Viktor Kharazia, PhD
Specialist
Physiology
School of Medicine

Websites

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• Justia (patents.justia.com)
• linkedin (linkedin.com)

Publications (66)

Top publication keywords:
Somatosensory CortexVentral Tegmental AreaGlial Cell Line-Derived Neurotrophic FactorSensationAlcohol DrinkingEthanolNeocortexOptogeneticsThalamic NucleiBinge DrinkingLIM Domain ProteinsReceptors, AMPACerebral CortexNADPH DehydrogenaseReceptors, N-Methyl-D-Aspartate

• Scalable method for micro-CT analysis enables large scale quantitative characterization of brain lesions and implants.
  Scientific reports 2020 Kastner DB, Kharazia V, Nevers R, Smyth C, Astudillo-Maya DA, Williams GM, Yang Z, Holobetz CM, Santina LD, Parkinson DY, Frank LM
• Widespread optogenetic expression in macaque cortex obtained with MR-guided, convection enhanced delivery (CED) of AAV vector to the thalamus.
  Journal of neuroscience methods 2017 Yazdan-Shahmorad A, Tian N, Kharazia V, Samaranch L, Kells A, Bringas J, He J, Bankiewicz K, Sabes PN
• GDNF is a fast-acting potent inhibitor of alcohol consumption and relapse.
  Proceedings of the National Academy of Sciences of the United States of America 2008 Carnicella S, Kharazia V, Jeanblanc J, Janak PH, Ron D
• Immunogold localization of AMPA and NMDA receptors in somatic sensory cortex of albino rat.
  The Journal of comparative neurology 1999 Kharazia VN, Weinberg RJ
• Glutamate in thalamic fibers terminating in layer IV of primary sensory cortex.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1994 Kharazia VN, Weinberg RJ

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• The choice-wide behavioral association study: data-driven identification of interpretable behavioral components.
  Nature communications 2026 Kastner DB, Yokota NO, Lee CY, Holobetz C, Chaudhry A, Williams G, Ton JN, Mehra M, Kharazia V, Parkinson DY, Romano JP, Dayan P
• Disruption of theta-timescale spiking impairs learning but spares hippocampal replay.
  bioRxiv : the preprint server for biology 2025 Joshi A, Comrie AE, Bray S, Mankili A, Guidera JA, Nevers R, Sun X, Monroe E, Kharazia V, Ly R, Maya DA, Morales-Rodriguez D, Yu J, Kiseleva A, Perez V, Frank LM
• High-density single-unit human cortical recordings using the Neuropixels probe.
  Neuron 2022 Chung JE, Sellers KK, Leonard MK, Gwilliams L, Xu D, Dougherty ME, Kharazia V, Metzger SL, Welkenhuysen M, Dutta B, Chang EF
• A versatile toolbox for studying cortical physiology in primates.
  Cell reports methods 2022 Khateeb K, Bloch J, Zhou J, Rahimi M, Griggs DJ, Kharazia VN, Le MN, Wang RK, Yazdan-Shahmorad A
• An Integrated Brain-Machine Interface Platform With Thousands of Channels.
  Journal of medical Internet research 2019 Musk E, Neuralink
• A Practical Method for Creating Targeted Focal Ischemic Stroke in the Cortex of Nonhuman Primates.
  Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 2019 Khateeb K, Yao Z, Kharazia VN, Burunova EP, Song S, Wang R, Yazdan-Shahmorad A
• The “sewing machine” for minimally invasive neural recording
  bioRxiv 578542; doi: https://doi.org/10.1101/578542 2019 Timothy L Hanson, Camilo A Diaz-Botia, Viktor Kharazia, Michel M Maharbiz, Philip N Sabes
• Targeted cortical reorganization using optogenetics in non-human primates.
  eLife 2018 Yazdan-Shahmorad A, Silversmith DB, Kharazia V, Sabes PN
• Limited Excessive Voluntary Alcohol Drinking Leads to Liver Dysfunction in Mice.
  Alcoholism, clinical and experimental research 2017 Wegner SA, Pollard KA, Kharazia V, Darevsky D, Perez L, Roychowdhury S, Xu A, Ron D, Nagy LE, Hopf FW
• A Large-Scale Interface for Optogenetic Stimulation and Recording in Nonhuman Primates.
