William Smith, MD
Assistant Professor
Psychiatry
School of Medicine

Billy Smith, MD is an assistant clinical professor at the University of California, San Francisco. He completed his geriatric psychiatry fellowship at UCSF in June 2023, adult psychiatry residency at UCSF in June 2022 and his medical training at Harvard Medical School in 2018. During his time in residency, Dr. Smith completed area of distinction programs in both LGBTQ+ mental health and Clinical Neuroscience.

Show full bio (49 words) Hide full bio

His clinical interests include caring for older LGBTQ+ adults, HIV and aging, acute psychiatry, and psychoanalytic psychotherapy. He is clinical work includes providing care at ZSFG on inpatient psychiatry as well as at UCSF in outpatient geriatric psychiatry with a focus on caring for older adults living with HIV.

Awards

Show all (2) Hide

• Laughlin Award for Clinical Excellence, UCSF, 2021-2022
• Resident Teaching Award, UCSF, 2019-2020

Education & Training

Show all (4) Hide

• Geriatric Psychiatry University of California San Francisco 06/2023
• Psychiatry University of California San Francisco 06/2022
• MD Medicine Harvard Medical School 05/2018
• BS Chemistry Northeastern University 05/2012

Publications (11)

Top publication keywords:
AgeismGender DysphoriaSpiro CompoundsHealth FacilitiesHistone Deacetylase 2Histone DeacetylasesLactamsMental DisordersGender IdentityDepsipeptidesHistone Deacetylase 1ThiazolesHistone Deacetylase InhibitorsTransgender PersonsNarration

• How to Draw on Narrative to Mitigate Ageism.
  AMA journal of ethics 2023 Smith W, Elkin D, Walaszek A
• Affirming Gender Identity of Patients With Serious Mental Illness.
  Psychiatric services (Washington, D.C.) 2018 Smith WB, Goldhammer H, Keuroghlian AS
• Development of a Potent and Selective HDAC8 Inhibitor.
  ACS medicinal chemistry letters 2016 Ingham OJ, Paranal RM, Smith WB, Escobar RA, Yueh H, Snyder T, Porco JA, Bradner JE, Beeler AB
• Modular synthesis and biological activity of pyridyl-based analogs of the potent Class I Histone Deacetylase Inhibitor Largazole.
  Bioorganic & medicinal chemistry 2015 Clausen DJ, Smith WB, Haines BE, Wiest O, Bradner JE, Williams RM
• Structure-guided DOT1L probe optimization by label-free ligand displacement.
  ACS chemical biology 2015 Yi JS, Federation AJ, Qi J, Dhe-Paganon S, Hadler M, Xu X, St Pierre R, Varca AC, Wu L, Marineau JJ, Smith WB, Souza A, Chory EJ, Armstrong SA, Bradner JE

Show all (6 more) Hide

• Syntheses and discovery of a novel class of cinnamic hydroxamates as histone deacetylase inhibitors by multimodality molecular imaging in living subjects.
  Cancer research 2014 Chan CT, Qi J, Smith W, Paranol R, Mazitschek R, West N, Reeves R, Chiosis G, Schreiber SL, Bradner JE, Paulmurugan R, Gambhir SS
• 7,9-Diaryl-1,6,8-trioxaspiro[4.5]dec-3-en-2-ones: readily accessible and highly potent anticancer compounds.
  Bioorganic & medicinal chemistry letters 2014 D'Erasmo MP, Smith WB, Munoz A, Mohandas P, Au AS, Marineau JJ, Quadri LE, Bradner JE, Murelli RP
• Genome-wide localization of small molecules.
  Nature biotechnology 2013 Anders L, Guenther MG, Qi J, Fan ZP, Marineau JJ, Rahl PB, Lovén J, Sigova AA, Smith WB, Lee TI, Bradner JE, Young RA
• Synthesis and HDAC inhibitory activity of isosteric thiazoline-oxazole largazole analogs.
  Bioorganic & medicinal chemistry letters 2013 Guerra-Bubb JM, Bowers AA, Smith WB, Paranal R, Estiu G, Wiest O, Bradner JE, Williams RM
• Selective HDAC1/HDAC2 inhibitors induce neuroblastoma differentiation.
  Chemistry & biology 2013 Frumm SM, Fan ZP, Ross KN, Duvall JR, Gupta S, VerPlank L, Suh BC, Holson E, Wagner FF, Smith WB, Paranal RM, Bassil CF, Qi J, Roti G, Kung AL, Bradner JE, Tolliday N, Stegmaier K
• Selective inhibition of BET bromodomains.
  Nature 2010 Filippakopoulos P, Qi J, Picaud S, Shen Y, Smith WB, Fedorov O, Morse EM, Keates T, Hickman TT, Felletar I, Philpott M, Munro S, McKeown MR, Wang Y, Christie AL, West N, Cameron MJ, Schwartz B, …