Walter Miller, MD
Professor Emeritus
Pediatrics
School of Medicine

Education & Training

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• Residency School of Medicine University of California, San Francisco

Websites

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• Profile at endocrine.medicine.ucsf.edu (endocrine.medicine.ucsf.edu)

Grants and Projects

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• Training Program in Pediatric Endocrinology, NIH, 1976-2021
• Bio-Organic Biomedical Mass Spectrometry Resource, NIH, 1982-2015
• Pharmacogenomics of Human P450 Oxidoreductase, NIH, 2005-2014
• Resource for Biocomputing, Visualization, and Informatics, NIH/NCRR, 1976-2012
• Molecular Biology of Steroidogenic P450 Enzymes, NIH, 1987-2012
• Androgen Production in Adrenarche and Pcos, NIH, 2002-2007
• Molecular Regulation of Steroidogenesis, NIH, 1990-2001
• Unique Bioassay Screening for Steroidogenic Enzyme Clone, NIH, 1986-1987
• Molecular Bases of Congenital Adrenal Hyperplasias, NIH, 1982-1985

Publications (134)

Top publication keywords:
TenascinSteroid 17-alpha-HydroxylaseCytochrome P-450 Enzyme SystemCholesterol Side-Chain Cleavage EnzymeAdrenal Hyperplasia, CongenitalAndrogensEndocrinologySteroid 21-HydroxylaseCholesterolPhosphoproteinsNADPH-Ferrihemoprotein ReductaseSteroidsAdrenal GlandsMutationMitochondrial Membranes

• History of Adrenal Research: From Ancient Anatomy to Contemporary Molecular Biology.
  Endocrine reviews 2023 Miller WL, White PC
• A Brief History of Congenital Adrenal Hyperplasia.
  Hormone research in paediatrics 2022 Miller WL, White PC
• A Brief History of the Pediatric Endocrine Society (PES).
  Hormone research in paediatrics 2022 Oberfield SE, Rogol AD, Miller WL
• Celebrating 50 Years of the Pediatric Endocrine Society (PES): Histories of Pediatric Endocrine Topics.
  Hormone research in paediatrics 2022 Oberfield SE, Rogol AD, Miller WL
• Rickets, Vitamin D, and Ca/P Metabolism.
  Hormone research in paediatrics 2022 Miller WL, Imel EA

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• Congenital Adrenal Hyperplasia-Current Insights in Pathophysiology, Diagnostics, and Management.
  Endocrine reviews 2022 Claahsen-van der Grinten HL, Speiser PW, Ahmed SF, Arlt W, Auchus RJ, Falhammar H, Flück CE, Guasti L, Huebner A, Kortmann BBM, Krone N, Merke DP, Miller WL, Nordenström A, Reisch N, Sandberg DE, …
• Steroidogenic electron-transfer factors and their diseases.
  Annals of pediatric endocrinology & metabolism 2021 Miller WL
• Considering Sex as a Biological Variable in Basic and Clinical Studies: An Endocrine Society Scientific Statement.
  Endocrine reviews 2021 Bhargava A, Arnold AP, Bangasser DA, Denton KM, Gupta A, Hilliard Krause LM, Mayer EA, McCarthy M, Miller WL, Raznahan A, Verma R
• A Novel Mitochondrial Complex of Aldosterone Synthase, Steroidogenic Acute Regulatory Protein, and Tom22 Synthesizes Aldosterone in the Rat Heart.
  The Journal of pharmacology and experimental therapeutics 2021 Bose HS, Whittal RM, Marshall B, Rajapaksha M, Wang NP, Bose M, Perry EW, Zhao ZQ, Miller WL
• Tenascin-X-Discovery and Early Research.
  Frontiers in immunology 2021 Miller WL
• Congenital Adrenal Hyperplasia: Time to Replace 17OHP with 21-Deoxycortisol.
  Hormone research in paediatrics 2019 Miller WL
• Response to Letter to the Editor: "Congenital Adrenal Hyperplasia Due to Steroid 21-Hydroxylase Deficiency: An Endocrine Society Clinical Practice Guideline".
  The Journal of clinical endocrinology and metabolism 2019 Speiser PW, Auchus RJ, Merke DP, Miller WL, White PC
• The "backdoor pathway" of androgen synthesis in human male sexual development.
