William Temple, MD
Clinical Fellow
Pediatrics
School of Medicine

Awards

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  • New Investigator Award, American Society of Transplantation and Cellular Therapy, 2024-2026
  • Clinical Research Training Institute Scholar, American Society of Hematology, 2023-2024
  • Research Training Award for Fellows, American Society of Hematology, 2022-2023
  • Physician-Scientist Fellowship Program Fellow, Chan Zuckerberg Biohub, 2020-2023
  • Chan Zuckerberg Biohub Physician-Scientist Fellowship Program Fellow, University of California, San Francisco, 2020-2023
  • 2018 House Staff Teaching Award, Honorable Mention, UCSF Pediatrics Residency, University of California, San Francisco, 2017-2018
  • Clinical and Translational Research Pathway, UCSF Pediatrics Residency Program, University of California, San Francisco, 2016-2019
  • Alpha Omega Alpha Honor Medical Society, University of California, San Francisco, 2012-2016
  • Howard Hughes Medical Institute Undergraduate Research Scholarship, University of California, Los Angeles, 2009-2011
  • Cell Therapy Training Course Scholar at University of Pennsylvania, International Society of Cell & Gene Therapy and American Society of Transplantation & Cell Therapy, 2023
  • Employee of the Month – UCSF Benioff Children’s Hospital Hematology/Oncology Unit, University of California, San Francisco, 2020
  • Magna Cum Laude Graduate, University of California, Los Angeles, 2011
  • Phi Beta Kappa, University of California, Los Angeles, 2011
  • Undergraduate Research Week Honoree, University of California, Los Angeles, 2011

Education & Training

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  • Advanced Fellow, Pediatric Blood & Marrow Transplantation and Immunotherapy UC San Francisco 07/2024
  • Postdoctoral Scholar, Cancer Immunotherapy UC San Francisco 06/2023
  • Clinical Fellow, Pediatric Hematology & Oncology UC San Francisco 07/2022
  • Pediatrics Residency UC San Francisco 06/2019
  • M.D. Medicine UC San Francisco 05/2016
  • B.S. Microbiology, Immunology, and Molecular Genetics UC Los Angeles 06/2011

Interests

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  • Primary Immunodeficiencies
  • Immunotherapy
  • Pediatrics
  • Blood & Marrow Transplantation
  • Oncology
  • Cancer Immunology
  • Hematology

Grants and Projects

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  • First-in-human phase 1 clinical trial evaluating CD72 nanoCARs for pediatric and young adult patients with relapsed/refractory B cell malignancies, American Society of Transplantation and Cellular Therapy "New Investigator Award", 2024-2026
  • CD72 nanoCARs for treatment of relapsed/refractory B cell malignancies, American Society of Hematology - Research Training Award for Fellows, 2022-2023
  • CD72 Nanobody-based CAR-T cells for relapsed/refractory B cell malignancies, Chan Zuckerberg Biohub Physician-Scientist Fellowship Program, 2020-2023
  • CD72 Nanobody-based CAR-T cells for relapsed/refractory B cell malignancies, NIH T32 - Research Training in Childhood Cancer, 2020-2022

Publications (17)

Top publication keywords:
Norepinephrine Plasma Membrane Transport ProteinsPrecursor B-Cell Lymphoblastic Leukemia-LymphomaImmunotherapy, Adoptive3-IodobenzylguanidineLymphoma, B-CellLymphoma, Non-HodgkinNeuroblastomaAntigens, Differentiation, B-LymphocyteVesicular Monoamine Transport ProteinsPrecursor T-Cell Lymphoblastic Leukemia-LymphomaGene Expression Regulation, NeoplasticPrecursor Cell Lymphoblastic Leukemia-LymphomaBurkitt LymphomaCamelids, New WorldGanglioneuroblastoma

