Tsukasa Kadota, MD, PhD
Postdoctoral Scholar
Medicine
School of Medicine

Education & Training

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• Ph.D. Respiratory Medicine The Jikei University School of Medicine 2021
• M.D. Medicine The Jikei University School of Medicine 2009

Publications (34)

Top publication keywords:
Idiopathic Pulmonary FibrosisExosomesMycobacterium avium-intracellulare InfectionRNA, NeoplasmCell CommunicationCell-Derived MicroparticlesMycobacterium avium ComplexMicroRNAsCellular SenescenceLung DiseasesClarithromycinExtracellular VesiclesPulmonary Disease, Chronic ObstructiveWnt Signaling PathwayMyofibroblasts

• Fibroblast-derived Extracellular Vesicles Induce Lung Cancer Progression in the Idiopathic Pulmonary Fibrosis Microenvironment.
  American journal of respiratory cell and molecular biology 2023 Fujita Y, Fujimoto S, Miyamoto A, Kaneko R, Kadota T, Watanabe N, Kizawa R, Kawamoto H, Watanabe J, Utsumi H, Wakui H, Minagawa S, Araya J, Ohtsuka T, Ochiya T, Kuwano K
• Anomalous Epithelial Variations and Ectopic Inflammatory Response in Chronic Obstructive Pulmonary Disease.
  American journal of respiratory cell and molecular biology 2022 Watanabe N, Fujita Y, Nakayama J, Mori Y, Kadota T, Hayashi Y, Shimomura I, Ohtsuka T, Okamoto K, Araya J, Kuwano K, Yamamoto Y
• Clinical features of organizing pneumonia in anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorders.
  Respiratory investigation 2022 Furube A, Kadota T, Gochi M, Saito S, Shibata S, Inaki S, Tone K, Takagi M, Matsuno H, Araya J, Yaguchi H, Kuwano K
• Involvement of Parkin-mediated mitophagy in the pathogenesis of chronic obstructive pulmonary disease-related sarcopenia.
  Journal of cachexia, sarcopenia and muscle 2022 Ito A, Hashimoto M, Tanihata J, Matsubayashi S, Sasaki R, Fujimoto S, Kawamoto H, Hosaka Y, Ichikawa A, Kadota T, Fujita Y, Takekoshi D, Ito S, Minagawa S, Numata T, Hara H, Matsuoka T, Udaka J, Araya…
• Extracellular vesicle-mediated cellular crosstalk in lung repair, remodelling and regeneration.
  European respiratory review : an official journal of the European Respiratory Society 2022 Kadota T, Fujita Y, Araya J, Ochiya T, Kuwano K

