William Seaman, MD
Professor
Medicine
School of Medicine
Education & Training
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- Diversity, Equity, and Inclusion Champion Training University of California 2018
- MD Medicine Harvard Medical School 1969
Websites
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- Profile at UCSF Cancer Center (cancer.ucsf.edu)
Grants and Projects
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- Role of the Tim-2 Receptor in Immunity and Autoimmunity, NIH, 2005-2010
- Alliance for Cellular Signaling, NIH, 2000-2008
- Biology of a New DAP12 Associated Receptor Family, NIH, 2001-2008
- SHPS-1 As a Regulator of Innate Immunity in Arthritis, NIH, 2004-2006
- Multipurpose Arthritis and Musculoskeletal Diseases Ctr, NIH, 1977-2003
- Transmembrane Signaling by Ly-49, NIH, 1996-2000
- Transmembrane Signaling in the Activation of Nk Cells, NIH, 1988-1997
- Intestinal Immune Response: Regulation and Mechanisms, NIH, 1983-1986
- Oxidative Regulation of Human Natural Killer Cells, NIH, 1983-1986
Publications (98)
Top publication keywords:
H-2 AntigensAntigens, SurfaceLectins, C-TypeUridine DiphosphatePhagocytosisAntigens, LyMembrane GlycoproteinsMacrophagesCytotoxicity, ImmunologicPhospholipase C betaComplement C5aKiller Cells, NaturalAnti-Asthmatic AgentsApoferritinsReceptors, Immunologic
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Georgia Abortion Law and Our Commitment to Patients.
Arthritis & rheumatology (Hoboken, N.J.) 2019 Craft JE, Crow MK, Lockshin MD, Salmon JE, Diamond B, Elkon KB, Flood J, Fox DA, Gabriel SE, Gilkeson GS, Hahn BH, Hardin J, Koopman WJ, Seaman WE, Wofsy D, Sergent JS, Uknis AB, Weinblatt ME -
New blood: Creative funding of disease-specific research.
Science translational medicine 2015 Seaman WE, Locksley RM, Welsh MJ -
Traumatic brain injury induces macrophage subsets in the brain.
European journal of immunology 2013 Hsieh CL, Kim CC, Ryba BE, Niemi EC, Bando JK, Locksley RM, Liu J, Nakamura MC, Seaman WE -
Iron uptake mediated by binding of H-ferritin to the TIM-2 receptor in mouse cells.
PloS one 2011 Han J, Seaman WE, Di X, Wang W, Willingham M, Torti FM, Torti SV -
Synergistic Ca2+ responses by G{alpha}i- and G{alpha}q-coupled G-protein-coupled receptors require a single PLC{beta} isoform that is sensitive to both G{beta}{gamma} and G{alpha}q.
The Journal of biological chemistry 2010 Rebres RA, Roach TI, Fraser ID, Philip F, Moon C, Lin KM, Liu J, Santat L, Cheadle L, Ross EM, Simon MI, Seaman WE
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Clostridium difficile toxin B differentially affects GPCR-stimulated Ca2+ responses in macrophages: independent roles for Rho and PLA2.
Journal of leukocyte biology 2010 Rebres RA, Moon C, Decamp D, Lin KM, Fraser ID, Milne SB, Roach TI, Brown HA, Seaman WE -
Binding and uptake of H-ferritin are mediated by human transferrin receptor-1.
Proceedings of the National Academy of Sciences of the United States of America 2010 Li L, Fang CJ, Ryan JC, Niemi EC, Lebrón JA, Björkman PJ, Arase H, Torti FM, Torti SV, Nakamura MC, Seaman WE -
A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia.
Journal of neurochemistry 2009 Hsieh CL, Koike M, Spusta SC, Niemi EC, Yenari M, Nakamura MC, Seaman WE -
TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria.
Journal of Experimental Medicine 2009 Elsa-Noah N'Diaye, Catherine S. Branda, Steven S. Branda, Lisette Nevarez, Marco Colonna, Clifford Lowell, Jessica A. Hamerman, William E. Seaman -
TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria.
