Wilfred Raymond
Specialist
Cardiovascular Research Inst
School of Medicine

Publications (26)

Top publication keywords:
Eosinophil PeroxidasePulmonary AlveoliPeptide HydrolasesAsthmaOsteopontinSerine EndopeptidasesChymasesPrimatesCathepsin GSputumHepatocyte Growth FactorSerumMucusalpha-MacroglobulinsMast Cells

• Peroxidase-mediated mucin cross-linking drives pathologic mucus gel formation in IL-13-stimulated airway epithelial cells.
  JCI insight 2024 Liegeois MA, Braunreuther M, Charbit AR, Raymond WW, Tang M, Woodruff PG, Christenson SA, Castro M, Erzurum SC, Israel E, Jarjour NN, Levy BD, Moore WC, Wenzel SE, Fuller GG, Fahy JV
• A novel DNase assay reveals low DNase activity in severe asthma.
  American journal of physiology. Lung cellular and molecular physiology 2024 Charbit AR, Liegeois MA, Raymond WW, Comhair SAA, Johansson MW, Hastie AT, Bleecker ER, Fajt M, Castro M, Sumino K, Erzurum SC, Israel E, Jarjour NN, Mauger DT, Moore WC, Wenzel SE, Woodruff PG, Levy …
• Utility of eosinophil peroxidase as a biomarker of eosinophilic inflammation in asthma.
  The Journal of allergy and clinical immunology 2024 Tang M, Charbit AR, Johansson MW, Jarjour NN, Denlinger LC, Raymond WW, Peters MC, Dunican EM, Castro M, Sumino K, Erzurum SC, Comhair SA, Moore WC, Levy BD, Israel E, Phipatanakul W, Phillips BR, …
• MICB Genomic Variant Is Associated with NKG2D-mediated Acute Lung Injury and Death.
  American journal of respiratory and critical care medicine 2024 Aguilar OA, Qualls AE, Gonzalez-Hinojosa MDR, Obeidalla S, Kerchberger VE, Tsao T, Singer JP, Looney MR, Raymond W, Hays SR, Golden JA, Kukreja J, Shaver CM, Ware LB, Christie J, Diamond JM, Lanier LL…
• A novel thiol-saccharide mucolytic for the treatment of muco-obstructive lung diseases.
  The European respiratory journal 2023 Addante A, Raymond W, Gitlin I, Charbit A, Orain X, Scheffler AW, Kuppe A, Duerr J, Daniltchenko M, Drescher M, Graeber SY, Healy AM, Oscarson S, Fahy JV, Mall MA

