Wade Smith, MD, PhD
Professor
Neurology
School of Medicine

He studies the HeadPulse- minute movements produced by the heart beat on the head. Alterations in the HeadPulse provide diagnostic tools for stroke, brain injury and other neurological conditions.

• Collateral Circulation in Thrombectomy for Stroke After 6 to 24 Hours in the DAWN Trial.
  Stroke 2021 Liebeskind DS, Saber H, Xiang B, Jadhav AP, Jovin TG, Haussen DC, Budzik RF, Bonafe A, Bhuva P, Yavagal DR, Hanel RA, Ribo M, Cognard C, Sila C, Hassan AE, Smith WS, Saver JL, Nogueira RG, DAWN …
• Serial ASPECTS in the DAWN Trial: Infarct Evolution and Clinical Impact.
  Stroke 2021 Liebeskind DS, Saber H, Bhuva P, Xiang B, Yoo AJ, Jadhav AP, Haussen DC, Budzik RF, Bonafe A, Yavagal DR, Hanel RA, Ribo M, Cognard C, Sila C, Hassan AE, Smith WS, Saver JL, Nogueira RG, Jovin TG
• The Neurological Examination Improves Cranial Accelerometry Large Vessel Occlusion Prediction Accuracy.
  Neurocritical care 2020 Keenan KJ, Lovoi PA, Smith WS
• Standardizing Brain Death Globally.
  JAMA neurology 2020 Smith WS
• Computed tomography perfusion abnormalities after carotid endarterectomy help in the diagnosis of reversible cerebral vasoconstriction syndrome.
  Journal of vascular surgery cases and innovative techniques 2020 Isikbay M, Narsinh KH, Arroyo S, Smith WS, Cooke DL, Higashida RT, Amans MR
• A Unique Signature of Cardiac-Induced Cranial Forces During Acute Large Vessel Stroke and Development of a Predictive Model.
  Neurocritical care 2020 Smith WS, Keenan KJ, Lovoi PA
• Impact of Periprocedural and Technical Factors and Patient Characteristics on Revascularization and Outcome in the DAWN Trial.
  Stroke 2019 Tekle WG, Hassan AE, Jadhav AP, Haussen DC, Budzik RF, Bonafe A, Bhuva P, Yavagal DR, Hanel RA, Ribo M, Cognard C, Sila CA, Smith WS, Saver JL, Liebeskind DS, Shields R, Nogueira RG, Jovin TG, DAWN …
• Benefit of Endovascular Thrombectomy by Mode of Onset: Secondary Analysis of the DAWN Trial.
  Stroke 2019 Jadhav AP, Aghaebrahim A, Jankowitz BT, Haussen DC, Budzik RF, Bonafe A, Bhuva P, Yavagal DR, Hanel RA, Hassan AE, Ribo M, Cognard C, Sila CA, Zhang Y, Smith WS, Saver JL, Liebeskind DS, Nogueira RG, …
• Outcome in Direct Versus Transfer Patients in the DAWN Controlled Trial.
  Stroke 2019 Aghaebrahim A, Jadhav AP, Hanel R, Sauvageau E, Granja MF, Zhang Y, Haussen DC, Budzik RF, Bonafe A, Bhuva P, Ribo M, Cognard C, Sila C, Yavagal D, Hassan AE, Smith WS, Saver J, Liebeskind DS, …
• Endovascular Stroke Therapy.
  Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2019 Smith WS
• Validation and iteration of CT perfusion defined malignant profile thresholds for acute ischemic stroke.
  International journal of stroke : official journal of the International Stroke Society 2019 Keenan KJ, Christensen S, Inoue M, Mlynash M, Albers GW, Smith WS
• The Speech Arm Vision Eyes (SAVE) scale predicts large vessel occlusion stroke as well as more complicated scales.
  Journal of neurointerventional surgery 2018 Keenan KJ, Smith WS
• Mechanical Thrombectomy in Patients With Milder Strokes and Large Vessel Occlusions.
  Stroke 2018 Nagel S, Bouslama M, Krause LU, Küpper C, Messer M, Petersen M, Lowens S, Herzberg M, Ringleb PA, Möhlenbruch MA, Tiedt S, Lima FO, Haussen DC, Smith WS, Lev MH, Nogueira RG
• Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct.