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• Aspiration of Cerebrospinal Fluid Rhinorrhea as a Cause of Non-resolving Pneumonia.
  Internal medicine (Tokyo, Japan) 2021 Takekoshi D, Inukai S, Hatano S, Fujimoto S, Kadota T, Takeda T, Omura K, Mori E, Araya J, Kuwano K
• Human bronchial epithelial cell-derived extracellular vesicle therapy for pulmonary fibrosis via inhibition of TGF-β-WNT crosstalk.
  Journal of extracellular vesicles 2021 Kadota T, Fujita Y, Araya J, Watanabe N, Fujimoto S, Kawamoto H, Minagawa S, Hara H, Ohtsuka T, Yamamoto Y, Kuwano K, Ochiya T
• Impaired TRIM16-Mediated Lysophagy in Chronic Obstructive Pulmonary Disease Pathogenesis.
  Journal of immunology (Baltimore, Md. : 1950) 2021 Araya J, Saito N, Hosaka Y, Ichikawa A, Kadota T, Fujita Y, Minagawa S, Hara H, Fujimoto S, Kawamoto H, Watanabe N, Ito A, Okuda K, Miyagawa H, Watanabe J, Takekoshi D, Utsumi H, Yoshida M, Hashimoto …
• Early prediction of COVID-19 severity using extracellular vesicle COPB2.
  Journal of extracellular vesicles 2021 Fujita Y, Hoshina T, Matsuzaki J, Yoshioka Y, Kadota T, Hosaka Y, Fujimoto S, Kawamoto H, Watanabe N, Sawaki K, Sakamoto Y, Miyajima M, Lee K, Nakaharai K, Horino T, Nakagawa R, Araya J, Miyato M, …
• Intercellular Communication by Vascular Endothelial Cell-Derived Extracellular Vesicles and Their MicroRNAs in Respiratory Diseases.
  Frontiers in molecular biosciences 2021 Fujimoto S, Fujita Y, Kadota T, Araya J, Kuwano K
• Extracellular Vesicles from Fibroblasts Induce Epithelial-Cell Senescence in Pulmonary Fibrosis.
  American journal of respiratory cell and molecular biology 2020 Kadota T, Yoshioka Y, Fujita Y, Araya J, Minagawa S, Hara H, Miyamoto A, Suzuki S, Fujimori S, Kohno T, Fujii T, Kishi K, Kuwano K, Ochiya T
• Chaperone-mediated autophagy receptor modulates tumor growth and chemoresistance in non-small cell lung cancer.
  Cancer science 2020 Ichikawa A, Fujita Y, Hosaka Y, Kadota T, Ito A, Yagishita S, Watanabe N, Fujimoto S, Kawamoto H, Saito N, Yoshida M, Hashimoto M, Minagawa S, Hara H, Motoi N, Yamamoto Y, Ochiya T, Araya J, Kuwano K
• Chaperone-Mediated Autophagy Suppresses Apoptosis via Regulation of the Unfolded Protein Response during Chronic Obstructive Pulmonary Disease Pathogenesis.
  Journal of immunology (Baltimore, Md. : 1950) 2020 Hosaka Y, Araya J, Fujita Y, Kadota T, Tsubouchi K, Yoshida M, Minagawa S, Hara H, Kawamoto H, Watanabe N, Ito A, Ichikawa A, Saito N, Okuda K, Watanabe J, Takekoshi D, Utsumi H, Hashimoto M, Wakui H,…
• A miRNA-based diagnostic model predicts resectable lung cancer in humans with high accuracy.
  Communications biology 2020 Asakura K, Kadota T, Matsuzaki J, Yoshida Y, Yamamoto Y, Nakagawa K, Takizawa S, Aoki Y, Nakamura E, Miura J, Sakamoto H, Kato K, Watanabe SI, Ochiya T
• Pulmonary Artery Pseudoaneurysm Caused by Lung Abscess.
  The American journal of the medical sciences 2020 Saito S, Kadota T, Gochi M
• Re-administration of pembrolizumab with prednisolone after pembrolizumab-induced nephrotic syndrome.
  European journal of cancer (Oxford, England : 1990) 2020 Saito S, Kadota T, Gochi M, Takagi M, Kuwano K
• Involvement of GPx4-Regulated Lipid Peroxidation in Idiopathic Pulmonary Fibrosis Pathogenesis.
  Journal of immunology (Baltimore, Md. : 1950) 2019 Tsubouchi K, Araya J, Yoshida M, Sakamoto T, Koumura T, Minagawa S, Hara H, Hosaka Y, Ichikawa A, Saito N, Kadota T, Kurita Y, Kobayashi K, Ito S, Fujita Y, Utsumi H, Hashimoto M, Wakui H, Numata T, …
• Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis.
  Nature communications 2019 Yoshida M, Minagawa S, Araya J, Sakamoto T, Hara H, Tsubouchi K, Hosaka Y, Ichikawa A, Saito N, Kadota T, Sato N, Kurita Y, Kobayashi K, Ito S, Utsumi H, Wakui H, Numata T, Kaneko Y, Mori S, Asano H, …
• Involvement of Lamin B1 Reduction in Accelerated Cellular Senescence during Chronic Obstructive Pulmonary Disease Pathogenesis.