  Neuron 2016 Yazdan-Shahmorad A, Diaz-Botia C, Hanson TL, Kharazia V, Ledochowitsch P, Maharbiz MM, Sabes PN
• A Transgenic Rat for Investigating the Anatomy and Function of Corticotrophin Releasing Factor Circuits.
  Frontiers in neuroscience 2015 Pomrenze MB, Millan EZ, Hopf FW, Keiflin R, Maiya R, Blasio A, Dadgar J, Kharazia V, De Guglielmo G, Crawford E, Janak PH, George O, Rice KC, Messing RO
• Increased behavioral responses to ethanol in Lmo3 knockout mice.
  Genes, brain, and behavior 2014 Savarese A, Zou ME, Kharazia V, Maiya R, Lasek AW
• Inhibition of striatal-enriched tyrosine phosphatase 61 in the dorsomedial striatum is sufficient to increased ethanol consumption.
  Journal of neurochemistry 2014 Darcq E, Hamida SB, Wu S, Phamluong K, Kharazia V, Xu J, Lombroso P, Ron D
• Protein tyrosine phosphatase α in the dorsomedial striatum promotes excessive ethanol-drinking behaviors.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Ben Hamida S, Darcq E, Wang J, Wu S, Phamluong K, Kharazia V, Ron D
• The α5 subunit regulates the expression and function of α4*-containing neuronal nicotinic acetylcholine receptors in the ventral-tegmental area.
  PloS one 2013 Chatterjee S, Santos N, Holgate J, Haass-Koffler CL, Hopf FW, Kharazia V, Lester H, Bonci A, Bartlett SE
• Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse.
  Nature neuroscience 2013 Barak S, Liu F, Ben Hamida S, Yowell QV, Neasta J, Kharazia V, Janak PH, Ron D
• The small G protein H-Ras in the mesolimbic system is a molecular gateway to alcohol-seeking and excessive drinking behaviors.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Ben Hamida S, Neasta J, Lasek AW, Kharazia V, Zou M, Carnicella S, Janak PH, Ron D
• Taok2 controls behavioral response to ethanol in mice.
  Genes, brain, and behavior 2012 Kapfhamer D, Taylor S, Zou ME, Lim JP, Kharazia V, Heberlein U
• Lmo4 in the basolateral complex of the amygdala modulates fear learning.
  PloS one 2012 Maiya R, Kharazia V, Lasek AW, Heberlein U
• PKCε phosphorylation of the sodium channel NaV1.8 increases channel function and produces mechanical hyperalgesia in mice.
  The Journal of clinical investigation 2012 Wu DF, Chandra D, McMahon T, Wang D, Dadgar J, Kharazia VN, Liang YJ, Waxman SG, Dib-Hajj SD, Messing RO
• Alk is a transcriptional target of LMO4 and ERα that promotes cocaine sensitization and reward.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Lasek AW, Gesch J, Giorgetti F, Kharazia V, Heberlein U
• Positive autoregulation of GDNF levels in the ventral tegmental area mediates long-lasting inhibition of excessive alcohol consumption.
  Translational psychiatry 2011 Barak S, Ahmadiantehrani S, Kharazia V, Ron D
• Nucleus accumbens-derived glial cell line-derived neurotrophic factor is a retrograde enhancer of dopaminergic tone in the mesocorticolimbic system.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Wang J, Carnicella S, Ahmadiantehrani S, He DY, Barak S, Kharazia V, Ben Hamida S, Zapata A, Shippenberg TS, Ron D
• Lmo4 in the nucleus accumbens regulates cocaine sensitivity.
  Genes, brain, and behavior 2010 Lasek AW, Kapfhamer D, Kharazia V, Gesch J, Giorgetti F, Heberlein U
• Protein Phosphatase 2a and glycogen synthase kinase 3 signaling modulate prepulse inhibition of the acoustic startle response by altering cortical M-Type potassium channel activity.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Kapfhamer D, Berger KH, Hopf FW, Seif T, Kharazia V, Bonci A, Heberlein U
• Differential regulation of behavioral tolerance to WIN55,212-2 by GASP1.