  The New England journal of medicine 2017 Nogueira RG, Jadhav AP, Haussen DC, Bonafe A, Budzik RF, Bhuva P, Yavagal DR, Ribo M, Cognard C, Hanel RA, Sila CA, Hassan AE, Millan M, Levy EI, Mitchell P, Chen M, English JD, Shah QA, Silver FL, …
• Periprocedural heparin use in acute ischemic stroke endovascular therapy: the TREVO 2 trial.
  Journal of neurointerventional surgery 2017 Winningham MJ, Haussen DC, Nogueira RG, Liebeskind DS, Smith WS, Lutsep HL, Jovin TG, Xiang B, Nahab F
• Endovascular Stroke Therapy.
  Seminars in thrombosis and hemostasis 2017 Caganap SD, Smith WS
• Field Assessment Stroke Triage for Emergency Destination: A Simple and Accurate Prehospital Scale to Detect Large Vessel Occlusion Strokes.
  Stroke 2016 Lima FO, Silva GS, Furie KL, Frankel MR, Lev MH, Camargo ÉC, Haussen DC, Singhal AB, Koroshetz WJ, Smith WS, Nogueira RG
• A low-cost, tablet-based option for prehospital neurologic assessment: The iTREAT Study.
  Neurology 2016 Chapman Smith SN, Govindarajan P, Padrick MM, Lippman JM, McMurry TL, Resler BL, Keenan K, Gunnell BS, Mehndiratta P, Chee CY, Cahill EA, Dietiker C, Cattell-Gordon DC, Smith WS, Perina DG, Solenski …
• Cranial Accelerometry Can Detect Cerebral Vasospasm Caused by Subarachnoid Hemorrhage.
  Neurocritical care 2015 Smith WS, Browne JL, Ko NU
• Emergency Neurologic Life Support (ENLS): Evolution of Management in the First Hour of a Neurological Emergency.
  Neurocritical care 2015 Miller CM, Pineda J, Corry M, Brophy G, Smith WS
• Brief History of Endovascular Acute Ischemic Stroke Treatment.
  Stroke 2015 Smith WS, Furlan AJ
• REVASCAT Trial: Further Advancement in Endovascular Stroke Therapy.
  Stroke 2015 Smith WS, Yan B
• Improved ischemic stroke outcome prediction using model estimation of outcome probability: the THRIVE-c calculation.
  International journal of stroke : official journal of the International Stroke Society 2015 Flint AC, Rao VA, Chan SL, Cullen SP, Faigeles BS, Smith WS, Bath PM, Wahlgren N, Ahmed N, Donnan GA, Johnston SC, SITS International and VISTA-plus investigators
• Detection of concussion using cranial accelerometry.
  Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine 2015 Auerbach PS, Baine JG, Schott ML, Greenhaw A, Acharya MG, Smith WS
• Effect of a balloon-expandable intracranial stent vs medical therapy on risk of stroke in patients with symptomatic intracranial stenosis: the VISSIT randomized clinical trial.
  JAMA 2015 Zaidat OO, Fitzsimmons BF, Woodward BK, Wang Z, Killer-Oberpfalzer M, Wakhloo A, Gupta R, Kirshner H, Megerian JT, Lesko J, Pitzer P, Ramos J, Castonguay AC, Barnwell S, Smith WS, Gress DR, VISSIT …
• A quality assurance initiative targeting radiation exposure to neuroscience patients in the intensive care unit.
  The Neurohospitalist 2015 Chan S, Josephson SA, Rosow L, Smith WS
• Time from onset of SIRS to antibiotic administration and outcomes after subarachnoid hemorrhage.
  Neurocritical care 2014 Guterman EL, Kamel H, Azran C, Shah MP, Claude Hemphill J, Smith WS, Navi BB
• The THRIVE score predicts symptomatic intracerebral hemorrhage after intravenous tPA administration in SITS-MOST.
  International journal of stroke : official journal of the International Stroke Society 2014 Flint AC, Gupta R, Smith WS, Kamel H, Faigeles BS, Cullen SP, Rao VA, Bath PM, Wahlgren N, Ahmed N, Donnan GA, SITS International and VISTA-plus investigators
• Predictors of functional dependence despite successful revascularization in large-vessel occlusion strokes.
  Stroke 2014 Shi ZS, Liebeskind DS, Xiang B, Ge SG, Feng L, Albers GW, Budzik R, Devlin T, Gupta R, Jansen O, Jovin TG, Killer-Oberpfalzer M, Lutsep HL, Macho J, Nogueira RG, Rymer M, Smith WS, Wahlgren N, …
• Carotid I's, L's and T's: collaterals shape the outcome of intracranial carotid occlusion in acute ischemic stroke.
