William Chen, MD
Postdoctoral Scholar
Radiation Oncology
School of Medicine

Education & Training

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• MD University of California, San Francisco 05/2018
• BS Biomedical Engineering Johns Hopkins University 05/2012

Publications (50)

Top publication keywords:
Radiotherapy, AdjuvantSupratentorial NeoplasmsRadiotherapy, Intensity-ModulatedRadiotherapy, ConformalSeizuresWaist CircumferenceConsciousness DisordersEpilepsyMeningiomaRadiosurgeryBrachytherapySalvage TherapyNeoplasm Recurrence, LocalMeningeal NeoplasmsAdrenal Gland Neoplasms

• Hypermitotic meningiomas harbor DNA methylation subgroups with distinct biological and clinical features.
  Neuro-oncology 2023 Choudhury A, Chen WC, Lucas CG, Bayley JC, Harmanci AS, Maas SLN, Santagata S, Klisch T, Perry A, Bi WL, Sahm F, Patel AJ, Magill ST, Raleigh DR
• Radiotherapy for meningiomas.
  Journal of neuro-oncology 2022 Chen WC, Perlow HK, Choudhury A, Nguyen MP, Mirchia K, Youngblood MW, Lucas CG, Palmer JD, Magill ST, Raleigh DR
• Resection with intraoperative cesium-131 brachytherapy as salvage therapy for recurrent brain tumors.
  Journal of neurosurgery 2022 Chen WC, Lafreniere M, Phuong C, Liu SJ, Baal JD, Lometti M, Morin O, Ziemer B, Vasudevan HN, Lucas CG, Hervey-Jumper SL, Theodosopoulos PV, Magill ST, Fogh S, Nakamura JL, Boreta L, Sneed PK, …
• Association of mental health diagnosis with race and all-cause mortality after a cancer diagnosis: Large-scale analysis of electronic health record data.
  Cancer 2021 Chen WC, Boreta L, Braunstein SE, Rabow MW, Kaplan LE, Tenenbaum JD, Morin O, Park CC, Hong JC
• Efficacy and Safety of Stereotactic Radiosurgery for Brainstem Metastases: A Systematic Review and Meta-analysis.
  JAMA oncology 2021 Chen WC, Baal UH, Baal JD, Pai JS, Boreta L, Braunstein SE, Raleigh DR
• Stereotactic Body Radiation Therapy and High-Dose-Rate Brachytherapy Boost in Combination With Intensity Modulated Radiation Therapy for Localized Prostate Cancer: A Single-Institution Propensity Score Matched Analysis.
  International journal of radiation oncology, biology, physics 2020 Chen WC, Li Y, Lazar A, Altun A, Descovich M, Nano T, Ziemer B, Sudhyadhom A, Cunha A, Thomas H, Gottschalk A, Hsu IC, Roach M
• A Prognostic Gene-Expression Signature and Risk Score for Meningioma Recurrence After Resection.
  Neurosurgery 2020 Chen WC, Vasudevan HN, Choudhury A, Pekmezci M, Lucas CG, Phillips J, Magill ST, Susko MS, Braunstein SE, Oberheim Bush NA, Boreta L, Nakamura JL, Villanueva-Meyer JE, Sneed PK, Perry A, McDermott MW,…
• Stereotactic Body Radiation Therapy of Adrenal Metastases: A Pooled Meta-Analysis and Systematic Review of 39 Studies with 1006 Patients.
  International journal of radiation oncology, biology, physics 2020 Chen WC, Baal JD, Baal U, Pai J, Gottschalk A, Boreta L, Braunstein SE, Raleigh DR
• Histopathological features predictive of local control of atypical meningioma after surgery and adjuvant radiotherapy.
  Journal of neurosurgery 2018 Chen WC, Magill ST, Wu A, Vasudevan HN, Morin O, Aghi MK, Theodosopoulos PV, Perry A, McDermott MW, Sneed PK, Braunstein SE, Raleigh DR
• Factors Associated With Pre- and Postoperative Seizures in 1033 Patients Undergoing Supratentorial Meningioma Resection.
  Neurosurgery 2017 Chen WC, Magill ST, Englot DJ, Baal JD, Wagle S, Rick JW, McDermott MW

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• Epigenetic reprogramming shapes the cellular landscape of schwannoma.