  PLoS biology 2019 Miller WL, Auchus RJ
• Congenital Adrenal Hyperplasia Due to Steroid 21-Hydroxylase Deficiency: An Endocrine Society Clinical Practice Guideline.
  The Journal of clinical endocrinology and metabolism 2018 Speiser PW, Arlt W, Auchus RJ, Baskin LS, Conway GS, Merke DP, Meyer-Bahlburg HFL, Miller WL, Murad MH, Oberfield SE, White PC
• MECHANISMS IN ENDOCRINOLOGY: Rare defects in adrenal steroidogenesis.
  European journal of endocrinology 2018 Miller WL
• Tenascin-X, Congenital Adrenal Hyperplasia, and the CAH-X Syndrome.
  Hormone research in paediatrics 2018 Miller WL, Merke DP
• The Hypothalamic-Pituitary-Adrenal Axis: A Brief History.
  Hormone research in paediatrics 2018 Miller WL
• Steroidogenesis: Unanswered Questions.
  Trends in endocrinology and metabolism: TEM 2017 Miller WL
• Melvin M. Grumbach, MD, 1925-2016
.
  Hormone research in paediatrics 2017 Miller WL
• In Memoriam: Melvin M. Grumbach, MD, (1925-2016) Pediatric Endocrinologist, Scientist, Educator, Leader.
  Pediatric endocrinology reviews : PER 2017 Miller WL
• In Memoriam: Melvin M. Grumbach (1925-2016).
  Endocrine reviews 2016 Miller WL
• In Memoriam: Melvin M. Grumbach (1925-2016).
  Endocrinology 2016 Miller WL
• Introduction to the 2016 Keith L. Parker Memorial Lecturer: Douglas M. Stocco, Ph.D.
  Molecular and cellular endocrinology 2016 Miller WL
• Alternative splicing of DENND1A, a PCOS candidate gene, generates variant 2.
  Molecular and cellular endocrinology 2016 Tee MK, Speek M, Legeza B, Modi B, Teves ME, McAllister JM, Strauss JF, Miller WL
• Genetic disorders of Vitamin D biosynthesis and degradation.
  The Journal of steroid biochemistry and molecular biology 2016 Miller WL
• Adrenocortical carcinoma in a 17th-century girl.
  The Journal of steroid biochemistry and molecular biology 2016 Else T, Auchus RJ, Miller WL
• Disorders in the initial steps of steroid hormone synthesis.
  The Journal of steroid biochemistry and molecular biology 2016 Miller WL
• The First Defect in Electron Transfer to Mitochondrial P450 Enzymes.
  Endocrinology 2016 Miller WL, Chung BC
• Electron transfer by human wild-type and A287P mutant P450 oxidoreductase assessed by transient kinetics: functional basis of P450 oxidoreductase deficiency.
  The Biochemical journal 2015 Jin Y, Chen M, Penning TM, Miller WL
• 150 years of congenital adrenal hyperplasia: translation and commentary of De Crecchio's classic paper from 1865.
  Endocrinology 2015 Delle Piane L, Rinaudo PF, Miller WL
• Fetal endocrine therapy for congenital adrenal hyperplasia should not be done.
  Best practice & research. Clinical endocrinology & metabolism 2015 Miller WL
• Potential role of increased oxygenation in altering perinatal adrenal steroidogenesis.
  Pediatric research 2014 Agrawal V, Tee MK, Qiao J, Muench MO, Miller WL
• Quantitation of CYP24A1 enzymatic activity with a simple two-hybrid system.
  The Journal of clinical endocrinology and metabolism 2014 Mugg A, Legeza B, Tee MK, Damm I, Long RK, Miller WL
• The post-translational regulation of 17,20 lyase activity.
  Molecular and cellular endocrinology 2014 Miller WL, Tee MK
• FGF-23 regulates CYP27B1 transcription in the kidney and in extra-renal tissues.
  PloS one 2013 Chanakul A, Zhang MY, Louw A, Armbrecht HJ, Miller WL, Portale AA, Perwad F
• Cortisol response to operative stress with anesthesia in healthy children.
  The Journal of clinical endocrinology and metabolism 2013 Taylor LK, Auchus RJ, Baskin LS, Miller WL
• Phosphorylation of human cytochrome P450c17 by p38α selectively increases 17,20 lyase activity and androgen biosynthesis.
