Vipul Kumar, MD, PhD
Clinical Fellow
Medicine
School of Medicine

Awards

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• Ruth L. Kirchstein National Research Service Award, F30, National Cancer Institute, 2014-2019
• Fellow of the Year, UCSF Department of Medicine, UCSF, 2022
• Rachel Pearline Award, UCSF, 2022
• Medical Scientist Training Program, Harvard Medical School, 2019
• Phi Beta Kappa, University of Pennsylvania, 2009

Education & Training

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• Residency, Internal Medicine UCSF 06/2021
• MD Harvard Medical School 05/2019
• PhD Cell Biology and Genetics Harvard Medical School 05/2017
• B.A./M.S Biochemistry/Chemistry University of Pennsylvania 05/2009

Grants and Projects

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• Alternative End-Joining in DNA Repair and Chromosomal Translocations, NIH, 2014-2019

Publications (15)

Top publication keywords:
DNA Breaks, Double-StrandedUrinary Bladder NeoplasmsImmunoglobulin Class SwitchingDNA End-Joining RepairV(D)J RecombinationKu AutoantigenEpidermisDNA-Binding ProteinsDNA Repair EnzymesCarcinoma, Transitional CellKeratinocytesPrecursor Cells, B-LymphoidHair FollicleDNA RepairKeratin-17

• Initial Experience with 68Ga-FAP-2286 PET Imaging in Patients with Urothelial Cancer.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2024 Koshkin VS, Kumar V, Kline B, Escobar D, Aslam M, Cooperberg MR, Aggarwal RR, de Kouchkovsky I, Chou J, Meng MV, Friedlander T, Porten S, Hope TA
• Central Nervous System Disease Progression Among Patients With Metastatic Urothelial Carcinoma Treated With Enfortumab Vedotin: A Case Series.
  Clinical genitourinary cancer 2023 Shipp C, Jindal T, Chou J, Friedlander TW, Koshkin VS, Kumar V
• Impact of Squamous Histology on Clinical Outcomes and Molecular Profiling in Metastatic Urothelial Carcinoma Patients Treated With Immune Checkpoint Inhibitors or Enfortumab Vedotin.
  Clinical genitourinary cancer 2023 Jindal T, Zhang L, Deshmukh P, Reyes K, Chan E, Kumar V, Zhu X, Maldonado E, Feng S, Johnson M, Angelidakis A, Kwon D, Desai A, Borno HT, Bose R, Wong A, Hong J, Carroll P, Meng M, Porten S, Aggarwal …
• Somatic alterations of TP53 and MDM2 associated with response to enfortumab vedotin in patients with advanced urothelial cancer.
  Frontiers in oncology 2023 Jindal T, Zhu X, Bose R, Kumar V, Maldonado E, Deshmukh P, Shipp C, Feng S, Johnson MS, Angelidakis A, Kwon D, Borno HT, de Kouchkovsky I, Desai A, Aggarwal R, Fong L, Small EJ, Wong A, Porten S, Chou…
• Ku70 suppresses alternative end joining in G1-arrested progenitor B cells.
  Proceedings of the National Academy of Sciences of the United States of America 2021 Liang Z, Kumar V, Le Bouteiller M, Zurita J, Kenrick J, Lin SG, Lou J, Hu J, Ye AY, Boboila C, Alt FW, Frock RL

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• Loss of H3K36 Methyltransferase SETD2 Impairs V(D)J Recombination during Lymphoid Development.
  iScience 2020 Chu SH, Chabon JR, Matovina CN, Minehart JC, Chen BR, Zhang J, Kumar V, Xiong Y, Callen E, Hung PJ, Feng Z, Koche RP, Liu XS, Chaudhuri J, Nussenzweig A, Sleckman BP, Armstrong SA
• DNA double-strand break response factors influence end-joining features of IgH class switch and general translocation junctions.
  Proceedings of the National Academy of Sciences of the United States of America 2018 Panchakshari RA, Zhang X, Kumar V, Du Z, Wei PC, Kao J, Dong J, Alt FW
• Histone methyltransferase MMSET promotes AID-mediated DNA breaks at the donor switch region during class switch recombination.
  Proceedings of the National Academy of Sciences of the United States of America 2017 Nguyen HV, Dong J, Panchakshari RA, Kumar V, Alt FW, Bories JC
• PAXX and XLF DNA repair factors are functionally redundant in joining DNA breaks in a G1-arrested progenitor B-cell line.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Kumar V, Alt FW, Frock RL
• Encyclopedia of Immunobiology (Michael Ratcliffe, Editor)
  NHEJ and other Repair Factors in V(D)J Recombination 2016 Vipul Kumar, Frederick W. Alt
• Reprint of "Functional overlaps between XLF and the ATM-dependent DNA double strand break response".
  DNA repair 2014 Kumar V, Alt FW, Oksenych V
• Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joining.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Oksenych V, Kumar V, Liu X, Guo C, Schwer B, Zha S, Alt FW
• Functional redundancy between repair factor XLF and damage response mediator 53BP1 in V(D)J recombination and DNA repair.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Oksenych V, Alt FW, Kumar V, Schwer B, Wesemann DR, Hansen E, Patel H, Su A, Guo C
• Autoimmune regulator (AIRE) contributes to Dectin-1-induced TNF-α production and complexes with caspase recruitment domain-containing protein 9 (CARD9), spleen tyrosine kinase (Syk), and Dectin-1.
  The Journal of allergy and clinical immunology 2011 Pedroza LA, Kumar V, Sanborn KB, Mace EM, Niinikoski H, Nadeau K, Vasconcelos Dde M, Perez E, Jyonouchi S, Jyonouchi H, Banerjee PP, Ruuskanen O, Condino-Neto A, Orange JS
• The autoimmune regulator (AIRE), which is defective in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy patients, is expressed in human epidermal and follicular keratinocytes and associates with the intermediate filament protein cytokeratin 17.
  The American journal of pathology 2011 Kumar V, Pedroza LA, Mace EM, Seeholzer S, Cotsarelis G, Condino-Neto A, Payne AS, Orange JS