William Hyun, MS
Professional Researcher
Laboratory Medicine
School of Medicine

Hyun has worked in the field of cytometry for more than twenty-five (25) years, nineteen (19) years as Director of the Laboratory for Cell Analysis (LCA). In 2014, Hyun initiated and was appointed Director of the Laboratory for Advanced Cytometry (LAC) and Director of the Sony Biotechnology Center in the Department of Laboratory Medicine. Hyun has past appointments in the Biomedical Sciences (BMS) and Tetrad Graduate Programs, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research and Affiliate Scientist appointments at Lawrence Berkeley National Lab (LBNL) and UC Berkeley (UCB). The LAC and Sony Biotechnology Center are focused on translating research science into the clinical cytology and pathology labs. Technology translation includes assay validation, development of CLIA/FDA approval processes, QC/QA procedures, automation and robotics, reimbursement coding, data handling, multiparametric data analysis and advanced presentation of results. Other technology areas include development of nanochips for soluble microanalysis and microfluidic chips for genomic and cytometric assays. The first effort in cellular bar coding resulted in the formation of a commercial company, Vitra Biosciences. Other efforts include encoded micro-fabricated chips, commercialized by True Materials, a startup housed in the UCSF QB3 Incubator and eventually purchased by Affymetrix. Another program has been investigating the use of bioscaffolds and molecular assembly along with 3D bio-printing for use in cytometric assays for stem cell engraftment, directional cell growth, surgical repair, and organoids for high content imaging assays like cellular invasion, migration and maturation studies. Some of this work is now commercialized by Fibralign Corporation. Working with the UCSF Abate lab, new partitioning technologies are being implemented for refined multiplex genomic and proteomic analysis at the single cell and single molecule level. Three commercial companies, Mission Bio, Scribe Bio and Fluent Biosciences, were founded to commercialize UCSF IP. Other developmental projects include mass spec flow and mass image cytometry, buoyancy bubble-based cell isolation (Akadeum Bio), single cell Western blot technology from the Herr lab at UC Berkeley (Zephyrus Bio, now BioTechne), and clinical single cell genomic diagnostics for oncology/pathology. Hyun is an angel investor/co-founder in several biotech startup companies, and currently sits on the Board of Mission Bio, Scribe Bio, Newbridge Media, Akadeum Biosciences, Fluent Bio and the Scientific Advisory Board of Fibralign Corporation, Intabio, and CellFe. Hyun is a venture partner at Genoa Ventures focused on early stage investments where biology meets technology. Hyun has current and past compensated consulting roles with ZEISS and CRI in the area of spectral microscopy, Becton Dickinson, Sony and Danaher Corporations in the area of flow cytometry and cell sorting, Bristol Meyer Squibb and Sanofi-Aventis/Regeneron in the area of high content screening. Past positions include investor/advisor to Accuri Cytometers, Vitra Biosciences, KAIROS, SEQ, True Materials, Biotrue, Symbiosis Biowares, and Unihart Biotech Pharma. Hyun has authored over 100 peer-reviewed publications.

• Troglitazone, the peroxisome proliferator-activated receptor-gamma agonist, induces antiproliferation and redifferentiation in human thyroid cancer cell lines.
  Thyroid : official journal of the American Thyroid Association 2005 Park JW, Zarnegar R, Kanauchi H, Wong MG, Hyun WC, Ginzinger DG, Lobo M, Cotter P, Duh QY, Clark OH
• Modulation of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by chemotherapy in thyroid cancer cell lines.
  Thyroid : official journal of the American Thyroid Association 2003 Park JW, Wong MG, Lobo M, Hyun WC, Duh QY, Clark OH
• The heat shock protein 90-binding geldanamycin inhibits cancer cell proliferation, down-regulates oncoproteins, and inhibits epidermal growth factor-induced invasion in thyroid cancer cell lines.
  The Journal of clinical endocrinology and metabolism 2003 Park JW, Yeh MW, Wong MG, Lobo M, Hyun WC, Duh QY, Clark OH
• Persistent oxidative stress in chromosomally unstable cells.
  Cancer research 2003 Limoli CL, Giedzinski E, Morgan WF, Swarts SG, Jones GD, Hyun W
• Alterations of neutrophil f-actin kinetics by tobacco smoke: implications for periodontal diseases.
  Journal of periodontal research 2002 Ryder MI, Wu TC, Kallaos SS, Hyun W
• CCAAT/enhancer binding protein alpha uses distinct domains to prolong pituitary cells in the growth 1 and DNA synthesis phases of the cell cycle.
  BMC cell biology 2002 Liu W, Enwright JF, Hyun W, Day RN, Schaufele F
• Lymphoid follicles are generated in high-grade cervical dysplasia and have differing characteristics depending on HIV status.
  The American journal of pathology 2002 Kobayashi A, Darragh T, Herndier B, Anastos K, Minkoff H, Cohen M, Young M, Levine A, Grant LA, Hyun W, Weinberg V, Greenblatt R, Smith-McCune K