William A. Weiss, MD, PhD
Professor
Neurology
School of Medicine
We develop and use in-vivo models for neural cancers to: 1) Identify genetic events that promote tumorigenesis. 2) Study cancer stem and progenitor cells. 3) Evaluate new targets, chemical genetic approaches, and mechanistic rationales for combining targeted agents.
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Stem cell biology, genetics, and developmental therapeutics in glioma. Aberrant EGFR signaling features prominently in glioma, the most common primary adult brain tumor. We generated a mouse model for glioma by over-expressing EGFR under the S100 beta promoter (Weiss, 2003). Expression of oncogenes in rare cancer-stem-like cells in the subventricular zone led to differentiation block and aberrant glial differentiation, resulting in astrocytoma (Persson, In revision). In contrast, murine oligodendrogliomas arose from abundant oligodendroglial progenitors in white matter. We described a progenitor origin for this more favorable form of glioma, demonstrating that a progenitor rather than a stem-cell origin underlies the improved outcome in patients (Persson, 2010). We were among the first to describe oncogene addiction driven by activated EGFR (Fan, 2002). We described and characterized dual inhibitors of PI3K and mTOR, demonstrating that these drugs blocked mTOR inhibitor-driven activation of Akt, that EGFR signaling to Akt was dispensable for arrest, that EGFR signaling to Protein Kinase C alpha was central to the ability of PI3K to signal to mTOR, and that blockade of PI3K, mTOR and autophagy converted cytostatic PI3K/mTOR inhibitors into cytotoxic agents (Fan, 2006-2010). Activated alleles of EGFR occur in brain and lung-cancers, yet EGFR inhibitors benefit only lung cancer. We traced this differential response to lower occupancy rates of EGFR inhibitors in brain as compared to lung cancer mutants (Barkovich 2012). EGFR is frequently co-amplified with EGFRvIII. We showed co-expression of EGFR and vIII in individual cells in human tumors, that vIII is a substrate for EGFR, and that co-expression drives STAT signaling (Fan et al, 2013).
Targeted expression of MYCN generate models of neuroblastoma and medulloblastoma in transgenic mice. Neuroblastoma is the third most common tumor of childhood. The proto-oncogene MYCN is amplified in 25% of neuroblastomas, marking incurable disease. We generated transgenic mice that mis-expressed MYCN in neural crest, that developed neuroblastoma, and that remain the standard GEM model used by the community (Weiss et al, 1997). Genome-wide screens revealed genetic alignment with human tumors (Weiss et al, 2002, Hackett et al, 2003). Through systems biology approaches, we identified altered neurotransmitter signaling through GABA as contributing to human and murine neuroblastoma, and described the alternative splicing landscape (Hackett et al, 2014; Chen et al, 2015). Murine neuroblastoma tumors mutant at p53 were therapy resistant, modeling relapsed, drug-resistant neuroblastoma (Chesler, 2006-8). MYCN blockade reduced VEGF signaling, promoting vascular collapse (Chanthery, 2012). We synthesized and solved the co-crystal structure of a new class of MYC/MYCN-degrading drugs that block a kinase-independent MYC/MYCN stabilizing function of Aurora Kinase, potently degrading MYCN in-vivo (Gustafson, Meyerowitz, Cancer Cell, 2014).
MYCN is mis-expresssed in the majority of medulloblastoma tumors. We used the Tet system to regulate MYCN expression and to image tumor-associated firefly luciferase expression in-vivo. Targeted expression of MYCN to the brains of transgenic mice led to luciferase and MYCN-positive medulloblastoma, (Swartling, 2010). We also transduced MYCN into murine neural stem cells, separately cultured from prenatal or postnatal mice, with cells from hindbrain generating medulloblastoma, and from forebrain generating glioma. Orthotopic transduction of prenatal cerebellar stem cells drove SHH-dependent, while both prenatal brainstem and postnatal cerebellar stem cells drove SHH-independent disease (Swartling 2012). Thus, distinct neural stem cell populations generated disparate brain tumors in response to MYCN.
Genome-wide sequencing efforts have generally failed to identify new driver mutations for the majority of high-risk neuroblastoma and medulloblastoma. In contrast, copy number analyses have identified recurrent regions of variation. Regions of gain or loss on any human chromosome correspond to multiple different chromosomes in the mouse, which is challenging to model. Thus, we are incorporating known driver mutations into engineered human induced pluripotent stem cells, and have generated humanized mouse models for neuroblastoma and medulloblastoma. These human based xenograft models represent a genetic platform to test copy number variation as cancer drivers, and to develop therapies.
LEADERSHIP. I am Professor of Neurology, Pediatrics, and Neurosurgery at UCSF, Director of Clinical Child Neurology at San Francisco General Hospital, Co-Leader of the Helen Diller Family Comprehensive Cancer Center’s Pediatrics Malignancies Program and Chair of the weekly seminar series in UCSF’s Helen Diller Family Comprehensive Cancer Center, and Project PI in UCSF’s Pediatric Brain Tumor Foundation Program. I edit Breaking Advances for Cancer Research, am associate editor of the NeuroOncology, Molecular and Cellular Biology, and Scientific Reports, serve on the Neuroblastoma Biology Committee for the Children’s Oncology Group, and am advise Research Programs at Stanford and at Saint Jude Children’s Research Hospital. I have organized two international meetings on mouse models for neural cancers for the NCI, was co-organizer of the Cold Spring Harbor Models and Mechanisms of Cancer meeting (2009-2014), and was founding organizer of the now annual Medulloblastoma in the Mountains, and Pediatric Infiltrating Glioma Meeings (which bring together international basic and clinical thought leaders to translate scientific findings into patient care). I was co-chair of the program meeting for the 2007 centennial AACR meeting, and have organized basic science sessions at annual AACR meetings for many years. I was an external advisor for programs at CHLA, Mayo Clinic and University of Calgary; and have been external reviewer of NCI’s Mouse Cancer Genetics Program (2003 and 2008) and of the Departments of Genetics and of Tumor Cell Biology at St. Jude’s Children’s Research Hospital (2009). I have been a good citizen of the NIH for many years, and was a permanent member of both the NINDS NSDA study section. I was also a permanent member of the Cancer Prevention and Research Institute of Texas (under Chuck Sherr).
MENTORING RECORD. I formally mentor neurologists Li Gan (Associate Prof of Neurology at UCSF) Hannah Green, MD (Associate Prof of Neurology at UCSF), and Audrey Foster-Barber (Associate Prof of Pediatric Neurology at UCSF), David Young (fellow in Child Neurology), Christopher McGraw (resident in Neurology), and Abrar Choudhury (first year MSTP). Other mentees include Clay Gustafson, MD-PhD (K08 recipient and Alex Lemonade Stand Career Awardee, Asst Prof of Pediatrics at UCSF), Anders Persson, PhD (independent investigator and Assistant Professor of Neurology at UCSF), Theo Nicolaides, MD, (K08 recipient, independent investigator and Assistant Professor of Pediatrics at UCSF), Qi-Wen Fan, MD-PhD, (up for promotion to Associate Professor of Neurology at UCSF), and Lou Chesler (former K08 recipient and Professor at ICR in London). I was formally a mentor to Jonathan Hecht, MD-PhD (Assistant Prof of Pediatric Neurology, Stanford), Manu Hegde MD-PhD (Assistant Prof of Neurology, UCSF), Sabine Mueller, MD-PhD (Assistant Professor of Pediatric Neurology at UCSF), Kendall Nash, MD (Assistant Professor of Pediatric Neurology at UCSF), Kyle Steinman, MD (Assistant Prof of Pediatric Neurology, Univ of Washington) and Raquel Gardner (Assistant Professor at UCSF). In addition to Drs. Fan, Gustafson, Nicolaides, and Persson, above, my former postdoctoral fellow mentees also include Yvan Chanthery, PhD (now Asst Professor at Santa Clara University), Lou Chesler, MD-PhD (former K08 recipient and now full Professor and independent investigator at the Royal Marsden Hospital, ICR, UK), and Fredrik J. Swartling, PhD, (Assistant Professor and independent investigator at Uppsalla University, Sweden). I mentor on average 4-5 postdocs in my lab. Miller Huang, a postdoc in my lab, was awarded a K99 in 2016. I have mentored 4 PhD students (all have graduated) and three MD-PhD student (one graduated) in my own lab, as well as a large number of medical students and undergraduates. In addition, I mentor a large number of graduate students as a non-thesis advisor, and through sitting on qualifying exam and thesis committees.