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  • Pre-and post-HSCT use of TKI therapy for fusion-driven B-ALL: A case series of five pediatric, adolescent and young adult patients.
    Cancer reports (Hoboken, N.J.) 2023 Shumock SS, Temple WC, Marinoff A, Aaronson K, Southworth E, Xirenayi S, Lee AG, Leung SG, Sweet-Cordero EA, Hermiston M, Higham C, Stieglitz E
  • Structural surfaceomics reveals an AML-specific conformation of integrin β2 as a CAR T cellular therapy target.
    Nature cancer 2023 Mandal K, Wicaksono G, Yu C, Adams JJ, Hoopmann MR, Temple WC, Izgutdina A, Escobar BP, Gorelik M, Ihling CH, Nix MA, Naik A, Xie WH, Hübner J, Rollins LA, Reid SM, Ramos E, Kasap C, Steri V, Serrano …
  • Diagnosis and management of lymphoblastic lymphoma in children, adolescents and young adults.
    Best practice & research. Clinical haematology 2023 Temple WC, Mueller S, Hermiston ML, Burkhardt B
  • Blood
    Structural Surfaceomics Reveals an AML-Specific Conformation of Integrin-β2 As an Immunotherapeutic Target 2022 Kamal Mandal, Gianina Wicaksono, Clinton Yu, Jarrett J Adams, Michael R Hoopmann, William C Temple, Bonell Patino Escobar, Maryna Gorelik, Christian Ihling, Matthew A Nix, Akul Naik, Emilio Ramos, Corynn Kasap, Veronica Steri, Juan Antonio Camara Serrano, Fernando Salangsang, Paul Phojanakong, Melanie McMillan, Victor Gavallos, Andrew D Leavitt, Andrea Sinz, Benjamin J. Huang, Elliot Stieglitz, Catherine Smith, Robert L Moritz, Sachdeva S Sidhu, Lan Huang, Arun P Wiita
  • Blood
    Humanized Nanobody Anti-CD72 CAR-T Cells Efficiently Eliminate B-Cell Malignancies Via Improved Affinity for CD72 but Induce Persistent Antigen Downregulation In Vivo 2022 William C Temple, Gianina Wicaksono, Akul Naik, Adila Izgutdina, Matthew A Nix, Elizabeth Young, Paul Phojanakong, Juan Antonio Camara Serrano, Veronica Steri, Fernando Salangsang, Arun P Wiita
  • Leukemia Research
    CD72 nanobody CAR-T cells have potent antitumor efficacy in B cell malignancies 2022 W. Temple, M. Nix, G. Wicaksono, D. Wang, P. Phojanakong, V. Steri, B. Hann, M. Hermiston, A. Wiita
  • Incorporating Radiomics into Machine Learning Models to Predict Outcomes of Neuroblastoma.
    Journal of digital imaging 2022 Liu G, Poon M, Zapala MA, Temple WC, Vo KT, Matthay KK, Mitra D, Seo Y
  • Blood
    CD72 Nanobody-Based CAR-T Cells Have Potent Anti-Tumor Efficacy in B Cell Malignancies 2021 Matthew A Nix, William C Temple, William Karlon, Donghui Wang, Paul Phojanakong, Veronica Steri, Byron Hann, Arun P Wiita
  • Maternal High-Protein and Low-Protein Diets Perturb Hypothalamus and Liver Transcriptome and Metabolic Homeostasis in Adult Mouse Offspring.
    Frontiers in genetics 2018 Martin LJ, Meng Q, Blencowe M, Lagarrigue S, Xiao S, Pan C, Wier J, Temple WC, Devaskar SU, Lusis AJ, Yang X
  • Advances in Neuroblastoma Research Conference. San Francisco, California
    Association of image-defined risk factors with clinical features, histopathology, and outcomes in neuroblastoma. 2018 Temple WC, Vo KT, Matthay KK, Abadi C, Michlitsch J, Phelps A, Behr S, Zapala MA.
  • Vesicular monoamine transporter protein expression correlates with clinical features, tumor biology, and MIBG avidity in neuroblastoma: a report from the Children's Oncology Group.
    European journal of nuclear medicine and molecular imaging 2015 Temple W, Mendelsohn L, Kim GE, Nekritz E, Gustafson WC, Lin L, Giacomini K, Naranjo A, Van Ryn C, Yanik GA, Kreissman SG, Hogarty M, Matthay KK, DuBois SG
  • ASCO Annual Meeting
    Vesicular monoamine transporter protein expression in neuroblastoma: A report from the Children’s Oncology Group. Journal of Clinical Oncology, 2015 ASCO Annual Meeting (May 29 - June 2, 2015). Vol 33, No 15_suppl (May 20 Supplement), 2015: 10043. 2015 DuBois SG, Temple W, Mendelsohn L, Kim G, Nekritz E, Gustafson WC, Lin L, Giacomini K, Naranjo A, Ryn VC, Yanik GA, Kreissman SG, Hogarty M, Matthay KK.