  Nature communications 2024 Liu SJ, Casey-Clyde T, Cho NW, Swinderman J, Pekmezci M, Dougherty MC, Foster K, Chen WC, Villanueva-Meyer JE, Swaney DL, Vasudevan HN, Choudhury A, Pak J, Breshears JD, Lang UE, Eaton CD, Hiam-Galvez…
• Functional interactions between neurofibromatosis tumor suppressors underlie Schwann cell tumor de-differentiation and treatment resistance.
  Nature communications 2024 Vasudevan HN, Payne E, Delley CL, John Liu S, Mirchia K, Sale MJ, Lastella S, Nunez MS, Lucas CG, Eaton CD, Casey-Clyde T, Magill ST, Chen WC, Braunstein SE, Perry A, Jacques L, Reddy AT, Pekmezci M, …
• Pan-cancer copy number variant analysis identifies optimized size thresholds and co-occurrence models for individualized risk-stratification.
  Research square 2024 Raleigh D, Nguyen M, Chen W, Zakimi N, Mirchia K, Lucas CH
• Targeted gene expression profiling predicts meningioma outcomes and radiotherapy responses.
  Nature medicine 2023 Chen WC, Choudhury A, Youngblood MW, Polley MC, Lucas CG, Mirchia K, Maas SLN, Suwala AK, Won M, Bayley JC, Harmanci AS, Harmanci AO, Klisch TJ, Nguyen MP, Vasudevan HN, McCortney K, Yu TJ, Bhave V, …
• Spatial genomic, biochemical, and cellular mechanisms drive meningioma heterogeneity and evolution.
  Research square 2023 Lucas CH, Mirchia K, Seo K, Najem H, Chen W, Zakimi N, Choudhury A, Liu SJ, Phillips J, Magill S, Horbinski C, Solomon D, Perry A, Vasudevan H, Heimberger A, Raleigh D
• Targeted gene expression profiling predicts meningioma outcomes and radiotherapy responses.
  Research square 2023 Raleigh D, Chen W, Choudhury A, Youngblood M, Polley MY, Lucas CH, Mirchia K, Maas S, Suwala A, Won M, Bayley J, Harmanci A, Harmanci A, Klisch T, Nguyen M, Vasudevan H, McCortney K, Yu T, Bhave V, …
• Even heterozygous loss of CDKN2A/B greatly accelerates recurrence in aggressive meningioma.
  Acta neuropathologica 2023 Khan AB, English CW, Chen WC, Athukuri P, Bayley JC, Brandt VL, Shetty A, Hadley CC, Choudhury A, Lu HC, Harmanci AO, Harmanci AS, Magill ST, Raleigh DR, Klisch TJ, Patel AJ
• A case (report) for mechanistic validation of meningioma molecular therapies.
  Neuro-oncology advances 2022 Nguyen MP, Seo K, Eaton CD, Lucas CG, Chen WC, Choudhury A, Young JS, Raleigh DR
• Intratumor and informatic heterogeneity influence meningioma molecular classification.
  Acta neuropathologica 2022 Vasudevan HN, Choudhury A, Hilz S, Villanueva-Meyer JE, Chen WC, Lucas CG, Braunstein SE, Oberheim Bush NA, Butowski N, Pekmezci M, McDermott MW, Perry A, Solomon DA, Magill ST, Raleigh DR
• Supervised machine learning algorithms demonstrate proliferation index correlates with long-term recurrence after complete resection of WHO grade I meningioma.
  Journal of neurosurgery 2022 Nguyen MP, Morshed RA, Dalle Ore CL, Cummins DD, Saggi S, Chen WC, Choudhury A, Ravi A, Raleigh DR, Magill ST, McDermott MW, Theodosopoulos PV
• Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities.
  Nature genetics 2022 Choudhury A, Magill ST, Eaton CD, Prager BC, Chen WC, Cady MA, Seo K, Lucas CG, Casey-Clyde TJ, Vasudevan HN, Liu SJ, Villanueva-Meyer JE, Lam TC, Pu JK, Li LF, Leung GK, Swaney DL, Zhang MY, Chan JW,…
• Reliability of patient self-report of cognition, awareness, and consciousness during seizures.
  Annals of clinical and translational neurology 2022 Zhao CW, Gebre R, Baykara Y, Chen W, Vitkovskiy P, Li N, Johnson M, Chen EY, Kluger D, Blumenfeld H
• Simulated driving in the epilepsy monitoring unit: Effects of seizure type, consciousness, and motor impairment.
