William Hoffman, MD
Professor
Surgery
School of Medicine

An innovator in the field of craniofacial and pediatric plastic surgery, he routinely performs complex and intricate surgeries, and works with orthodontists and other specialists to correct abnormalities in children's facial appearances while improving their breathing and ability to eat. He also treats adults, performing complex facial reconstructions as well as aesthetic facial surgeries, including facelifts, rhinoplasty (nose reshaping) and blepharoplasty (eyelid surgery). He is UCSF's chief of plastic and reconstructive surgery.

Hoffman is widely published, and his research interests include the biology of hemangiomas, fetal surgery for facial deformities and improving cleft lip surgery. Working with the California Society of Plastic Surgeons, Hoffman led a successful effort to pass legislation in California that greatly expands insurance coverage for children with cleft lip and palate. Hoffman has been named to U.S. News & World Report's list of America's best doctors for the past 15 years, a distinction reserved for the top 1 percent of physicians in the nation for a given specialty.

Hoffman earned his medical degree from the University of Rochester School of Medicine & Dentistry. At UCSF, he completed a residency in general surgery and a residency in plastic surgery, serving as chief resident. He then completed a fellowship in craniofacial and cleft lip surgery at NYU Langone Health.

Hoffman is treasurer of the California Society of Plastic Surgeons. He serves as a senior examiner for the American Board of Plastic Surgery and on its craniofacial surgery advisory council. He is past president of the American Association of Pediatric Plastic Surgeons and American Society of Maxillofacial Surgeons.

• Patient-Reported Outcomes in Gender-Affirming Facial Surgery: Recommendations from a Multidisciplinary Gender Health Panel.
  Facial plastic surgery & aesthetic medicine 2023 Zebolsky AL, Gulati A, Badiee RK, Pardo ST, Deutsch MB, Knott PD, Park AM, Pomerantz JH, Hoffman WY, Seth R
• Robotic repair of perineal hernias: a video vignette and review of the literature.
  Surgical endoscopy 2022 Watanaskul S, Schwab ME, Colley A, Chern H, Varma MG, Hoffman WY, Sarin A
• Preventing Rectourethral Fistula Recurrence With Gracilis Flap.
  Annals of plastic surgery 2022 Park KM, Rosli YY, Simms A, Lentz R, Bharadia DR, Breyer B, Hoffman WY
• Superior Long-term Appearance of Strip Craniectomy Compared with Cranial Vault Reconstruction in Metopic Craniosynostosis.
  Plastic and reconstructive surgery. Global open 2022 Badiee RK, Popowitz E, Mark IT, Alcon A, Hwang J, Rorison E, Auguste KI, Hoffman WY, Sun PP, Pomerantz JH
• Assessing the Readability of Online Patient Education Resources Related to Gynecomastia.
  Annals of plastic surgery 2021 Nnamani Silva ON, Ammanuel SG, Segobiano BM, Edwards CS, Hoffman WY
• Long-term Speech Outcomes of Cleft Palate Repair in Robin Sequence versus Isolated Cleft Palate.
  Plastic and reconstructive surgery. Global open 2021 Logjes RJH, Upton S, Mendelsohn BA, Badiee RK, Breugem CC, Hoffman WY, Pomerantz JH
• Craniectomy with microvascular flap reconstruction in a patient taking infliximab for vasculitis.
  BMJ case reports 2020 Nnamani Silva ON, Nguyen AB, Hoffman WY
• Concurrent presentation of brain arteriovenous malformation, peripheral arteriovenous malformation, and cerebellar astrocytoma: Case report.
  Interdisciplinary neurosurgery : Advanced techniques and case management 2020 Gautam A, Sun Z, Winkler E, Su H, McCalmont TH, Kim H, Tihan T, Hoffman WY, Dowd CF, Frieden IJ, Cooke DL
• Trainee Exposure and Education for Minimally Invasive Gender-Affirming Procedures.
  Dermatologic clinics 2019 Buhalog B, Peebles JK, Mansh M, Kim EA, Knott PD, Hoffman W, Seth R, Alcon A, Arron ST
• High-Yield Purification, Preservation, and Serial Transplantation of Human Satellite Cells.