Education & Training
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- Residency Neurology/Child Neurology UCSF 1994
- Residency Pediatrics Children's Hospital 1991
- MD-PhD Medicine/Cancer Biology Stanford University 1989
- Postdoc Cancer Biology (under J. Michael Bishop) UCSF 1988
- BS Biology Tufts University 1982
Interests
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- Mouse Models for Cancer
- Brain Cancer
- Glioma
- Neuroblastoma
- Medulloblastoma
- Pediatric Cancer
- Developmental Therapeutics
- MYCN
- Kinase Biology
Websites
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- Profile at UCSF Cancer Center (cancer.ucsf.edu)
- Weiss lab (waweisslab.ucsf.edu)
Grants and Projects
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- Prevention and treatment of lethal metastases in group 3 medulloblastoma, NIH, 2018-2023
- Brain Tumor SPORE Grant, NIH, 2002-2023
- Improving the efficacy of mTOR inhibition, NIH, 2018-2023
- Discovering and Exploiting Mechanisms of Neuroblastoma Therapy Resistance, NIH/NCI, 2017-2022
- Integrating targeted and immunotherapy to treat genetically heterogeneous cancers, NIH, 2017-2022
- Mouse models to discover new drivers of medulloblastoma, NIH, 2011-2022
- Precision Medicine For Pediatric Low-Grade Gliomas, NIH/NINDS, 2015-2020
- Targeting BET-bromodomains in neuroblastoma, NIH/NINDS, 2015-2020
- MYCN, mTOR and translation control in medulloblastoma, NIH, 2014-2019
- Murine Neuroblastoma Models for Preclinical Therapeutics, NIH/NCI, 2003-2017
- Integrating mass cytometric and transcriptomic profiles of solid tumors, NIH/NCI, 2014-2017
- Genetic network analysis of cancer targets, NIH/NCI, 2013-2017
- Biophysical and molecular dialogue of glioma cells and the brain microenvironment, NIH, 2011-2016
- Biology and Therapy of High Risk Neuroblastoma, NIH/NCI, 2000-2015
- Medulloblastoma and Metastases, NIH/NCI, 2010-2015
- Mycn and Medulloblastoma, NIH/NCI, 2009-2013
- Modifiers of Tumor Susceptibility in Murine Neuroblastoma, NIH/NINDS, 2007-2012
- Imaging Kinase Activity In Vivo, NIH/NINDS, 2005-2007
- Pediatric Clinical Research Center, NIH, 1981-2007
- Genetics of a Transgenic Mouse Model for Neuroblastoma, NIH/NINDS, 2000-2005
Publications (206)
Top publication keywords:
MedulloblastomaTOR Serine-Threonine KinasesMolecular Targeted TherapyNeoplastic Stem CellsGene Expression Regulation, NeoplasticProtein Kinase InhibitorsGlioblastomaNuclear ProteinsGliomaBrain NeoplasmsCerebellar NeoplasmsNeuroblastomaN-Myc Proto-Oncogene ProteinErbB ReceptorsOncogene Proteins
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ALK upregulates POSTN and WNT signaling to drive neuroblastoma.
Cell reports 2024 Huang M, Fang W, Farrel A, Li L, Chronopoulos A, Nasholm N, Cheng B, Zheng T, Yoda H, Barata MJ, Porras T, Miller ML, Zhen Q, Ghiglieri L, McHenry L, Wang L, Asgharzadeh S, Park J, Gustafson WC, … -
Aurora Kinase A inhibition enhances DNA damage and tumor cell death with 131I-MIBG therapy in high-risk neuroblastoma.
Research square 2024 Kumar P, Koach J, Nekritz E, Mukherjee S, Braun BS, DuBois SG, Nasholm N, Haas-Kogan D, Matthay KK, Weiss WA, Gustafson C, Seo Y -
Author Correction: Diagnostic yield of pediatric and prenatal exome sequencing in a diverse population.
NPJ genomic medicine 2023 Slavotinek A, Rego S, Sahin-Hodoglugil N, Kvale M, Lianoglou B, Yip T, Hoban H, Outram S, Anguiano B, Chen F, Michelson J, Cilio RM, Curry C, Gallagher RC, Gardner M, Kuperman R, Mendelsohn B, Sherr E… -
The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling.
Nature communications 2023 Ng VH, Spencer Z, Neitzel LR, Nayak A, Loberg MA, Shen C, Kassel SN, Kroh HK, An Z, Anthony CC, Bryant JM, Lawson A, Goldsmith L, Benchabane H, Hansen AG, Li J, D'Souza S, Lebensohn AM, Rohatgi R, … -
PRDM6 promotes medulloblastoma by repressing chromatin accessibility and altering gene expression.
bioRxiv : the preprint server for biology 2023 Schmidt C, Cohen S, Gudenas BL, Husain S, Carlson A, Westelman S, Wang L, Phillips JJ, Northcott PA, Weiss WA, Schwer B
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Hedgehog target genes regulate lipid metabolism to drive basal cell carcinoma and medulloblastoma.
Research square 2023 Daggubati V, Vykunta A, Choudhury A, Qadeer Z, Mirchia K, Saulnier O, Zakimi N, Hines K, Paul M, Wang L, Jura N, Xu L, Reiter J, Taylor M, Weiss W, Raleigh D -
Diagnostic yield of pediatric and prenatal exome sequencing in a diverse population.
NPJ genomic medicine 2023 Slavotinek A, Rego S, Sahin-Hodoglugil N, Kvale M, Lianoglou B, Yip T, Hoban H, Outram S, Anguiano B, Chen F, Michelson J, Cilio RM, Curry C, Gallagher RC, Gardner M, Kuperman R, Mendelsohn B, Sherr E… -
Loss of phosphatase CTDNEP1 potentiates aggressive medulloblastoma by triggering MYC amplification and genomic instability.
Nature communications 2023 Luo Z, Xin D, Liao Y, Berry K, Ogurek S, Zhang F, Zhang L, Zhao C, Rao R, Dong X, Li H, Yu J, Lin Y, Huang G, Xu L, Xin M, Nishinakamura R, Yu J, Kool M, Pfister SM, Roussel MF, Zhou W, Weiss WA, … -
Clinical significance and molecular annotation of cellular morphometric subtypes in lower-grade gliomas discovered by machine learning.
Neuro-oncology 2023 Liu XP, Jin X, Seyed Ahmadian S, Yang X, Tian SF, Cai YX, Chawla K, Snijders AM, Xia Y, van Diest PJ, Weiss WA, Mao JH, Li ZQ, Vogel H, Chang H -
N-myc-Mediated Translation Control Is a Therapeutic Vulnerability in Medulloblastoma.
Cancer research 2023 Kuzuoglu-Ozturk D, Aksoy O, Schmidt C, Lea R, Larson JD, Phelps RRL, Nasholm N, Holt M, Contreras A, Huang M, Wong-Michalak S, Shao H, Wechsler-Reya R, Phillips JJ, Gestwicki JE, Ruggero D, Weiss WA -
Wnt Signaling in the Phenotype and Function of Tumor-Associated Macrophages.
Cancer research 2023 Tigue ML, Loberg MA, Goettel JA, Weiss WA, Lee E, Weiss VL -
Epigenetic Rewiring Underlies SMARCA4-Dependent Maintenance of Progenitor State in Pediatric H3K27M Diffuse Midline Glioma.
Cancer discovery 2022 Beytagh MC, Weiss WA -
Author Correction: Failure of human rhombic lip differentiation underlies medulloblastoma formation.
Nature 2022 Hendrikse LD, Haldipur P, Saulnier O, Millman J, Sjoboen AH, Erickson AW, Ong W, Gordon V, Coudière-Morrison L, Mercier AL, Shokouhian M, Suárez RA, Ly M, Borlase S, Scott DS, Vladoiu MC, Farooq H, … -
Transposon Mutagenesis Reveals RBMS3 Silencing as a Promoter of Malignant Progression of BRAFV600E-Driven Lung Tumorigenesis.
Cancer research 2022 Vaishnavi A, Juan J, Jacob M, Stehn C, Gardner EE, Scherzer MT, Schuman S, Van Veen JE, Murphy B, Hackett CS, Dupuy AJ, Chmura SA, van der Weyden L, Newberg JY, Liu A, Mann K, Rust AG, Weiss WA, … -
Failure of human rhombic lip differentiation underlies medulloblastoma formation.
Nature 2022 Hendrikse LD, Haldipur P, Saulnier O, Millman J, Sjoboen AH, Erickson AW, Ong W, Gordon V, Coudière-Morrison L, Mercier AL, Shokouhian M, Suárez RA, Ly M, Borlase S, Scott DS, Vladoiu MC, Farooq H, … -
Brain-restricted mTOR inhibition with binary pharmacology.
Nature 2022 Zhang Z, Fan Q, Luo X, Lou K, Weiss WA, Shokat KM -
Developing Bottom-Up Induced Pluripotent Stem Cell Derived Solid Tumor Models Using Precision Genome Editing Technologies.
The CRISPR journal 2022 Becklin KL, Draper GM, Madden RA, Kluesner MG, Koga T, Huang M, Weiss WA, Spector LG, Largaespada DA, Moriarity BS, Webber BR -
EGFR ligands dictate tumour suppression.
Nature cell biology 2022 Beytagh MC, Weiss WA -
CD55, a potential immunotherapeutic target for MYCN-amplified neuroblastoma.
Neuro-oncology 2022 Yoda H, Weiss WA -
Nuclear tetraspanin 8 promotes breast cancer progression.
Cell research 2022 Sandoval K, Weiss WA -
Generation of immunocompetent syngeneic allograft mouse models for pediatric diffuse midline glioma.
Neuro-oncology advances 2022 du Chatinier A, Meel MH, Das AI, Metselaar DS, Waranecki P, Bugiani M, Breur M, Simonds EF, Lu ED, Weiss WA, Garcia Vallejo JJ, Hoving EW, Phoenix TN, Hulleman E -
Anti-GD2 synergizes with CD47 blockade to mediate tumor eradication.