  Epilepsia 2021 Kumar A, Martin R, Chen W, Bauerschmidt A, Youngblood MW, Cunningham C, Si Y, Ezeani C, Kratochvil Z, Bronen J, Thomson J, Riordan K, Yoo JY, Shirka R, Manganas L, Krestel H, Hirsch LJ, Blumenfeld H
• An artificial intelligence framework integrating longitudinal electronic health records with real-world data enables continuous pan-cancer prognostication.
  Nature cancer 2021 Morin O, Vallières M, Braunstein S, Ginart JB, Upadhaya T, Woodruff HC, Zwanenburg A, Chatterjee A, Villanueva-Meyer JE, Valdes G, Chen W, Hong JC, Yom SS, Solberg TD, Löck S, Seuntjens J, Park C, …
• Letter: Patterns of Intermediate- and High-Risk Meningioma Recurrence After Treatment With Postoperative External Beam Radiotherapy.
  Neurosurgery 2021 Susko MS, Chen WC, Vasudevan HN, Magill ST, Lucas CG, Oberheim Bush NA, Solomon DA, Theodosopoulos PV, McDermott MW, Villanueva-Meyer JE, Boreta L, Nakamura JL, Sneed PK, Braunstein SE, Raleigh DR
• Efficacy and safety of magnetic resonance-guided focused ultrasound for the treatment of painful bone metastases: a systematic review and meta-analysis.
  Skeletal radiology 2021 Baal JD, Chen WC, Baal U, Wagle S, Baal JH, Link TM, Bucknor MD
• Image-Guided Percutaneous Ablation of Adrenal Metastases: A Meta-Analysis of Efficacy and Safety.
  Journal of vascular and interventional radiology : JVIR 2021 Pan S, Baal JD, Chen WC, Baal U, Pai JS, Baal JH, Zagoria R
• Histopathologic findings in malignant peripheral nerve sheath tumor predict response to radiotherapy and overall survival.
  Neuro-oncology advances 2020 Lucas CG, Vasudevan HN, Chen WC, Magill ST, Braunstein SE, Jacques L, Dahiya S, Rodriguez FJ, Horvai AE, Perry A, Pekmezci M, Raleigh DR
• Clonal ZEB1-Driven Mesenchymal Transition Promotes Targetable Oncologic Antiangiogenic Therapy Resistance.
  Cancer research 2020 Chandra A, Jahangiri A, Chen W, Nguyen AT, Yagnik G, Pereira MP, Jain S, Garcia JH, Shah SS, Wadhwa H, Joshi RS, Weiss J, Wolf KJ, Lin JG, Müller S, Rick JW, Diaz AA, Gilbert LA, Kumar S, Aghi MK
• Radiation therapy of meningioma.
  Handbook of clinical neurology 2020 Chen WC, Braunstein SE
• Integrated models incorporating radiologic and radiomic features predict meningioma grade, local failure, and overall survival.
  Neuro-oncology advances 2019 Morin O, Chen WC, Nassiri F, Susko M, Magill ST, Vasudevan HN, Wu A, Vallières M, Gennatas ED, Valdes G, Pekmezci M, Alcaide-Leon P, Choudhury A, Interian Y, Mortezavi S, Turgutlu K, Bush NAO, Solberg…
• Meningioma metastases: incidence and proposed screening paradigm.
  Journal of neurosurgery 2019 Dalle Ore CL, Magill ST, Yen AJ, Shahin MN, Lee DS, Lucas CG, Chen WC, Viner JA, Aghi MK, Theodosopoulos PV, Raleigh DR, Villanueva-Meyer JE, McDermott MW
• Factors Associated with Osteoid Osteoma Recurrence after CT-Guided Radiofrequency Ablation.
  Journal of vascular and interventional radiology : JVIR 2019 Baal JD, Pai JS, Chen WC, Joseph GB, O'Donnell RJ, Link TM
• A Switch and Wave of Neuronal Activity in the Cerebral Cortex During the First Second of Conscious Perception.
  Cerebral cortex (New York, N.Y. : 1991) 2019 Herman WX, Smith RE, Kronemer SI, Watsky RE, Chen WC, Gober LM, Touloumes GJ, Khosla M, Raja A, Horien CL, Morse EC, Botta KL, Hirsch LJ, Alkawadri R, Gerrard JL, Spencer DD, Blumenfeld H
• Preoperative and postoperative prediction of long-term meningioma outcomes.
  PloS one 2018 Gennatas ED, Wu A, Braunstein SE, Morin O, Chen WC, Magill ST, Gopinath C, Villaneueva-Meyer JE, Perry A, McDermott MW, Solberg TD, Valdes G, Raleigh DR
• Petrous Face Meningiomas: Classification, Clinical Syndromes, and Surgical Outcomes.
