Umesh Masharani, MBBS
Professor
Medicine
School of Medicine

Masharani's research focuses mainly on diabetes, with a particular interest in insulin resistance. He collaborates with colleagues in the family medicine departments to examine the relationships among glucose control, depression and psychosocial stress in people with diabetes. He is part of the islet auto-transplantation group, which has an active program managing patients who require surgical removal of the pancreas for chronic pancreatitis and are candidates for islet auto-transplant, a procedure that allows the patient's body to continue producing insulin. The islet transplant group is also studying donor islet transplants as a treatment for type 1 diabetes.

In addition, Masharani is collaborating with Dr. George Brooks, a professor of integrative biology at the University of California, Berkeley, to examine the impact of exercise and aging on mitochondrial function.

Masharani earned his bachelor's degree in physiological sciences at the University of Oxford. He earned his medical degree at Middlesex Health in London. He completed his residency in internal medicine at University Hospitals Birmingham NHS Foundation Trust in Birmingham, England. He completed a fellowship in endocrinology at UCSF.

• A Multi-Modal Approach to Islet and Pancreas Transplantation With Calcineurin-Sparing Immunosuppression Maintains Long-Term Insulin Independence in Patients With Type I Diabetes.
  Transplant international : official journal of the European Society for Organ Transplantation 2023 Wisel SA, Posselt AM, Szot GL, Nunez M, Santos-Parker K, Gardner JM, Worner G, Roll GR, Syed S, Kelly Y, Ward C, Tavakol M, Johnson K, Masharani U, Stock PG
• Cardiovascular and Renal Benefits of Novel Diabetes Drugs by Baseline Cardiovascular Risk: A Systematic Review, Meta-analysis, and Meta-regression.
  Diabetes care 2023 Rodriguez-Valadez JM, Tahsin M, Fleischmann KE, Masharani U, Yeboah J, Park M, Li L, Weber E, Li Y, Berkalieva A, Max W, Hunink MGM, Ferket BS
• Spectrum of Clinical Presentations, Imaging Findings, and HLA Types in Immune Checkpoint Inhibitor-Induced Hypophysitis.
  Journal of the Endocrine Society 2023 Quandt Z, Kim S, Villanueva-Meyer J, Coupe C, Young A, Kang JH, Yazdany J, Schmajuk G, Rush S, Ziv E, Perdigoto AL, Herold K, Lechner MG, Su MA, Tyrrell JB, Bluestone J, Anderson M, Masharani U
• Diabetes Technology Meeting 2022.
  Journal of diabetes science and technology 2023 Huang J, Yeung AM, DuBord AY, Wolpert H, Jacobs PG, Lee WA, Drincic A, Spanakis EK, Sherr JL, Prahalad P, Fleming A, Hsiao VC, Kompala T, Lal RA, Fayfman M, Ginsberg BH, Galindo RJ, Stuhr A, Chase JG,…
• Hospital Diabetes Meeting 2022.
  Journal of diabetes science and technology 2022 Huang J, Yeung AM, Nguyen KT, Xu NY, Preiser JC, Rushakoff RJ, Seley JJ, Umpierrez GE, Wallia A, Drincic AT, Gianchandani R, Lansang MC, Masharani U, Mathioudakis N, Pasquel FJ, Schmidt S, Shah VN, …
• Diabetes Technology Meeting 2021.
  Journal of diabetes science and technology 2022 Xu NY, Nguyen KT, DuBord AY, Pickup J, Sherr JL, Teymourian H, Cengiz E, Ginsberg BH, Cobelli C, Ahn D, Bellazzi R, Bequette BW, Gandrud Pickett L, Parks L, Spanakis EK, Masharani U, Akturk HK, Melish…
• The ubiquity of diabetes distress among adults with type 1 diabetes in an urban, academic practice: A template for intervention.
