Vincent Auyeung, MD, PhD
Assistant Professor
Medicine
School of Medicine

Education & Training

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• Residency Internal Medicine UCSF 06/2016
• MD Medicine Harvard Medical School 06/2014
• PhD Molecular Biology MIT 06/2012
• BS Biology Caltech 06/2005
• Fellowship Pulmonary and Critical Care Medicine UCSF

Websites

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• Lab website (vcalab.ucsf.edu)

Grants and Projects

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• IRE1? mediated dysregulation of the pulmonary epithelium in lung fibrosis, NIH, 2021-2026
• The unfolded protein response and TGF-Beta signaling in pulmonary fibrosis, NIH, 2019-2021

Publications (13)

Top publication keywords:
Metabolic DiseasesIdiopathic Pulmonary FibrosisMicroRNAsEndoribonucleasesProtein Kinase InhibitorsCell ExtractsPulmonary FibrosisCaenorhabditis elegansRibonuclease IIIAlveolar Epithelial CellsAdenosine TriphosphateRNA Processing, Post-TranscriptionalNucleotide MotifsInverted Repeat SequencesEndoplasmic Reticulum Stress

• Impaired Myofibroblast Proliferation is a Central Feature of Pathologic Post-Natal Alveolar Simplification.
  bioRxiv : the preprint server for biology 2023 Khan IS, Molina C, Ren X, Auyeung VC, Cohen M, Tsukui T, Atakilit A, Sheppard D
• BCL-2 Modulates IRE1α Activation to Attenuate ER Stress and Pulmonary Fibrosis.
  American journal of respiratory cell and molecular biology 2023 Jourdan Le Saux C, Ho TC, Brumwell AM, Kathiriya JJ, Wei Y, Hughes JB, Garakani K, Atabai K, Auyeung VC, Papa FR, Chapman HA
• IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosis.
  American journal of physiology. Lung cellular and molecular physiology 2022 Auyeung VC, Downey MS, Thamsen M, Wenger TA, Backes BJ, Sheppard D, Papa FR
• ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR.
  Nature chemical biology 2021 Feldman HC, Ghosh R, Auyeung VC, Mueller JL, Kim JH, Potter ZE, Vidadala VN, Perera BGK, Olivier A, Backes BJ, Zikherman J, Papa FR, Maly DJ
• Stuck in a Moment: Does Abnormal Persistence of Epithelial Progenitors Drive Pulmonary Fibrosis?
  American journal of respiratory and critical care medicine 2021 Auyeung VC, Sheppard D

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• Management and Outcomes of Critically-III Patients with COVID-19 Pneumonia at a Safety-net Hospital in San Francisco, a Region with Early Public Health Interventions: A Case Series.
  medRxiv : the preprint server for health sciences 2020 Vanderburg S, Alipanah N, Crowder R, Yoon C, Wang R, Thakur N, Slown K, Shete PB, Rofael M, Metcalfe JZ, Merrifield C, Marquez C, Malcolm K, Lipnick M, Jain V, Gomez A, Burns G, Brown LB, Berger C, …
• Small Molecules to Improve ER Proteostasis in Disease.
  Trends in pharmacological sciences 2019 Gonzalez-Teuber V, Albert-Gasco H, Auyeung VC, Papa FR, Mallucci GR, Hetz C
• Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung.
  PloS one 2019 Thamsen M, Ghosh R, Auyeung VC, Brumwell A, Chapman HA, Backes BJ, Perara G, Maly DJ, Sheppard D, Papa FR
• Beyond secondary structure: primary-sequence determinants license pri-miRNA hairpins for processing.
  Cell 2013 Auyeung VC, Ulitsky I, McGeary SE, Bartel DP
• Mammalian microRNAs: experimental evaluation of novel and previously annotated genes.
  Genes & development 2010 Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP
• The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors.
  Proceedings of the National Academy of Sciences of the United States of America 2008 D'Alise AM, Auyeung V, Feuerer M, Nishio J, Fontenot J, Benoist C, Mathis D
• Optimization and functional effects of stable short hairpin RNA expression in primary human lymphocytes via lentiviral vectors.
  Molecular therapy : the journal of the American Society of Gene Therapy 2006 An DS, Qin FX, Auyeung VC, Mao SH, Kung SK, Baltimore D, Chen IS
• A fluorophore attached to nicotinic acetylcholine receptor beta M2 detects productive binding of agonist to the alpha delta site.
  Proceedings of the National Academy of Sciences of the United States of America 2004 Dahan DS, Dibas MI, Petersson EJ, Auyeung VC, Chanda B, Bezanilla F, Dougherty DA, Lester HA