  World neurosurgery 2018 Magill ST, Rick JW, Chen WC, Haase DA, Raleigh DR, Aghi MK, Theodosopoulos PV, McDermott MW
• Seizure Outcomes in Occipital Lobe and Posterior Quadrant Epilepsy Surgery: A Systematic Review and Meta-Analysis.
  Neurosurgery 2018 Harward SC, Chen WC, Rolston JD, Haglund MM, Englot DJ
• Salvage therapy outcomes for atypical meningioma.
  Journal of neuro-oncology 2018 Chen WC, Hara J, Magill ST, Wu A, Aghi MK, Theodosopoulos PV, Perry A, McDermott MW, Sneed PK, Raleigh DR, Braunstein SE
• Presenting Symptoms and Prognostic Factors for Symptomatic Outcomes Following Resection of Meningioma.
  World neurosurgery 2017 Wu A, Garcia MA, Magill ST, Chen W, Vasudevan HN, Perry A, Theodosopoulos PV, McDermott MW, Braunstein SE, Raleigh DR
• Cross-activating c-Met/β1 integrin complex drives metastasis and invasive resistance in cancer.
  Proceedings of the National Academy of Sciences of the United States of America 2017 Jahangiri A, Nguyen A, Chandra A, Sidorov MK, Yagnik G, Rick J, Han SW, Chen W, Flanigan PM, Schneidman-Duhovny D, Mascharak S, De Lay M, Imber B, Park CC, Matsumoto K, Lu K, Bergers G, Sali A, Weiss …
• Cognitive Decline, Body Mass Index, and Waist Circumference in Community-Dwelling Elderly Participants.
  Journal of geriatric psychiatry and neurology 2017 Rodríguez-Fernández JM, Danies E, Martínez-Ortega J, Chen WC
• Impaired Serotonergic Brainstem Function during and after Seizures.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Zhan Q, Buchanan GF, Motelow JE, Andrews J, Vitkovskiy P, Chen WC, Serout F, Gummadavelli A, Kundishora A, Furman M, Li W, Bo X, Richerson GB, Blumenfeld H
• Human bedside evaluation versus automatic responsiveness testing in epilepsy (ARTiE).
  Epilepsia 2015 Touloumes G, Morse E, Chen WC, Gober L, Dente J, Lilenbaum R, Katzenstein E, Pacelli A, Johnson E, Si Y, Sivaraju A, Grover E, Khozein R, Cunningham C, Hirsch LJ, Blumenfeld H
• Rhythmic 3-4Hz discharge is insufficient to produce cortical BOLD fMRI decreases in generalized seizures.
  NeuroImage 2015 Youngblood MW, Chen WC, Mishra AM, Enamandram S, Sanganahalli BG, Motelow JE, Bai HX, Frohlich F, Gribizis A, Lighten A, Hyder F, Blumenfeld H
• Cortical network switching: possible role of the lateral septum and cholinergic arousal.
  Brain stimulation 2014 Li W, Motelow JE, Zhan Q, Hu YC, Kim R, Chen WC, Blumenfeld H
• Impaired consciousness in partial seizures is bimodally distributed.
  Neurology 2014 Cunningham C, Chen WC, Shorten A, McClurkin M, Choezom T, Schmidt CP, Chu V, Bozik A, Best C, Chapman M, Furman M, Detyniecki K, Giacino JT, Blumenfeld H
• Ictal spread of medial temporal lobe seizures with and without secondary generalization: an intracranial electroencephalography analysis.
  Epilepsia 2014 Yoo JY, Farooque P, Chen WC, Youngblood MW, Zaveri HP, Gerrard JL, Spencer DD, Hirsch LJ, Blumenfeld H
• Epilepsy and driving: potential impact of transient impaired consciousness.
  Epilepsy & behavior : E&B 2014 Chen WC, Chen EY, Gebre RZ, Johnson MR, Li N, Vitkovskiy P, Blumenfeld H
• Seizure localization using three-dimensional surface projections of intracranial EEG power.
  NeuroImage 2013 Lee HW, Youngblood MW, Farooque P, Han X, Jhun S, Chen WC, Goncharova I, Vives K, Spencer DD, Zaveri H, Hirsch LJ, Blumenfeld H
• Serpin-derived peptides are antiangiogenic and suppress breast tumor xenograft growth.
  Translational oncology 2012 Koskimaki JE, Rosca EV, Rivera CG, Lee E, Chen W, Pandey NB, Popel AS