  Diabetic medicine : a journal of the British Diabetic Association 2022 Masharani U, Strycker LA, Fisher L
• Lifetime Cardiovascular Disease Risk by Coronary Artery Calcium Score in Individuals With and Without Diabetes: An Analysis From the Multi-Ethnic Study of Atherosclerosis.
  Diabetes care 2022 Ferket BS, Hunink MGM, Masharani U, Max W, Yeboah J, Burke GL, Fleischmann KE
• A Glycemia Risk Index (GRI) of Hypoglycemia and Hyperglycemia for Continuous Glucose Monitoring Validated by Clinician Ratings.
  Journal of diabetes science and technology 2022 Klonoff DC, Wang J, Rodbard D, Kohn MA, Li C, Liepmann D, Kerr D, Ahn D, Peters AL, Umpierrez GE, Seley JJ, Xu NY, Nguyen KT, Simonson G, Agus MSD, Al-Sofiani ME, Armaiz-Pena G, Bailey TS, Basu A, …
• Disconnected Pancreatic Duct Syndrome: Pancreatitis of the Disconnected Pancreas and Its Role in the Development of Diabetes Mellitus.
  Clinical and translational gastroenterology 2022 Thiruvengadam NR, Forde KA, Miranda J, Kim C, Behr S, Masharani U, Arain MA
• A multidisciplinary approach to optimizing care of patients treated with alpelisib.
  Breast (Edinburgh, Scotland) 2021 Rugo HS, Lacouture ME, Goncalves MD, Masharani U, Aapro MS, O'Shaughnessy JA
• Hyperlactatemia in diabetic ketoacidosis.
  Diabetic medicine : a journal of the British Diabetic Association 2021 Masharani U, Strycker LA, Lazar AA, Wu K, Brooks GA
• Diabetes Technology Meeting 2020.
  Journal of diabetes science and technology 2021 Shang T, Zhang JY, Bequette BW, Raymond JK, Coté G, Sherr JL, Castle J, Pickup J, Pavlovic Y, Espinoza J, Messer LH, Heise T, Mendez CE, Kim S, Ginsberg BH, Masharani U, Galindo RJ, Klonoff DC
• Long-term Predictions of Incident Coronary Artery Calcium to 85 Years of Age for Asymptomatic Individuals With and Without Type 2 Diabetes.
  Diabetes care 2021 Ferket BS, Hunink MGM, Masharani U, Max W, Yeboah J, Fleischmann KE
• Estimating Long-Term Health Utility Scores and Expenditures for Cardiovascular Disease From the Medical Expenditure Panel Survey.
  Circulation. Cardiovascular quality and outcomes 2021 Morey JR, Jiang S, Klein S, Max W, Masharani U, Fleischmann KE, Hunink MGM, Ferket BS
• Letter to the Editor: "Approach to the Patient with Thyrotoxicosis Using Telemedicine".
  The Journal of clinical endocrinology and metabolism 2021 Neinstein AB, Masharani U
• Calcium Stimulation Test for Insulinoma Localization in an End-stage Renal Disease Patient on Diazoxide.
  Journal of the Endocrine Society 2020 Kim S, Conrad M, Chuang E, Cai L, Masharani U, Murphy EJ
• Patients with ACVR1R206H mutations have an increased prevalence of cardiac conduction abnormalities on electrocardiogram in a natural history study of Fibrodysplasia Ossificans Progressiva.
  Orphanet journal of rare diseases 2020 Kou S, De Cunto C, Baujat G, Wentworth KL, Grogan DR, Brown MA, Di Rocco M, Keen R, Al Mukaddam M, le Quan Sang KH, Masharani U, Kaplan FS, Pignolo RJ, Hsiao EC
• Economic costs of implementing group interventions to reduce diabetes distress in adults with type 1 diabetes mellitus in the T1-REDEEM trial.
  Journal of diabetes and its complications 2019 Shumway M, Fisher L, Hessler D, Bowyer V, Polonsky WH, Masharani U
• There is value in treating elevated levels of diabetes distress: the clinical impact of targeted interventions in adults with Type 1 diabetes.
