Tyler Detomasi, PhD
Postdoctoral Scholar
Pharmaceutical Chemistry
School of Pharmacy

Publications (12)

Top publication keywords:
LactamsLeucineCytidineNeurospora crassaVibrio choleraeLeucyl AminopeptidaseSerine ProteasesMiddle East Respiratory Syndrome CoronavirusFungal ProteinsBacterial ProteinsMixed Function OxygenasesAntiviral AgentsMolecular Docking SimulationHydroxylaminesProtease Inhibitors

• Discovery of Coronavirus Main Protease Inhibitors with Enhanced Brain Exposure and Potent Oral Efficacy in SARS-CoV-2 and MERS Infection Models.
  Journal of medicinal chemistry 2026 Lizzadro L, Li J, Taha TY, Degotte G, Detomasi TC, Zapatero-Belinchon FJ, Hantz ER, Huang S, Matsui Y, Henderson WR, McCann JT, Montano M, Rosecrans J, Torres Pomares DF, McGovern BL, Diaz-Tapia R, …
• Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus MPro inhibitors with potent in vivo efficacy.
  Science advances 2025 Detomasi TC, Degotte G, Huang S, Suryawanshi RK, Diallo A, Lizzadro L, Zapatero-Belinchón FJ, Taha TY, Li J, Richards AL, Hantz ER, Alam Z, Montano M, McCavitt-Malvido M, Gumpena R, Partridge JR, …
• Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins.
  Science (New York, N.Y.) 2025 Jain A, Heremans I, Rademaker G, Detomasi TC, Rohweder P, Anderson D, Zhang J, Hernandez GA, Gupta S, von Linde T, Lange M, Spacci M, Luo J, Citron YR, Olzmann JA, Dawson DW, Craik CS, Bommer G, …
• Leucine Aminopeptidase LyLAP enables lysosomal degradation of membrane proteins.
  bioRxiv : the preprint server for biology 2024 Jain A, Heremans I, Rademaker G, Detomasi TC, Hernandez GA, Zhang J, Gupta S, von Linde T, Lange M, Spacci M, Rohweder P, Anderson D, Citron YR, Olzmann JA, Dawson DW, Craik CS, Bommer G, Perera RM, …
• Proteases influence colony aggregation behavior in Vibrio cholerae.
  The Journal of biological chemistry 2023 Detomasi TC, Batka AE, Valastyan JS, Hydorn MA, Craik CS, Bassler BL, Marletta MA

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• Large library docking for novel SARS-CoV-2 main protease non-covalent and covalent inhibitors.
  Protein science : a publication of the Protein Society 2023 Fink EA, Bardine C, Gahbauer S, Singh I, Detomasi TC, White K, Gu S, Wan X, Chen J, Ary B, Glenn I, O'Connell J, O'Donnell H, Fajtová P, Lyu J, Vigneron S, Young NJ, Kondratov IS, Alisoltani A, Simons…
• A Prototype Assay Multiplexing SARS-CoV-2 3CL-Protease and Angiotensin-Converting Enzyme 2 for Saliva-Based Diagnostics in COVID-19.
  Biosensors 2023 Suresh V, Sheik DA, Detomasi TC, Zhao T, Zepeda T, Saladi S, Rajesh UC, Byers K, Craik CS, Davisson VJ
• Characterization of a unique polysaccharide monooxygenase from the plant pathogen Magnaporthe oryzae.
  Proceedings of the National Academy of Sciences of the United States of America 2023 Martinez-D'Alto A, Yan X, Detomasi TC, Sayler RI, Thomas WC, Talbot NJ, Marletta MA
• A moonlighting function of a chitin polysaccharide monooxygenase, CWR-1, in Neurospora crassa allorecognition.
  eLife 2022 Detomasi TC, Rico-Ramírez AM, Sayler RI, Gonçalves AP, Marletta MA, Glass NL
• A dual-fluorophore sensor approach for ratiometric fluorescence imaging of potassium in living cells.
  Chemical science 2020 Wang Z, Detomasi TC, Chang CJ
• Substrate selectivity in starch polysaccharide monooxygenases.
  The Journal of biological chemistry 2019 Vu VV, Hangasky JA, Detomasi TC, Henry SJW, Ngo ST, Span EA, Marletta MA
• A Modular Ionophore Platform for Liver-Directed Copper Supplementation in Cells and Animals.
  Journal of the American Chemical Society 2018 Su TA, Shihadih DS, Cao W, Detomasi TC, Heffern MC, Jia S, Stahl A, Chang CJ