Nature medicine 2022 Theruvath J, Menard M, Smith BAH, Linde MH, Coles GL, Dalton GN, Wu W, Kiru L, Delaidelli A, Sotillo E, Silberstein JL, Geraghty AC, Banuelos A, Radosevich MT, Dhingra S, Heitzeneder S, Tousley A, … -
All eyes on a phosphatase in glioma stem cells.
The Journal of experimental medicine 2021 Lindquist RA, Weiss WA -
Subgroup and subtype-specific outcomes in adult medulloblastoma.
Acta neuropathologica 2021 Coltin H, Sundaresan L, Smith KS, Skowron P, Massimi L, Eberhart CG, Schreck KC, Gupta N, Weiss WA, Tirapelli D, Carlotti C, Li KKW, Ryzhova M, Golanov A, Zheludkova O, Absalyamova O, Okonechnikov K, … -
A SHHecret target of relapsed medulloblastoma: Astrocytes.
The Journal of experimental medicine 2021 Qadeer ZA, Weiss WA -
The synergy of BET inhibitors with aurora A kinase inhibitors in MYCN-amplified neuroblastoma is heightened with functional TP53.
Neoplasia (New York, N.Y.) 2021 Yi JS, Sias-Garcia O, Nasholm N, Hu X, Iniguez AB, Hall MD, Davis M, Guha R, Moreno-Smith M, Barbieri E, Duong K, Koach J, Qi J, Bradner JE, Stegmaier K, Weiss WA, Gustafson WC -
Deep immune profiling reveals targetable mechanisms of immune evasion in immune checkpoint inhibitor-refractory glioblastoma.
Journal for immunotherapy of cancer 2021 Simonds EF, Lu ED, Badillo O, Karimi S, Liu EV, Tamaki W, Rancan C, Downey KM, Stultz J, Sinha M, McHenry LK, Nasholm NM, Chuntova P, Sundström A, Genoud V, Shahani SA, Wang LD, Brown CE, Walker PR, … -
Heterozygous ANKRD17 loss-of-function variants cause a syndrome with intellectual disability, speech delay, and dysmorphism.
American journal of human genetics 2021 Chopra M, McEntagart M, Clayton-Smith J, Platzer K, Shukla A, Girisha KM, Kaur A, Kaur P, Pfundt R, Veenstra-Knol H, Mancini GMS, Cappuccio G, Brunetti-Pierri N, Kortüm F, Hempel M, Denecke J, Lehman … -
The transcriptional landscape of Shh medulloblastoma.
Nature communications 2021 Skowron P, Farooq H, Cavalli FMG, Morrissy AS, Ly M, Hendrikse LD, Wang EY, Djambazian H, Zhu H, Mungall KL, Trinh QM, Zheng T, Dai S, Stucklin ASG, Vladoiu MC, Fong V, Holgado BL, Nor C, Wu X, Abd-… -
An expanded universe of cancer targets.
Cell 2021 Hahn WC, Bader JS, Braun TP, Califano A, Clemons PA, Druker BJ, Ewald AJ, Fu H, Jagu S, Kemp CJ, Kim W, Kuo CJ, McManus M, B Mills G, Mo X, Sahni N, Schreiber SL, Talamas JA, Tamayo P, Tyner JW, … -
Integrated molecular and clinical analysis of low-grade gliomas in children with neurofibromatosis type 1 (NF1).
Acta neuropathologica 2021 Fisher MJ, Jones DTW, Li Y, Guo X, Sonawane PS, Waanders AJ, Phillips JJ, Weiss WA, Resnick AC, Gosline S, Banerjee J, Guinney J, Gnekow A, Kandels D, Foreman NK, Korshunov A, Ryzhova M, Massimi L, … -
Drugging the "Undruggable" MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers.
Cancer research 2021 Wolpaw AJ, Bayliss R, Büchel G, Dang CV, Eilers M, Gustafson WC, Hansen GH, Jura N, Knapp S, Lemmon MA, Levens D, Maris JM, Marmorstein R, Metallo SJ, Park JR, Penn LZ, Rape M, Roussel MF, Shokat KM, … -
Utility of Human-Derived Models for Glioblastoma.
Cancer discovery 2020 Luo X, Weiss WA -
Pattern of Relapse and Treatment Response in WNT-Activated Medulloblastoma.
Cell reports. Medicine 2020 Nobre L, Zapotocky M, Khan S, Fukuoka K, Fonseca A, McKeown T, Sumerauer D, Vicha A, Grajkowska WA, Trubicka J, Li KKW, Ng HK, Massimi L, Lee JY, Kim SK, Zelcer S, Vasiljevic A, Faure-Conter C, Hauser… -
Depatuxizumab Mafodotin (ABT-414)-induced Glioblastoma Cell Death Requires EGFR Overexpression, but not EGFRY1068 Phosphorylation.
Molecular cancer therapeutics 2020 von Achenbach C, Silginer M, Blot V, Weiss WA, Weller M -
Betacellulin drives therapy resistance in glioblastoma.
Neuro-oncology 2020 Fan Q, An Z, Wong RA, Luo X, Lu ED, Baldwin A, Mayekar MK, Haderk F, Shokat KM, Bivona TG, Weiss WA -
Conversations on mutism: risk stratification for cerebellar mutism based on medulloblastoma subtype.
Neuro-oncology 2020 Russ JB, Weiss WA -
Translating Basic Science Discoveries into Improved Outcomes for Glioblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2020 Dirks PB, Gilbert MR, Holland EC, Maher EA, Weiss WA -
Cooperative Blockade of PKCα and JAK2 Drives Apoptosis in Glioblastoma.
Cancer research 2019 Wong RA, Luo X, Lu M, An Z, Haas-Kogan DA, Phillips JJ, Shokat KM, Weiss WA, Fan QW -
Correction: EGFR Cooperates with EGFRvIII to Recruit Macrophages in Glioblastoma.
Cancer research 2019 An Z, Knobbe-Thomsen CB, Wan X, Fan QW, Reifenberger G, Weiss WA -
ATRX In-Frame Fusion Neuroblastoma Is Sensitive to EZH2 Inhibition via Modulation of Neuronal Gene Signatures.
Cancer cell 2019 Qadeer ZA, Valle-Garcia D, Hasson D, Sun Z, Cook A, Nguyen C, Soriano A, Ma A, Griffiths LM, Zeineldin M, Filipescu D, Jubierre L, Chowdhury A, Deevy O, Chen X, Finkelstein DB, Bahrami A, Stewart E, … -
Recurrent noncoding U1 snRNA mutations drive cryptic splicing in SHH medulloblastoma.
Nature 2019 Suzuki H, Kumar SA, Shuai S, Diaz-Navarro A, Gutierrez-Fernandez A, De Antonellis P, Cavalli FMG, Juraschka K, Farooq H, Shibahara I, Vladoiu MC, Zhang J, Abeysundara N, Przelicki D, Skowron P, Gauer … -
Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse.
Cancer cell 2019 Zhang L, He X, Liu X, Zhang F, Huang LF, Potter AS, Xu L, Zhou W, Zheng T, Luo Z, Berry KP, Pribnow A, Smith SM, Fuller C, Jones BV, Fouladi M, Drissi R, Yang ZJ, Gustafson WC, Remke M, Pomeroy SL, … -
Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers.
Cell reports 2019 Chatterjee N, Pazarentzos E, Mayekar MK, Gui P, Allegakoen DV, Hrustanovic G, Olivas V, Lin L, Verschueren E, Johnson JR, Hofree M, Yan JJ, Newton BW, Dollen JV, Earnshaw CH, Flanagan J, Chan E, … -
Driving Neuronal Differentiation through Reversal of an ERK1/2-miR-124-SOX9 Axis Abrogates Glioblastoma Aggressiveness.
Cell reports 2019 Sabelström H, Petri R, Shchors K, Jandial R, Schmidt C, Sacheva R, Masic S, Yuan E, Fenster T, Martinez M, Saxena S, Nicolaides TP, Ilkhanizadeh S, Berger MS, Snyder EY, Weiss WA, Jakobsson J, Persson… -
In Vitro Assay to Study Tumor-macrophage Interaction.
Journal of visualized experiments : JoVE 2019 An Z, Weiss WA -
Mechanisms of Resistance to EGFR Inhibition Reveal Metabolic Vulnerabilities in Human GBM.
Molecular cancer therapeutics 2019 McKinney A, Lindberg OR, Engler JR, Chen KY, Kumar A, Gong H, Lu KV, Simonds EF, Cloughesy TF, Liau LM, Prados M, Bollen AW, Berger MS, Shieh JTC, James CD, Nicolaides TP, Yong WH, Lai A, Hegi ME, … -
Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis.
Cell stem cell 2019 Huang M, Tailor J, Zhen Q, Gillmor AH, Miller ML, Weishaupt H, Chen J, Zheng T, Nash EK, McHenry LK, An Z, Ye F, Takashima Y, Clarke J, Ayetey H, Cavalli FMG, Luu B, Moriarity BS, Ilkhanizadeh S, … -
Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma.