  The Journal of biological chemistry 2013 Tee MK, Miller WL
• Steroid hormone synthesis in mitochondria.
  Molecular and cellular endocrinology 2013 Miller WL
• Of marsupials and men: "Backdoor" dihydrotestosterone synthesis in male sexual differentiation.
  Molecular and cellular endocrinology 2013 Biason-Lauber A, Miller WL, Pandey AV, Flück CE
• Varied clinical presentations of seven patients with mutations in CYP11A1 encoding the cholesterol side-chain cleavage enzyme, P450scc.
  The Journal of clinical endocrinology and metabolism 2013 Tee MK, Abramsohn M, Loewenthal N, Harris M, Siwach S, Kaplinsky A, Markus B, Birk O, Sheffield VC, Parvari R, Pavari R, Hershkovitz E, Miller WL
• Human cytochromes P450 in health and disease.
  Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2013 Nebert DW, Wikvall K, Miller WL
• P450 oxidoreductase: genotyping, expression, purification of recombinant protein, and activity assessments of wild-type and mutant protein.
  Methods in molecular biology (Clifton, N.J.) 2013 Agrawal V, Miller WL
• Distinguishing deficiencies in the steroidogenic acute regulatory protein and the cholesterol side chain cleavage enzyme causing neonatal adrenal failure.
  The Journal of pediatrics 2012 Gucev ZS, Tee MK, Chitayat D, Wherrett DK, Miller WL
• Prenatal treatment of congenital adrenal hyperplasia: risks outweigh benefits.
  American journal of obstetrics and gynecology 2012 Miller WL, Witchel SF
• A brief history of adrenal research: steroidogenesis - the soul of the adrenal.
  Molecular and cellular endocrinology 2012 Miller WL
• P450 oxidoreductase deficiency: a disorder of steroidogenesis with multiple clinical manifestations.
  Science signaling 2012 Miller WL
• Defects in androgen biosynthesis causing 46,XY disorders of sexual development.
  Seminars in reproductive medicine 2012 Auchus RJ, Miller WL
• Effect of P450 oxidoreductase variants on the metabolism of model substrates mediated by CYP2C9.1, CYP2C9.2, and CYP2C9.3.
  Pharmacogenetics and genomics 2012 Subramanian M, Agrawal V, Sandee D, Tam HK, Miller WL, Tracy TS
• Role of mitochondria in steroidogenesis.
  Best practice & research. Clinical endocrinology & metabolism 2012 Papadopoulos V, Miller WL
• Prenatal treatment of congenital adrenal hyperplasia-not standard of care.
  Journal of genetic counseling 2012 Witchel SF, Miller WL
• Expression of P450c17 in the human fetal nervous system.
  Endocrinology 2012 Schonemann MD, Muench MO, Tee MK, Miller WL, Mellon SH
• Congenital adrenal hyperplasia--more dogma bites the dust.
  The Journal of clinical endocrinology and metabolism 2012 Auchus RJ, Miller WL
• The syndrome of 17,20 lyase deficiency.
  The Journal of clinical endocrinology and metabolism 2011 Miller WL
• Early steps in steroidogenesis: intracellular cholesterol trafficking.
  Journal of lipid research 2011 Miller WL, Bose HS
• Why boys will be boys: two pathways of fetal testicular androgen biosynthesis are needed for male sexual differentiation.
  American journal of human genetics 2011 Flück CE, Meyer-Böni M, Pandey AV, Kempná P, Miller WL, Schoenle EJ, Biason-Lauber A
• High-yield expression of a catalytically active membrane-bound protein: human P450 oxidoreductase.
  Endocrinology 2011 Sandee D, Miller WL
• Transcriptional regulation of the human P450 oxidoreductase gene: hormonal regulation and influence of promoter polymorphisms.
  Molecular endocrinology (Baltimore, Md.) 2011 Tee MK, Huang N, Damm I, Miller WL
• Guidelines for the Development of Comprehensive Care Centers for Congenital Adrenal Hyperplasia: Guidance from the CARES Foundation Initiative.
  International journal of pediatric endocrinology 2011 Auchus RJ, Witchel SF, Leight KR, Aisenberg J, Azziz R, Bachega TA, Baker LA, Baratz AB, Baskin LS, Berenbaum SA, Breault DT, Cerame BI, Conway GS, Eugster EA, Fracassa S, Gearhart JP, Geffner ME, …
• Role of mitochondria in steroidogenesis.