  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2010 Martini L, Thompson D, Kharazia V, Whistler JL
• Endogenous BDNF in the dorsolateral striatum gates alcohol drinking.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Jeanblanc J, He DY, Carnicella S, Kharazia V, Janak PH, Ron D
• Protein kinase Cdelta regulates ethanol intoxication and enhancement of GABA-stimulated tonic current.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Choi DS, Wei W, Deitchman JK, Kharazia VN, Lesscher HM, McMahon T, Wang D, Qi ZH, Sieghart W, Zhang C, Shokat KM, Mody I, Messing RO
• Morphine-induced receptor endocytosis in a novel knockin mouse reduces tolerance and dependence.
  Current biology : CB 2008 Kim JA, Bartlett S, He L, Nielsen CK, Chang AM, Kharazia V, Waldhoer M, Ou CJ, Taylor S, Ferwerda M, Cado D, Whistler JL
• Mind bomb-2 is an E3 ligase that ubiquitinates the N-methyl-D-aspartate receptor NR2B subunit in a phosphorylation-dependent manner.
  The Journal of biological chemistry 2007 Jurd R, Thornton C, Wang J, Luong K, Phamluong K, Kharazia V, Gibb SL, Ron D
• Amygdala protein kinase C epsilon regulates corticotropin-releasing factor and anxiety-like behavior.
  Genes, brain, and behavior 2007 Lesscher HM, McMahon T, Lasek AW, Chou WH, Connolly J, Kharazia V, Messing RO
• Acute cocaine exposure alters spine density and long-term potentiation in the ventral tegmental area.
  The European journal of neuroscience 2007 Sarti F, Borgland SL, Kharazia VN, Bonci A
• Ligand-induced down-regulation of the cannabinoid 1 receptor is mediated by the G-protein-coupled receptor-associated sorting protein GASP1.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006 Martini L, Waldhoer M, Pusch M, Kharazia V, Fong J, Lee JH, Freissmuth C, Whistler JL
• PKCepsilon increases endothelin converting enzyme activity and reduces amyloid plaque pathology in transgenic mice.
  Proceedings of the National Academy of Sciences of the United States of America 2006 Choi DS, Wang D, Yu GQ, Zhu G, Kharazia VN, Paredes JP, Chang WS, Deitchman JK, Mucke L, Messing RO
• Localization of the scaffolding protein RACK1 in the developing and adult mouse brain.
  Brain research 2006 Ashique AM, Kharazia V, Yaka R, Phamluong K, Peterson AS, Ron D
• Dopamine responsiveness is regulated by targeted sorting of D2 receptors.
  Proceedings of the National Academy of Sciences of the United States of America 2005 Bartlett SE, Enquist J, Hopf FW, Lee JH, Gladher F, Kharazia V, Waldhoer M, Mailliard WS, Armstrong R, Bonci A, Whistler JL
• RACK1 and brain-derived neurotrophic factor: a homeostatic pathway that regulates alcohol addiction.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2004 McGough NN, He DY, Logrip ML, Jeanblanc J, Phamluong K, Luong K, Kharazia V, Janak PH, Ron D
• Neutrophil protein kinase Cdelta as a mediator of stroke-reperfusion injury.
  The Journal of clinical investigation 2004 Chou WH, Choi DS, Zhang H, Mu D, McMahon T, Kharazia VN, Lowell CA, Ferriero DM, Messing RO
• Light microscopic study of GluR1 and calbindin expression in interneurons of neocortical microgyral malformations.
  Neuroscience 2003 Kharazia VN, Jacobs KM, Prince DA
• A developmental switch of AMPA receptor subunits in neocortical pyramidal neurons.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2002 Kumar SS, Bacci A, Kharazia V, Huguenard JR
• Biochemical and morphological characterization of an intracellular membrane compartment containing AMPA receptors.
  Neuropharmacology 2001 Lee SH, Valtschanoff JG, Kharazia VN, Weinberg R, Sheng M
• Changes of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate receptors in layer V of epileptogenic, chronically isolated rat neocortex.