The Journal of cell biology 2009 N'Diaye EN, Branda CS, Branda SS, Nevarez L, Colonna M, Lowell C, Hamerman JA, Seaman WE -
Tim-2 is the receptor for H-ferritin on oligodendrocytes.
Journal of neurochemistry 2008 Todorich B, Zhang X, Slagle-Webb B, Seaman WE, Connor JR -
Signaling and cross-talk by C5a and UDP in macrophages selectively use PLCbeta3 to regulate intracellular free calcium.
The Journal of biological chemistry 2008 Roach TI, Rebres RA, Fraser ID, Decamp DL, Lin KM, Sternweis PC, Simon MI, Seaman WE -
The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12.
Infection and immunity 2008 Charles JF, Humphrey MB, Zhao X, Quarles E, Nakamura MC, Aderem A, Seaman WE, Smith KD -
A single lentiviral vector platform for microRNA-based conditional RNA interference and coordinated transgene expression.
Proceedings of the National Academy of Sciences of the United States of America 2006 Shin KJ, Wall EA, Zavzavadjian JR, Santat LA, Liu J, Hwang JI, Rebres R, Roach T, Seaman W, Simon MI, Fraser ID -
Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12.
Journal of immunology (Baltimore, Md. : 1950) 2006 Hamerman JA, Jarjoura JR, Humphrey MB, Nakamura MC, Seaman WE, Lanier LL -
TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2005 Humphrey MB, Daws MR, Spusta SC, Niemi EC, Torchia JA, Lanier LL, Seaman WE, Nakamura MC -
Clinical academic rheumatology: comment on the article by Wickersham et al.
Arthritis and rheumatism 2005 Seaman WE -
TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis.
The Journal of experimental medicine 2005 Chen TT, Li L, Chung DH, Allen CD, Torti SV, Torti FM, Cyster JG, Chen CY, Brodsky FM, Niemi EC, Nakamura MC, Seaman WE, Daws MR -
Analysis of the major patterns of B cell gene expression changes in response to short-term stimulation with 33 single ligands.
Journal of immunology (Baltimore, Md. : 1950) 2004 Zhu X, Hart R, Chang MS, Kim JW, Lee SY, Cao YA, Mock D, Ke E, Saunders B, Alexander A, Grossoehme J, Lin KM, Yan Z, Hsueh R, Lee J, Scheuermann RH, Fruman DA, Seaman W, Subramaniam S, Sternweis P, … -
Expression and activation of signal regulatory protein alpha on astrocytomas.
Cancer research 2004 Chen TT, Brown EJ, Huang EJ, Seaman WE -
CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formation.
Journal of immunology (Baltimore, Md. : 1950) 2003 Chung DH, Humphrey MB, Nakamura MC, Ginzinger DG, Seaman WE, Daws MR -
Pattern recognition by TREM-2: binding of anionic ligands.
Journal of immunology (Baltimore, Md. : 1950) 2003 Daws MR, Sullam PM, Niemi EC, Chen TT, Tchao NK, Seaman WE -
Overview of the Alliance for Cellular Signaling.
Nature 2002 Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, Gold M, Weiss A, Stull JT, Berridge MJ, … -
Characterization of TREM-3, an activating receptor on mouse macrophages: definition of a family of single Ig domain receptors on mouse chromosome 17.
European journal of immunology 2002 Chung DH, Seaman WE, Daws MR -
Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family.
European journal of immunology 2001 Daws MR, Lanier LL, Seaman WE, Ryan JC -
Activating Ly-49D and inhibitory Ly-49A natural killer cell receptors demonstrate distinct requirements for interaction with H2-D(d).
The Journal of experimental medicine 2000 Nakamura MC, Hayashi S, Niemi EC, Ryan JC, Seaman WE -
Natural killer cells and natural killer T cells.
Arthritis and rheumatism 2000 Seaman WE -
Natural killing of xenogeneic cells mediated by the mouse Ly-49D receptor.