  Journal of neurointerventional surgery 2014 Liebeskind DS, Flint AC, Budzik RF, Xiang B, Smith WS, Duckwiler GR, Nogueira RG, MERCI and Multi-MERCI Investigators
• Symptom differences and pretreatment asymptomatic interval affect outcomes of stenting for intracranial atherosclerotic disease.
  AJNR. American journal of neuroradiology 2014 Alexander MD, Meyers PM, English JD, Stradford TR, Sung S, Smith WS, Halbach VV, Higashida RT, Dowd CF, Cooke DL, Hetts SW
• Prognosis of untreated strokes due to anterior circulation proximal intracranial arterial occlusions detected by use of computed tomography angiography.
  JAMA neurology 2014 Lima FO, Furie KL, Silva GS, Lev MH, Camargo EC, Singhal AB, Harris GJ, Halpern EF, Koroshetz WJ, Smith WS, Nogueira RG
• Stroke treatment academic industry roundtable: research priorities in the assessment of neurothrombectomy devices.
  Stroke 2013 Saver JL, Jovin TG, Smith WS, Albers GW, Baron JC, Boltze J, Broderick JP, Davis LA, Demchuk AM, DeSena S, Fiehler J, Gorelick PB, Hacke W, Holt B, Jahan R, Jing H, Khatri P, Kidwell CS, Lees KR, Lev …
• THRIVE score predicts ischemic stroke outcomes and thrombolytic hemorrhage risk in VISTA.
  Stroke 2013 Flint AC, Faigeles BS, Cullen SP, Kamel H, Rao VA, Gupta R, Smith WS, Bath PM, Donnan GA, VISTA Collaboration
• THRIVE score predicts outcomes with a third-generation endovascular stroke treatment device in the TREVO-2 trial.
  Stroke 2013 Flint AC, Xiang B, Gupta R, Nogueira RG, Lutsep HL, Jovin TG, Albers GW, Liebeskind DS, Sanossian N, Smith WS, TREVO-2 Trialists
• Good outcome rate of 35% in IV-tPA-treated patients with computed tomography angiography confirmed severe anterior circulation occlusive stroke.
  Stroke 2013 González RG, Furie KL, Goldmacher GV, Smith WS, Kamalian S, Payabvash S, Harris GJ, Halpern EF, Koroshetz WJ, Camargo EC, Dillon WP, Lev MH
• Setting priorities for stroke care and research.
  International journal of stroke : official journal of the International Stroke Society 2013 Morgenstern LB, Smith WS
• Design of the Vitesse Intracranial Stent Study for Ischemic Therapy (VISSIT) trial in symptomatic intracranial stenosis.
  Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2012 Zaidat OO, Castonguay AC, Fitzsimmons BF, Woodward BK, Wang Z, Killer-Oberpfalzer M, Wakhloo A, Gupta R, Kirshner H, Eliasziw M, Thomas Megerian J, Shetty S, Yoklavich Guilhermier M, Barnwell S, Smith…
• Trajectory of functional recovery after hospital discharge for subarachnoid hemorrhage.
  Neurocritical care 2012 Navi BB, Kamel H, Hemphill JC, Smith WS
• Pilot randomized trial of outpatient cardiac monitoring after cryptogenic stroke.
  Stroke 2012 Kamel H, Navi BB, Elijovich L, Josephson SA, Yee AH, Fung G, Johnston SC, Smith WS
• The totaled health risks in vascular events (THRIVE) score predicts ischemic stroke outcomes independent of thrombolytic therapy in the NINDS tPA trial.
  Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2012 Kamel H, Patel N, Rao VA, Cullen SP, Faigeles BS, Smith WS, Flint AC
• Density of thrombus on admission CT predicts revascularization efficacy in large vessel occlusion acute ischemic stroke.
  Stroke 2012 Moftakhar P, English JD, Cooke DL, Kim WT, Stout C, Smith WS, Dowd CF, Higashida RT, Halbach VV, Hetts SW
• Emergency Neurological Life Support (ENLS): what to do in the first hour of a neurological emergency.
  Neurocritical care 2012 Smith WS, Weingart S
• Emergency neurologic life support: meningitis and encephalitis.
  Neurocritical care 2012 Gaieski DF, Nathan BR, Weingart SD, Smith WS
• Emergency neurological life support: acute ischemic stroke.