  Neuroscience 2001 Kharazia VN, Prince DA
• Postlesional epilepsy: the ultimate brain plasticity.
  Epilepsia 2000 Jacobs KM, Graber KD, Kharazia VN, Parada I, Prince DA
• Mechanisms underlying epileptogenesis in cortical malformations.
  Epilepsy research 1999 Jacobs KM, Kharazia VN, Prince DA
• Nitric oxide synthase-containing projections to the ventrobasal thalamus in the rat.
  Anatomy and embryology 1999 Usunoff KG, Kharazia VN, Valtschanoff JG, Schmidt HH, Weinberg RJ
• Immunocytochemical demonstration of reduced glutathione in neurons of rat forebrain.
  Brain research 1999 Maybodi L, Pow DV, Kharazia VN, Weinberg RJ
• Direct interaction of CASK/LIN-2 and syndecan heparan sulfate proteoglycan and their overlapping distribution in neuronal synapses.
  The Journal of cell biology 1998 Hsueh YP, Yang FC, Kharazia V, Naisbitt S, Cohen AR, Weinberg RJ, Sheng M
• Differential regional expression and ultrastructural localization of alpha-actinin-2, a putative NMDA receptor-anchoring protein, in rat brain.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1998 Wyszynski M, Kharazia V, Shanghvi R, Rao A, Beggs AH, Craig AM, Weinberg R, Sheng M
• Tangential synaptic distribution of NMDA and AMPA receptors in rat neocortex.
  Neuroscience letters 1997 Kharazia VN, Weinberg RJ
• Arginine and NADPH diaphorase in the rat ventroposterior thalamic nucleus.
  Brain research 1997 Kharazia VN, Petrusz P, Usunoff K, Weinberg RJ, Rustioni A
• Glutamate receptors in spinal motoneurons after sciatic nerve transection.
  Neuroscience 1996 Popratiloff A, Kharazia VN, Weinberg RJ, Laonipon B, Rustioni A
• EM colocalization of AMPA and NMDA receptor subunits at synapses in rat cerebral cortex.
  Neuroscience letters 1996 Kharazia VN, Phend KD, Rustioni A, Weinberg RJ
• GluR1-immunopositive interneurons in rat neocortex.
  The Journal of comparative neurology 1996 Kharazia VN, Wenthold RJ, Weinberg RJ
• Type I nitric oxide synthase fully accounts for NADPH-diaphorase in rat striatum, but not cortex.
  Neuroscience 1994 Kharazia VN, Schmidt HH, Weinberg RJ
• Glutamate in terminals of thalamocortical fibers in rat somatic sensory cortex.
  Neuroscience letters 1993 Kharazia VN, Weinberg RJ
• Neurons in rat cerebral cortex that synthesize nitric oxide: NADPH diaphorase histochemistry, NOS immunocytochemistry, and colocalization with GABA.
  Neuroscience letters 1993 Valtschanoff JG, Weinberg RJ, Kharazia VN, Schmidt HH, Nakane M, Rustioni A
• Neurons in rat hippocampus that synthesize nitric oxide.
  The Journal of comparative neurology 1993 Valtschanoff JG, Weinberg RJ, Kharazia VN, Nakane M, Schmidt HH
• [Co-determination of taurine and other free amino acids in the brain during complex immunohistochemical study of the cat and rat somatosensory cortex].
  Doklady Akademii nauk 1992 Kharaziia VN, Suderevskaia EI, B'erg A, Batuev AS, Rinvik E, Rinvik E, Ottersen DP
• [Research into the problem of central inhibition at the Physiological School of Petersburg-Leningrad University].
  Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova 1991 Batuev AS, Sokolova LV, Kharaziia VN
• The role of inhibitory processes in the formation of functional properties of neurons in vibrissal projection zone of the cat somatosensory cortex.
  Experimental brain research 1989 Batuev AS, Alexandrov AA, Scheynikov NA, Kcharazia VN, Chan CA
• [The role of inhibition processes in the development of functional properties of neurons of the vibrissa projection area in the cat somatosensory cortex].
  Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 1987 Batuev AS, Aleksandrov AA, Shcheinikov NA, Kharaziia VN, Chan TC