Journal of immunology (Baltimore, Md. : 1950) 1999 Nakamura MC, Naper C, Niemi EC, Spusta SC, Rolstad B, Butcher GW, Seaman WE, Ryan JC -
Mouse Ly-49D recognizes H-2Dd and activates natural killer cell cytotoxicity.
The Journal of experimental medicine 1999 Nakamura MC, Linnemeyer PA, Niemi EC, Mason LH, Ortaldo JR, Ryan JC, Seaman WE -
DAP12-mediated signal transduction in natural killer cells. A dominant role for the Syk protein-tyrosine kinase.
The Journal of biological chemistry 1998 McVicar DW, Taylor LS, Gosselin P, Willette-Brown J, Mikhael AI, Geahlen RL, Nakamura MC, Linnemeyer P, Seaman WE, Anderson SK, Ortaldo JR, Mason LH -
The alpha2 domain of H-2Dd restricts the allelic specificity of the murine NK cell inhibitory receptor Ly-49A.
Journal of immunology (Baltimore, Md. : 1950) 1998 Sundbäck J, Nakamura MC, Waldenström M, Niemi EC, Seaman WE, Ryan JC, Kärre K -
Natural killer cells and recognition of MHC class I molecules: new perspectives and challenges in immunology.
Scandinavian journal of immunology 1998 Rolstad B, Seaman WE -
Mouse Ly-49A interrupts early signaling events in natural killer cell cytotoxicity and functionally associates with the SHP-1 tyrosine phosphatase.
The Journal of experimental medicine 1997 Nakamura MC, Niemi EC, Fisher MJ, Shultz LD, Seaman WE, Ryan JC -
Divergent functions of lectin-like receptors on NK cells.
Immunological reviews 1997 Ryan JC, Seaman WE -
Recognition and Signaling by Mouse Ly-49 Receptors.
Molecular Basis of NK Cell Recognition and Function 1996 William E. Seaman, Brian Daniels, Jay Ryan, Mary Nakamura, Eréne Niemi -
Recognition and Signaling by Mouse Ly-49 Receptors.
1996 William E. Seaman, Brian Daniels, Jay Ryan, Mary Nakamura, Eré;ne Niemi -
An autosomal dominant locus, Nka, mapping to the Ly-49 region of a rat natural killer (NK) gene complex, controls NK cell lysis of allogeneic lymphocytes.
The Journal of experimental medicine 1996 Dissen E, Ryan JC, Seaman WE, Fossum S -
Recognition and signaling by mouse Ly-49 receptors.
Chemical immunology 1996 Seaman WE, Daniels B, Ryan J, Nakamura M, Niemi E -
NKR-P1A is a target-specific receptor that activates natural killer cell cytotoxicity.
The Journal of experimental medicine 1995 Ryan JC, Niemi EC, Nakamura MC, Seaman WE -
A family of murine NK cell receptors specific for target cell MHC class I molecules.
Seminars in immunology 1995 Yokoyama WM, Daniels BF, Seaman WE, Hunziker R, Margulies DH, Smith HR -
Ly-49A, a receptor for H-2Dd, has a functional carbohydrate recognition domain.
Immunity 1994 Daniels BF, Nakamura MC, Rosen SD, Yokoyama WM, Seaman WE -
A natural killer cell receptor specific for a major histocompatibility complex class I molecule.
The Journal of experimental medicine 1994 Daniels BF, Karlhofer FM, Seaman WE, Yokoyama WM -
The Ly-49 and NKR-P1 gene families encoding lectin-like receptors on natural killer cells: the NK gene complex.
Annual review of immunology 1993 Yokoyama WM, Seaman WE -
Molecular cloning of the NK1.1 antigen, a member of the NKR-P1 family of natural killer cell activation molecules.
Journal of immunology (Baltimore, Md. : 1950) 1992 Ryan JC, Turck J, Niemi EC, Yokoyama WM, Seaman WE -
The OX-44 molecule couples to signaling pathways and is associated with CD2 on rat T lymphocytes and a natural killer cell line.