Nature communications 2019 Lee C, Rudneva VA, Erkek S, Zapatka M, Chau LQ, Tacheva-Grigorova SK, Garancher A, Rusert JM, Aksoy O, Lea R, Mohammad HP, Wang J, Weiss WA, Grimes HL, Pfister SM, Northcott PA, Wechsler-Reya RJ -
Single-cell RNA-Seq of follicular lymphoma reveals malignant B-cell types and coexpression of T-cell immune checkpoints.
Blood 2018 Andor N, Simonds EF, Czerwinski DK, Chen J, Grimes SM, Wood-Bouwens C, Zheng GXY, Kubit MA, Greer S, Weiss WA, Levy R, Ji HP -
Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling.
Cancer cell 2018 Iniguez AB, Alexe G, Wang EJ, Roti G, Patel S, Chen L, Kitara S, Conway A, Robichaud AL, Stolte B, Bandopadhayay P, Goodale A, Pantel S, Lee Y, Cheff DM, Hall MD, Guha R, Davis MI, Menard M, Nasholm N… -
GateFinder: projection-based gating strategy optimization for flow and mass cytometry.
Bioinformatics (Oxford, England) 2018 Aghaeepour N, Simonds EF, Knapp DJHF, Bruggner RV, Sachs K, Culos A, Gherardini PF, Samusik N, Fragiadakis GK, Bendall SC, Gaudilliere B, Angst MS, Eaves CJ, Weiss WA, Fantl WJ, Nolan GP -
A CK1α Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2018 Rodriguez-Blanco J, Li B, Long J, Shen C, Yang F, Orton D, Collins S, Kasahara N, Ayad NG, McCrea HJ, Roussel MF, Weiss WA, Capobianco AJ, Robbins DJ -
An oncolytic measles virus-sensitive Group 3 medulloblastoma model in immune-competent mice.
Neuro-oncology 2018 Lal S, Carrera D, Phillips JJ, Weiss WA, Raffel C -
EGFR Cooperates with EGFRvIII to Recruit Macrophages in Glioblastoma.
Cancer research 2018 An Z, Knobbe-Thomsen CB, Wan X, Fan QW, Reifenberger G, Weiss WA -
A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases.
Cell 2018 Garzia L, Kijima N, Morrissy AS, De Antonellis P, Guerreiro-Stucklin A, Holgado BL, Wu X, Wang X, Parsons M, Zayne K, Manno A, Kuzan-Fischer C, Nor C, Donovan LK, Liu J, Qin L, Garancher A, Liu KW, … -
Dual HDAC and PI3K Inhibition Abrogates NFκB- and FOXM1-Mediated DNA Damage Response to Radiosensitize Pediatric High-Grade Gliomas.
Cancer research 2018 Pal S, Kozono D, Yang X, Fendler W, Fitts W, Ni J, Alberta JA, Zhao J, Liu KX, Bian J, Truffaux N, Weiss WA, Resnick AC, Bandopadhayay P, Ligon KL, DuBois SG, Mueller S, Chowdhury D, Haas-Kogan DA -
Metastatic group 3 medulloblastoma is driven by PRUNE1 targeting NME1-TGF-β-OTX2-SNAIL via PTEN inhibition.
Brain : a journal of neurology 2018 Ferrucci V, de Antonellis P, Pennino FP, Asadzadeh F, Virgilio A, Montanaro D, Galeone A, Boffa I, Pisano I, Scognamiglio I, Navas L, Diana D, Pedone E, Gargiulo S, Gramanzini M, Brunetti A, Danielson… -
A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment.
Cancer cell 2018 Griveau A, Seano G, Shelton SJ, Kupp R, Jahangiri A, Obernier K, Krishnan S, Lindberg OR, Yuen TJ, Tien AC, Sabo JK, Wang N, Chen I, Kloepper J, Larrouquere L, Ghosh M, Tirosh I, Huillard E, Alvarez-… -
Combined BET bromodomain and CDK2 inhibition in MYC-driven medulloblastoma.
Oncogene 2018 Bolin S, Borgenvik A, Persson CU, Sundström A, Qi J, Bradner JE, Weiss WA, Cho YJ, Weishaupt H, Swartling FJ -
A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases.
Cell 2018 Garzia L, Kijima N, Morrissy AS, De Antonellis P, Guerreiro-Stucklin A, Holgado BL, Wu X, Wang X, Parsons M, Zayne K, Manno A, Kuzan-Fischer C, Nor C, Donovan LK, Liu J, Qin L, Garancher A, Liu KW, … -
Antisecretory Factor-Mediated Inhibition of Cell Volume Dynamics Produces Antitumor Activity in Glioblastoma.
Molecular cancer research : MCR 2018 Ilkhanizadeh S, Sabelström H, Miroshnikova YA, Frantz A, Zhu W, Idilli A, Lakins JN, Schmidt C, Quigley DA, Fenster T, Yuan E, Trzeciak JR, Saxena S, Lindberg OR, Mouw JK, Burdick JA, Magnitsky S, … -
Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies.
Oncogene 2018 An Z, Aksoy O, Zheng T, Fan QW, Weiss WA -
CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2.
The Journal of clinical investigation 2017 Chen L, Alexe G, Dharia NV, Ross L, Iniguez AB, Conway AS, Wang EJ, Veschi V, Lam N, Qi J, Gustafson WC, Nasholm N, Vazquez F, Weir BA, Cowley GS, Ali LD, Pantel S, Jiang G, Harrington WF, Lee Y, … -
Neuroblastoma Metastases: Leveraging the Avian Neural Crest.
Cancer cell 2017 Zheng T, Ménard M, Weiss WA -
Cross-activating c-Met/β1 integrin complex drives metastasis and invasive resistance in cancer.
Proceedings of the National Academy of Sciences of the United States of America 2017 Jahangiri A, Nguyen A, Chandra A, Sidorov MK, Yagnik G, Rick J, Han SW, Chen W, Flanigan PM, Schneidman-Duhovny D, Mascharak S, De Lay M, Imber B, Park CC, Matsumoto K, Lu K, Bergers G, Sali A, Weiss … -
CNS Anticancer Drug Discovery and Development: 2016 conference insights.
CNS oncology 2017 Levin VA, Abrey LE, Heffron TP, Tonge PJ, Dar AC, Weiss WA, Gallo JM -
Inhibition of WNT signaling attenuates self-renewal of SHH-subgroup medulloblastoma.
Oncogene 2017 Rodriguez-Blanco J, Pednekar L, Penas C, Li B, Martin V, Long J, Lee E, Weiss WA, Rodriguez C, Mehrdad N, Nguyen DM, Ayad NG, Rai P, Capobianco AJ, Robbins DJ -
Inhibiting 4EBP1 in Glioblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2017 Fan QW, Nicolaides TP, Weiss WA -
Glioblastoma cellular cross-talk converges on NF-κB to attenuate EGFR inhibitor sensitivity.
Genes & development 2017 Zanca C, Villa GR, Benitez JA, Thorne AH, Koga T, D'Antonio M, Ikegami S, Ma J, Boyer AD, Banisadr A, Jameson NM, Parisian AD, Eliseeva OV, Barnabe GF, Liu F, Wu S, Yang H, Wykosky J, Frazer KA, … -
Intertumoral Heterogeneity within Medulloblastoma Subgroups.
Cancer cell 2017 Cavalli FMG, Remke M, Rampasek L, Peacock J, Shih DJH, Luu B, Garzia L, Torchia J, Nor C, Morrissy AS, Agnihotri S, Thompson YY, Kuzan-Fischer CM, Farooq H, Isaev K, Daniels C, Cho BK, Kim SK, Wang KC… -
Targeting Alpha Toxin To Mitigate Its Lethal Toxicity in Ferret and Rabbit Models of Staphylococcus aureus Necrotizing Pneumonia.
Antimicrobial agents and chemotherapy 2017 Diep BA, Hilliard JJ, Le VT, Tkaczyk C, Le HN, Tran VG, Rao RL, Dip EC, Pereira-Franchi EP, Cha P, Jacobson S, Broome R, Cheng LI, Weiss W, Prokai L, Nguyen V, Stover CK, Sellman BR -
A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma.
Cancer cell 2017 Fan Q, Aksoy O, Wong RA, Ilkhanizadeh S, Novotny CJ, Gustafson WC, Truong AY, Cayanan G, Simonds EF, Haas-Kogan D, Phillips JJ, Nicolaides T, Okaniwa M, Shokat KM, Weiss WA -
Pediatric high-grade glioma: biologically and clinically in need of new thinking.
Neuro-oncology 2017 Jones C, Karajannis MA, Jones DTW, Kieran MW, Monje M, Baker SJ, Becher OJ, Cho YJ, Gupta N, Hawkins C, Hargrave D, Haas-Kogan DA, Jabado N, Li XN, Mueller S, Nicolaides T, Packer RJ, Persson AI, … -
Acquired resistance to BRAF inhibition in BRAFV600E mutant gliomas.
Oncotarget 2017 Yao TW, Zhang J, Prados M, Weiss WA, James CD, Nicolaides T -
Breast density estimation from high spectral and spatial resolution MRI.
Journal of medical imaging (Bellingham, Wash.) 2016 Li H, Weiss WA, Medved M, Abe H, Newstead GM, Karczmar GS, Giger ML -
Combined BRAFV600E and MEK blockade for BRAFV600E-mutant gliomas.
