William Whetstone, MD
Professor
Emergency Medicine
School of Medicine

Education & Training

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• Residency Department of Emergency Medicine University of Michigan 1997
• M.D. M.D. University of Colorado 1994
• BS Aerospace Engineering University of Colorado 1990

Websites

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• Clinical Profile at UCSF Medical Center (ucsfhealth.org)
• Profile at emergency.ucsf.edu (emergency.ucsf.edu)

Videos

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• time equals neurons: spinal cord management in the first 4 hours (youtube.com)

Grants and Projects

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• The Role of Thrombin and PAR-1 in Spinal Cord Injury, NIH, 2002-2008

Publications (54)

Top publication keywords:
Monitoring, IntraoperativeEvoked Potentials, MotorNational Institute of Neurological Disorders and Stroke (U.S.)Recovery of FunctionDecompression, SurgicalCervical CordArterial PressureSpinal Cord InjuriesSpinal InjuriesLocomotionSpinal CordActivating Transcription Factor 3Receptor, PAR-1Vasoconstrictor AgentsWhite Matter

• The correlation of neurosurgery motor examinations with ISNCSCI motor examinations in patients with spinal cord injury: a multicenter TRACK-SCI study.
  Journal of neurosurgery. Spine 2024 Lui A, Bonney PA, Burke J, Kanter JH, Yue JK, Takegami N, Tarapore PE, Huang M, Mummaneni PV, Dhall SS, Hemmerle DD, Ferguson AR, Torres-Espin A, Duong-Fernandez X, Lai N, Saigal R, Pan J, Singh V, …
• 254 Initiation of Low Molecular Weight Heparin Within 24 Hours Is Safe and Effective for VTE Prophylaxis in Spinal Cord Injury Patients.
  Neurosurgery 2024 Austin Lui, Timothy Chryssikos, Arati Patel, Christine Park, Abel Torres, Nikolaos Kyritsis, Debra P. Hemmerle, Xuan Duong Fernandez, Rajiv Saigal, Jason Talbott, Jonathan S. Pan, Adam Ferguson, …
• ATF3 is a neuron-specific biomarker for spinal cord injury and ischaemic stroke.
  Clinical and translational medicine 2024 Pan JZ, Wang Z, Sun W, Pan P, Li W, Sun Y, Chen S, Lin A, Tan W, He L, Greene J, Yao V, An L, Liang R, Li Q, Yu J, Zhang L, Kyritsis N, Fernandez XD, Moncivais S, Mendoza E, Fung P, Wang G, Niu X, Du …
• Correction: Expert-augmented automated machine learning optimizes hemodynamic predictors of spinal cord injury outcome.
  PloS one 2023 Chou A, Torres-Espin A, Kyritsis N, Huie JR, Khatry S, Funk J, Hay J, Lofgreen A, Shah R, McCann C, Pascual LU, Amorim E, Weinstein PR, Manley GT, Dhall SS, Pan JZ, Bresnahan JC, Beattie MS, Whetstone…
• Safety and comparative efficacy of initiating low-molecular-weight heparin within 24 hours of injury or surgery for venous thromboembolism prophylaxis in patients with spinal cord injury: a prospective TRACK-SCI registry study.
  Neurosurgical focus 2023 Lui A, Park C, Chryssikos T, Radabaugh H, Patel A, Aabedi AA, Ferguson AR, Torres Espin A, Mummaneni PV, Dhall SS, Duong-Fernandez X, Saigal R, Chou A, Pan J, Singh V, Hemmerle DD, Kyritsis N, Talbott…