  Endocrine development 2010 Miller WL
• Partial defect in the cholesterol side-chain cleavage enzyme P450scc (CYP11A1) resembling nonclassic congenital lipoid adrenal hyperplasia.
  The Journal of clinical endocrinology and metabolism 2010 Sahakitrungruang T, Tee MK, Blackett PR, Miller WL
• Clinical, biochemical, and molecular characterization of macronodular adrenocortical hyperplasia of the zona reticularis: a new syndrome.
  The Journal of clinical endocrinology and metabolism 2010 Ghayee HK, Rege J, Watumull LM, Nwariaku FE, Carrick KS, Rainey WE, Miller WL, Auchus RJ
• Consequences of POR mutations and polymorphisms.
  Molecular and cellular endocrinology 2010 Miller WL, Agrawal V, Sandee D, Tee MK, Huang N, Choi JH, Morrissey K, Giacomini KM
• The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders.
  Endocrine reviews 2010 Miller WL, Auchus RJ
• Effects of genetic variants of human P450 oxidoreductase on catalysis by CYP2D6 in vitro.
  Pharmacogenetics and genomics 2010 Sandee D, Morrissey K, Agrawal V, Tam HK, Kramer MA, Tracy TS, Giacomini KM, Miller WL
• Substrate-specific modulation of CYP3A4 activity by genetic variants of cytochrome P450 oxidoreductase.
  Pharmacogenetics and genomics 2010 Agrawal V, Choi JH, Giacomini KM, Miller WL
• Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency: an Endocrine Society clinical practice guideline.
  The Journal of clinical endocrinology and metabolism 2010 Speiser PW, Azziz R, Baskin LS, Ghizzoni L, Hensle TW, Merke DP, Meyer-Bahlburg HF, Miller WL, Montori VM, Oberfield SE, Ritzen M, White PC, Endocrine Society
• Naturally-occurring mutation in the calcium-sensing receptor reveals the significance of extracellular domain loop III region for class C G-protein-coupled receptor function.
  The Journal of clinical endocrinology and metabolism 2010 Dong Q, Cheng Z, Chang W, Blackman BE, Conte FA, Hu J, Shoback D, Miller WL
• A Summary of the Endocrine Society Clinical Practice Guidelines on Congenital Adrenal Hyperplasia due to Steroid 21-Hydroxylase Deficiency.
  International journal of pediatric endocrinology 2010 Speiser PW, Azziz R, Baskin LS, Ghizzoni L, Hensle TW, Merke DP, Meyer-Bahlburg HF, Miller WL, Montori VM, Oberfield SE, Ritzen M, White PC
• Clinical, genetic, and functional characterization of four patients carrying partial loss-of-function mutations in the steroidogenic acute regulatory protein (StAR).
  The Journal of clinical endocrinology and metabolism 2010 Sahakitrungruang T, Soccio RE, Lang-Muritano M, Walker JM, Achermann JC, Miller WL
• Functional characterization of vasopressin receptor 2 mutations causing partial and complete congenital nephrogenic diabetes insipidus in Thai families.
  Hormone research in paediatrics 2010 Sahakitrungruang T, Tee MK, Rattanachartnarong N, Shotelersuk V, Suphapeetiporn K, Miller WL
• Human cytochrome p450c17: single step purification and phosphorylation of serine 258 by protein kinase a.
  Endocrinology 2010 Wang YH, Tee MK, Miller WL
• Did Akhenaten have the Antley-Bixler syndrome?
  Annals of internal medicine 2009 Miller WL
• Clinical, genetic, and enzymatic characterization of P450 oxidoreductase deficiency in four patients.
  The Journal of clinical endocrinology and metabolism 2009 Sahakitrungruang T, Huang N, Tee MK, Agrawal V, Russell WE, Crock P, Murphy N, Migeon CJ, Miller WL
• Nomenclature for alleles of the cytochrome P450 oxidoreductase gene.
  Pharmacogenetics and genomics 2009 Sim SC, Miller WL, Zhong XB, Arlt W, Ogata T, Ding X, Wolf CR, Flück CE, Pandey AV, Henderson CJ, Porter TD, Daly AK, Nebert DW, Ingelman-Sundberg M
• Novel P450c17 mutation H373D causing combined 17alpha-hydroxylase/17,20-lyase deficiency.
