Willow Coyote-Maestas, PhD, MS
Assistant Professor
Bioengineering
School of Pharmacy

Awards

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• Investigator, Chan Zuckerberg Biohub, 2023-2028
• Hanna Gray Fellow, Howard Hughes Medical Institute, 2021-2027
• Fellow, Quantitative Biology Institute, 2021-2023
• Milne-Brandenbrug Research Award, University of Minnesota, Twin Cities, 2020
• Ross A. Gortner Research Award, University of Minnesota, Twin Cities, 2019
• Gilliam Fellow, Howard Hughes Medical Institute, 2018-2021
• Graduate Research Fellowship, National Science Foundation, 2017-2018
• All Nations Louis Stokes Alliances for Minority Participation in STEM, National Science Foundation, 2013-2014

Education & Training

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• PhD Biochemistry, Molecular Biology & Biophysics University of Minnesota, Twin Cities 01/2021
• MS Bioinformatics & Computational Biology University of Minnesota 11/2019
• BS Chemistry The Evergreen State College 06/2014
• BA Environmental Studies The Evergreen State College 06/2014

Websites

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• Coyote-Maestas Lab Website (wcoyotelab.com)

Publications (12)

Top publication keywords:
DNA Transposable ElementsRecombination, GeneticBiophysicsINDEL MutationProtein DomainsPotassium ChannelsMutagenesis, InsertionalIon Channel GatingProtein EngineeringProteinsEvolution, MolecularAllosteric SiteBacteriophagesPotassium Channels, Inwardly RectifyingMutation, Missense

• Profiling the proximal proteome of the activated μ-opioid receptor.
  Nature chemical biology 2024 Polacco BJ, Lobingier BT, Blythe EE, Abreu N, Khare P, Howard MK, Gonzalez-Hernandez AJ, Xu J, Li Q, Novy B, Naing ZZC, Shoichet BK, Coyote-Maestas W, Levitz J, Krogan NJ, Von Zastrow M, Hüttenhain R
• Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain.
  bioRxiv : the preprint server for biology 2023 Estevam GO, Linossi EM, Macdonald CB, Espinoza CA, Michaud JM, Coyote-Maestas W, Collisson EA, Jura N, Fraser JS
• The full spectrum of OCT1 (SLC22A1) mutations bridges transporter biophysics to drug pharmacogenomics.
  bioRxiv : the preprint server for biology 2023 Yee SW, Macdonald C, Mitrovic D, Zhou X, Koleske ML, Yang J, Silva DB, Grimes PR, Trinidad D, More SS, Kachuri L, Witte JS, Delemotte L, Giacomini KM, Coyote-Maestas W
• DIMPLE: deep insertion, deletion, and missense mutation libraries for exploring protein variation in evolution, disease, and biology.
  Genome biology 2023 Macdonald CB, Nedrud D, Grimes PR, Trinidad D, Fraser JS, Coyote-Maestas W
• Determinants of trafficking, conduction, and disease within a K+ channel revealed through multiparametric deep mutational scanning.
  eLife 2022 Coyote-Maestas W, Nedrud D, He Y, Schmidt D

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• Probing ion channel functional architecture and domain recombination compatibility by massively parallel domain insertion profiling.
  Nature communications 2021 Coyote-Maestas W, Nedrud D, Suma A, He Y, Matreyek KA, Fowler DM, Carnevale V, Myers CL, Schmidt D
• ORACLE reveals a bright future to fight bacteria.
  eLife 2021 Coyote-Maestas W, Fraser JS
• A large-scale survey of pairwise epistasis reveals a mechanism for evolutionary expansion and specialization of PDZ domains.
  Proteins 2021 Nedrud D, Coyote-Maestas W, Schmidt D
• Targeted insertional mutagenesis libraries for deep domain insertion profiling.
  Nucleic acids research 2020 Coyote-Maestas W, Nedrud D, Okorafor S, He Y, Schmidt D
• Targeted insertional mutagenesis libraries for deep domain insertion profiling.
  Nucleic acids research 2020 Coyote-Maestas W, Nedrud D, Okorafor S, He Y, Schmidt D
• Domain insertion permissibility-guided engineering of allostery in ion channels.
  Nature communications 2019 Coyote-Maestas W, He Y, Myers CL, Schmidt D
• Two distinct pools of B12 analogs reveal community interdependencies in the ocean.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Heal KR, Qin W, Ribalet F, Bertagnolli AD, Coyote-Maestas W, Hmelo LR, Moffett JW, Devol AH, Armbrust EV, Stahl DA, Ingalls AE