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• 188 American Spinal Injury Association (ASIA) Impairment Scale (AIS) Conversion Underestimates Neurological Recovery Following Traumatic Spinal Cord Injury.
  Neurosurgery 2023 Winward Choy, Nikolaos Kyritsis, Xuan Duong Fernandez, Adam Ferguson, Debra P. Hemmerle, Lisa U. Pascual, Vineeta Singh, Jason Talbott, Jonathan Pan, Abel Torres, William Whetstone, J. Russell Huie, …
• Hypotension requiring vasopressor treatment and increased cardiac complications in elderly spinal cord injury patients: a prospective TRACK-SCI registry study.
  Journal of neurosurgery. Spine 2023 Agarwal N, Blitstein J, Lui A, Torres-Espin A, Vasnarungruengkul C, Burke J, Mummaneni PV, Dhall SS, Weinstein PR, Duong-Fernandez X, Chou A, Pan J, Singh V, Ferguson AR, Hemmerle DD, Kyritsis N, …
• Expert-augmented automated machine learning optimizes hemodynamic predictors of spinal cord injury outcome.
  PloS one 2022 Chou A, Torres-Espin A, Kyritsis N, Huie JR, Khatry S, Funk J, Hay J, Lofgreen A, Shah R, McCann C, Pascual LU, Amorim E, Weinstein PR, Manley GT, Dhall SS, Pan JZ, Bresnahan JC, Beattie MS, Whetstone…
• Decision tree-based machine learning analysis of intraoperative vasopressor use to optimize neurological improvement in acute spinal cord injury.
  Neurosurgical focus 2022 Agarwal N, Aabedi AA, Torres-Espin A, Chou A, Wozny TA, Mummaneni PV, Burke JF, Ferguson AR, Kyritsis N, Dhall SS, Weinstein PR, Duong-Fernandez X, Pan J, Singh V, Hemmerle DD, Talbott JF, Whetstone …
• Appendicular Fracture and Polytrauma Correlate with Outcome of Spinal Cord Injury: A Transforming Research and Clinical Knowledge in Spinal Cord Injury Study.
  Journal of neurotrauma 2022 Miclau TA, Torres-Espin A, Morshed S, Morioka K, Huie JR, El Naga AN, Chou A, Pascual L, Duong-Fernandez X, Kuo YH, Weinstein P, Dhall SS, Bresnahan JC, Beattie MS, Digiorgio A, Ferguson AR, …
• Topological network analysis of patient similarity for precision management of acute blood pressure in spinal cord injury.
  eLife 2021 Torres-Espín A, Haefeli J, Ehsanian R, Torres D, Almeida CA, Huie JR, Chou A, Morozov D, Sanderson N, Dirlikov B, Suen CG, Nielson JL, Kyritsis N, Hemmerle DD, Talbott JF, Manley GT, Dhall SS, …
• Diagnostic blood RNA profiles for human acute spinal cord injury.
  The Journal of experimental medicine 2021 Kyritsis N, Torres-Espín A, Schupp PG, Huie JR, Chou A, Duong-Fernandez X, Thomas LH, Tsolinas RE, Hemmerle DD, Pascual LU, Singh V, Pan JZ, Talbott JF, Whetstone WD, Burke JF, DiGiorgio AM, Weinstein…
• Meeting Proceedings for SCI 2020: Launching a Decade of Disruption in Spinal Cord Injury Research.
  Journal of neurotrauma 2021 Morse LR, Field-Fote EC, Contreras-Vidal J, Noble-Haeusslein LJ, Rodreick M, Shields RK, Sofroniew M, Wudlick R, Zanca JM, SCI 2020 Working Group
• Atlas-based Volumetric Analysis of Blunt Spinal Cord Contusion Injury.
  Neurosurgery 2020 John F Burke, Nikhil Mummaneni, Adam Ferguson, J. Russell Huie, Leigh H Thomas, Lisa Pascual, Anthony M DiGiorgio, Debra P Hemmerle, Vineeta Singh, Abel Torres, Nikolaos Kyritsis, Philip R Weinstein, …
• Injury volume extracted from MRI predicts neurologic outcome in acute spinal cord injury: A prospective TRACK-SCI pilot study.
  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2020 Mummaneni N, Burke JF, DiGiorgio AM, Thomas LH, Duong-Fernandez X, Harris M, Pascual LU, Ferguson AR, Russell Huie J, Pan JZ, Hemmerle DD, Singh V, Torres-Espin A, Omondi C, Kyritsis N, Weinstein PR, …
