Sze Chun Winson Ho, MD
Assistant Professor
Neurological Surgery
School of Medicine

His laboratory research focuses on developing novel immunotherapies for the treatment of brain tumors, with a particular interest in studying the role of Protein Phosphatase 2A (PP2A) in modulating anti-tumor immunity. He received his M.D. from Yale University School of Medicine and completed his residency in the joint neurosurgery program of the University of Virginia and the National Institutes of Health. Following his residency, he completed a fellowship in pediatric neurosurgery at Intermountain Primary Children’s Medical Center at the University of Utah in Salt Lake City. He was an Assistant Professor in Neurosurgery at University of Texas at Austin from 2019-2022 prior to joining UCSF.

• Diffuse intrinsic pontine glioma (DIPG): A review of current and emerging treatment strategies.
  Cancer letters 2024 Weisbrod LJ, Thiraviyam A, Vengoji R, Shonka N, Jain M, Ho W, Batra SK, Salehi A
• Glioma-Immune Cell Crosstalk in Tumor Progression.
  Cancers 2024 Elguindy M, Young JS, Mondal I, Lu RO, Ho WS
• Neoadjuvant Chemotherapy with Laser Interstitial Thermal Therapy in Central Nervous System Neuroblastoma: Illustrative Case and Literature Review.
  Brain sciences 2023 Chung JE, Iqbal O, Krishnan C, Harrod V, Tyler-Kabara E, Lu RO, Ho WS
• New Developments in the Pathogenesis, Therapeutic Targeting, and Treatment of Pediatric Medulloblastoma.
  Cancers 2022 Fang FY, Rosenblum JS, Ho WS, Heiss JD
• Targeting Mitochondrial Oxidative Phosphorylation in Glioblastoma Therapy.
  Neuromolecular medicine 2021 Wu Z, Ho WS, Lu R
• MRI-guided laser interstitial thermal therapy using the Visualase system and Navigus frameless stereotaxy in an infant: technical case report.
  Journal of neurosurgery. Pediatrics 2021 Lee JJ, Clarke D, Hoverson E, Tyler-Kabara EC, Ho WS
• Mitochondrial Dysfunction, Macrophage, and Microglia in Brain Cancer.
  Frontiers in cell and developmental biology 2021 Lu RO, Ho WS
• Extreme Lateral Transodontoid Approach for Resection of Clival Chordoma: 2-Dimensional Operative Video.
  Operative neurosurgery (Hagerstown, Md.) 2020 Joyce EJ, Cohen MA, Ho W, Brockmeyer DL, Couldwell WT
• Induction of Immune Response Against Metastatic Tumors via Vaccination of Mannan-BAM, TLR Ligands and Anti-CD40 Antibody (MBTA).
  Advanced therapeutics 2020 Medina R, Wang H, Caisová V, Cui J, Indig IH, Uher O, Ye J, Nwankwo A, Sanchez V, Wu T, Nduom E, Heiss J, Gilbert MR, Terabe M, Ho W, Zenka J, Pacak K, Zhuang Z
• A comparison of the accuracy of fetal MRI and prenatal ultrasonography at predicting lesion level and perinatal motor outcome in patients with myelomeningocele.
  Neurosurgical focus 2019 Sherrod BA, Ho WS, Hedlund A, Kennedy A, Ostrander B, Bollo RJ
• Correction to: Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop.
  Journal for immunotherapy of cancer 2019 Bedognetti D, Ceccarelli M, Galluzzi L, Lu R, Palucka K, Samayoa J, Spranger S, Warren S, Wong KK, Ziv E, Chowell D, Coussens LM, De Carvalho DD, DeNardo DG, Galon J, Kaufman HL, Kirchhoff T, Lotze MT…
• Small posterior fossa in Chiari I malformation affected families is significantly linked to 1q43-44 and 12q23-24.11 using whole exome sequencing.