  Diabetic medicine : a journal of the British Diabetic Association 2019 Hessler D, Fisher L, Polonsky W, Strycker L, Parra J, Bowyer V, Dedhia M, Masharani U
• Toward effective interventions to reduce diabetes distress among adults with type 1 diabetes: Enhancing Emotion regulation and cognitive skills.
  Patient education and counseling 2019 Fisher L, Hessler D, Polonsky W, Strycker L, Bowyer V, Masharani U
• Ectopic Thyroid-Stimulating Hormone-Secreting Pituitary Adenoma of the Nasopharynx Diagnosed by Gallium 68 DOTATATE Positron Emission Tomography/Computed Tomography.
  World neurosurgery 2019 Kim S, Dillon WP, Hope TA, El-Sayed IH, van Zante A, Wu K, Masharani U
• Therapeutic advances for blocking heterotopic ossification in fibrodysplasia ossificans progressiva.
  British journal of clinical pharmacology 2019 Wentworth KL, Masharani U, Hsiao EC
• Methadone-Associated Hypoglycemia in Chronic Renal Failure Masquerading as an Insulinoma.
  Pain medicine (Malden, Mass.) 2018 Masharani U, Alba D
• T1-REDEEM: A Randomized Controlled Trial to Reduce Diabetes Distress Among Adults With Type 1 Diabetes.
  Diabetes care 2018 Fisher L, Hessler D, Polonsky WH, Masharani U, Guzman S, Bowyer V, Strycker L, Ahmann A, Basina M, Blumer I, Chloe C, Kim S, Peters AL, Shumway M, Weihs K, Wu P
• Emotion regulation contributes to the development of diabetes distress among adults with type 1 diabetes.
  Patient education and counseling 2017 Fisher L, Hessler D, Polonsky W, Strycker L, Guzman S, Bowyer V, Blumer I, Masharani U
• Diabetes distress is linked with worsening diabetes management over time in adults with Type 1 diabetes.
  Diabetic medicine : a journal of the British Diabetic Association 2017 Hessler DM, Fisher L, Polonsky WH, Masharani U, Strycker LA, Peters AL, Blumer I, Bowyer V
• 11C-L-methyl methionine dynamic PET/CT of skeletal muscle: response to protein supplementation compared to L-[ring 13C6] phenylalanine infusion with serial muscle biopsy.
  Annals of nuclear medicine 2017 Arentson-Lantz EJ, Saeed IH, Frassetto LA, Masharani U, Harnish RJ, Seo Y, VanBrocklin HF, Hawkins RA, Mari-Aparici C, Pampaloni MH, Slater J, Paddon-Jones D, Lang TF
• Complicated Case Presentation: Management of Pancreatic Neuroendocrine Tumors in Multiple Endocrine Neoplasia Type 1.
  Pancreas 2017 Mulvey CK, Van Loon K, Bergsland EK, Masharani U, Nakakura EK
• Diabetes distress in adults with type 1 diabetes: Prevalence, incidence and change over time.
  Journal of diabetes and its complications 2016 Fisher L, Hessler D, Polonsky W, Strycker L, Masharani U, Peters A
• Advantages and Limitations of Androgen Receptor-Based Methods for Detecting Anabolic Androgenic Steroid Abuse as Performance Enhancing Drugs.
  PloS one 2016 Bailey K, Yazdi T, Masharani U, Tyrrell B, Butch A, Schaufele F
• Prevalence of depression in Type 1 diabetes and the problem of over-diagnosis.
  Diabetic medicine : a journal of the British Diabetic Association 2016 Fisher L, Hessler DM, Polonsky WH, Masharani U, Peters AL, Blumer I, Strycker LA
• A Comparative Analysis of the Safety, Efficacy, and Cost of Islet Versus Pancreas Transplantation in Nonuremic Patients With Type 1 Diabetes.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2015 Moassesfar S, Masharani U, Frassetto LA, Szot GL, Tavakol M, Stock PG, Posselt AM
• A Case of Hypercalcemia and Overexpression of CYP27B1 in Skeletal Muscle Lesions in a Patient with HIV Infection After Cosmetic Injections with Polymethylmethacrylate (PMMA) for Wasting.