• XGBoost, a Machine Learning Method, Predicts Neurological Recovery in Patients with Cervical Spinal Cord Injury.
  Neurotrauma reports 2020 Inoue T, Ichikawa D, Ueno T, Cheong M, Inoue T, Whetstone WD, Endo T, Nizuma K, Tominaga T
• Transforming Research and Clinical Knowledge in Spinal Cord Injury (TRACK-SCI): an overview of initial enrollment and demographics.
  Neurosurgical focus 2020 Tsolinas RE, Burke JF, DiGiorgio AM, Thomas LH, Duong-Fernandez X, Harris MH, Yue JK, Winkler EA, Suen CG, Pascual LU, Ferguson AR, Huie JR, Pan JZ, Hemmerle DD, Singh V, Torres-Espin A, Omondi C, …
• Clinical Implementation of Novel Spinal Cord Perfusion Pressure Protocol in Acute Traumatic Spinal Cord Injury at U.S. Level I Trauma Center: TRACK-SCI Study.
  World neurosurgery 2019 Yue JK, Hemmerle DD, Winkler EA, Thomas LH, Fernandez XD, Kyritsis N, Pan JZ, Pascual LU, Singh V, Weinstein PR, Talbott JF, Huie JR, Ferguson AR, Whetstone WD, Manley GT, Beattie MS, Bresnahan JC, …
• Initial Experience of Spinal Cord Perfusion Pressure Goals in Lieu of Mean Arterial Pressure Goals in Acute Traumatic Spinal Cord Injury at a United States Level I Trauma Center: A Transforming Research and Clinical Knowledge-Spinal Cord Injury Study.
  Neurosurgery 2019 John K Yue, Debra P Hemmerle, Hansen Deng, Ethan A Winkler, Leigh H Thomas, Xuan Duong Fernandez, Pavan S Upadhyayula, Nikolaos Kyritsis, Lisa U Pascual, Vineeta Singh, Philip R Weinstein, Jason …
• In Reply: Ultra-Early (<12 Hours) Surgery Correlates With Higher Rate of American Spinal Injury Association Impairment Scale Conversion After Cervical Spinal Cord Injury.
  Neurosurgery 2019 Burke JF, Yue JK, Ngwenya LB, Winkler EA, Talbott JF, Pan JZ, Ferguson AR, Beattie MS, Bresnahan JC, Haefeli J, Whetstone WD, Suen CG, Huang MC, Manley GT, Tarapore PE, Dhall SS
• Ultra-Early (<12 Hours) Surgery Correlates With Higher Rate of American Spinal Injury Association Impairment Scale Conversion After Cervical Spinal Cord Injury.
  Neurosurgery 2019 Burke JF, Yue JK, Ngwenya LB, Winkler EA, Talbott JF, Pan JZ, Ferguson AR, Beattie MS, Bresnahan JC, Haefeli J, Whetstone WD, Suen CG, Huang MC, Manley GT, Tarapore PE, Dhall SS
• Convolutional Neural Network-Based Automated Segmentation of the Spinal Cord and Contusion Injury: Deep Learning Biomarker Correlates of Motor Impairment in Acute Spinal Cord Injury.
  AJNR. American journal of neuroradiology 2019 McCoy DB, Dupont SM, Gros C, Cohen-Adad J, Huie RJ, Ferguson A, Duong-Fernandez X, Thomas LH, Singh V, Narvid J, Pascual L, Kyritsis N, Beattie MS, Bresnahan JC, Dhall S, Whetstone W, Talbott JF, …
• Value of aggressive surgical and intensive care unit in elderly patients with traumatic spinal cord injury.
  Neurosurgical focus 2019 Lau D, Dalle Ore CL, Tarapore PE, Huang M, Manley G, Singh V, Mummaneni PV, Beattie M, Bresnahan J, Ferguson AR, Talbott JF, Whetstone W, Dhall SS
• Neurotrauma and Critical Care of the Spine. By Jack Jallo, MD, PhD, and Alexander R. Vaccaro, MD, PhD, MBA. New York: Thieme Medical Publishers, 2018; 225 pp; $179.99 (hardcover).
  Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 2019 Whetstone WD
• Yield of Emergent CT in Patients With Epilepsy Presenting With a Seizure.
  The Neurohospitalist 2018 Kvam KA, Douglas VC, Whetstone WD, Josephson SA, Betjemann JP
• Motor Evoked Potentials Correlate With Magnetic Resonance Imaging and Early Recovery After Acute Spinal Cord Injury.
  Neurosurgery 2018 Dhall SS, Haefeli J, Talbott JF, Ferguson AR, Readdy WJ, Bresnahan JC, Beattie MS, Pan JZ, Manley GT, Whetstone WD
• Low Yield of Paired Head and Cervical Spine Computed Tomography in Blunt Trauma Evaluation.