The Journal of experimental medicine 1992 Bell GM, Seaman WE, Niemi EC, Imboden JB -
NKR-P1, an activating molecule on rat natural killer cells, stimulates phosphoinositide turnover and a rise in intracellular calcium.
Journal of immunology (Baltimore, Md. : 1950) 1991 Ryan JC, Niemi EC, Goldfien RD, Hiserodt JC, Seaman WE -
cDNA cloning of mouse NKR-P1 and genetic linkage with LY-49. Identification of a natural killer cell gene complex on mouse chromosome 6.
Journal of immunology (Baltimore, Md. : 1950) 1991 Yokoyama WM, Ryan JC, Hunter JJ, Smith HR, Stark M, Seaman WE -
Divergent regulation of phospholipase C-alpha and phospholipase C-gamma transcripts during activation of a human T cell line.
Journal of immunology (Baltimore, Md. : 1950) 1991 Goldfien RD, Seaman WE, Hempel WM, Imboden JB -
Characterization of signal-transducing molecules on natural killer cells.
Biochemical Society transactions 1991 Imboden JB, Bell G, Seaman WE -
Molecular cloning of gp42, a cell-surface molecule that is selectively induced on rat natural killer cells by interleukin 2: glycolipid membrane anchoring and capacity for transmembrane signaling.
The Journal of experimental medicine 1991 Seaman WE, Niemi EC, Stark MR, Goldfien RD, Pollock AS, Imboden JB -
Identification and characterization of a cell-surface molecule that is selectively induced on rat lymphokine-activated killer cells.
Journal of immunology (Baltimore, Md. : 1950) 1989 Imboden JB, Eriksson EC, McCutcheon M, Reynolds CW, Seaman WE -
Induction of immune tolerance during administration of monoclonal antibody to L3T4 does not depend on depletion of L3T4+ cells.
Journal of immunology (Baltimore, Md. : 1950) 1988 Carteron NL, Wofsy D, Seaman WE -
Receptor-specific mechanisms for the responses of human leukocytes to leukotrienes.
Annals of the New York Academy of Sciences 1988 Goetzl EJ, Sherman JW, Ratnoff WD, Harvey JP, Eriksson E, Seaman WE, Baud L, Koo CH -
Selective manipulation of the immune response in vivo by monoclonal antibodies.
Annual review of medicine 1988 Seaman WE, Wofsy D -
Randomized, double-blind, placebo-controlled study of the treatment of the painful shoulder.
Arthritis and rheumatism 1987 Petri M, Dobrow R, Neiman R, Whiting-O'Keefe Q, Seaman WE -
Regulation of autoimmunity and donor cell engraftment by recipient Lyt-2+ cells during the graft-versus-host reaction.
The Journal of experimental medicine 1987 Harper SE, Roubinian JR, Seaman WE -
Depletion of natural killer cells in mice by monoclonal antibody to NK-1.1. Reduction in host defense against malignancy without loss of cellular or humoral immunity.
Journal of immunology (Baltimore, Md. : 1950) 1987 Seaman WE, Sleisenger M, Eriksson E, Koo GC -
Inositol trisphosphate is generated by a rat natural killer cell tumor in response to target cells or to crosslinked monoclonal antibody OX-34: possible signaling role for the OX-34 determinant during activation by target cells.
Proceedings of the National Academy of Sciences of the United States of America 1987 Seaman WE, Eriksson E, Dobrow R, Imboden JB -
Reversal of advanced murine lupus in NZB/NZW F1 mice by treatment with monoclonal antibody to L3T4.
Journal of immunology (Baltimore, Md. : 1950) 1987 Wofsy D, Seaman WE -
In vivo effects of antilymphocyte antibodies on immunity and autoimmunity.
Memórias do Instituto Oswaldo Cruz 1987 William E. Seaman, Nancy Gutstein, David Wofsy -
Rejection of skin grafts and generation of cytotoxic T cells by mice depleted of L3T4+ cells.