  The Journal of clinical endocrinology and metabolism 2009 Sahakitrungruang T, Tee MK, Speiser PW, Miller WL
• Androgen synthesis in adrenarche.
  Reviews in endocrine & metabolic disorders 2009 Miller WL
• Identification, characterization and rescue of a novel vasopressin-2 receptor mutation causing nephrogenic diabetes insipidus.
  Clinical endocrinology 2008 Ranadive SA, Ersoy B, Favre H, Cheung CC, Rosenthal SM, Miller WL, Vaisse C
• Extraadrenal 21-hydroxylation by CYP2C19 and CYP3A4: effect on 21-hydroxylase deficiency.
  The Journal of clinical endocrinology and metabolism 2008 Gomes LG, Huang N, Agrawal V, Mendonça BB, Bachega TA, Miller WL
• Genetic variation in human P450 oxidoreductase.
  Molecular and cellular endocrinology 2008 Miller WL, Huang N, Agrawal V, Giacomini KM
• Pharmacogenetics of P450 oxidoreductase: effect of sequence variants on activities of CYP1A2 and CYP2C19.
  Pharmacogenetics and genomics 2008 Agrawal V, Huang N, Miller WL
• Homozygous mutation G539R in the gene for P450 oxidoreductase in a family previously diagnosed as having 17,20-lyase deficiency.
  The Journal of clinical endocrinology and metabolism 2008 Hershkovitz E, Parvari R, Wudy SA, Hartmann MF, Gomes LG, Loewental N, Miller WL
• The serine phosphorylation hypothesis of polycystic ovary syndrome: a unifying mechanism for hyperandrogenemia and insulin resistance.
  Fertility and sterility 2008 Bremer AA, Miller WL
• The common P450 oxidoreductase variant A503V is not a modifier gene for 21-hydroxylase deficiency.
  The Journal of clinical endocrinology and metabolism 2008 Gomes LG, Huang N, Agrawal V, Mendonça BB, Bachega TA, Miller WL
• Genetic and clinical features of p450 oxidoreductase deficiency.
  Hormone research 2008 Scott RR, Miller WL
• Steroidogenic activity of StAR requires contact with mitochondrial VDAC1 and phosphate carrier protein.
  The Journal of biological chemistry 2008 Bose M, Whittal RM, Miller WL, Bose HS
• Genetics of P450 oxidoreductase: sequence variation in 842 individuals of four ethnicities and activities of 15 missense mutations.
  Proceedings of the National Academy of Sciences of the United States of America 2008 Huang N, Agrawal V, Giacomini KM, Miller WL
• StAR-like activity and molten globule behavior of StARD6, a male germ-line protein.
  Biochemistry 2008 Bose HS, Whittal RM, Ran Y, Bose M, Baker BY, Miller WL
• Pathways leading to phosphorylation of p450c17 and to the posttranslational regulation of androgen biosynthesis.
  Endocrinology 2008 Tee MK, Dong Q, Miller WL
• Severe combined adrenal and gonadal deficiency caused by novel mutations in the cholesterol side chain cleavage enzyme, P450scc.
  The Journal of clinical endocrinology and metabolism 2008 Kim CJ, Lin L, Huang N, Quigley CA, AvRuskin TW, Achermann JC, Miller WL
• P450 oxidoreductase deficiency - a new form of congenital adrenal hyperplasia.
  Endocrine development 2008 Flück CE, Pandey AV, Huang N, Agrawal V, Miller WL
• Steroidogenic enzymes.
  Endocrine development 2008 Miller WL
• Vitamin D 1alpha-hydroxylase gene mutations in patients with 1alpha-hydroxylase deficiency.
  The Journal of clinical endocrinology and metabolism 2007 Kim CJ, Kaplan LE, Perwad F, Huang N, Sharma A, Choi Y, Miller WL, Portale AA
• Apparent manifesting heterozygosity in P450 oxidoreductase deficiency and its effect on coexisting 21-hydroxylase deficiency.
  The Journal of clinical endocrinology and metabolism 2007 Scott RR, Gomes LG, Huang N, Van Vliet G, Miller WL
• Steroidogenic acute regulatory protein (StAR), a novel mitochondrial cholesterol transporter.
