Tristan Owens, PhD
Postdoctoral Scholar
Biochemistry and Biophysics
School of Medicine

Publications (14)

Top publication keywords:
Escherichia coli ProteinsNovobiocinAdenosine TriphosphatePhenylalanine-tRNA LigaseCell MembranePeptidoglycanBacterial ProteinsMultiprotein ComplexesCell WallTeichoic AcidsATP-Binding Cassette TransportersStaphylococcus aureusVibrio choleraeLipopolysaccharidesAdenosine Triphosphatases

• CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.
  Research square 2021 Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, …
• CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.
  bioRxiv : the preprint server for biology 2021 Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, …
• Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking.
  Science advances 2021 Schuller M, Correy GJ, Gahbauer S, Fearon D, Wu T, Díaz RE, Young ID, Carvalho Martins L, Smith DH, Schulze-Gahmen U, Owens TW, Deshpande I, Merz GE, Thwin AC, Biel JT, Peters JK, Moritz M, Herrera N,…
• Simple Secondary Amines Inhibit Growth of Gram-Negative Bacteria through Highly Selective Binding to Phenylalanyl-tRNA Synthetase.
  Journal of the American Chemical Society 2021 Baidin V, Owens TW, Lazarus MB, Kahne D
• Fragment Binding to the Nsp3 Macrodomain of SARS-CoV-2 Identified Through Crystallographic Screening and Computational Docking.
  bioRxiv : the preprint server for biology 2020 Schuller M, Correy GJ, Gahbauer S, Fearon D, Wu T, Díaz RE, Young ID, Martins LC, Smith DH, Schulze-Gahmen U, Owens TW, Deshpande I, Merz GE, Thwin AC, Biel JT, Peters JK, Moritz M, Herrera N, …

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• Structure and reconstitution of a hydrolase complex that may release peptidoglycan from the membrane after polymerization.
  Nature microbiology 2020 Schaefer K, Owens TW, Page JE, Santiago M, Kahne D, Walker S
• Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
  Science (New York, N.Y.) 2020 Gordon DE, Hiatt J, Bouhaddou M, Rezelj VV, Ulferts S, Braberg H, Jureka AS, Obernier K, Guo JZ, Batra J, Kaake RM, Weckstein AR, Owens TW, Gupta M, Pourmal S, Titus EW, Cakir M, Soucheray M, McGregor…
• Combining Mutations That Inhibit Two Distinct Steps of the ATP Hydrolysis Cycle Restores Wild-Type Function in the Lipopolysaccharide Transporter and Shows that ATP Binding Triggers Transport.
  mBio 2019 Simpson BW, Pahil KS, Owens TW, Lundstedt EA, Davis RM, Kahne D, Ruiz N
• Structural basis of unidirectional export of lipopolysaccharide to the cell surface.
  Nature 2019 Owens TW, Taylor RJ, Pahil KS, Bertani BR, Ruiz N, Kruse AC, Kahne D
• Novobiocin Enhances Polymyxin Activity by Stimulating Lipopolysaccharide Transport.
  Journal of the American Chemical Society 2018 Mandler MD, Baidin V, Lee J, Pahil KS, Owens TW, Kahne D
• Substrate Preferences Establish the Order of Cell Wall Assembly in Staphylococcus aureus.
  Journal of the American Chemical Society 2018 Schaefer K, Owens TW, Kahne D, Walker S
• The Antibiotic Novobiocin Binds and Activates the ATPase That Powers Lipopolysaccharide Transport.
  Journal of the American Chemical Society 2017 May JM, Owens TW, Mandler MD, Simpson BW, Lazarus MB, Sherman DJ, Davis RM, Okuda S, Massefski W, Ruiz N, Kahne D
• Antibiotic That Inhibits the ATPase Activity of an ATP-Binding Cassette Transporter by Binding to a Remote Extracellular Site.
  Journal of the American Chemical Society 2017 Matano LM, Morris HG, Hesser AR, Martin SES, Lee W, Owens TW, Laney E, Nakaminami H, Hooper D, Meredith TC, Walker S
• Identification of Residues in the Lipopolysaccharide ABC Transporter That Coordinate ATPase Activity with Extractor Function.
  mBio 2016 Simpson BW, Owens TW, Orabella MJ, Davis RM, May JM, Trauger SA, Kahne D, Ruiz N