Transplantation 1986 Woodcock J, Wofsy D, Eriksson E, Scott JH, Seaman WE -
Induction of immune tolerance by administration of monoclonal antibody to L3T4.
Journal of immunology (Baltimore, Md. : 1950) 1986 Gutstein NL, Seaman WE, Scott JH, Wofsy D -
Cocaine increases natural killer cell activity.
The Journal of clinical investigation 1986 Van Dyke C, Stesin A, Jones R, Chuntharapai A, Seaman W -
Analysis of the function of L3T4+ T cells by in vivo treatment with monoclonal antibody to L3T4.
Immunologic research 1986 Wofsy D, Seaman WE -
Inhibition of humoral immunity in vivo by monoclonal antibody to L3T4: studies with soluble antigens in intact mice.
Journal of immunology (Baltimore, Md. : 1950) 1985 Wofsy D, Mayes DC, Woodcock J, Seaman WE -
Human synovial dendritic cells. Direct observation of transition to fibroblasts.
The Journal of rheumatology 1985 Hendler PL, Lavoie PE, Werb Z, Chan J, Seaman WE -
Harvesting of leukocytes from intestinal lumen in murine giardiasis and preliminary characterization of these cells.
Digestive diseases and sciences 1985 Heyworth MF, Owen RL, Seaman WE, Schaefer FW, Jones AL -
Successful treatment of autoimmunity in NZB/NZW F1 mice with monoclonal antibody to L3T4.
The Journal of experimental medicine 1985 Wofsy D, Seaman WE -
Treatment of murine lupus with monoclonal anti-T cell antibody.
Journal of immunology (Baltimore, Md. : 1950) 1985 Wofsy D, Ledbetter JA, Hendler PL, Seaman WE -
THE POTENTIAL ROLE OF ARACHIDONIC ACID METABOLISM IN NATURAL KILLER CELL ACTIVITY11Supported by Public Health Service grants Nos. CA34529 and AI5384 and by the Veterans Administration.
Mechanisms of Cytotoxicity by NK Cells 1985 William E. Seaman, Janet Woodcock, Colin G. Brooks -
Human and murine natural killer cell activity may require lipoxygenation of arachidonic acid.
The Journal of allergy and clinical immunology 1984 Seaman WE, Woodcock J -
The proliferating cells in autoimmune MRL/lpr mice lack L3T4, an antigen on "helper" T cells that is involved in the response to class II major histocompatibility antigens.
Journal of immunology (Baltimore, Md. : 1950) 1984 Wofsy D, Hardy RR, Seaman WE -
Monocytosis in the BXSB model for systemic lupus erythematosus.
The Journal of experimental medicine 1984 Wofsy D, Kerger CE, Seaman WE -
Human natural killer cell activity is reversibly inhibited by antagonists of lipoxygenation.
Journal of immunology (Baltimore, Md. : 1950) 1983 Seaman WE -
Natural killing activity in Sjögren's syndrome. An analysis of defective mechanisms.
Arthritis and rheumatism 1983 Miyasaka N, Seaman W, Bakshi A, Sauvezie B, Strand V, Pope R, Talal N -
Treatment of autoimmune MRL/Ipr mice with monoclonal antibody to Thy-1.2: a single injection has sustained effects on lymphoproliferation and renal disease.
Journal of immunology (Baltimore, Md. : 1950) 1983 Seaman WE, Wofsy D, Greenspan JS, Ledbetter JA -
Thymic influences on autoimmunity in MRL-lpr mice.
Scandinavian journal of immunology 1982 Wofsy D, Ledbetter JA, Roubinian JR, Seaman WE, Talal N -
Suppression of natural killing in vitro by monocytes and polymorphonuclear leukocytes: requirement for reactive metabolites of oxygen.
The Journal of clinical investigation 1982 Seaman WE, Gindhart TD, Blackman MA, Dalal B, Talal N, Werb Z -
The Lyt-2, Lyt-3 macromolecules: structural and functional studies.