  The Journal of emergency medicine 2018 Graterol J, Beylin M, Whetstone WD, Matzoll A, Burke R, Talbott J, Rodriguez RM
• Data-Driven Comparison Of Acute Imaging Biomarkers For Spinal Cord Injury: A Prospective TRACK-SCI Pilot Study (S42.006).
  Neurology 2018 J. Russell Huie, Jason Talbott, Vineeta Singh, Xuan Duong Fernandez, Rachel Tsolinas, Lisa Pascual, Jonathan Pan, Nikolaos Kyritsis, Dolores Torres, Michael Beattie, Jacqueline Bresnahan, Adam …
• 141.
  Critical Care Medicine 2018 Vineeta Singh, J. Russell Huie, Dolores Torres, Adam Ferguson, Michael Beattie, Jacqueline Bresnahan, Jonathan Pan, Lisa Pascual, Jason Talbott, Rachel Tsolinas, Xuan Fernandez, William Whetstone, …
• Safety and effectiveness of early chemical deep venous thrombosis prophylaxis after spinal cord injury: pilot prospective data.
  Neurosurgical focus 2017 DiGiorgio AM, Tsolinas R, Alazzeh M, Haefeli J, Talbott JF, Ferguson AR, Bresnahan JC, Beattie MS, Manley GT, Whetstone WD, Mummaneni PV, Dhall SS
• Poster 466: Prospective Determination of Clinical Neurologic Level of Injury with Early MRI Following Blunt Traumatic Spinal Cord Injury.
  PM&R 2017 Lisa U. Pascual, J. Russell Huie, William D. Whetstone, Sanjay S. Dhall, Geoffrey T. Manley, Jacqueline C. Bresnahan, Michael S. Beattie, Vineeta Singh, Adam R. Ferguson, Rachel E. Tsolinas, Jason F. …
• Protease-Activated Receptor-1 Supports Locomotor Recovery by Biased Agonist Activated Protein C after Contusive Spinal Cord Injury.
  PloS one 2017 Whetstone WD, Walker B, Trivedi A, Lee S, Noble-Haeusslein LJ, Hsu JC
• Multivariate Analysis of MRI Biomarkers for Predicting Neurologic Impairment in Cervical Spinal Cord Injury.
  AJNR. American journal of neuroradiology 2016 Haefeli J, Mabray MC, Whetstone WD, Dhall SS, Pan JZ, Upadhyayula P, Manley GT, Bresnahan JC, Beattie MS, Ferguson AR, Talbott JF
• Failure of Mean Arterial Pressure Goals to Improve Outcomes Following Penetrating Spinal Cord Injury.
  Neurosurgery 2016 Readdy WJ, Saigal R, Whetstone WD, Mefford AN, Ferguson AR, Talbott JF, Inoue T, Bresnahan JC, Beattie MS, Pan J, Manley GT, Dhall SS
• Higher Mean Arterial Pressure Values Correlate with Neurologic Improvement in Patients with Initially Complete Spinal Cord Injuries.
  World neurosurgery 2016 Catapano JS, John Hawryluk GW, Whetstone W, Saigal R, Ferguson A, Talbott J, Bresnahan J, Dhall S, Pan J, Beattie M, Manley G
• 182 Ultra-Early (<12 Hours) Decompression Improves Recovery After Spinal Cord Injury Compared to Early (12-24 Hours) Decompression.
  Neurosurgery 2016 Burke JF, Yue JK, Ngwenya LB, Winkler EA, Talbott J, Pan J, Ferguson A, Beattie M, Bresnahan J, Haefeli J, Whetstone W, Suen C, Huang MC, Manley GT, Tarapore PE, Dhall SS
• Failure of Mean Arterial Pressure Goals to Improve Outcomes Following Penetrating Spinal Cord Injury.
  Neurosurgery 2016 Readdy WJ, Saigal R, Whetstone WD, Mefford A, Ferguson AR, Talbott JF, Inoue T, Bresnahan JC, Beattie MS, Pan J, Manley GT, Dhall SS
• Multidimensional Analysis of Magnetic Resonance Imaging Predicts Early Impairment in Thoracic and Thoracolumbar Spinal Cord Injury.
  Journal of neurotrauma 2016 Mabray MC, Talbott JF, Whetstone WD, Dhall SS, Phillips DB, Pan JZ, Manley GT, Bresnahan JC, Beattie MS, Haefeli J, Ferguson AR
• Mean Arterial Blood Pressure Correlates with Neurological Recovery after Human Spinal Cord Injury: Analysis of High Frequency Physiologic Data.
  Journal of neurotrauma 2015 Hawryluk G, Whetstone W, Saigal R, Ferguson A, Talbott J, Bresnahan J, Dhall S, Pan J, Beattie M, Manley G
