Vinh Q. Nguyen
Specialist
Vice Chanc Research
Chancellor/EVC/FAS

Publications (24)

Top publication keywords:
Transplantation ToleranceIslets of Langerhans TransplantationInterleukin-2T-LymphocytesCRISPR-Cas SystemsKiller Cells, NaturalDuodenumDiabetes Mellitus, Type 1T-Lymphocytes, RegulatoryImmunotherapy, AdoptiveGene Regulatory NetworksReceptors, Antigen, T-Cell, gamma-deltaIslets of LangerhansConsumer Product SafetyInsulin-Secreting Cells

• Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains.
  Nature cell biology 2024 Zwick RK, Kasparek P, Palikuqi B, Viragova S, Weichselbaum L, McGinnis CS, McKinley KL, Rathnayake A, Vaka D, Nguyen V, Trentesaux C, Reyes E, Gupta AR, Gartner ZJ, Locksley RM, Gardner JM, Itzkovitz …
• CRISPR screens decode cancer cell pathways that trigger γδ T cell detection.
  Nature 2023 Mamedov MR, Vedova S, Freimer JW, Sahu AD, Ramesh A, Arce MM, Meringa AD, Ota M, Chen PA, Hanspers K, Nguyen VQ, Takeshima KA, Rios AC, Pritchard JK, Kuball J, Sebestyen Z, Adams EJ, Marson A
• Selective decrease of donor-reactive Tregs after liver transplantation limits Treg therapy for promoting allograft tolerance in humans.
  Science translational medicine 2022 Tang Q, Leung J, Peng Y, Sanchez-Fueyo A, Lozano JJ, Lam A, Lee K, Greenland JR, Hellerstein M, Fitch M, Li KW, Esensten JH, Putnam AL, Lares A, Nguyen V, Liu W, Bridges ND, Odim J, Demetris AJ, …
• Obesity alters pathology and treatment response in inflammatory disease.
  Nature 2022 Bapat SP, Whitty C, Mowery CT, Liang Y, Yoo A, Jiang Z, Peters MC, Zhang LJ, Vogel I, Zhou C, Nguyen VQ, Li Z, Chang C, Zhu WS, Hastie AT, He H, Ren X, Qiu W, Gayer SG, Liu C, Choi EJ, Fassett M, …
• CRISPR activation and interference screens decode stimulation responses in primary human T cells.
  Science (New York, N.Y.) 2022 Schmidt R, Steinhart Z, Layeghi M, Freimer JW, Bueno R, Nguyen VQ, Blaeschke F, Ye CJ, Marson A

