey K, Middlestadt M, O'Leary KJ, Nutescu EA, Chen T, Lee JC, Ruhnke GW, George D, House L, van Wijk XMR, Yeo KJ, Choksi A, Hartman SW, Knoebel RW, Friedman PN, Rasmussen LV, Ratain … -
Large inter-assay difference of serum creatinine in pediatric population: a threat to accurate staging of chronic kidney disease.
Pediatric nephrology (Berlin, Germany) 2021 Lao K, Sykes E, van Wijk XMR, Li J, Williams J, Gherasim C, Sun Q -
Validation of a Large Custom-Designed Pharmacogenomics Panel on an Array Genotyping Platform.
The journal of applied laboratory medicine 2021 Tang NY, Pei X, George D, House L, Danahey K, Lipschultz E, Ratain MJ, O'Donnell PH, Yeo KJ, van Wijk XMR -
Impact of CYP2D6 Pharmacogenomic Status on Pain Control Among Opioid-Treated Oncology Patients.
The oncologist 2021 Reizine N, Danahey K, Schierer E, Liu P, Middlestadt M, Ludwig J, Truong TM, van Wijk XMR, Yeo KJ, Malec M, Ratain MJ, O'Donnell PH -
Role of von Willebrand Factor in COVID-19 Associated Coagulopathy.
The journal of applied laboratory medicine 2021 Mei ZW, van Wijk XMR, Pham HP, Marin MJ -
A retrospective analysis of high sensitivity cardiac troponin-T ranges in non-myocardial infarction emergency department visits.
BMC cardiovascular disorders 2021 Kong N, Chua RFM, Besser SA, Heelan L, Nathan S, Spiegel TF, van Wijk XMR, Tabit CE -
Short-term analytical imprecision for a fifth generation cardiac troponin T assay does not exceed rule-in and rule-out thresholds of the ESC 0/1-h algorithm.
Clinica chimica acta; international journal of clinical chemistry 2021 Tang NY, Datoru AD, van Wijk XMR -
Evaluation of Biomarkers in Sepsis: High Dimethylarginine (ADMA and SDMA) Concentrations Are Associated with Mortality.
The journal of applied laboratory medicine 2021 van Wijk XMR, Yun C, Lynch KL -
Cardiac Troponin Composition Characterization after Non ST-Elevation Myocardial Infarction: Relation with Culprit Artery, Ischemic Time Window, and Severity of Injury.
Clinical chemistry 2021 Damen SAJ, Cramer GE, Dieker HJ, Gehlmann H, Ophuis TJMO, Aengevaeren WRM, Fokkert M, Verheugt FWA, Suryapranata H, Wu AH, van Wijk XMR, Brouwer MA -
Implementation of pharmacogenomic testing in oncology care (PhOCus): study protocol of a pragmatic, randomized clinical trial.
Therapeutic advances in medical oncology 2020 Reizine N, Vokes EE, Liu P, Truong TM, Nanda R, Fleming GF, Catenacci DVT, Pearson AT, Parsad S, Danahey K, van Wijk XMR, Yeo KJ, Ratain MJ, O'Donnell PH -
Analytical and Clinical Evaluation of the Automated Elecsys Anti-SARS-CoV-2 Antibody Assay on the Roche cobas e602 Analyzer.
American journal of clinical pathology 2020 Chan CW, Parker K, Tesic V, Baldwin A, Tang NY, van Wijk XMR, Yeo KJ -
A comparison of venous blood gas analysis with paired specimens collected in syringes and evacuated blood collection tubes.
Clinica chimica acta; international journal of clinical chemistry 2020 Tang NY, Leanse JH, Tesic V, van Wijk XMR -
Evaluation of interference effects from hemolysis, icterus and lipemia on the Roche Elecsys® Anti-SARS-CoV-2 assay.
Clinica chimica acta; international journal of clinical chemistry 2020 Tang NY, Yeo KJ, van Wijk XMR -
Pharmacogenomic-Based Decision Support to Predict Adherence to Medications.
Clinical pharmacology and therapeutics 2020 Christian C, Borden BA, Danahey K, Yeo KJ, van Wijk XMR, Ratain MJ, O'Donnell PH -
Can We Improve Current Cancer Screening Programs?