  Neurocritical care 2012 Gross H, Sung G, Weingart SD, Smith WS
• Emergency neurological life support: acute non-traumatic weakness.
  Neurocritical care 2012 Flower O, Bowles C, Wijdicks E, Weingart SD, Smith WS
• Emergency neurological life support: airway, ventilation, and sedation.
  Neurocritical care 2012 Seder DB, Riker RR, Jagoda A, Smith WS, Weingart SD
• Emergency neurological life support: approach to the patient with coma.
  Neurocritical care 2012 Huff JS, Stevens RD, Weingart SD, Smith WS
• Emergency neurological life support: intracerebral hemorrhage.
  Neurocritical care 2012 Andrews CM, Jauch EC, Hemphill JC, Smith WS, Weingart SD
• Emergency neurological life support: intracranial hypertension and herniation.
  Neurocritical care 2012 Stevens RD, Huff JS, Duckworth J, Papangelou A, Weingart SD, Smith WS
• Emergency neurological life support: resuscitation following cardiac arrest.
  Neurocritical care 2012 Rittenberger JC, Polderman KH, Smith WS, Weingart SD
• Emergency neurological life support: spinal cord compression (SCC).
  Neurocritical care 2012 O'Phelan KH, Bunney EB, Weingart SD, Smith WS
• Emergency neurological life support: status epilepticus.
  Neurocritical care 2012 Claassen J, Silbergleit R, Weingart SD, Smith WS
• Emergency neurological life support: subarachnoid hemorrhage.
  Neurocritical care 2012 Edlow JA, Samuels O, Smith WS, Weingart SD
• Emergency neurological life support: traumatic brain injury.
  Neurocritical care 2012 Swadron SP, LeRoux P, Smith WS, Weingart SD
• Emergency neurological life support: traumatic spine injury.
  Neurocritical care 2012 Stein DM, Roddy V, Marx J, Smith WS, Weingart SD
• Validation of the Totaled Health Risks In Vascular Events (THRIVE) score for outcome prediction in endovascular stroke treatment.
  International journal of stroke : official journal of the International Stroke Society 2012 Flint AC, Kamel H, Rao VA, Cullen SP, Faigeles BS, Smith WS
• Trevo versus Merci retrievers for thrombectomy revascularisation of large vessel occlusions in acute ischaemic stroke (TREVO 2): a randomised trial.
  Lancet (London, England) 2012 Nogueira RG, Lutsep HL, Gupta R, Jovin TG, Albers GW, Walker GA, Liebeskind DS, Smith WS, TREVO 2 Trialists
• Brain death in children: why does it have to be so complicated?
  Annals of neurology 2012 Wijdicks EF, Smith WS
• Endovascular mechanical thrombectomy for the treatment of acute ischemic stroke due to arterial dissection.
  Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences 2012 Fields JD, Lutsep HL, Rymer MR, Budzik RF, Devlin TG, Baxter BW, Malek R, Padidar AM, Barnwell SL, Smith WS, Merci Registry Investigators
• Organ donation after cardiac death in amyotrophic lateral sclerosis.
  Annals of neurology 2012 Toossi S, Lomen-Hoerth C, Josephson SA, Gropper MA, Roberts J, Patton K, Smith WS
• Improved outcome prediction using CT angiography in addition to standard ischemic stroke assessment: results from the STOPStroke study.
  PloS one 2012 González RG, Lev MH, Goldmacher GV, Smith WS, Payabvash S, Harris GJ, Halpern EF, Koroshetz WJ, Camargo EC, Dillon WP, Furie KL
• Advances in stroke: critical care and emergency medicine.
  Stroke 2012 Smith WS, Schwab S
• Accuracy of neurovascular fellows' prognostication of outcome after subarachnoid hemorrhage.
  Stroke 2012 Navi BB, Kamel H, McCulloch CE, Nakagawa K, Naravetla B, Moheet AM, Wong C, Johnston SC, Hemphill JC, Smith WS
• Evaluation and management of increased intracranial pressure.
  Continuum (Minneapolis, Minn.) 2011 Nakagawa K, Smith WS
• Higher degrees of recanalization after mechanical thrombectomy for acute stroke are associated with improved outcome and decreased mortality: pooled analysis of the MERCI and Multi MERCI trials.