  Calcified tissue international 2015 Hindi SM, Wang Y, Jones KD, Nussbaum JC, Chang Y, Masharani U, Bikle D, Shoback DM, Hsiao EC
• Metabolic and physiologic effects from consuming a hunter-gatherer (Paleolithic)-type diet in type 2 diabetes.
  European journal of clinical nutrition 2015 Masharani U, Sherchan P, Schloetter M, Stratford S, Xiao A, Sebastian A, Nolte Kennedy M, Frassetto L
• Understanding the sources of diabetes distress in adults with type 1 diabetes.
  Journal of diabetes and its complications 2015 Fisher L, Polonsky WH, Hessler DM, Masharani U, Blumer I, Peters AL, Strycker LA, Bowyer V
• Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer's disease.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 Kapogiannis D, Boxer A, Schwartz JB, Abner EL, Biragyn A, Masharani U, Frassetto L, Petersen RC, Miller BL, Goetzl EJ
• Prediabetic living kidney donors have preserved kidney function at 10 years after donation.
  Transplantation 2014 Chandran S, Masharani U, Webber AB, Wojciechowski DM
• Impact of baseline patient characteristics on interventions to reduce diabetes distress: the role of personal conscientiousness and diabetes self-efficacy.
  Diabetic medicine : a journal of the British Diabetic Association 2014 Fisher L, Hessler D, Masharani U, Strycker L
• Reductions in regimen distress are associated with improved management and glycemic control over time.
  Diabetes care 2013 Hessler D, Fisher L, Glasgow RE, Strycker LA, Dickinson LM, Arean PA, Masharani U
• Pathways to quality inpatient management of hyperglycemia and diabetes: a call to action.
  Diabetes care 2013 Draznin B, Gilden J, Golden SH, Inzucchi SE, PRIDE investigators, Baldwin D, Bode BW, Boord JB, Braithwaite SS, Cagliero E, Dungan KM, Falciglia M, Figaro MK, Hirsch IB, Klonoff D, Korytkowski MT, …
• REDEEM: a pragmatic trial to reduce diabetes distress.
  Diabetes care 2013 Fisher L, Hessler D, Glasgow RE, Arean PA, Masharani U, Naranjo D, Strycker LA
• Chromium supplementation in non-obese non-diabetic subjects is associated with a decline in insulin sensitivity.
  BMC endocrine disorders 2012 Masharani U, Gjerde C, McCoy S, Maddux BA, Hessler D, Goldfine ID, Youngren JF
• Young adult African American patients with type 2 diabetes: a high risk patient sub-group with few supports for good diabetes management.
  Journal of health psychology 2011 Hessler DM, Fisher L, Naranjo D, Masharani U
• Does vertebral bone marrow fat content correlate with abdominal adipose tissue, lumbar spine bone mineral density, and blood biomarkers in women with type 2 diabetes mellitus?
  Journal of magnetic resonance imaging : JMRI 2011 Baum T, Yap SP, Karampinos DC, Nardo L, Kuo D, Burghardt AJ, Masharani UB, Schwartz AV, Li X, Link TM
• Insulin resistance in non-obese subjects is associated with activation of the JNK pathway and impaired insulin signaling in skeletal muscle.
  PloS one 2011 Masharani UB, Maddux BA, Li X, Sakkas GK, Mulligan K, Schambelan M, Goldfine ID, Youngren JF
• Islet transplantation in type 1 diabetic patients using calcineurin inhibitor-free immunosuppressive protocols based on T-cell adhesion or costimulation blockade.