  Journal of immunology (Baltimore, Md. : 1950) 2019 Saito N, Araya J, Ito S, Tsubouchi K, Minagawa S, Hara H, Ito A, Nakano T, Hosaka Y, Ichikawa A, Kadota T, Yoshida M, Fujita Y, Utsumi H, Kurita Y, Kobayashi K, Hashimoto M, Wakui H, Numata T, Kaneko …
• Clinical Application of Mesenchymal Stem Cell-Derived Extracellular Vesicle-Based Therapeutics for Inflammatory Lung Diseases.
  Journal of clinical medicine 2018 Fujita Y, Kadota T, Araya J, Ochiya T, Kuwano K
• PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis.
  Autophagy 2018 Araya J, Tsubouchi K, Sato N, Ito S, Minagawa S, Hara H, Hosaka Y, Ichikawa A, Saito N, Kadota T, Yoshida M, Fujita Y, Utsumi H, Kobayashi K, Yanagisawa H, Hashimoto M, Wakui H, Ishikawa T, Numata T, …
• Extracellular Vesicles: New Players in Lung Immunity.
  American journal of respiratory cell and molecular biology 2018 Fujita Y, Kadota T, Araya J, Ochiya T, Kuwano K
• Emerging role of extracellular vesicles as a senescence-associated secretory phenotype: Insights into the pathophysiology of lung diseases.
  Molecular aspects of medicine 2017 Kadota T, Fujita Y, Yoshioka Y, Araya J, Kuwano K, Ochiya T
• Azithromycin attenuates myofibroblast differentiation and lung fibrosis development through proteasomal degradation of NOX4.
  Autophagy 2017 Tsubouchi K, Araya J, Minagawa S, Hara H, Ichikawa A, Saito N, Kadota T, Sato N, Yoshida M, Kurita Y, Kobayashi K, Ito S, Fujita Y, Utsumi H, Yanagisawa H, Hashimoto M, Wakui H, Yoshii Y, Ishikawa T, …
• Pirfenidone inhibits myofibroblast differentiation and lung fibrosis development during insufficient mitophagy.
  Respiratory research 2017 Kurita Y, Araya J, Minagawa S, Hara H, Ichikawa A, Saito N, Kadota T, Tsubouchi K, Sato N, Yoshida M, Kobayashi K, Ito S, Fujita Y, Utsumi H, Yanagisawa H, Hashimoto M, Wakui H, Yoshii Y, Ishikawa T, …
• Extracellular vesicles in lung cancer-From bench to bedside.
  Seminars in cell & developmental biology 2017 Kadota T, Yoshioka Y, Fujita Y, Kuwano K, Ochiya T
• Exosomes: toward clinical application.
  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2017 Kadota T, Yoshioka Y, Fujita Y, Ochiya T
• Extracellular Vesicles in Chronic Obstructive Pulmonary Disease.
  International journal of molecular sciences 2016 Kadota T, Fujita Y, Yoshioka Y, Araya J, Kuwano K, Ochiya T
• Metformin attenuates lung fibrosis development via NOX4 suppression.
  Respiratory research 2016 Sato N, Takasaka N, Yoshida M, Tsubouchi K, Minagawa S, Araya J, Saito N, Fujita Y, Kurita Y, Kobayashi K, Ito S, Hara H, Kadota T, Yanagisawa H, Hashimoto M, Utsumi H, Wakui H, Kojima J, Numata T, …
• Involvement of PARK2-Mediated Mitophagy in Idiopathic Pulmonary Fibrosis Pathogenesis.
  Journal of immunology (Baltimore, Md. : 1950) 2016 Kobayashi K, Araya J, Minagawa S, Hara H, Saito N, Kadota T, Sato N, Yoshida M, Tsubouchi K, Kurita Y, Ito S, Fujita Y, Takasaka N, Utsumi H, Yanagisawa H, Hashimoto M, Wakui H, Kojima J, Shimizu K, …
• Analysis of drug treatment outcome in clarithromycin-resistant Mycobacterium avium complex lung disease.
  BMC infectious diseases 2016 Kadota T, Matsui H, Hirose T, Suzuki J, Saito M, Akaba T, Kobayashi K, Akashi S, Kawashima M, Tamura A, Nagai H, Akagawa S, Kobayashi N, Ohta K
• Suppression of autophagy by extracellular vesicles promotes myofibroblast differentiation in COPD pathogenesis.
  Journal of extracellular vesicles 2015 Fujita Y, Araya J, Ito S, Kobayashi K, Kosaka N, Yoshioka Y, Kadota T, Hara H, Kuwano K, Ochiya T
• Pathogens in COPD exacerbations identified by comprehensive real-time PCR plus older methods.
  International journal of chronic obstructive pulmonary disease 2015 Shimizu K, Yoshii Y, Morozumi M, Chiba N, Ubukata K, Uruga H, Hanada S, Saito N, Kadota T, Ito S, Wakui H, Takasaka N, Minagawa S, Kojima J, Hara H, Numata T, Kawaishi M, Saito K, Araya J, Kaneko Y, …
• Organizing pneumonia complicated by cyst and pneumothorax formation.
  Internal medicine (Tokyo, Japan) 2012 Kadota T, Shimizu K, Tsurushige C, Kawaishi M, Araya J, Nakayama K, Kuwano K, Hano H