Immunological reviews 1982 Ledbetter JA, Seaman WE -
Suppression or enhancement of natural killing does not alter tolerance to bovine gamma globulin.
Journal of clinical & laboratory immunology 1981 Loeb JM, Talal N, Abensohn-Lee M, Seaman WE -
Surface antigens on mouse natural killer cells: use of monoclonal antibodies to inhibit or to enrich cytotoxic activity.
Journal of immunology (Baltimore, Md. : 1950) 1981 Seaman WE, Talal N, Herzenberg LA, Herzenberg LA, Ledbetter JA -
Natural killing by spleen cells from W/Wv and Sl/Sld anemic mice.
Experimental hematology 1981 Seaman WE, Talal N -
Lyt-2 and lyt-3 antigens are on two different polypeptide subunits linked by disulfide bonds. Relationship of subunits to T cell cytolytic activity.
The Journal of experimental medicine 1981 Ledbetter JA, Seaman WE, Tsu TT, Herzenberg LA -
Natural killing of tumor cells by human peripheral blood cells. Suppression of killing in vitro by tumor-promoting phorbol diesters.
The Journal of clinical investigation 1981 Seaman WE, Gindhart TD, Blackman MA, Dalal B, Talal N, Werb Z -
Effect of 89Sr on immunity and autoimmunity in NZB/NZW F1 mice.
Journal of immunology (Baltimore, Md. : 1950) 1980 Seaman WE, Blackman MA, Greenspan JS, Talal N -
THE EFFECT OF 17ß-ESTRADIOL ON NATURAL KILLING IN THE MOUSE.
Natural Cell-mediated Immunity Against Tumors 1980 William E. Seaman, Norman Talal -
Natural killing in estrogen-treated mice responds poorly to poly I.C despite normal stimulation of circulating interferon.
Journal of immunology (Baltimore, Md. : 1950) 1979 Seaman WE, Merigan TC, Talal N -
Effect of estrogen on natural killer cells.
Arthritis and rheumatism 1979 Seaman WE, Gindhart TD -
Natural killer cells, bone, and the bone marrow: studies in estrogen-treated mice and in congenitally osteopetrotic (mi/mi) mice.
Journal of immunology (Baltimore, Md. : 1950) 1979 Seaman WE, Gindhart TD, Greenspan JS, Blackman MA, Talal N -
beta-Estradiol reduces natural killer cells in mice.
Journal of immunology (Baltimore, Md. : 1950) 1978 Seaman WE, Blackman MA, Gindhart TD, Roubinian JR, Loeb JM, Talal N -
Hepatic injury due to acetaminophen or salicylates.
The Western journal of medicine 1978 Seaman WE -
Letter: Effect of salicylates on creatinine clearance.
British medical journal 1976 Plotz P, Kimberly R, Gill JR, Seaman W -
Effect of aspirin on liver tests in patients with RA or SLE and in normal volunteers.
Arthritis and rheumatism 1976 Seaman WE, Plotz PH -
Systemic lupus erythematosus. Contrasts and comparisons.
Annals of internal medicine 1975 Decker JL, Steinberg AD, Gershwin ME, Seaman WE, Klippel JH, Plotz PH, Paget SA -
Avascular necrosis of the talus, scaphoid, and metatarsal head in systemic lupus erythematosus.
Clinical orthopaedics and related research 1974 Aptekar RG, Klippel JH, Becker KE, Carson DA, Seaman WE, Decker JL -
Proceedings: Aspirin-induced hepatotoxicity in patients with RA or systemic lupus erythematosus (SLE).
Arthritis and rheumatism 1974 Seaman WE, Plotz PH, Ishak KG -
Letter: Aspirin and hepatotoxicity: addendum.
Annals of internal medicine 1974 Seaman WE, Ishak KG, Plotz PH -
Aspirin-induced hepatotoxicity in patients with systemic lupus erythematosus.
Annals of internal medicine 1974 Seaman WE, Ishak KG, Plotz PH