  Transplantation 2010 Posselt AM, Szot GL, Frassetto LA, Masharani U, Tavakol M, Amin R, McElroy J, Ramos MD, Kerlan RK, Fong L, Vincenti F, Bluestone JA, Stock PG
• Patient age: a neglected factor when considering disease management in adults with type 2 diabetes.
  Patient education and counseling 2010 Hessler DM, Fisher L, Mullan JT, Glasgow RE, Masharani U
• High-resolution peripheral quantitative computed tomographic imaging of cortical and trabecular bone microarchitecture in patients with type 2 diabetes mellitus.
  The Journal of clinical endocrinology and metabolism 2010 Burghardt AJ, Issever AS, Schwartz AV, Davis KA, Masharani U, Majumdar S, Link TM
• Islet transplantation in type 1 diabetics using an immunosuppressive protocol based on the anti-LFA-1 antibody efalizumab.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2010 Posselt AM, Bellin MD, Tavakol M, Szot GL, Frassetto LA, Masharani U, Kerlan RK, Fong L, Vincenti FG, Hering BJ, Bluestone JA, Stock PG
• Effects of controlled-release alpha lipoic acid in lean, nondiabetic patients with polycystic ovary syndrome.
  Journal of diabetes science and technology 2010 Masharani U, Gjerde C, Evans JL, Youngren JF, Goldfine ID
• Teplizumab therapy for type 1 diabetes.
  Expert opinion on biological therapy 2010 Masharani UB, Becker J
• Clinical islet transplantation at the University of California, San Francisco.
  Clinical transplants 2010 Posselt AM, Szot GL, Frassetto LA, Masharani U, Stock PG
• Diabetes distress but not clinical depression or depressive symptoms is associated with glycemic control in both cross-sectional and longitudinal analyses.
  Diabetes care 2009 Fisher L, Mullan JT, Arean P, Glasgow RE, Hessler D, Masharani U
• Influence of gender on the relationship between insulin sensitivity, adiposity, and plasma lipids in lean nondiabetic subjects.
  Metabolism: clinical and experimental 2009 Masharani U, Goldfine ID, Youngren JF
• Daily negative mood affects fasting glucose in type 2 diabetes.
  Health psychology : official journal of the Division of Health Psychology, American Psychological Association 2009 Skaff MM, Mullan JT, Almeida DM, Hoffman L, Masharani U, Mohr D, Fisher L
• Update on systemic management of diabetes.
  International ophthalmology clinics 2009 Masharani U, Rushakoff RJ
• A longitudinal study of affective and anxiety disorders, depressive affect and diabetes distress in adults with Type 2 diabetes.
  Diabetic medicine : a journal of the British Diabetic Association 2008 Fisher L, Skaff MM, Mullan JT, Arean P, Glasgow R, Masharani U
• Laparoscopic enucleation of insulinomas.
  Archives of surgery (Chicago, Ill. : 1960) 2007 Sweet MP, Izumisato Y, Way LW, Clark OH, Masharani U, Duh QY
• Technical evaluation of in vivo abdominal fat and IMCL quantification using MRI and MRSI at 3 T.
  Magnetic resonance imaging 2007 Li X, Youngren JF, Hyun B, Sakkas GK, Mulligan K, Majumdar S, Masharani UB, Schambelan M, Goldfine ID
• Clinical depression versus distress among patients with type 2 diabetes: not just a question of semantics.
  Diabetes care 2007 Fisher L, Skaff MM, Mullan JT, Arean P, Mohr D, Masharani U, Glasgow R, Laurencin G
• Negative life events and quality of life in adults with asthma.
  Thorax 2006 Archea C, Yen IH, Chen H, Eisner MD, Katz PP, Masharani U, Yelin EH, Earnest G, Blanc PD
• A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes.
  Diabetes 2005 Herold KC, Gitelman SE, Masharani U, Hagopian W, Bisikirska B, Donaldson D, Rother K, Diamond B, Harlan DM, Bluestone JA
• Impact of exogenous glucocorticoid use on salivary cortisol measurements among adults with asthma and rhinitis.