Clinical chemistry 2020 Marin MJ, van Wijk XMR -
False-Positive Hepatitis B Surface Antibody Results: An Example of Reagent Carryover.
The journal of applied laboratory medicine 2020 Tang NY, Groboske SE, Baldwin AD, Yeo KJ, van Wijk XMR -
A root cause analysis of 'falsely elevated' oxygen saturation: investigation of pneumatic tube transport and differences between estimated and measured saturation in a critical patient population.
Clinical chemistry and laboratory medicine 2020 van Wijk XMR, Leanse JH, Poinier A, Uriel N, O'Connor MF, Weber SG, Tesic V, Staneva I -
The ImPreSS Trial: Implementation of Point-of-Care Pharmacogenomic Decision Support in Perioperative Care.
Clinical pharmacology and therapeutics 2019 Truong TM, Apfelbaum J, Shahul S, Anitescu M, Danahey K, Knoebel RW, Liebovitz D, Karrison T, van Wijk XMR, Yeo KJ, Meltzer D, Ratain MJ, O'Donnell PH -
Evaluation of a New Generation Automated Assay for 25-Hydroxy Vitamin D Based on Competitive Protein Binding.
The journal of applied laboratory medicine 2019 Asif M, Groboske SE, Leung EKY, Yeo KJ, van Wijk XMR -
Cardiac troponin I is present in plasma of type 1 myocardial infarction patients and patients with troponin I elevations due to other etiologies as complex with little free I.
Clinical biochemistry 2019 van Wijk XMR, Claassen S, Enea NS, Li P, Yang S, Brouwer MA, Cramer GE, Zuk R, Lynch KL, Wu AHB -
A Liquid-Chromatography High-Resolution Mass Spectrometry Method for Non-FDA Approved Benzodiazepines.
Journal of analytical toxicology 2019 van Wijk XMR, Yun C, Hooshfar S, Arens AM, Lung D, Wu AHB, Lynch KL -
Mass spectrometry in emergency toxicology: Current state and future applications.
Critical reviews in clinical laboratory sciences 2019 Van Wijk XMR, Goodnough R, Colby JM -
Losing sight of the Forest for the trees: Why clinical laboratories need to perform their own interference studies.
Clinica chimica acta; international journal of clinical chemistry 2018 Marin MJ, van Wijk XMR, Yeo KJ -
Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type.
Scientific reports 2017 Ihse E, Yamakado H, van Wijk XM, Lawrence R, Esko JD, Masliah E -
Anticholinergic toxicity associated with ingestion of water containing lupini bean extract.
Clinical toxicology (Philadelphia, Pa.) 2017 Li K, van Wijk XMR, Hayashi S, Lynch KL, Wu AHB, Smollin CG -
Cocaine use is associated with a higher prevalence of elevated ST2 concentrations.
Clinical biochemistry 2017 van Wijk XMR, Vittinghoff E, Wu AHB, Lynch KL, Riley ED -
Whole-Genome Sequencing of Invasion-Resistant Cells Identifies Laminin α2 as a Host Factor for Bacterial Invasion.
mBio 2017 van Wijk XM, Döhrmann S, Hallström BM, Li S, Voldborg BG, Meng BX, McKee KK, van Kuppevelt TH, Yurchenco PD, Palsson BO, Lewis NE, Nizet V, Esko JD -
Synthetic agents off the darknet: a case of U-47700 and phenazepam abuse.
Clinical toxicology (Philadelphia, Pa.) 2016 Vo KT, van Wijk XM, Wu AH, Lynch KL, Ho RY -
A comparison of methods for evaluation of a case of suspected macro-aspartate aminotransferase.
Clinica chimica acta; international journal of clinical chemistry 2016 van Wijk XMR, Magee CA, Wu AHB, Tana MM, Lynch KL -
Adverse Effects From Counterfeit Alprazolam Tablets.
JAMA internal medicine 2016 Arens AM, van Wijk XM, Vo KT, Lynch KL, Wu AH, Smollin CG -
Counterfeit Norco Poisoning Outbreak - San Francisco Bay Area, California, March 25-April 5, 2016.