  European journal of human genetics : EJHG 2019 Musolf AM, Ho WSC, Long KA, Zhuang Z, Argersinger DP, Sun H, Moiz BA, Simpson CL, Mendelevich EG, Bogdanov EI, Bailey-Wilson JE, Heiss JD
• Complex Chiari malformation: using craniovertebral junction metrics to guide treatment.
  Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 2019 Ho WSC, Brockmeyer DL
• Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop.
  Journal for immunotherapy of cancer 2019 Bedognetti D, Ceccarelli M, Galluzzi L, Lu R, Palucka K, Samayoa J, Spranger S, Warren S, Wong KK, Ziv E, Chowell D, Coussens LM, De Carvalho DD, DeNardo DG, Galon J, Kaufman HL, Kirchhoff T, Lotze MT…
• Severe cranial deformity following cerebrospinal fluid diversion in an adolescent with osteogenesis imperfecta.
  Journal of neurosurgery. Pediatrics 2018 Ho WS, Jane JA
• A dynamic in vivo-like organotypic blood-brain barrier model to probe metastatic brain tumors.
  Scientific reports 2016 Xu H, Li Z, Yu Y, Sizdahkhani S, Ho WS, Yin F, Wang L, Zhu G, Zhang M, Jiang L, Zhuang Z, Qin J
• Characterization of the blood brain barrier in pediatric central nervous system neoplasms.
  Journal of interdisciplinary histopathology 2016 Hong CS, Ho W, Piazza MG, Ray-Chaudhury A, Zhuang Z, Heiss JD
• Protein Phosphatase 2A Inhibition with LB100 Enhances Radiation-Induced Mitotic Catastrophe and Tumor Growth Delay in Glioblastoma.
  Molecular cancer therapeutics 2015 Gordon IK, Lu J, Graves CA, Huntoon K, Frerich JM, Hanson RH, Wang X, Hong CS, Ho W, Feldman MJ, Ikejiri B, Bisht K, Chen XS, Tandle A, Yang C, Arscott WT, Ye D, Heiss JD, Lonser RR, Camphausen K, …
• LB100, a small molecule inhibitor of PP2A with potent chemo- and radio-sensitizing potential.
  Cancer biology & therapy 2015 Hong CS, Ho W, Zhang C, Yang C, Elder JB, Zhuang Z
• Endovascular intervention for delayed stenosis of extracranial-intracranial bypass saphenous vein grafts.
  Journal of neurointerventional surgery 2012 Qahwash O, Alaraj A, Aletich V, Charbel FT, Bulsara KR, Ho W, Valyi-Nagy T, Amin-Hanjani S
• Rare copy number variants in tourette syndrome disrupt genes in histaminergic pathways and overlap with autism.
  Biological psychiatry 2011 Fernandez TV, Sanders SJ, Yurkiewicz IR, Ercan-Sencicek AG, Kim YS, Fishman DO, Raubeson MJ, Song Y, Yasuno K, Ho WS, Bilguvar K, Glessner J, Chu SH, Leckman JF, King RA, Gilbert DL, Heiman GA, …
• Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations.
  Nature 2010 Bilgüvar K, Oztürk AK, Louvi A, Kwan KY, Choi M, Tatli B, Yalnizoglu D, Tüysüz B, Caglayan AO, Gökben S, Kaymakçalan H, Barak T, Bakircioglu M, Yasuno K, Ho W, Sanders S, Zhu Y, Yilmaz S, Dinçer A, …
• Viral strategies for studying the brain, including a replication-restricted self-amplifying delta-G vesicular stomatis virus that rapidly expresses transgenes in brain and can generate a multicolor golgi-like expression.
  The Journal of comparative neurology 2009 van den Pol AN, Ozduman K, Wollmann G, Ho WS, Simon I, Yao Y, Rose JK, Ghosh P
• Bystander attenuation of neuronal and astrocyte intercellular communication by murine cytomegalovirus infection of glia.
  Journal of virology 2007 Ho WS, van den Pol AN