  Psychoneuroendocrinology 2005 Masharani U, Shiboski S, Eisner MD, Katz PP, Janson SL, Granger DA, Blanc PD
• Impact of the home indoor environment on adult asthma and rhinitis.
  Journal of occupational and environmental medicine 2005 Blanc PD, Eisner MD, Katz PP, Yen IH, Archea C, Earnest G, Janson S, Masharani UB, Quinlan PJ, Hammond SK, Thorne PS, Balmes JR, Trupin L, Yelin EH
• Insulin secretion in type 1 diabetes.
  Diabetes 2004 Steele C, Hagopian WA, Gitelman S, Masharani U, Cavaghan M, Rother KI, Donaldson D, Harlan DM, Bluestone J, Herold KC
• Properties of triglyceride-rich and cholesterol-rich lipoproteins in the remnant-like particle fraction of human blood plasma.
  Journal of lipid research 2002 Campos E, Kotite L, Blanche P, Mitsugi Y, Frost PH, Masharani U, Krauss RM, Havel RJ
• Peptide mapping and characterisation of glycation patterns of the glima 38 antigen recognised by autoantibodies in Type I diabetic patients.
  Diabetologia 2000 Roll U, Turck CW, Gitelman SE, Rosenthal SM, Nolte MS, Masharani U, Ziegler AG, Baekkeskov S
• Troglitazone-induced fulminant hepatic failure. Acute Liver Failure Study Group.
  Digestive diseases and sciences 2000 Murphy EJ, Davern TJ, Shakil AO, Shick L, Masharani U, Chow H, Freise C, Lee WM, Bass NM
• The endocrine complications of acquired immunodeficiency syndrome.
  Advances in internal medicine 1993 Masharani U, Schambelan M
• Restriction fragment length polymorphisms of the apolipoprotein A-I, C-III, A-IV gene locus. Relationships with lipids, apolipoproteins, and premature coronary artery disease.
  Atherosclerosis 1991 Ordovas JM, Civeira F, Genest J, Craig S, Robbins AH, Meade T, Pocovi M, Frossard PM, Masharani U, Wilson PW
• BglII restriction fragment length polymorphisms at the human p53 gene locus.
  Human genetics 1990 Masharani U, Wolf D
• DNA polymorphisms of the apolipoprotein B gene in patients with premature coronary artery disease.
  Atherosclerosis 1990 Genest JJ, Ordovas JM, McNamara JR, Robbins AM, Meade T, Cohn SD, Salem DN, Wilson PW, Masharani U, Frossard PM
• HinfI RFLP at the human renin (REN) gene locus.
  Nucleic acids research 1989 Masharani U
• DraI and ScaI RFLPs at human tyrosine hydroxylase (TH) gene locus.
  Nucleic acids research 1988 Tinklenberg KJ, Masharani U, Coleman RT, Taylor J, Cawthorn R, Frossard P
• MspI and HindIII restriction fragment length polymorphisms at the human Na,K-ATPase beta-subunit (ATP1B) gene locus.
  Human genetics 1988 Masharani U, Frossard PM
• NsiI and ScaI restriction fragment length polymorphisms at the atrial natriuretic peptides (ANP) gene locus.
  Human genetics 1988 Masharani U, Nakashima PF, Lim DW, Frossard PM
• EcoRI and NsiI RFLPs at a human PLA2 gene on chromosome 1.
  Nucleic acids research 1988 Masharani U, Coleman RT, Johnson LK, Seilhamer JJ
• BanII and ScaI RFLPs at the human p53 gene locus.
  Nucleic acids research 1988 Masharani U, Wolf D, Frossard PM
• Two EcoT14I RFLPs at the human renin (REN) gene locus.
  Nucleic acids research 1988 Masharani U, Baxter JD, Frossard PM
• MboI RFLP at the human renin (ren) gene locus.
  Nucleic acids research 1988 Masharani U, Frossard PM