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• Exploring antiviral and anti-inflammatory effects of thiol drugs in COVID-19.
  American journal of physiology. Lung cellular and molecular physiology 2022 Khanna K, Raymond WW, Jin J, Charbit AR, Gitlin I, Tang M, Werts AD, Barrett EG, Cox JM, Birch SM, Martinelli R, Sperber HS, Franz S, Duff T, Hoffmann M, Healy AM, Oscarson S, Pöhlmann S, Pillai SK, …
• Thiol drugs decrease SARS-CoV-2 lung injury in vivo and disrupt SARS-CoV-2 spike complex binding to ACE2 in vitro.
  bioRxiv : the preprint server for biology 2021 Khanna K, Raymond W, Jin J, Charbit AR, Gitlin I, Tang M, Werts AD, Barrett EG, Cox JM, Birch SM, Martinelli R, Sperber HS, Franz S, Pillai S, Healy AM, Duff T, Oscarson S, Hoffmann M, Pöhlmann S, …
• Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma.
  American journal of respiratory and critical care medicine 2019 Lachowicz-Scroggins ME, Dunican EM, Charbit AR, Raymond W, Looney MR, Peters MC, Gordon ED, Woodruff PG, Lefrançais E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, …
• Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
  The Journal of clinical investigation 2018 Dunican EM, Elicker BM, Gierada DS, Nagle SK, Schiebler ML, Newell JD, Raymond WW, Lachowicz-Scroggins ME, Di Maio S, Hoffman EA, Castro M, Fain SB, Jarjour NN, Israel E, Levy BD, Erzurum SC, Wenzel …
• Divergent Inhibitor Susceptibility among Airway Lumen-Accessible Tryptic Proteases.
  PloS one 2015 Nimishakavi S, Raymond WW, Gruenert DC, Caughey GH
• Regulation of hepatocyte growth factor in mice with pneumonia by peptidases and trans-alveolar flux.
  PloS one 2015 Raymond WW, Xu X, Nimishakavi S, Le C, McDonald DM, Caughey GH
• Mutational tail loss is an evolutionary mechanism for liberating marapsins and other type I serine proteases from transmembrane anchors.
  The Journal of biological chemistry 2013 Raman K, Trivedi NN, Raymond WW, Ganesan R, Kirchhofer D, Verghese GM, Craik CS, Schneider EL, Nimishakavi S, Caughey GH
• Activity and inhibition of prostasin and matriptase on apical and basolateral surfaces of human airway epithelial cells.
  American journal of physiology. Lung cellular and molecular physiology 2012 Nimishakavi S, Besprozvannaya M, Raymond WW, Craik CS, Gruenert DC, Caughey GH
• The αvβ6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells.
  The Journal of clinical investigation 2012 Sugimoto K, Kudo M, Sundaram A, Ren X, Huang K, Bernstein X, Wang Y, Raymond WW, Erle DJ, Abrink M, Caughey GH, Huang X, Sheppard D
• Secreted osteopontin is highly polymerized in human airways and fragmented in asthmatic airway secretions.
  PloS one 2011 Arjomandi M, Frelinger J, Donde A, Wong H, Yellamilli A, Raymond W
• How immune peptidases change specificity: cathepsin G gained tryptic function but lost efficiency during primate evolution.
  Journal of immunology (Baltimore, Md. : 1950) 2010 Raymond WW, Trivedi NN, Makarova A, Ray M, Craik CS, Caughey GH
• Ex vivo sputum analysis reveals impairment of protease-dependent mucus degradation by plasma proteins in acute asthma.
  American journal of respiratory and critical care medicine 2009 Innes AL, Carrington SD, Thornton DJ, Kirkham S, Rousseau K, Dougherty RH, Raymond WW, Caughey GH, Muller SJ, Fahy JV
• Alpha 2-macroglobulin capture allows detection of mast cell chymase in serum and creates a reservoir of angiotensin II-generating activity.
  Journal of immunology (Baltimore, Md. : 1950) 2009 Raymond WW, Su S, Makarova A, Wilson TM, Carter MC, Metcalfe DD, Caughey GH
• Guinea pig chymase is leucine-specific: a novel example of functional plasticity in the chymase/granzyme family of serine peptidases.
  The Journal of biological chemistry 2008 Caughey GH, Beauchamp J, Schlatter D, Raymond WW, Trivedi NN, Banner D, Mauser H, Fingerle J
• Chimerism, point mutation, and truncation dramatically transformed mast cell delta-tryptases during primate evolution.
  The Journal of allergy and clinical immunology 2008 Trivedi NN, Raymond WW, Caughey GH
• Mast cell and neutrophil peptidases attack an inactivation segment in hepatocyte growth factor to generate NK4-like antagonists.
  The Journal of biological chemistry 2005 Raymond WW, Cruz AC, Caughey GH
• Mastin is a gelatinolytic mast cell peptidase resembling a mini-proteasome.
  Archives of biochemistry and biophysics 2005 Raymond WW, Sommerhoff CP, Caughey GH
• Matrix metalloproteinase-2 and -9 expression increases in Mycoplasma-infected airways but is not required for microvascular remodeling.
  American journal of physiology. Lung cellular and molecular physiology 2004 Baluk P, Raymond WW, Ator E, Coussens LM, McDonald DM, Caughey GH
• Albumin is a substrate of human chymase. Prediction by combinatorial peptide screening and development of a selective inhibitor based on the albumin cleavage site.
  The Journal of biological chemistry 2003 Raymond WW, Ruggles SW, Craik CS, Caughey GH
• Structure of human pro-chymase: a model for the activating transition of granule-associated proteases.
  Biochemistry 2003 Reiling KK, Krucinski J, Miercke LJ, Raymond WW, Caughey GH, Stroud RM
• Lys40 but not Arg143 influences selectivity of angiotensin conversion by human alpha-chymase.
  Biochimica et biophysica acta 2002 Muilenburg DJ, Raymond WW, Wolters PJ, Caughey GH