  AJNR. American journal of neuroradiology 2011 Fields JD, Lutsep HL, Smith WS, MERCI Multi MERCI Investigators
• Effect of time to reperfusion on clinical outcome of anterior circulation strokes treated with thrombectomy: pooled analysis of the MERCI and Multi MERCI trials.
  Stroke 2011 Nogueira RG, Smith WS, Sung G, Duckwiler G, Walker G, Roberts R, Saver JL, Liebeskind DS, MERCI and Multi MERCI Writing Committee
• Detection of atrial fibrillation and secondary stroke prevention using telemetry and ambulatory cardiac monitoring.
  Current atherosclerosis reports 2011 Kamel H, Smith WS
• Elevated BNP is associated with vasospasm-independent cerebral infarction following aneurysmal subarachnoid hemorrhage.
  Neurocritical care 2011 Taub PR, Fields JD, Wu AH, Miss JC, Lawton MT, Smith WS, Young WL, Zaroff JG, Ko NU
• Paradoxical vasoconstrictive effect in the contralateral hemisphere after carotid stenting.
  Neurology 2011 Nakagawa K, Smith WS
• Safety of periprocedural heparin in acute ischemic stroke endovascular therapy: the multi MERCI trial.
  Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2011 Nahab F, Walker GA, Dion JE, Smith WS
• Temporal stability of dysmorphic fusiform aneurysms of the intracranial internal carotid artery.
  Journal of vascular and interventional radiology : JVIR 2011 Boussel L, Rayz V, Martin A, Lawton M, Higashida R, Smith WS, Young WL, Saloner D
• The prognosis for aphasia in stroke.
  Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2010 Maas MB, Lev MH, Ay H, Singhal AB, Greer DM, Smith WS, Harris GJ, Halpern EF, Koroshetz WJ, Furie KL
• Intracranial large vessel occlusion as a predictor of decline in functional status after transient ischemic attack.
  Stroke 2010 Poisson SN, Nguyen-Huynh MN, Johnston SC, Furie KL, Lev MH, Smith WS
• Cardiac rupture after intravenous t-PA administration in acute ischemic stroke.
  Neurocritical care 2010 Dhand A, Nakagawa K, Nagpal S, Gelfand JM, Kim AS, Smith WS, Tihan T
• The pattern of leptomeningeal collaterals on CT angiography is a strong predictor of long-term functional outcome in stroke patients with large vessel intracranial occlusion.
  Stroke 2010 Lima FO, Furie KL, Silva GS, Lev MH, Camargo EC, Singhal AB, Harris GJ, Halpern EF, Koroshetz WJ, Smith WS, Yoo AJ, Nogueira RG
• Comparison of computed tomography angiography and transesophageal echocardiography for evaluating aortic arch disease.
  Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2010 Barazangi N, Wintermark M, Lease K, Rao R, Smith W, Josephson SA
• Gender differences in outcomes after ischemic stroke: role of ischemic lesion volume and intracranial large-artery occlusion.
  Cerebrovascular diseases (Basel, Switzerland) 2010 Silva GS, Lima FO, Camargo EC, Smith WS, Lev MH, Harris GJ, Halpern EF, Koroshetz W, Furie KL
• Ventilator-associated pneumonia in a neurologic intensive care unit does not lead to increased mortality.
  Neurocritical care 2010 Josephson SA, Moheet AM, Gropper MA, Nichols AD, Smith WS
• Improvement in intensive care unit outcomes in patients with subarachnoid hemorrhage after initiation of neurointensivist co-management.
  Journal of neurosurgery 2010 Josephson SA, Douglas VC, Lawton MT, English JD, Smith WS, Ko NU
• Wake-up stroke: clinical and neuroimaging characteristics.
  Cerebrovascular diseases (Basel, Switzerland) 2010 Silva GS, Lima FO, Camargo EC, Smith WS, Singhal AB, Greer DM, Ay H, Lev MH, Harris GJ, Halpern EF, Sonni S, Koroshetz W, Furie KL
• Functional contrast-enhanced CT for evaluation of acute ischemic stroke does not increase the risk of contrast-induced nephropathy.
  AJNR. American journal of neuroradiology 2009 Lima FO, Lev MH, Levy RA, Silva GS, Ebril M, de Camargo EC, Pomerantz S, Singhal AB, Greer DM, Ay H, González RG, Koroshetz WJ, Smith WS, Furie KL
• Reperfusion is a more accurate predictor of follow-up infarct volume than recanalization: a proof of concept using CT in acute ischemic stroke patients.
