Wanida Ono, DDS, PhD
Professor
Orofacial Sciences
School of Dentistry

Publications (44)

Top publication keywords:
Growth PlateReceptor, Parathyroid Hormone, Type 1Dental SacTooth DiseasesChemokine CXCL12Parathyroid Hormone-Related ProteinChondrocytesBone DevelopmentOdontogenesisTooth RootTooth EruptionAlveolar ProcessStem CellsDental PapillaOsteogenesis

• Mesenchymal Stem Cells in Socket Healing and MRONJ.
  Orthodontics & craniofacial research 2025 Arai Y, Tsutsumi-Arai C, English JD, Ono N, Ono W
• A Hedgehog-Foxf axis coordinates dental follicle-derived alveolar bone formation.
  Nature communications 2025 Nagata M, Gadhvi GT, Komori T, Arai Y, Tsutsumi-Arai C, Chu AKY, Nye SN, Yang Y, Orikasa S, Takahashi A, Carlsson P, Zheng WJ, Welch JD, Ono N, Ono W
• Wnt-directed CXCL12-expressing apical papilla progenitor cells drive tooth root formation.
  Nature communications 2025 Nagata M, Gadhvi GT, Komori T, Arai Y, Manabe H, Chu AKY, Kaur R, Ali M, Yang Y, Tsutsumi-Arai C, Nakai Y, Matsushita Y, Tokavanich N, Zheng WJ, Welch JD, Ono N, Ono W
• RUNX2 is essential for maintaining synchondrosis chondrocytes and cranial base growth.
  Bone research 2025 Hallett SA, Dixon A, Marrale I, Batoon L, Brenes J, Zhou A, Arbiv A, Kaartinen V, Allen B, Ono W, Franceschi RT, Ono N
• Control of alveolar bone development, homeostasis, and socket healing by salt-inducible kinases.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2025 Tokavanich N, Chan B, Strauss K, Castro Andrade CD, Arai Y, Nagata M, Foretz M, Brooks DJ, Ono N, Ono W, Wein MN

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• Mandibular Condylar Cartilage in Development and Diseases: A PTHrP-Centric View.
  Orthodontics & craniofacial research 2025 Tsutsumi-Arai C, Tran A, Arai Y, Ono W, Ono N
• Control of alveolar bone development, homeostasis, and socket healing by salt inducible kinases.
  bioRxiv : the preprint server for biology 2024 Tokavanich N, Chan B, Strauss K, Castro Andrade CD, Arai Y, Nagata M, Foretz M, Brooks DJ, Ono N, Ono W, Wein MN
• Etiological Mechanisms and Genetic/Biological Modulation Related to PTH1R in Primary Failure of Tooth Eruption.
  Calcified tissue international 2024 Li XX, Wang MT, Wu ZF, Sun Q, Ono N, Nagata M, Zang XL, Ono W
• Hedgehog activation promotes osteogenic fates of growth plate resting zone chondrocytes through transient clonal competency.
  JCI insight 2024 Orikasa S, Matsushita Y, Manabe H, Fogge M, Lee Z, Mizuhashi K, Sakagami N, Ono W, Ono N
• Endosteal stem cells at the bone-blood interface: A double-edged sword for rapid bone formation: Bone marrow endosteal stem cells provide a robust source of bone-making osteoblasts both in normal and abnormal bone formation.
  BioEssays : news and reviews in molecular, cellular and developmental biology 2023 Matsushita Y, Liu J, Chu AKY, Ono W, Welch JD, Ono N
• Mechanisms of Osteoclastogenesis in Orthodontic Tooth Movement and Orthodontically Induced Tooth Root Resorption.
  Journal of bone metabolism 2023 Nakai Y, Praneetpong N, Ono W, Ono N
• Multi-omics analysis in developmental bone biology.