Journal of neuro-oncology 2016 Zhang J, Yao TW, Hashizume R, Hariono S, Barkovich KJ, Fan QW, Prados M, James CD, Weiss WA, Nicolaides T -
Cholesterol: An Achilles' Heel for Glioblastoma?
Cancer cell 2016 An Z, Weiss WA -
Neuroblastoma.
Nature reviews. Disease primers 2016 Matthay KK, Maris JM, Schleiermacher G, Nakagawara A, Mackall CL, Diller L, Weiss WA -
IKK/NF-κB signaling contributes to glioblastoma stem cell maintenance.
Oncotarget 2016 Rinkenbaugh AL, Cogswell PC, Calamini B, Dunn DE, Persson AI, Weiss WA, Lo DC, Baldwin AS -
Critical Role of Alpha-Toxin and Protective Effects of Its Neutralization by a Human Antibody in Acute Bacterial Skin and Skin Structure Infections.
Antimicrobial agents and chemotherapy 2016 Le VT, Tkaczyk C, Chau S, Rao RL, Dip EC, Pereira-Franchi EP, Cheng L, Lee S, Koelkebeck H, Hilliard JJ, Yu XQ, Datta V, Nguyen V, Weiss W, Prokai L, O'Day T, Stover CK, Sellman BR, Diep BA -
Inhibition of mTOR-kinase destabilizes MYCN and is a potential therapy for MYCN-dependent tumors.
Oncotarget 2016 Vaughan L, Clarke PA, Barker K, Chanthery Y, Gustafson CW, Tucker E, Renshaw J, Raynaud F, Li X, Burke R, Jamin Y, Robinson SP, Pearson A, Maira M, Weiss WA, Workman P, Chesler L -
BRAF Status in Personalizing Treatment Approaches for Pediatric Gliomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2016 Olow A, Mueller S, Yang X, Hashizume R, Meyerowitz J, Weiss W, Resnick AC, Waanders AJ, Stalpers LJ, Berger MS, Gupta N, James CD, Petritsch CK, Haas-Kogan DA -
Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis.
The Lancet. Oncology 2016 Thompson EM, Hielscher T, Bouffet E, Remke M, Luu B, Gururangan S, McLendon RE, Bigner DD, Lipp ES, Perreault S, Cho YJ, Grant G, Kim SK, Lee JY, Rao AAN, Giannini C, Li KKW, Ng HK, Yao Y, Kumabe T, … -
Erratum to: Survival advantage combining a BRAF inhibitor and radiation in BRAF V600E-mutant glioma.
Journal of neuro-oncology 2016 Dasgupta T, Olow AK, Yang X, Hashizume R, Nicolaides TP, Tom M, Aoki Y, Berger MS, Weiss WA, Stalpers LJ, Prados M, James CD, Mueller S, Haas-Kogan DA -
Generating trunk neural crest from human pluripotent stem cells.
Scientific reports 2016 Huang M, Miller ML, McHenry LK, Zheng T, Zhen Q, Ilkhanizadeh S, Conklin BR, Bronner ME, Weiss WA -
Divergent clonal selection dominates medulloblastoma at recurrence.
Nature 2016 Morrissy AS, Garzia L, Shih DJ, Zuyderduyn S, Huang X, Skowron P, Remke M, Cavalli FM, Ramaswamy V, Lindsay PE, Jelveh S, Donovan LK, Wang X, Luu B, Zayne K, Li Y, Mayoh C, Thiessen N, Mercier E, … -
Rational design of a monomeric and photostable far-red fluorescent protein for fluorescence imaging in vivo.
Protein science : a publication of the Protein Society 2015 Yu D, Dong Z, Gustafson WC, Ruiz-González R, Signor L, Marzocca F, Borel F, Klassen MP, Makhijani K, Royant A, Jan YN, Weiss WA, Guo S, Shu X -
Survival advantage combining a BRAF inhibitor and radiation in BRAF V600E-mutant glioma.
Journal of neuro-oncology 2015 Dasgupta T, Olow AK, Yang X, Hashizume R, Nicolaides TP, Tom M, Aoki Y, Berger MS, Weiss WA, Stalpers LJ, Prados M, James CD, Mueller S, Haas-Kogan DA -
EGFR blockade prevents glioma escape from BRAFV600E targeted therapy.
Oncotarget 2015 Yao TW, Zhang J, Prados M, Weiss WA, James CD, Nicolaides T -
STAT3 Blockade Inhibits Radiation-Induced Malignant Progression in Glioma.
Cancer research 2015 Lau J, Ilkhanizadeh S, Wang S, Miroshnikova YA, Salvatierra NA, Wong RA, Schmidt C, Weaver VM, Weiss WA, Persson AI -
EAG2 potassium channel with evolutionarily conserved function as a brain tumor target.
Nature neuroscience 2015 Huang X, He Y, Dubuc AM, Hashizume R, Zhang W, Reimand J, Yang H, Wang TA, Stehbens SJ, Younger S, Barshow S, Zhu S, Cooper MK, Peacock J, Ramaswamy V, Garzia L, Wu X, Remke M, Forester CM, Kim CC, … -
Downregulation of MYCN through PI3K Inhibition in Mouse Models of Pediatric Neural Cancer.
Frontiers in oncology 2015 Cage TA, Chanthery Y, Chesler L, Grimmer M, Knight Z, Shokat K, Weiss WA, Gustafson WC -
Spinal Myxopapillary Ependymomas Demonstrate a Warburg Phenotype.
Clinical cancer research : an official journal of the American Association for Cancer Research 2015 Mack SC, Agnihotri S, Bertrand KC, Wang X, Shih DJ, Witt H, Hill N, Zayne K, Barszczyk M, Ramaswamy V, Remke M, Thompson Y, Ryzhova M, Massimi L, Grajkowska W, Lach B, Gupta N, Weiss WA, Guha A, … -
Preliminary assessment of dispersion versus absorption analysis of high spectral and spatial resolution magnetic resonance images in the diagnosis of breast cancer.
Journal of medical imaging (Bellingham, Wash.) 2015 Weiss WA, Medved M, Karczmar GS, Giger ML -
A new "angle" on kinase inhibitor design: Prioritizing amphosteric activity above kinase inhibition.
Molecular & cellular oncology 2015 Meyerowitz JG, Weiss WA, Gustafson WC -
The genetics of splicing in neuroblastoma.
Cancer discovery 2015 Chen J, Hackett CS, Zhang S, Song YK, Bell RJ, Molinaro AM, Quigley DA, Balmain A, Song JS, Costello JF, Gustafson WC, Van Dyke T, Kwok PY, Khan J, Weiss WA -
WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma.
Acta neuropathologica communications 2014 Zhukova N, Ramaswamy V, Remke M, Martin DC, Castelo-Branco P, Zhang CH, Fraser M, Tse K, Poon R, Shih DJ, Baskin B, Ray PN, Bouffet E, Dirks P, von Bueren AO, Pfaff E, Korshunov A, Jones DT, Northcott… -
Combined MYC and P53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease.
Cancer cell 2014 Hill RM, Kuijper S, Lindsey JC, Petrie K, Schwalbe EC, Barker K, Boult JK, Williamson D, Ahmad Z, Hallsworth A, Ryan SL, Poon E, Robinson SP, Ruddle R, Raynaud FI, Howell L, Kwok C, Joshi A, Nicholson… -
Radiotherapy followed by aurora kinase inhibition targets tumor-propagating cells in human glioblastoma.
Molecular cancer therapeutics 2014 Li N, Maly DJ, Chanthery YH, Sirkis DW, Nakamura JL, Berger MS, James CD, Shokat KM, Weiss WA, Persson AI -
Expression quantitative trait loci and receptor pharmacology implicate Arg1 and the GABA-A receptor as therapeutic targets in neuroblastoma.
Cell reports 2014 Hackett CS, Quigley DA, Wong RA, Chen J, Cheng C, Song YK, Wei JS, Pawlikowska L, Bao Y, Goldenberg DD, Nguyen K, Gustafson WC, Rallapalli SK, Cho YJ, Cook JM, Kozlov S, Mao JH, Van Dyke T, Kwok PY, … -
Drugging MYCN through an allosteric transition in Aurora kinase A.
Cancer cell 2014 Gustafson WC, Meyerowitz JG, Nekritz EA, Chen J, Benes C, Charron E, Simonds EF, Seeger R, Matthay KK, Hertz NT, Eilers M, Shokat KM, Weiss WA -
When deletions gain functions: commandeering epigenetic mechanisms.
Cancer cell 2014 Chen J, Weiss WA -
An improved monomeric infrared fluorescent protein for neuronal and tumour brain imaging.
Nature communications 2014 Yu D, Gustafson WC, Han C, Lafaye C, Noirclerc-Savoye M, Ge WP, Thayer DA, Huang H, Kornberg TB, Royant A, Jan LY, Jan YN, Weiss WA, Shu X -
Assessment and prognostic significance of the epidermal growth factor receptor vIII mutation in glioblastoma patients treated with concurrent and adjuvant temozolomide radiochemotherapy.