  Stroke 2009 Soares BP, Tong E, Hom J, Cheng SC, Bredno J, Boussel L, Smith WS, Wintermark M
• Emergency treatment of acute ischemic stroke: expanding the time window.
  Current treatment options in neurology 2009 Nogueira RG, Smith WS
• Predictors of good clinical outcomes, mortality, and successful revascularization in patients with acute ischemic stroke undergoing thrombectomy: pooled analysis of the Mechanical Embolus Removal in Cerebral Ischemia (MERCI) and Multi MERCI Trials.
  Stroke 2009 Nogueira RG, Liebeskind DS, Sung G, Duckwiler G, Smith WS, MERCI, Multi MERCI Writing Committee
• Significance of large vessel intracranial occlusion causing acute ischemic stroke and TIA.
  Stroke 2009 Smith WS, Lev MH, English JD, Camargo EC, Chou M, Johnston SC, Gonzalez G, Schaefer PW, Dillon WP, Koroshetz WJ, Furie KL
• National Institutes of Health Stroke Scale score is poorly predictive of proximal occlusion in acute cerebral ischemia.
  Stroke 2009 Maas MB, Furie KL, Lev MH, Ay H, Singhal AB, Greer DM, Harris GJ, Halpern E, Koroshetz WJ, Smith WS
• Collateral vessels on CT angiography predict outcome in acute ischemic stroke.
  Stroke 2009 Maas MB, Lev MH, Ay H, Singhal AB, Greer DM, Smith WS, Harris GJ, Halpern E, Kemmling A, Koroshetz WJ, Furie KL
• Synaptic linkages between corticomotoneuronal cells affecting forelimb muscles in behaving primates.
  Journal of neurophysiology 2009 Smith WS, Fetz EE
• Synaptic interactions between forelimb-related motor cortex neurons in behaving primates.
  Journal of neurophysiology 2009 Smith WS, Fetz EE
• Intermittent atrial fibrillation may account for a large proportion of otherwise cryptogenic stroke: a study of 30-day cardiac event monitors.
  Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2009 Elijovich L, Josephson SA, Fung GL, Smith WS
• Phase-contrast magnetic resonance imaging measurements in intracranial aneurysms in vivo of flow patterns, velocity fields, and wall shear stress: comparison with computational fluid dynamics.
  Magnetic resonance in medicine 2009 Boussel L, Rayz V, Martin A, Acevedo-Bolton G, Lawton MT, Higashida R, Smith WS, Young WL, Saloner D
• Cerebrovascular complications of methamphetamine abuse.
  Neurocritical care 2009 Ho EL, Josephson SA, Lee HS, Smith WS
• Safety and efficacy of endovascular thrombectomy in patients with abnormal hemostasis: pooled analysis of the MERCI and multi MERCI trials.
  Stroke 2008 Nogueira RG, Smith WS, MERCI and Multi MERCI Writing Committee
• Hyperdense basilar artery sign on unenhanced CT predicts thrombus and outcome in acute posterior circulation stroke.
  Stroke 2008 Goldmakher GV, Camargo EC, Furie KL, Singhal AB, Roccatagliata L, Halpern EF, Chou MJ, Biagini T, Smith WS, Harris GJ, Dillon WP, Gonzalez RG, Koroshetz WJ, Lev MH
• Comparison of mechanical embolectomy and intraarterial thrombolysis in acute ischemic stroke within the MCA: MERCI and Multi MERCI compared to PROACT II.
  Neurocritical care 2008 Josephson SA, Saver JL, Smith WS, Merci and Multi Merci Investigators
• Aneurysm growth occurs at region of low wall shear stress: patient-specific correlation of hemodynamics and growth in a longitudinal study.
  Stroke 2008 Boussel L, Rayz V, McCulloch C, Martin A, Acevedo-Bolton G, Lawton M, Higashida R, Smith WS, Young WL, Saloner D
• Visual grading system for vasospasm based on perfusion CT imaging: comparisons with conventional angiography and quantitative perfusion CT.
  Cerebrovascular diseases (Basel, Switzerland) 2008 Wintermark M, Dillon WP, Smith WS, Lau BC, Chaudhary S, Liu S, Yu M, Fitch M, Chien JD, Higashida RT, Ko NU
• Perfusion CT compared to H(2) (15)O/O (15)O PET in patients with chronic cervical carotid artery occlusion.