MMWR. Morbidity and mortality weekly report 2016 Vo KT, van Wijk XM, Lynch KL, Wu AH, Smollin CG -
Heparan Sulfate Modulates Neutrophil and Endothelial Function in Antibacterial Innate Immunity.
Infection and immunity 2015 Xu D, Olson J, Cole JN, van Wijk XM, Brinkmann V, Zychlinsky A, Nizet V, Esko JD, Chang YC -
A common sugar-nucleotide-mediated mechanism of inhibition of (glycosamino)glycan biosynthesis, as evidenced by 6F-GalNAc (Ac3).
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015 van Wijk XM, Lawrence R, Thijssen VL, van den Broek SA, Troost R, van Scherpenzeel M, Naidu N, Oosterhof A, Griffioen AW, Lefeber DJ, van Delft FL, van Kuppevelt TH -
Release of cardiac troponin using a high sensitivity assay after exercise: Type 2 acute myocardial infarction?
Clinica chimica acta; international journal of clinical chemistry 2015 Aw TC, van Wijk XM, Wu AH, Jaffe AS -
A new ultra-high sensitivity troponin I assay for chest pain patients with no evidence of troponin I using a conventional assay.
Clinical biochemistry 2014 Wu AH, van Wijk XM -
'Immunosequencing' of heparan sulfate from human cell lines and rat kidney: the (GlcNS6S-IdoA2S)₃ motif, recognized by antibody NS4F5, is located towards the non-reducing end.
The Biochemical journal 2014 van Wijk XM, Oosterhof A, Versteeg EM, van de Westerlo EM, van Kuppevelt TH -
Modulation of heparan sulfate in the glomerular endothelial glycocalyx decreases leukocyte influx during experimental glomerulonephritis.
Kidney international 2014 Rops AL, Loeven MA, van Gemst JJ, Eversen I, Van Wijk XM, Dijkman HB, van Kuppevelt TH, Berden JH, Rabelink TJ, Esko JD, van der Vlag J -
Heparan sulfate in angiogenesis: a target for therapy.
Angiogenesis 2013 van Wijk XM, van Kuppevelt TH -
Interfering with UDP-GlcNAc metabolism and heparan sulfate expression using a sugar analogue reduces angiogenesis.
ACS chemical biology 2013 van Wijk XM, Thijssen VL, Lawrence R, van den Broek SA, Dona M, Naidu N, Oosterhof A, van de Westerlo EM, Kusters LJ, Khaled Y, Jokela TA, Nowak-Sliwinska P, Kremer H, Stringer SE, Griffioen AW, van … -
The distribution and function of chondroitin sulfate and other sulfated glycosaminoglycans in the human bladder and their contribution to the protective bladder barrier.
The Journal of urology 2012 Janssen DA, van Wijk XM, Jansen KC, van Kuppevelt TH, Heesakkers JP, Schalken JA -
The polybasic insertion in autotaxin α confers specific binding to heparin and cell surface heparan sulfate proteoglycans.
The Journal of biological chemistry 2012 Houben AJ, van Wijk XM, van Meeteren LA, van Zeijl L, van de Westerlo EM, Hausmann J, Fish A, Perrakis A, van Kuppevelt TH, Moolenaar WH -
Extraction and structural analysis of glycosaminoglycans from formalin-fixed, paraffin-embedded tissues.
Glycobiology 2012 van Wijk XM, Vallen MJ, van de Westerlo EM, Oosterhof A, Hao W, Versteeg EM, Raben J, Wismans RG, Smetsers TF, Dijkman HB, Schalkwijk J, van Kuppevelt TH -
Polymorphisms in CACNA1E and Camk2d are associated with seizure susceptibility of Sprague-Dawley rats.
Epilepsy research 2010 Rijkers K, Mescheriakova J, Majoie M, Lemmens E, van Wijk X, Philippens M, Van Kranen-Mastenbroek V, Schijns O, Vles J, Hoogland G -
A 4-deoxy analogue of N-acetyl-D-glucosamine inhibits heparan sulphate expression and growth factor binding in vitro.
Experimental cell research 2010 van Wijk XM, Oosterhof A, van den Broek SA, Griffioen AW, ten Dam GB, Rutjes FP, van Delft FL, van Kuppevelt TH