International journal of cancer 2014 Weller M, Kaulich K, Hentschel B, Felsberg J, Gramatzki D, Pietsch T, Simon M, Westphal M, Schackert G, Tonn JC, von Deimling A, Davis T, Weiss WA, Loeffler M, Reifenberger G, German Glioma Network -
The prenatal origins of cancer.
Nature reviews. Cancer 2014 Marshall GM, Carter DR, Cheung BB, Liu T, Mateos MK, Meyerowitz JG, Weiss WA -
Epigenomic alterations define lethal CIMP-positive ependymomas of infancy.
Nature 2014 Mack SC, Witt H, Piro RM, Gu L, Zuyderduyn S, Stütz AM, Wang X, Gallo M, Garzia L, Zayne K, Zhang X, Ramaswamy V, Jäger N, Jones DT, Sill M, Pugh TJ, Ryzhova M, Wani KM, Shih DJ, Head R, Remke M, … -
Cytogenetic prognostication within medulloblastoma subgroups.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2014 Shih DJ, Northcott PA, Remke M, Korshunov A, Ramaswamy V, Kool M, Luu B, Yao Y, Wang X, Dubuc AM, Garzia L, Peacock J, Mack SC, Wu X, Rolider A, Morrissy AS, Cavalli FM, Jones DT, Zitterbart K, Faria … -
Alternative splicing in cancer: implications for biology and therapy.
Oncogene 2014 Chen J, Weiss WA -
Glial progenitors as targets for transformation in glioma.
Advances in cancer research 2014 Ilkhanizadeh S, Lau J, Huang M, Foster DJ, Wong R, Frantz A, Wang S, Weiss WA, Persson AI -
Residual analysis of the water resonance signal in breast lesions imaged with high spectral and spatial resolution (HiSS) MRI: a pilot study.
Medical physics 2014 Weiss WA, Medved M, Karczmar GS, Giger ML -
Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma.
Science (New York, N.Y.) 2013 Johnson BE, Mazor T, Hong C, Barnes M, Aihara K, McLean CY, Fouse SD, Yamamoto S, Ueda H, Tatsuno K, Asthana S, Jalbert LE, Nelson SJ, Bollen AW, Gustafson WC, Charron E, Weiss WA, Smirnov IV, Song JS… -
BET bromodomain inhibition of MYC-amplified medulloblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Bandopadhayay P, Bergthold G, Nguyen B, Schubert S, Gholamin S, Tang Y, Bolin S, Schumacher SE, Zeid R, Masoud S, Yu F, Vue N, Gibson WJ, Paolella BR, Mitra SS, Cheshier SH, Qi J, Liu KW, Wechsler-… -
Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group.
Acta neuropathologica 2013 Gottardo NG, Hansford JR, McGlade JP, Alvaro F, Ashley DM, Bailey S, Baker DL, Bourdeaut F, Cho YJ, Clay M, Clifford SC, Cohn RJ, Cole CH, Dallas PB, Downie P, Doz F, Ellison DW, Endersby R, Fisher PG… -
TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma.
Acta neuropathologica 2013 Remke M, Ramaswamy V, Peacock J, Shih DJ, Koelsche C, Northcott PA, Hill N, Cavalli FM, Kool M, Wang X, Mack SC, Barszczyk M, Morrissy AS, Wu X, Agnihotri S, Luu B, Jones DT, Garzia L, Dubuc AM, … -
EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma.
Cancer cell 2013 Fan QW, Cheng CK, Gustafson WC, Charron E, Zipper P, Wong RA, Chen J, Lau J, Knobbe-Thomsen C, Weller M, Jura N, Reifenberger G, Shokat KM, Weiss WA -
Fundamental differences in promoter CpG island DNA hypermethylation between human cancer and genetically engineered mouse models of cancer.
Epigenetics 2013 Diede SJ, Yao Z, Keyes CC, Tyler AE, Dey J, Hackett CS, Elsaesser K, Kemp CJ, Neiman PE, Weiss WA, Olson JM, Tapscott SJ -
It takes two to tango: Dual inhibition of PI3K and MAPK in rhabdomyosarcoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Jahangiri A, Weiss WA -
Neuroblastoma and MYCN.
Cold Spring Harbor perspectives in medicine 2013 Huang M, Weiss WA -
Starvation favors glioma stem cells.
Nature neuroscience 2013 Ilkhanizadeh S, Weiss WA -
Imaging-based chemical screening reveals activity-dependent neural differentiation of pluripotent stem cells.
eLife 2013 Sun Y, Dong Z, Jin T, Ang KH, Huang M, Haston KM, Peng J, Zhong TP, Finkbeiner S, Weiss WA, Arkin MR, Jan LY, Guo S -
Blockade of glioma proliferation through allosteric inhibition of JAK2.
Science signaling 2013 He K, Qi Q, Chan CB, Xiao G, Liu X, Tucker-Burden C, Wang L, Mao H, Lu X, McDonald FE, Luo H, Fan QW, Weiss WA, Sun SY, Brat DJ, Ye K -
Subgroup-specific prognostic implications of TP53 mutation in medulloblastoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2013 Zhukova N, Ramaswamy V, Remke M, Pfaff E, Shih DJ, Martin DC, Castelo-Branco P, Baskin B, Ray PN, Bouffet E, von Bueren AO, Jones DT, Northcott PA, Kool M, Sturm D, Pugh TJ, Pomeroy SL, Cho YJ, … -
A robust method to derive functional neural crest cells from human pluripotent stem cells.
American journal of stem cells 2013 Kreitzer FR, Salomonis N, Sheehan A, Huang M, Park JS, Spindler MJ, Lizarraga P, Weiss WA, So PL, Conklin BR -
What underlies the diversity of brain tumors?
Cancer metastasis reviews 2013 Swartling FJ, Hede SM, Weiss WA -
G34, another connection between MYCN and a pediatric tumor.
Cancer discovery 2013 Huang M, Weiss WA -
Molecular imaging of neuroblastoma progression in TH-MYCN transgenic mice.
Molecular imaging and biology 2013 Quarta C, Cantelli E, Nanni C, Ambrosini V, D'ambrosio D, Di Leo K, Angelucci S, Zagni F, Lodi F, Marengo M, Weiss WA, Pession A, Tonelli R, Fanti S -
Using a preclinical mouse model of high-grade astrocytoma to optimize p53 restoration therapy.
Proceedings of the National Academy of Sciences of the United States of America 2013 Shchors K, Persson AI, Rostker F, Tihan T, Lyubynska N, Li N, Swigart LB, Berger MS, Hanahan D, Weiss WA, Evan GI -
Th-MYCN mice with caspase-8 deficiency develop advanced neuroblastoma with bone marrow metastasis.
Cancer research 2013 Teitz T, Inoue M, Valentine MB, Zhu K, Rehg JE, Zhao W, Finkelstein D, Wang YD, Johnson MD, Calabrese C, Rubinstein M, Hakem R, Weiss WA, Lahti JM -
Targeting MYCN in neuroblastoma by BET bromodomain inhibition.
Cancer discovery 2013 Puissant A, Frumm SM, Alexe G, Bassil CF, Qi J, Chanthery YH, Nekritz EA, Zeid R, Gustafson WC, Greninger P, Garnett MJ, McDermott U, Benes CH, Kung AL, Weiss WA, Bradner JE, Stegmaier K -
Tumor dosimetry using [124I]m-iodobenzylguanidine microPET/CT for [131I]m-iodobenzylguanidine treatment of neuroblastoma in a murine xenograft model.
Molecular imaging and biology 2012 Seo Y, Gustafson WC, Dannoon SF, Nekritz EA, Lee CL, Murphy ST, VanBrocklin HF, Hernandez-Pampaloni M, Haas-Kogan DA, Weiss WA, Matthay KK -
Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma.
Acta neuropathologica 2012 Dubuc AM, Remke M, Korshunov A, Northcott PA, Zhan SH, Mendez-Lago M, Kool M, Jones DT, Unterberger A, Morrissy AS, Shih D, Peacock J, Ramaswamy V, Rolider A, Wang X, Witt H, Hielscher T, Hawkins C, … -
Subgroup-specific structural variation across 1,000 medulloblastoma genomes.
Nature 2012 Northcott PA, Shih DJ, Peacock J, Garzia L, Morrissy AS, Zichner T, Stütz AM, Korshunov A, Reimand J, Schumacher SE, Beroukhim R, Ellison DW, Marshall CR, Lionel AC, Mack S, Dubuc A, Yao Y, Ramaswamy … -
Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics.
Genes & development 2012 Huang X, Dubuc AM, Hashizume R, Berg J, He Y, Wang J, Chiang C, Cooper MK, Northcott PA, Taylor MD, Barnes MJ, Tihan T, Chen J, Hackett CS, Weiss WA, James CD, Rowitch DH, Shuman MA, Jan YN, Jan LY -
Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma.
Proceedings of the National Academy of Sciences of the United States of America 2012 Cheng CK, Gustafson WC, Charron E, Houseman BT, Zunder E, Goga A, Gray NS, Pollok B, Oakes SA, James CD, Shokat KM, Weiss WA, Fan QW -
PTEN promoter methylation and activation of the PI3K/Akt/mTOR pathway in pediatric gliomas and influence on clinical outcome.