  The Japanese dental science review 2023 Matsushita Y, Noguchi A, Ono W, Ono N
• Growth plate resting zone chondrocytes acquire transient clonal competency upon Hedgehog activation and efficiently transform into trabecular bone osteoblasts.
  bioRxiv : the preprint server for biology 2023 Orikasa S, Matsushita Y, Fogge M, Mizuhashi K, Sakagami N, Ono W, Ono N
• Hes1 marks peri-condensation mesenchymal cells that generate both chondrocytes and perichondrial cells in early bone development.
  The Journal of biological chemistry 2023 Matsushita Y, Manabe H, Ohyama T, Nakamura S, Nagata M, Ono W, Ono N
• Bone marrow endosteal stem cells dictate active osteogenesis and aggressive tumorigenesis.
  Nature communications 2023 Matsushita Y, Liu J, Chu AKY, Tsutsumi-Arai C, Nagata M, Arai Y, Ono W, Yamamoto K, Saunders TL, Welch JD, Ono N
• Effects of antiresorptive medications on tooth root formation and tooth eruption in paediatric patients.
  Orthodontics & craniofacial research 2023 Arai Y, English JD, Ono N, Ono W
• The fate of early perichondrial cells in developing bones.
  Nature communications 2022 Matsushita Y, Chu AKY, Tsutsumi-Arai C, Orikasa S, Nagata M, Wong SY, Welch JD, Ono W, Ono N
• Primary failure of tooth eruption: Etiology and management.
  The Japanese dental science review 2022 Yamaguchi T, Hosomichi K, Shirota T, Miyamoto Y, Ono W, Ono N
• Diverse stem cells for periodontal tissue formation and regeneration.
  Genesis (New York, N.Y. : 2000) 2022 Nagata M, English JD, Ono N, Ono W
• Cranial Base Synchondrosis Lacks PTHrP-Expressing Column-Forming Chondrocytes.
  International journal of molecular sciences 2022 Hallett SA, Zhou A, Herzog C, Arbiv A, Ono W, Ono N
• Cranial Base Synchondrosis: Chondrocytes at the Hub.
  International journal of molecular sciences 2022 Hallett SA, Ono W, Franceschi RT, Ono N
• Toward Marrow Adipocytes: Adipogenic Trajectory of the Bone Marrow Stromal Cell Lineage.
  Frontiers in endocrinology 2022 Matsushita Y, Ono W, Ono N
• Synergy of single-cell sequencing analyses and in vivo lineage-tracing approaches: A new opportunity for stem cell biology.
  Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al 2022 Matsushita Y, Ono W, Ono N
• The Role of Wnt Signaling in Postnatal Tooth Root Development.
  Frontiers in dental medicine 2021 Tokavanich N, Wein MN, English JD, Ono N, Ono W
• Single-Cell Transcriptomic Analysis Reveals Developmental Relationships and Specific Markers of Mouse Periodontium Cellular Subsets.
  Frontiers in dental medicine 2021 Nagata M, Chu AKY, Ono N, Welch JD, Ono W
• Chondrocytes in the resting zone of the growth plate are maintained in a Wnt-inhibitory environment.
  eLife 2021 Hallett SA, Matsushita Y, Ono W, Sakagami N, Mizuhashi K, Tokavanich N, Nagata M, Zhou A, Hirai T, Kronenberg HM, Ono N
• The hypertrophic chondrocyte: To be or not to be.
  Histology and histopathology 2021 Hallett SA, Ono W, Ono N
• Intercellular Interactions of an Adipogenic CXCL12-Expressing Stromal Cell Subset in Murine Bone Marrow.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2021 Matsushita Y, Chu AKY, Ono W, Welch JD, Ono N
• Flow Cytometry-Based Analysis of the Mouse Bone Marrow Stromal and Perivascular Compartment.