  Stem cell reports 2018 Garcia SM, Tamaki S, Lee S, Wong A, Jose A, Dreux J, Kouklis G, Sbitany H, Seth R, Knott PD, Heaton C, Ryan WR, Kim EA, Hansen SL, Hoffman WY, Pomerantz JH
• Palatal Fistula Risk after Primary Palatoplasty: A Retrospective Comparison of a Humanitarian Organization and Tertiary Hospitals.
  The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 2018 Daniels KM, Yang Yu E, Maine RG, Heng Y, Yang L, Shi B, Corlew DS, Hoffman WY, Gregory GA
• Otologic Disease Following Palatoplasty In International Cleft Palate Cohort.
  The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 2017 Markey J, Maine R, Daniels K, Yu EY, Gregory G, Hoffman W, Palacios J
• Recalcitrant Invasive Skin Cancer of the Scalp: Combined Extirpation and Microsurgical Reconstruction Without Cranioplasty.
  The Journal of craniofacial surgery 2017 Cho GJ, Wang F, Garcia SM, Viner J, Hoffman WY, McDermott MW, Pomerantz JH
• Distraction Osteogenesis of Multiple Ribs for the Treatment of Acquired Thoracic Dystrophy.
  Pediatrics 2016 Piper ML, Delrosario L, Hoffman WY
• Breast Hypoplasia as a Complication of an Untreated Infantile Hemangioma.
  Pediatric dermatology 2016 Theiler M, Hoffman WY, Frieden IJ
• Human Satellite Cell Transplantation and Regeneration from Diverse Skeletal Muscles.
  Stem cell reports 2015 Xu X, Wilschut KJ, Kouklis G, Tian H, Hesse R, Garland C, Sbitany H, Hansen S, Seth R, Knott PD, Hoffman WY, Pomerantz JH
• MRI phenotypes of localized intravascular coagulopathy in venous malformations.
  Pediatric radiology 2015 Koo KS, Dowd CF, Mathes EF, Rosbe KW, Hoffman WY, Frieden IJ, Hess CP
• Atypical MRI features in soft-tissue arteriovenous malformation: a novel imaging appearance with radiologic-pathologic correlation.
  Pediatric radiology 2015 Patel AS, Schulman JM, Ruben BS, Hoffman WY, Dowd CF, Frieden IJ, Hess CP
• Palatal fistula risk after primary palatoplasty: a retrospective comparison of humanitarian operations and tertiary hospitals.
  Lancet (London, England) 2015 Daniels KM, Yu EY, Maine RG, Corlew S, Bing S, Hoffman WY, Gregory GA
• Perineal flap reconstruction following oncologic anorectal extirpation: an outcomes assessment.
  Plastic and reconstructive surgery 2015 Wang ED, Conkling N, Xu X, Chern H, Finlayson E, Varma MG, Hansen SL, Foster RD, Hoffman WY, Sbitany H
• Aspirin therapy in venous malformation: a retrospective cohort study of benefits, side effects, and patient experiences.
  Pediatric dermatology 2014 Nguyen JT, Koerper MA, Hess CP, Dowd CF, Hoffman WY, Dickman M, Frieden IJ
• The effects of immunosuppressive medications on outcomes in microvascular free tissue transfer.
  Plastic and reconstructive surgery 2014 Sbitany H, Xu X, Hansen SL, Young DM, Hoffman WY
• Memory regulatory T cells reside in human skin.
  The Journal of clinical investigation 2014 Sanchez Rodriguez R, Pauli ML, Neuhaus IM, Yu SS, Arron ST, Harris HW, Yang SH, Anthony BA, Sverdrup FM, Krow-Lucal E, MacKenzie TC, Johnson DS, Meyer EH, Löhr A, Hsu A, Koo J, Liao W, Gupta R, …
• Early versus later presentations of venous malformations: where and why?
  Pediatric dermatology 2013 Vogel SA, Hess CP, Dowd CF, Hoffman WY, Kane AJ, Rajaii R, Frieden IJ
• Frequency of surgical correction for maxillary hypoplasia in cleft lip and palate.
  The Journal of craniofacial surgery 2012 Oberoi S, Hoffman WY, Chigurupati R, Vargervik K
• Craniofacial team management in Apert syndrome.