Neuro-oncology 2012 Mueller S, Phillips J, Onar-Thomas A, Romero E, Zheng S, Wiencke JK, McBride SM, Cowdrey C, Prados MD, Weiss WA, Berger MS, Gupta N, Haas-Kogan DA -
Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC.
Cancer cell 2012 Swartling FJ, Savov V, Persson AI, Chen J, Hackett CS, Northcott PA, Grimmer MR, Lau J, Chesler L, Perry A, Phillips JJ, Taylor MD, Weiss WA -
Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy.
Proceedings of the National Academy of Sciences of the United States of America 2012 Huillard E, Hashizume R, Phillips JJ, Griveau A, Ihrie RA, Aoki Y, Nicolaides T, Perry A, Waldman T, McMahon M, Weiss WA, Petritsch C, James CD, Rowitch DH -
Guidelines for the use and interpretation of assays for monitoring autophagy.
Autophagy 2012 Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes … -
Matching mice to malignancy: molecular subgroups and models of medulloblastoma.
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 2012 Lau J, Schmidt C, Markant SL, Taylor MD, Wechsler-Reya RJ, Weiss WA -
Kinetics of inhibitor cycling underlie therapeutic disparities between EGFR-driven lung and brain cancers.
Cancer discovery 2012 Barkovich KJ, Hariono S, Garske AL, Zhang J, Blair JA, Fan QW, Shokat KM, Nicolaides T, Weiss WA -
Subgroup-specific alternative splicing in medulloblastoma.
Acta neuropathologica 2012 Dubuc AM, Morrissy AS, Kloosterhof NK, Northcott PA, Yu EP, Shih D, Peacock J, Grajkowska W, van Meter T, Eberhart CG, Pfister S, Marra MA, Weiss WA, Scherer SW, Rutka JT, French PJ, Taylor MD -
Clonal selection drives genetic divergence of metastatic medulloblastoma.
Nature 2012 Wu X, Northcott PA, Dubuc A, Dupuy AJ, Shih DJ, Witt H, Croul S, Bouffet E, Fults DW, Eberhart CG, Garzia L, Van Meter T, Zagzag D, Jabado N, Schwartzentruber J, Majewski J, Scheetz TE, Pfister SM, … -
Paracrine signaling through MYCN enhances tumor-vascular interactions in neuroblastoma.
Science translational medicine 2012 Chanthery YH, Gustafson WC, Itsara M, Persson A, Hackett CS, Grimmer M, Charron E, Yakovenko S, Kim G, Matthay KK, Weiss WA -
Inhibition of PI3K-Akt-mTOR signaling in glioblastoma by mTORC1/2 inhibitors.
Methods in molecular biology (Clifton, N.J.) 2012 Fan QW, Weiss WA -
Biological and clinical heterogeneity of MYCN-amplified medulloblastoma.
Acta neuropathologica 2011 Korshunov A, Remke M, Kool M, Hielscher T, Northcott PA, Williamson D, Pfaff E, Witt H, Jones DT, Ryzhova M, Cho YJ, Wittmann A, Benner A, Weiss WA, von Deimling A, Scheurlen W, Kulozik AE, Clifford … -
Targeted therapy for BRAFV600E malignant astrocytoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011 Nicolaides TP, Li H, Solomon DA, Hariono S, Hashizume R, Barkovich K, Baker SJ, Paugh BS, Jones C, Forshew T, Hindley GF, Hodgson JG, Kim JS, Rowitch DH, Weiss WA, Waldman TA, James CD -
Genetically engineered murine models--contribution to our understanding of the genetics, molecular pathology and therapeutic targeting of neuroblastoma.
Seminars in cancer biology 2011 Chesler L, Weiss WA -
Asymmetry-defective oligodendrocyte progenitors are glioma precursors.
Cancer cell 2011 Sugiarto S, Persson AI, Munoz EG, Waldhuber M, Lamagna C, Andor N, Hanecker P, Ayers-Ringler J, Phillips J, Siu J, Lim DA, Vandenberg S, Stallcup W, Berger MS, Bergers G, Weiss WA, Petritsch C -
Delineation of two clinically and molecularly distinct subgroups of posterior fossa ependymoma.
Cancer cell 2011 Witt H, Mack SC, Ryzhova M, Bender S, Sill M, Isserlin R, Benner A, Hielscher T, Milde T, Remke M, Jones DT, Northcott PA, Garzia L, Bertrand KC, Wittmann A, Yao Y, Roberts SS, Massimi L, Van Meter T,… -
Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct.
Acta neuropathologica 2011 Northcott PA, Hielscher T, Dubuc A, Mack S, Shih D, Remke M, Al-Halabi H, Albrecht S, Jabado N, Eberhart CG, Grajkowska W, Weiss WA, Clifford SC, Bouffet E, Rutka JT, Korshunov A, Pfister S, Taylor MD -
PCDH10 is a candidate tumour suppressor gene in medulloblastoma.
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 2011 Bertrand KC, Mack SC, Northcott PA, Garzia L, Dubuc A, Pfister SM, Rutka JT, Weiss WA, Taylor MD -
Autophagy and Akt promote survival in glioma.
Autophagy 2011 Fan QW, Weiss WA -
Cooperation of the HDAC inhibitor vorinostat and radiation in metastatic neuroblastoma: efficacy and underlying mechanisms.
Cancer letters 2011 Mueller S, Yang X, Sottero TL, Gragg A, Prasad G, Polley MY, Weiss WA, Matthay KK, Davidoff AM, DuBois SG, Haas-Kogan DA -
Vorinostat increases expression of functional norepinephrine transporter in neuroblastoma in vitro and in vivo model systems.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011 More SS, Itsara M, Yang X, Geier EG, Tadano MK, Seo Y, Vanbrocklin HF, Weiss WA, Mueller S, Haas-Kogan DA, Dubois SG, Matthay KK, Giacomini KM -
Principles and current strategies for targeting autophagy for cancer treatment.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011 Amaravadi RK, Lippincott-Schwartz J, Yin XM, Weiss WA, Takebe N, Timmer W, DiPaola RS, Lotze MT, White E -
Inhibition of PI3K/mTOR pathways in glioblastoma and implications for combination therapy with temozolomide.
Neuro-oncology 2011 Prasad G, Sottero T, Yang X, Mueller S, James CD, Weiss WA, Polley MY, Ozawa T, Berger MS, Aftab DT, Prados MD, Haas-Kogan DA -
Non-stem cell origin for oligodendroglioma.
Cancer cell 2010 Persson AI, Petritsch C, Swartling FJ, Itsara M, Sim FJ, Auvergne R, Goldenberg DD, Vandenberg SR, Nguyen KN, Yakovenko S, Ayers-Ringler J, Nishiyama A, Stallcup WB, Berger MS, Bergers G, McKnight TR,… -
Akt and autophagy cooperate to promote survival of drug-resistant glioma.
Science signaling 2010 Fan QW, Cheng C, Hackett C, Feldman M, Houseman BT, Nicolaides T, Haas-Kogan D, James CD, Oakes SA, Debnath J, Shokat KM, Weiss WA -
Radiation dose estimation using preclinical imaging with 124I-metaiodobenzylguanidine (MIBG) PET.
Medical physics 2010 Lee CL, Wahnishe H, Sayre GA, Cho HM, Kim HJ, Hernandez-Pampaloni M, Hawkins RA, Dannoon SF, VanBrocklin HF, Itsara M, Weiss WA, Yang X, Haas-Kogan DA, Matthay KK, Seo Y -
Addiction to B-MYB.
Oncotarget 2010 Gustafson WC, Weiss WA -
Pleiotropic role for MYCN in medulloblastoma.
Genes & development 2010 Swartling FJ, Grimmer MR, Hackett CS, Northcott PA, Fan QW, Goldenberg DD, Lau J, Masic S, Nguyen K, Yakovenko S, Zhe XN, Gilmer HC, Collins R, Nagaoka M, Phillips JJ, Jenkins RB, Tihan T, Vandenberg … -
Intratumoral therapy of glioblastoma multiforme using genetically engineered transferrin for drug delivery.
Cancer research 2010 Yoon DJ, Kwan BH, Chao FC, Nicolaides TP, Phillips JJ, Lam GY, Mason AB, Weiss WA, Kamei DT -
Myc proteins as therapeutic targets.
Oncogene 2010 Gustafson WC, Weiss WA -
Targeting the RTK-PI3K-mTOR axis in malignant glioma: overcoming resistance.
Current topics in microbiology and immunology 2010 Fan QW, Weiss WA -
A translational end-run for a rare, genetically enigmatic tumor.
Cancer biology & therapy 2009 Hackett CS, Weiss WA -
Whole-body sleeping beauty mutagenesis can cause penetrant leukemia/lymphoma and rare high-grade glioma without associated embryonic lethality.
Cancer research 2009 Collier LS, Adams DJ, Hackett CS, Bendzick LE, Akagi K, Davies MN, Diers MD, Rodriguez FJ, Bender AM, Tieu C, Matise I, Dupuy AJ, Copeland NG, Jenkins NA, Hodgson JG, Weiss WA, Jenkins RB, Largaespada… -
Cyclic GMP-dependent protein kinase II inhibits cell proliferation, Sox9 expression and Akt phosphorylation in human glioma cell lines.