  Neuroradiology 2008 Kamath A, Smith WS, Powers WJ, Cianfoni A, Chien JD, Videen T, Lawton MT, Finley B, Dillon WP, Wintermark M
• Local cortical hypoperfusion imaged with CT perfusion during postictal Todd's paresis.
  Neuroradiology 2008 Mathews MS, Smith WS, Wintermark M, Dillon WP, Binder DK
• Endothelial nitric oxide synthase polymorphism (-786T->C) and increased risk of angiographic vasospasm after aneurysmal subarachnoid hemorrhage.
  Stroke 2008 Ko NU, Rajendran P, Kim H, Rutkowski M, Pawlikowska L, Kwok PY, Higashida RT, Lawton MT, Smith WS, Zaroff JG, Young WL
• Mechanical thrombectomy for acute ischemic stroke: final results of the Multi MERCI trial.
  Stroke 2008 Smith WS, Sung G, Saver J, Budzik R, Duckwiler G, Liebeskind DS, Lutsep HL, Rymer MM, Higashida RT, Starkman S, Gobin YP, Multi MERCI Investigators, Frei D, Grobelny T, Hellinger F, Huddle D, Kidwell …
• How accurate is CT angiography in evaluating intracranial atherosclerotic disease?
  Stroke 2008 Nguyen-Huynh MN, Wintermark M, English J, Lam J, Vittinghoff E, Smith WS, Johnston SC
• Prospective evaluation of multidetector-row CT angiography for the diagnosis of vasospasm following subarachnoid hemorrhage: a comparison with digital subtraction angiography.
  Cerebrovascular diseases (Basel, Switzerland) 2007 Chaudhary SR, Ko N, Dillon WP, Yu MB, Liu S, Criqui GI, Higashida RT, Smith WS, Wintermark M
• Acute brain infarct: detection and delineation with CT angiographic source images versus nonenhanced CT scans.
  Radiology 2007 Camargo EC, Furie KL, Singhal AB, Roccatagliata L, Cunnane ME, Halpern EF, Harris GJ, Smith WS, Gonzalez RG, Koroshetz WJ, Lev MH
• Systematic comparison of perfusion-CT and CT-angiography in acute stroke patients.
  Annals of neurology 2007 Tan JC, Dillon WP, Liu S, Adler F, Smith WS, Wintermark M
• Mechanical thrombectomy of intracranial internal carotid occlusion: pooled results of the MERCI and Multi MERCI Part I trials.
  Stroke 2007 Flint AC, Duckwiler GR, Budzik RF, Liebeskind DS, Smith WS, MERCI and Multi MERCI Writing Committee
• Intra-arterial thrombolytic therapy for acute basilar occlusion: pro.
  Stroke 2007 Smith WS
• Can emergency medicine physicians accurately identify i.v. t-PA eligible acute stroke patients?
  Neurocritical care 2007 Smith WS
• Technology Insight: recanalization with drugs and devices during acute ischemic stroke.
  Nature clinical practice. Neurology 2007 Smith WS
• Effect of a US National Institutes of Health programme of clinical trials on public health and costs.
  Lancet (London, England) 2006 Johnston SC, Rootenberg JD, Katrak S, Smith WS, Elkins JS
• Cardiovascular predictors of in-patient mortality after subarachnoid hemorrhage.
  Neurocritical care 2006 Yarlagadda S, Rajendran P, Miss JC, Banki NM, Kopelnik A, Wu AH, Ko N, Gelb AW, Lawton MT, Smith WS, Young WL, Zaroff JG
• Hypernatremia predicts adverse cardiovascular and neurological outcomes after SAH.
  Neurocritical care 2006 Fisher LA, Ko N, Miss J, Tung PP, Kopelnik A, Banki NM, Gardner D, Smith WS, Lawton MT, Zaroff JG
• Predictors of left ventricular regional wall motion abnormalities after subarachnoid hemorrhage.
  Neurocritical care 2006 Kothavale A, Banki NM, Kopelnik A, Yarlagadda S, Lawton MT, Ko N, Smith WS, Drew B, Foster E, Zaroff JG
• Prognostic significance of angiographically confirmed large vessel intracranial occlusion in patients presenting with acute brain ischemia.
  Neurocritical care 2006 Smith WS, Tsao JW, Billings ME, Johnston SC, Hemphill JC, Bonovich DC, Dillon WP
• An evidence-based causative classification system for acute ischemic stroke.