  American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics 2012 Oberoi S, Hoffman WY, Vargervik K
• Team management and treatment outcomes for patients with hemifacial microsomia.
  American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics 2012 Ohtani J, Hoffman WY, Vargervik K, Oberoi S
• Comparison of fistula rates after palatoplasty for international and local surgeons on surgical missions in Ecuador with rates at a craniofacial center in the United States.
  Plastic and reconstructive surgery 2012 Maine RG, Hoffman WY, Palacios-Martinez JH, Corlew DS, Gregory GA
• Quality of life for patients requiring surgical resection and reconstruction for mandibular osteoradionecrosis: 10-year experience at the University of California San Francisco.
  Head & neck 2011 Chang EI, Leon P, Hoffman WY, Schmidt BL
• Ten-year retrospective analysis of incisional herniorrhaphy following renal transplantation.
  Archives of surgery (Chicago, Ill. : 1960) 2011 Chang EI, Galvez MG, Padilla BE, Freise CE, Foster RD, Hoffman WY
• Early white discoloration of infantile hemangioma: a sign of impending ulceration.
  Archives of dermatology 2010 Maguiness SM, Hoffman WY, McCalmont TH, Frieden IJ
• Three-dimensional assessment of the eruption path of the canine in individuals with bone-grafted alveolar clefts using cone beam computed tomography.
  The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 2010 Oberoi S, Gill P, Chigurupati R, Hoffman WY, Hatcher DC, Vargervik K
• Implantable venous Doppler monitoring in head and neck free flap reconstruction increases the salvage rate.
  Plastic and reconstructive surgery 2010 Paydar KZ, Hansen SL, Chang DS, Hoffman WY, Leon P
• Team care for the patient with cleft: UCSF protocols and outcomes.
  The Journal of craniofacial surgery 2009 Vargervik K, Oberoi S, Hoffman WY
• Volumetric assessment of secondary alveolar bone grafting using cone beam computed tomography.
  The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 2009 Oberoi S, Chigurupati R, Gill P, Hoffman WY, Vargervik K
• Hemimaxillofacial dysplasia: a variable presentation.
  The Journal of craniofacial surgery 2008 Porwal R, Ousterhout DK, Hoffman WY, Vargervik K, Oberoi S
• Superficial temporal artery and vein as recipient vessels for facial and scalp microsurgical reconstruction.
  Plastic and reconstructive surgery 2007 Hansen SL, Foster RD, Dosanjh AS, Mathes SJ, Hoffman WY, Leon P
• Hemangiomas and homeobox gene expression.
  The Journal of craniofacial surgery 2006 Hansen SL, Dosanjh A, Young DM, Boudreau N, Hoffman WY
• A role for Hox A5 in regulating angiogenesis and vascular patterning.
  Lymphatic research and biology 2005 Rhoads K, Arderiu G, Charboneau A, Hansen SL, Hoffman W, Boudreau N
• Extended medial gastrocnemius rotational flap for treatment of chronic knee extensor mechanism deficiency in patients with and without total knee arthroplasty.
  Clinical orthopaedics and related research 2004 Busfield BT, Huffman GR, Nahai F, Hoffman W, Ries MD
• Clinical characteristics and management of vascular anomalies: findings of a multidisciplinary vascular anomalies clinic.
  Archives of dermatology 2004 Mathes EF, Haggstrom AN, Dowd C, Hoffman WY, Frieden IJ
• Outcome of tongue-lip plication in patients with severe Pierre Robin sequence.
  The Journal of craniofacial surgery 2003 Hoffman W
• Reversed latissimus dorsi muscle flap for repair of recurrent congenital diaphragmatic hernia.
  Journal of pediatric surgery 2003 Sydorak RM, Hoffman W, Lee H, Yingling CD, Longaker M, Chang J, Smith B, Harrison MR, Albanese CT
• Reconstruction with rectus abdominis myocutaneous free flap after orbital exenteration in children.
  Archives of ophthalmology (Chicago, Ill. : 1960) 2001 Uusitalo M, Ibarra M, Fulton L, Kaplan M, Hoffman W, Lee C, Carter S, O'Brien J
• Giant congenital melanocytic nevi: the significance of neurocutaneous melanosis in neurologically asymptomatic children.