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• IL-6 and TNFα Drive Extensive Proliferation of Human Tregs Without Compromising Their Lineage Stability or Function.
  Frontiers in immunology 2021 Skartsis N, Peng Y, Ferreira LMR, Nguyen V, Ronin E, Muller YD, Vincenti F, Tang Q
• Polyclonal Regulatory T Cell Manufacturing Under cGMP: A Decade of Experience.
  Frontiers in immunology 2021 Balcerek J, Shy BR, Putnam AL, Masiello LM, Lares A, Dekovic F, Acevedo L, Lee MR, Nguyen V, Liu W, Paruthiyil S, Xu J, Leinbach AS, Bluestone JA, Tang Q, Esensten JH
• The effect of low-dose IL-2 and Treg adoptive cell therapy in patients with type 1 diabetes.
  JCI insight 2021 Dong S, Hiam-Galvez KJ, Mowery CT, Herold KC, Gitelman SE, Esensten JH, Liu W, Lares AP, Leinbach AS, Lee M, Nguyen V, Tamaki SJ, Tamaki W, Tamaki CM, Mehdizadeh M, Putnam AL, Spitzer MH, Ye CJ, Tang …
• Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immune Tolerance.
  Frontiers in immunology 2021 Muller YD, Ferreira LMR, Ronin E, Ho P, Nguyen V, Faleo G, Zhou Y, Lee K, Leung KK, Skartsis N, Kaul AM, Mulder A, Claas FHJ, Wells JA, Bluestone JA, Tang Q
• The SIRPα-CD47 immune checkpoint in NK cells.
  The Journal of experimental medicine 2021 Deuse T, Hu X, Agbor-Enoh S, Jang MK, Alawi M, Saygi C, Gravina A, Tediashvili G, Nguyen VQ, Liu Y, Valantine H, Lanier LL, Schrepfer S
• Functional CRISPR dissection of gene networks controlling human regulatory T cell identity.
  Nature immunology 2020 Schumann K, Raju SS, Lauber M, Kolb S, Shifrut E, Cortez JT, Skartsis N, Nguyen VQ, Woo JM, Roth TL, Yu R, Nguyen MLT, Simeonov DR, Nguyen DN, Targ S, Gate RE, Tang Q, Bluestone JA, Spitzer MH, Ye CJ,…
• Landscape of stimulation-responsive chromatin across diverse human immune cells.
  Nature genetics 2019 Calderon D, Nguyen MLT, Mezger A, Kathiria A, Müller F, Nguyen V, Lescano N, Wu B, Trombetta J, Ribado JV, Knowles DA, Gao Z, Blaeschke F, Parent AV, Burt TD, Anderson MS, Criswell LA, Greenleaf WJ, …
• Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells.
  Nature cell biology 2019 Nair GG, Liu JS, Russ HA, Tran S, Saxton MS, Chen R, Juang C, Li ML, Nguyen VQ, Giacometti S, Puri S, Xing Y, Wang Y, Szot GL, Oberholzer J, Bhushan A, Hebrok M
• Polyclonal Regulatory T Cell Therapy for Control of Inflammation in Kidney Transplants.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2017 Chandran S, Tang Q, Sarwal M, Laszik ZG, Putnam AL, Lee K, Leung J, Nguyen V, Sigdel T, Tavares EC, Yang JYC, Hellerstein M, Fitch M, Bluestone JA, Vincenti F
• Mitigating Ischemic Injury of Stem Cell-Derived Insulin-Producing Cells after Transplant.
  Stem cell reports 2017 Faleo G, Russ HA, Wisel S, Parent AV, Nguyen V, Nair GG, Freise JE, Villanueva KE, Szot GL, Hebrok M, Tang Q
• Cutting Edge: Origins, Recruitment, and Regulation of CD11c+ Cells in Inflamed Islets of Autoimmune Diabetes Mice.
  Journal of immunology (Baltimore, Md. : 1950) 2017 Klementowicz JE, Mahne AE, Spence A, Nguyen V, Satpathy AT, Murphy KM, Tang Q
• Assessment of Immune Isolation of Allogeneic Mouse Pancreatic Progenitor Cells by a Macroencapsulation Device.
  Transplantation 2016 Faleo G, Lee K, Nguyen V, Tang Q
• Type 1 diabetes immunotherapy using polyclonal regulatory T cells.
  Science translational medicine 2015 Bluestone JA, Buckner JH, Fitch M, Gitelman SE, Gupta S, Hellerstein MK, Herold KC, Lares A, Lee MR, Li K, Liu W, Long SA, Masiello LM, Nguyen V, Putnam AL, Rieck M, Sayre PH, Tang Q
• Therapeutic regulatory T cells subvert effector T cell function in inflamed islets to halt autoimmune diabetes.
  Journal of immunology (Baltimore, Md. : 1950) 2015 Mahne AE, Klementowicz JE, Chou A, Nguyen V, Tang Q
• Menin determines K-RAS proliferative outputs in endocrine cells.
  The Journal of clinical investigation 2014 Chamberlain CE, Scheel DW, McGlynn K, Kim H, Miyatsuka T, Wang J, Nguyen V, Zhao S, Mavropoulos A, Abraham AG, O'Neill E, Ku GM, Cobb MH, Martin GR, German MS
• Failure to achieve normal metabolic response in non-obese diabetic mice and streptozotocin-induced diabetic mice after transplantation of primary murine hepatocytes electroporated with the human proinsulin gene (p3MTChins).
  Transplantation proceedings 2014 Lee RH, Roll G, Nguyen V, Willenbring H, Tang Q, Kang SM, Stock PG
• An evolving autoimmune microenvironment regulates the quality of effector T cell restimulation and function.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Friedman RS, Lindsay RS, Lilly JK, Nguyen V, Sorensen CM, Jacobelli J, Krummel MF
• Attenuation of donor-reactive T cells allows effective control of allograft rejection using regulatory T cell therapy.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2013 Lee K, Nguyen V, Lee KM, Kang SM, Tang Q
• IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.
  Cell metabolism 2012 Lerner AG, Upton JP, Praveen PV, Ghosh R, Nakagawa Y, Igbaria A, Shen S, Nguyen V, Backes BJ, Heiman M, Heintz N, Greengard P, Hui S, Tang Q, Trusina A, Oakes SA, Papa FR