• Complications and outcomes of vasopressor usage in acute traumatic central cord syndrome.
  Journal of neurosurgery. Spine 2015 Readdy WJ, Whetstone WD, Ferguson AR, Talbott JF, Inoue T, Saigal R, Bresnahan JC, Beattie MS, Pan JZ, Manley GT, Dhall SS
• The Brain and Spinal Injury Center score: a novel, simple, and reproducible method for assessing the severity of acute cervical spinal cord injury with axial T2-weighted MRI findings.
  Journal of neurosurgery. Spine 2015 Talbott JF, Whetstone WD, Readdy WJ, Ferguson AR, Bresnahan JC, Saigal R, Hawryluk GW, Beattie MS, Mabray MC, Pan JZ, Manley GT, Dhall SS
• Simple text-messaging intervention is associated with improved door-to-needle times for acute ischemic stroke.
  Stroke 2014 Burnett MM, Zimmermann L, Coralic Z, Quon T, Whetstone W, Kim AS
• 161 Complications and Duration of Vasopressor Usage for Acute Traumatic Central Cord Syndrome.
  Neurosurgery 2014 Sanjay S. Dhall, Geoffrey T. Manley, Tomoo S. Inoue, William Whetstone
• 162 Higher Mean Arterial Blood Pressures Following Spinal Cord Injury are Associated With Greater Neurological Recovery.
  Neurosurgery 2014 Gregory W.J. Hawryluk, William Whetstone, Rajiv Saigal, Adam Ferguson, Jason Talbott, Jacqueline Bresnahan, Jonathan Pan, Michael Beattie, Sanjay S. Dhall, Geoffrey T. Manley
• Medical and surgical management after spinal cord injury: vasopressor usage, early surgerys, and complications.
  Journal of neurotrauma 2013 Inoue T, Manley GT, Patel N, Whetstone WD
• A Simple, Real-Time Text-Messaging Intervention Is Associated with Improvements Door-to-Needle Times for Acute Ischemic Stroke (S02.007).
  Neurology 2013 Molly Burnett, Lara Zimmermann, Zlatan Coralic, Tina Quon, William Whetstone, Anthony Kim
• The use of neuroimaging studies and neurological consultation to evaluate dizzy patients in the emergency department.
  The Neurohospitalist 2013 Navi BB, Kamel H, Shah MP, Grossman AW, Wong C, Poisson SN, Whetstone WD, Josephson SA, Johnston SC, Kim AS
• Rate and predictors of serious neurologic causes of dizziness in the emergency department.
  Mayo Clinic proceedings 2012 Navi BB, Kamel H, Shah MP, Grossman AW, Wong C, Poisson SN, Whetstone WD, Josephson SA, Johnston SC, Kim AS
• Application of the ABCD2 score to identify cerebrovascular causes of dizziness in the emergency department.
  Stroke 2012 Navi BB, Kamel H, Shah MP, Grossman AW, Wong C, Poisson SN, Whetstone WD, Josephson SA, Johnston SC, Kim AS
• Age is a determinant of leukocyte infiltration and loss of cortical volume after traumatic brain injury.
  Developmental neuroscience 2010 Claus CP, Tsuru-Aoyagi K, Adwanikar H, Walker B, Manvelyan H, Whetstone W, Noble-Haeusslein LJ
• Traumatic injury to the immature brain: inflammation, oxidative injury, and iron-mediated damage as potential therapeutic targets.
  NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics 2006 Potts MB, Koh SE, Whetstone WD, Walker BA, Yoneyama T, Claus CP, Manvelyan HM, Noble-Haeusslein LJ
• Prehospital Management of SCI Individuals with Extremity Fractures
  Topics in Spinal Cord Injury Rehabilitation 2005 William Whetstone
• Endothelin-mediated induction of heme oxygenase-1 in the spinal cord is attenuated in transgenic mice overexpressing superoxide dismutase.
  Brain research 2004 Weinzierl M, Mautes AE, Whetstone W, Lin Y, Noble-Haeusslein LJ
• Blood-spinal cord barrier after spinal cord injury: relation to revascularization and wound healing.
  Journal of neuroscience research 2003 Whetstone WD, Hsu JY, Eisenberg M, Werb Z, Noble-Haeusslein LJ