  Biochimica et biophysica acta 2007 Miller WL
• Cholesterol binding does not predict activity of the steroidogenic acute regulatory protein, StAR.
  The Journal of biological chemistry 2007 Baker BY, Epand RF, Epand RM, Miller WL
• Mechanism of StAR's regulation of mitochondrial cholesterol import.
  Molecular and cellular endocrinology 2007 Miller WL
• StAR search--what we know about how the steroidogenic acute regulatory protein mediates mitochondrial cholesterol import.
  Molecular endocrinology (Baltimore, Md.) 2006 Miller WL
• Nonclassic congenital lipoid adrenal hyperplasia: a new disorder of the steroidogenic acute regulatory protein with very late presentation and normal male genitalia.
  The Journal of clinical endocrinology and metabolism 2006 Baker BY, Lin L, Kim CJ, Raza J, Smith CP, Miller WL, Achermann JC
• P450 oxidoreductase deficiency: a new form of congenital adrenal hyperplasia.
  Current opinion in pediatrics 2006 Flück CE, Miller WL
• P450 oxidoreductase deficiency: a new disorder of steroidogenesis.
  Annals of the New York Academy of Sciences 2005 Miller WL, Huang N, Pandey AV, Flück CE, Agrawal V
• A pH-dependent molten globule transition is required for activity of the steroidogenic acute regulatory protein, StAR.
  The Journal of biological chemistry 2005 Baker BY, Yaworsky DC, Miller WL
• Nephrogenic syndrome of inappropriate antidiuresis.
  The New England journal of medicine 2005 Feldman BJ, Rosenthal SM, Vargas GA, Fenwick RG, Huang EA, Matsuda-Abedini M, Lustig RH, Mathias RS, Portale AA, Miller WL, Gitelman SE
• Regulation of cytochrome b5 gene transcription by Sp3, GATA-6, and steroidogenic factor 1 in human adrenal NCI-H295A cells.
  Molecular endocrinology (Baltimore, Md.) 2005 Huang N, Dardis A, Miller WL
• Diversity and function of mutations in p450 oxidoreductase in patients with Antley-Bixler syndrome and disordered steroidogenesis.
  American journal of human genetics 2005 Huang N, Pandey AV, Agrawal V, Reardon W, Lapunzina PD, Mowat D, Jabs EW, Van Vliet G, Sack J, Flück CE, Miller WL
• Minireview: regulation of steroidogenesis by electron transfer.
  Endocrinology 2005 Miller WL
• Effects of anticonvulsants on human p450c17 (17alpha-hydroxylase/17,20 lyase) and 3beta-hydroxysteroid dehydrogenase type 2.
  Epilepsia 2005 Flück CE, Yaworsky DC, Miller WL
• Regulation of 17,20 lyase activity by cytochrome b5 and by serine phosphorylation of P450c17.
  The Journal of biological chemistry 2005 Pandey AV, Miller WL
• Disorders of androgen synthesis--from cholesterol to dehydroepiandrosterone.
  Medical principles and practice : international journal of the Kuwait University, Health Science Centre 2005 Miller WL
• A genetic isolate of congenital lipoid adrenal hyperplasia with atypical clinical findings.
  The Journal of clinical endocrinology and metabolism 2004 Chen X, Baker BY, Abduljabbar MA, Miller WL
• P450 oxidoreductase deficiency.
  Lancet (London, England) 2004 Miller WL, Huang N, Flück CE, Pandey AV
• P450 oxidoreductase deficiency: a new disorder of steroidogenesis affecting all microsomal P450 enzymes.
  Endocrine research 2004 Pandey AV, Flück CE, Huang N, Tajima T, Fujieda K, Miller WL
• Peripheral-type benzodiazepine receptor-mediated action of steroidogenic acute regulatory protein on cholesterol entry into leydig cell mitochondria.
  Molecular endocrinology (Baltimore, Md.) 2004 Hauet T, Yao ZX, Bose HS, Wall CT, Han Z, Li W, Hales DB, Miller WL, Culty M, Papadopoulos V
• pH-dependent Interactions of the carboxyl-terminal helix of steroidogenic acute regulatory protein with synthetic membranes.
  The Journal of biological chemistry 2004 Yaworsky DC, Baker BY, Bose HS, Best KB, Jensen LB, Bell JD, Baldwin MA, Miller WL
• LBP proteins modulate SF1-independent expression of P450scc in human placental JEG-3 cells.