  Annals of neurology 2005 Ay H, Furie KL, Singhal A, Smith WS, Sorensen AG, Koroshetz WJ
• Does extracorporeal circulation harm the brain?
  Neurology 2005 Smith WS, Mapstone M
• Initial Glasgow Coma Scale score predicts outcome following thrombolysis for posterior circulation stroke.
  Archives of neurology 2005 Tsao JW, Hemphill JC, Johnston SC, Smith WS, Bonovich DC
• Safety and efficacy of mechanical embolectomy in acute ischemic stroke: results of the MERCI trial.
  Stroke 2005 Smith WS, Sung G, Starkman S, Saver JL, Kidwell CS, Gobin YP, Lutsep HL, Nesbit GM, Grobelny T, Rymer MM, Silverman IE, Higashida RT, Budzik RF, Marks MP, MERCI Trial Investigators
• Incidence of contrast nephropathy from cerebral CT angiography and CT perfusion imaging.
  Neurology 2005 Josephson SA, Dillon WP, Smith WS
• Relationship between brain tissue oxygen tension and CT perfusion: feasibility and initial results.
  AJNR. American journal of neuroradiology 2005 Hemphill JC, Smith WS, Sonne DC, Morabito D, Manley GT
• Cerebral blood flow changes after endovascular treatment of cerebrovascular stenoses.
  AJNR. American journal of neuroradiology 2005 Ko NU, Achrol AS, Chopra M, Saha M, Gupta D, Smith WS, Higashida RT, Young WL
• Accuracy of dynamic perfusion CT with deconvolution in detecting acute hemispheric stroke.
  AJNR. American journal of neuroradiology 2005 Wintermark M, Fischbein NJ, Smith WS, Ko NU, Quist M, Dillon WP
• Prevalence and implications of diastolic dysfunction after subarachnoid hemorrhage.
  Neurocritical care 2005 Kopelnik A, Fisher L, Miss JC, Banki N, Tung P, Lawton MT, Ko N, Smith WS, Drew B, Foster E, Zaroff J
• Cardiac injury after subarachnoid hemorrhage is independent of the type of aneurysm therapy.
  Neurosurgery 2004 Miss JC, Kopelnik A, Fisher LA, Tung PP, Banki NM, Lawton MT, Smith WS, Dowd CF, Zaroff JG
• Neurotoxicity of intra-arterial papaverine preserved with chlorobutanol used for the treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage.
  Stroke 2004 Smith WS, Dowd CF, Johnston SC, Ko NU, DeArmond SJ, Dillon WP, Setty D, Lawton MT, Young WL, Higashida RT, Halbach VV
• Dynamic perfusion CT: optimizing the temporal resolution and contrast volume for calculation of perfusion CT parameters in stroke patients.
  AJNR. American journal of neuroradiology 2004 Wintermark M, Smith WS, Ko NU, Quist M, Schnyder P, Dillon WP
• Regionalization of treatment for subarachnoid hemorrhage: a cost-utility analysis.
  Circulation 2004 Bardach NS, Olson SJ, Elkins JS, Smith WS, Lawton MT, Johnston SC
• Continuous bleeding from a basilar terminus aneurysm imaged with CT angiography and conventional angiography.
  Neurocritical care 2004 Josephson SA, Dillon WP, Dowd CF, Malek R, Lawton MT, Smith WS
• Pathophysiology of focal cerebral ischemia: a therapeutic perspective.
  Journal of vascular and interventional radiology : JVIR 2004 Smith WS
• Simultanagnosia through the eyes of an artist.
  Neurology 2003 Smith WS, Mindelzun RE, Miller B
• Factors influencing outcome and treatment effect in PROACT II.
  Stroke 2003 Wechsler LR, Roberts R, Furlan AJ, Higashida RT, Dillon W, Roberts H, Rowley HA, Pettigrew LC, Callahan AS, Bruno A, Fayad P, Smith WS, Firszt CM, Schulz GA, PROACT II Investigators
• Safety and feasibility of a CT protocol for acute stroke: combined CT, CT angiography, and CT perfusion imaging in 53 consecutive patients.
  AJNR. American journal of neuroradiology 2003 Smith WS, Roberts HC, Chuang NA, Ong KC, Lee TJ, Johnston SC, Dillon WP
• Angioplasty for intracranial symptomatic vertebrobasilar ischemia.
  Neurosurgery 2002 Gress DR, Smith WS, Dowd CF, Van Halbach V, Finley RJ, Higashida RT