  Plastic and reconstructive surgery 2001 Foster RD, Williams ML, Barkovich AJ, Hoffman WY, Mathes SJ, Frieden IJ
• Complex abdominal wall reconstruction: a comparison of flap and mesh closure.
  Annals of surgery 2000 Mathes SJ, Steinwald PM, Foster RD, Hoffman WY, Anthony JP
• Natural history of fetuses with cleft lip.
  Plastic and reconstructive surgery 1999 Lopoo JB, Hedrick MH, Chasen S, Montgomery L, Chervenak FA, Goldstein R, Hoffman WY, Harrison MR, Longaker MT
• A new in utero sheep model for unilateral coronal craniosynostosis.
  Plastic and reconstructive surgery 1998 Stelnicki EJ, Vanderwall K, Hoffman WY, Harrison MR, Glowacki J, Longaker MT
• The in utero correction of unilateral coronal craniosynostosis.
  Plastic and reconstructive surgery 1998 Stelnicki EJ, Vanderwall K, Harrison MR, Longaker MT, Kaban LB, Hoffman WY
• Bone morphogenetic protein-2 induces scar formation and skin maturation in the second trimester fetus.
  Plastic and reconstructive surgery 1998 Stelnicki EJ, Longaker MT, Holmes D, Vanderwall K, Harrison MR, Largman C, Hoffman WY
• Intracranial migration of microplates versus wires in neonatal pigs after frontal advancement.
  The Journal of craniofacial surgery 1998 Stelnicki EJ, Hoffman W
• Flap selection as a determinant of success in pressure sore coverage.
  Archives of surgery (Chicago, Ill. : 1960) 1997 Foster RD, Anthony JP, Mathes SJ, Hoffman WY, Young D, Eshima I
• Ischial pressure sore coverage: a rationale for flap selection.
  British journal of plastic surgery 1997 Foster RD, Anthony JP, Mathes SJ, Hoffman WY
• A method for repairing zygomatic arch fractures using a hydroxyapatite cement paste (BoneSource).
  The Journal of craniofacial surgery 1997 Stelnicki EJ, Hoffman WY, Ousterhout DK
• Reconstruction of a complex midfacial defect with the folded fibular free flap and osseointegrated implants.
  Annals of plastic surgery 1996 Anthony JP, Foster RD, Sharma AB, Kearns GJ, Hoffman WY, Pogrel MA
• Percutaneous access to the uterus for fetal surgery.
  Journal of laparoendoscopic surgery 1996 VanderWall KJ, Meuli M, Szabo Z, Bruch SW, Kohl T, Hoffman WY, Adzick NS, Harrison MR
• A prospective study of early soft tissue coverage of grade IIIB tibial fractures.
  The Journal of trauma 1994 Trabulsy PP, Kerley SM, Hoffman WY
• The effects of facial nerve ablation on craniofacial skeletal development in neonatal rabbits.
  Plastic and reconstructive surgery 1994 Hoffman WY, McCarthy JG
• Limb salvage and wound coverage in patients with large ischemic ulcers: a multidisciplinary approach with revascularization and free tissue transfer.
  Journal of vascular surgery 1993 Ciresi KF, Anthony JP, Hoffman WY, Bowersox JC, Reilly LM, Rapp JH
• Immediate flap coverage in the treatment of large surgical defects after tumor resection.
  Surgery, gynecology & obstetrics 1993 Anthony JP, Mathes SJ, Hoffman WY
• Reanimation of the paralyzed face.
  Otolaryngologic clinics of North America 1992 Hoffman WY
• Influence of radiotherapy on microvascular reconstruction in the head and neck region.
  American journal of surgery 1991 Kiener JL, Hoffman WY, Mathes SJ
• Computerized tomographic analysis of orbital hypertelorism repair: spatial relationship of the globe and the bony orbit.
  Annals of plastic surgery 1990 Hoffman WY, McCarthy JG, Cutting CB, Zide BM
• Rigid internal fixation vs. traditional techniques for the treatment of mandible fractures.
  The Journal of trauma 1990 Hoffman WY, Barton RM, Price M, Mathes SJ