  Molecular endocrinology (Baltimore, Md.) 2004 Huang N, Miller WL
• P450 oxidoreductase deficiency: a new disorder of steroidogenesis with multiple clinical manifestations.
  Trends in endocrinology and metabolism: TEM 2004 Miller WL
• Vitamin D 25-hydroxylase deficiency.
  Molecular genetics and metabolism 2004 Dong Q, Miller WL
• Near-miss apparent SIDS from adrenal crisis.
  The Journal of pediatrics 2004 Gassner HL, Toppari J, Quinteiro González S, Miller WL
• Lack of defects in androgen production in children with hypospadias.
  The Journal of clinical endocrinology and metabolism 2004 Holmes NM, Miller WL, Baskin LS
• Cinnamic acid based thiazolidinediones inhibit human P450c17 and 3beta-hydroxysteroid dehydrogenase and improve insulin sensitivity independent of PPARgamma agonist activity.
  Journal of molecular endocrinology 2004 Arlt W, Neogi P, Gross C, Miller WL
• GATA-4 and GATA-6 modulate tissue-specific transcription of the human gene for P450c17 by direct interaction with Sp1.
  Molecular endocrinology (Baltimore, Md.) 2004 Flück CE, Miller WL
• Mutant P450 oxidoreductase causes disordered steroidogenesis with and without Antley-Bixler syndrome.
  Nature genetics 2004 Flück CE, Tajima T, Pandey AV, Arlt W, Okuhara K, Verge CF, Jabs EW, Mendonça BB, Fujieda K, Miller WL
• Molten globule structure and steroidogenic activity of N-218 MLN64 in human placental mitochondria.
  Endocrinology 2004 Tuckey RC, Bose HS, Czerwionka I, Miller WL
• Steroid 17alpha-hydroxylase deficiency--not rare everywhere.
  The Journal of clinical endocrinology and metabolism 2004 Miller WL
• Lack of mutations in CYP2D6 and CYP27 in patients with apparent deficiency of vitamin D 25-hydroxylase.
  Molecular genetics and metabolism 2003 Lin CJ, Dardis A, Wijesuriya SD, Abdullah MA, Casella SJ, Miller WL
• Dexamethasone does not exert direct intracellular feedback on steroidogenesis in human adrenal NCI-H295A cells.
  The Journal of endocrinology 2003 Dardis A, Miller WL
• The 17, 20-lyase activity of cytochrome p450c17 from human fetal testis favors the delta5 steroidogenic pathway.
  The Journal of clinical endocrinology and metabolism 2003 Flück CE, Miller WL, Auchus RJ
• Formation and functioning of fused cholesterol side-chain cleavage enzymes.
  DNA and cell biology 2003 Nazarov PA, Drutsa VL, Miller WL, Shkumatov VM, Luzikov VN, Novikova LA
• Differential regulation of steroid hormone biosynthesis in R2C and MA-10 Leydig tumor cells: role of SR-B1-mediated selective cholesteryl ester transport.
  Biology of reproduction 2003 Rao RM, Jo Y, Leers-Sucheta S, Bose HS, Miller WL, Azhar S, Stocco DM
• Vitamin D biosynthesis and vitamin D 1 alpha-hydroxylase deficiency.
  Endocrine development 2003 Miller WL, Portale AA
• Androgen biosynthesis from cholesterol to DHEA.
  Molecular and cellular endocrinology 2002 Miller WL
• The steroidogenic acute regulatory protein, StAR, works only at the outer mitochondrial membrane.
  Endocrine research 2002 Bose HS, Lingappa VR, Miller WL
• Clinical, genetic, and functional characterization of adrenocorticotropin receptor mutations using a novel receptor assay.
  The Journal of clinical endocrinology and metabolism 2002 Flück CE, Martens JW, Conte FA, Miller WL
• Rapid regulation of steroidogenesis by mitochondrial protein import.
  Nature 2002 Bose HS, Lingappa VR, Miller WL
• Dietary phosphorus transcriptionally regulates 25-hydroxyvitamin D-1alpha-hydroxylase gene expression in the proximal renal tubule.
  Endocrinology 2002 Zhang MY, Wang X, Wang JT, Compagnone NA, Mellon SH, Olson JL, Tenenhouse HS, Miller WL, Portale AA