  Methods in molecular biology (Clifton, N.J.) 2021 Matsushita Y, Ono W, Ono N
• Bone regeneration via skeletal cell lineage plasticity: All hands mobilized for emergencies: Quiescent mature skeletal cells can be activated in response to injury and robustly participate in bone regeneration through cellular plasticity.
  BioEssays : news and reviews in molecular, cellular and developmental biology 2020 Matsushita Y, Ono W, Ono N
• Unveiling diversity of stem cells in dental pulp and apical papilla using mouse genetic models: a literature review.
  Cell and tissue research 2020 Nagata M, Ono N, Ono W
• Skeletal Stem Cells for Bone Development and Repair: Diversity Matters.
  Current osteoporosis reports 2020 Matsushita Y, Ono W, Ono N
• Growth plate skeletal stem cells and their transition from cartilage to bone.
  Bone 2020 Matsushita Y, Ono W, Ono N
• A Wnt-mediated transformation of the bone marrow stromal cell identity orchestrates skeletal regeneration.
  Nature communications 2020 Matsushita Y, Nagata M, Kozloff KM, Welch JD, Mizuhashi K, Tokavanich N, Hallett SA, Link DC, Nagasawa T, Ono W, Ono N
• A three-dimensional analysis of primary failure of eruption in humans and mice.
  Oral diseases 2019 Tokavanich N, Gupta A, Nagata M, Takahashi A, Matsushita Y, Yatabe M, Ruellas A, Cevidanes L, Maki K, Yamaguchi T, Ono N, Ono W
• Salt-inducible kinases dictate parathyroid hormone 1 receptor action in bone development and remodeling.
  The Journal of clinical investigation 2019 Nishimori S, O'Meara MJ, Castro CD, Noda H, Cetinbas M, da Silva Martins J, Ayturk U, Brooks DJ, Bruce M, Nagata M, Ono W, Janton CJ, Bouxsein ML, Foretz M, Berdeaux R, Sadreyev RI, Gardella TJ, …
• Growth Plate Chondrocytes: Skeletal Development, Growth and Beyond.
  International journal of molecular sciences 2019 Hallett SA, Ono W, Ono N
• Growth Plate Borderline Chondrocytes Behave as Transient Mesenchymal Precursor Cells.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2019 Mizuhashi K, Nagata M, Matsushita Y, Ono W, Ono N
• Autocrine regulation of mesenchymal progenitor cell fates orchestrates tooth eruption.
  Proceedings of the National Academy of Sciences of the United States of America 2018 Takahashi A, Nagata M, Gupta A, Matsushita Y, Yamaguchi T, Mizuhashi K, Maki K, Ruellas AC, Cevidanes LS, Kronenberg HM, Ono N, Ono W
• Resting zone of the growth plate houses a unique class of skeletal stem cells.
  Nature 2018 Mizuhashi K, Ono W, Matsushita Y, Sakagami N, Takahashi A, Saunders TL, Nagasawa T, Kronenberg HM, Ono N
• Parathyroid hormone receptor signalling in osterix-expressing mesenchymal progenitors is essential for tooth root formation.
  Nature communications 2016 Ono W, Sakagami N, Nishimori S, Ono N, Kronenberg HM
• A subset of chondrogenic cells provides early mesenchymal progenitors in growing bones.
  Nature cell biology 2014 Ono N, Ono W, Nagasawa T, Kronenberg HM
• Vasculature-associated cells expressing nestin in developing bones encompass early cells in the osteoblast and endothelial lineage.
  Developmental cell 2014 Ono N, Ono W, Mizoguchi T, Nagasawa T, Frenette PS, Kronenberg HM
• A novel population of cells expressing both hematopoietic and mesenchymal markers is present in the normal adult bone marrow and is augmented in a murine model of marrow fibrosis.
  The American journal of pathology 2011 Ohishi M, Ono W, Ono N, Khatri R, Marzia M, Baker EK, Root SH, Wilson TL, Iwamoto Y, Kronenberg HM, Aguila HL, Purton LE, Schipani E