Oncogene 2009 Swartling FJ, Ferletta M, Kastemar M, Weiss WA, Westermark B -
Adenovirus-mediated hPNPase(old-35) gene transfer as a therapeutic strategy for neuroblastoma.
Journal of cellular physiology 2009 Van Maerken T, Sarkar D, Speleman F, Dent P, Weiss WA, Fisher PB -
The side story of stem-like glioma cells.
Cell stem cell 2009 Persson AI, Weiss WA -
EGFR signals to mTOR through PKC and independently of Akt in glioma.
Science signaling 2009 Fan QW, Cheng C, Knight ZA, Haas-Kogan D, Stokoe D, James CD, McCormick F, Shokat KM, Weiss WA -
PI3K signaling in glioma--animal models and therapeutic challenges.
Brain pathology (Zurich, Switzerland) 2009 Cheng CK, Fan QW, Weiss WA -
Chemotherapy-induced apoptosis in a transgenic model of neuroblastoma proceeds through p53 induction.
Neoplasia (New York, N.Y.) 2008 Chesler L, Goldenberg DD, Collins R, Grimmer M, Kim GE, Tihan T, Nguyen K, Yakovenko S, Matthay KK, Weiss WA -
A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition.
The Biochemical journal 2008 Torbett NE, Luna-Moran A, Knight ZA, Houk A, Moasser M, Weiss W, Shokat KM, Stokoe D -
Involvement of RhoA, ROCK I and myosin II in inverted orientation of epithelial polarity.
EMBO reports 2008 Yu W, Shewan AM, Brakeman P, Eastburn DJ, Datta A, Bryant DM, Fan QW, Weiss WA, Zegers MM, Mostov KE -
miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells.
BMC medicine 2008 Silber J, Lim DA, Petritsch C, Persson AI, Maunakea AK, Yu M, Vandenberg SR, Ginzinger DG, James CD, Costello JF, Bergers G, Weiss WA, Alvarez-Buylla A, Hodgson JG -
Characterization of structurally distinct, isoform-selective phosphoinositide 3'-kinase inhibitors in combination with radiation in the treatment of glioblastoma.
Molecular cancer therapeutics 2008 Chen JS, Zhou LJ, Entin-Meer M, Yang X, Donker M, Knight ZA, Weiss W, Shokat KM, Haas-Kogan D, Stokoe D -
BMPs oppose Math1 in cerebellar development and in medulloblastoma.
Genes & development 2008 Grimmer MR, Weiss WA -
Nordihydroguaiaretic acid inhibits insulin-like growth factor signaling, growth, and survival in human neuroblastoma cells.
Journal of cellular biochemistry 2007 Meyer GE, Chesler L, Liu D, Gable K, Maddux BA, Goldenberg DD, Youngren JF, Goldfine ID, Weiss WA, Matthay KK, Rosenthal SM -
Recognizing and exploiting differences between RNAi and small-molecule inhibitors.
Nature chemical biology 2007 Weiss WA, Taylor SS, Shokat KM -
Malignant progression and blockade of angiogenesis in a murine transgenic model of neuroblastoma.
Cancer research 2007 Chesler L, Goldenberg DD, Seales IT, Satchi-Fainaro R, Grimmer M, Collins R, Struett C, Nguyen KN, Kim G, Tihan T, Bao Y, Brekken RA, Bergers G, Folkman J, Weiss WA -
A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma.
Cancer research 2007 Fan QW, Cheng CK, Nicolaides TP, Hackett CS, Knight ZA, Shokat KM, Weiss WA -
Cell lines from MYCN transgenic murine tumours reflect the molecular and biological characteristics of human neuroblastoma.
European journal of cancer (Oxford, England : 1990) 2007 Cheng AJ, Cheng NC, Ford J, Smith J, Murray JE, Flemming C, Lastowska M, Jackson MS, Hackett CS, Weiss WA, Marshall GM, Kees UR, Norris MD, Haber M -
Structure-guided development of affinity probes for tyrosine kinases using chemical genetics.
Nature chemical biology 2007 Blair JA, Rauh D, Kung C, Yun CH, Fan QW, Rode H, Zhang C, Eck MJ, Weiss WA, Shokat KM -
Brain tumors in S100beta-v-erbB transgenic rats.
Journal of neuropathology and experimental neurology 2006 Ohgaki H, Kita D, Favereaux A, Huang H, Homma T, Dessen P, Weiss WA, Kleihues P, Heppner FL -
Childhood tumors of the nervous system as disorders of normal development.
Current opinion in pediatrics 2006 Grimmer MR, Weiss WA -
Genotype-phenotype correlations in tuberous sclerosis: who and how to treat.
Annals of neurology 2006 Goh S, Weiss WA -
Isoform specific inhibitors of PI3 kinase in glioma.
Cell cycle (Georgetown, Tex.) 2006 Fan QW, Weiss WA -
Inhibition of phosphatidylinositol 3-kinase destabilizes Mycn protein and blocks malignant progression in neuroblastoma.
Cancer research 2006 Chesler L, Schlieve C, Goldenberg DD, Kenney A, Kim G, McMillan A, Matthay KK, Rowitch D, Weiss WA -
A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma.
Cancer cell 2006 Fan QW, Knight ZA, Goldenberg DD, Yu W, Mostov KE, Stokoe D, Shokat KM, Weiss WA -
A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling.
Cell 2006 Knight ZA, Gonzalez B, Feldman ME, Zunder ER, Goldenberg DD, Williams O, Loewith R, Stokoe D, Balla A, Toth B, Balla T, Weiss WA, Williams RL, Shokat KM -
Chemical genetic approaches to the development of cancer therapeutics.
Current opinion in genetics & development 2005 Fan QW, Weiss WA -
Epigenome analyses using BAC microarrays identify evolutionary conservation of tissue-specific methylation of SHANK3.
Nature genetics 2005 Ching TT, Maunakea AK, Jun P, Hong C, Zardo G, Pinkel D, Albertson DG, Fridlyand J, Mao JH, Shchors K, Weiss WA, Costello JF -
Shared epigenetic mechanisms in human and mouse gliomas inactivate expression of the growth suppressor SLC5A8.
Cancer research 2005 Hong C, Maunakea A, Jun P, Bollen AW, Hodgson JG, Goldenberg DD, Weiss WA, Costello JF -
RNA interference against a glioma-derived allele of EGFR induces blockade at G2M.
Oncogene 2005 Fan QW, Weiss WA -
Mechanisms of embryonal tumor initiation: distinct roles for MycN expression and MYCN amplification.
Proceedings of the National Academy of Sciences of the United States of America 2004 Hansford LM, Thomas WD, Keating JM, Burkhart CA, Peaston AE, Norris MD, Haber M, Armati PJ, Weiss WA, Marshall GM -
Can mouse models for brain tumors inform treatment in pediatric patients?
Seminars in cancer biology 2004 Weiss WA, Banerjee A -
Combinatorial efficacy achieved through two-point blockade within a signaling pathway-a chemical genetic approach.
Cancer research 2003 Fan QW, Specht KM, Zhang C, Goldenberg DD, Shokat KM, Weiss WA -
Effects of MYCN antisense oligonucleotide administration on tumorigenesis in a murine model of neuroblastoma.
Journal of the National Cancer Institute 2003 Burkhart CA, Cheng AJ, Madafiglio J, Kavallaris M, Mili M, Marshall GM, Weiss WA, Khachigian LM, Norris MD, Haber M -
Genome-wide array CGH analysis of murine neuroblastoma reveals distinct genomic aberrations which parallel those in human tumors.
Cancer research 2003 Hackett CS, Hodgson JG, Law ME, Fridlyand J, Osoegawa K, de Jong PJ, Nowak NJ, Pinkel D, Albertson DG, Jain A, Jenkins R, Gray JW, Weiss WA -
Genetic determinants of malignancy in a mouse model for oligodendroglioma.
Cancer research 2003 Weiss WA, Burns MJ, Hackett C, Aldape K, Hill JR, Kuriyama H, Kuriyama N, Milshteyn N, Roberts T, Wendland MF, DePinho R, Israel MA -
Neuropathology of genetically engineered mice: consensus report and recommendations from an international forum.
Oncogene 2002 Weiss WA, Israel M, Cobbs C, Holland E, James CD, Louis DN, Marks C, McClatchey AI, Roberts T, Van Dyke T, Wetmore C, Chiu IM, Giovannini M, Guha A, Higgins RJ, Marino S, Radovanovic I, Reilly K, … -
A head holder for magnetic resonance imaging that allows the stereotaxic alignment of spontaneously occurring intracranial mouse tumors.
Journal of neuroscience methods 2002 Tada T, Wendland M, Watson N, Kuriyama N, Kuriyama H, Roberts T, Burns M, Weiss W, Israel MA -
Genetics of brain tumors.
Current opinion in pediatrics 2000 Weiss WA -
Genome-wide screen for allelic imbalance in a mouse model for neuroblastoma.
Cancer research 2000 Weiss WA, Godfrey T, Francisco C, Bishop JM -
Targeted expression of MYCN causes neuroblastoma in transgenic mice.
The EMBO journal 1997 Weiss WA, Aldape K, Mohapatra G, Feuerstein BG, Bishop JM