Trevor Fidler, PhD
Assistant Professor
Cardiovascular Research Inst
School of Medicine

Education & Training

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• Postdoctoral Fellow Molecular Medicine Columbia University 2023
• PhD Pharmacology & Toxicology University of Utah 2016
• BS Biochemistry New Mexico State University 2010

Interests

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• fibroblast
• clonal hematopoiesis
• Ppm1d
• Inflammasome
• macrophage
• hematopoiesis
• Jak2
• atherosclerosis

Websites

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• Fidler Lab (trevorfidler.ucsf.edu)

Grants and Projects

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• Mechanisms of Atherogenesis in Clonal Hematopoiesis, NIH/NHLBI, 2023-2026

Publications (25)

Top publication keywords:
MacrophagesDiabetes Mellitus, ExperimentalInflammasomesPlatelet ActivationCytoplasmic GranulesGlucose Transporter Type 1Superoxide DismutaseGlucoseGlucose Transporter Type 3Blood PlateletsCell DegranulationMegakaryocytesAtherosclerosisFibrosisJanus Kinase 2

• An epigenetic switch in macrophages promotes fibrosis in the failing heart.
  Nature cardiovascular research 2024 Tall AR, Fidler TP
• Suppression of IL-1β promotes beneficial accumulation of fibroblast-like cells in atherosclerotic plaques in clonal hematopoiesis.
  Nature cardiovascular research 2024 Fidler TP, Dunbar A, Kim E, Hardaway B, Pauli J, Xue C, Abramowicz S, Xiao T, O'Connor K, Sachs N, Wang N, Maegdefessel L, Levine R, Reilly M, Tall AR
• Genetic modification of inflammation- and clonal hematopoiesis-associated cardiovascular risk.
  The Journal of clinical investigation 2023 Yu Z, Fidler TP, Ruan Y, Vlasschaert C, Nakao T, Uddin MM, Mack T, Niroula A, Heimlich JB, Zekavat SM, Gibson CJ, Griffin GK, Wang Y, Peloso GM, Heard-Costa N, Levy D, Vasan RS, Aguet F, Ardlie KG, …
• Hematopoietic NLRP3 and AIM2 Inflammasomes Promote Diabetes-Accelerated Atherosclerosis, but Increased Necrosis Is Independent of Pyroptosis.
  Diabetes 2023 Hsu CC, Fidler TP, Kanter JE, Kothari V, Kramer F, Tang J, Tall AR, Bornfeldt KE
• Endogenous SOD2 (Superoxide Dismutase) Regulates Platelet-Dependent Thrombin Generation and Thrombosis During Aging.
  Arteriosclerosis, thrombosis, and vascular biology 2022 Sonkar VK, Eustes AS, Ahmed A, Jensen M, Solanki MV, Swamy J, Kumar R, Fidler TP, Houtman JCD, Allen BG, Spitz DR, Abel ED, Dayal S

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• Erythroid lineage Jak2V617F expression promotes atherosclerosis through erythrophagocytosis and macrophage ferroptosis.
  The Journal of clinical investigation 2022 Liu W, Östberg N, Yalcinkaya M, Dou H, Endo-Umeda K, Tang Y, Hou X, Xiao T, Fidler TP, Abramowicz S, Yang YG, Soehnlein O, Tall AR, Wang N
• Modulation of the NLRP3 inflammasome by Sars-CoV-2 Envelope protein.
  Scientific reports 2021 Yalcinkaya M, Liu W, Islam MN, Kotini AG, Gusarova GA, Fidler TP, Papapetrou EP, Bhattacharya J, Wang N, Tall AR
• Oxidized Phospholipids Promote NETosis and Arterial Thrombosis in LNK(SH2B3) Deficiency.
  Circulation 2021 Dou H, Kotini A, Liu W, Fidler T, Endo-Umeda K, Sun X, Olszewska M, Xiao T, Abramowicz S, Yalcinkaya M, Hardaway B, Tsimikas S, Que X, Bick A, Emdin C, Natarajan P, Papapetrou EP, Witztum JL, Wang N, …
• The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis.
  Nature 2021 Fidler TP, Xue C, Yalcinkaya M, Hardaway B, Abramowicz S, Xiao T, Liu W, Thomas DG, Hajebrahimi MA, Pircher J, Silvestre-Roig C, Kotini AG, Luchsinger LL, Wei Y, Westerterp M, Snoeck HW, Papapetrou EP…
• Inhibition of JAK2 Suppresses Myelopoiesis and Atherosclerosis in Apoe-/- Mice.
  Cardiovascular drugs and therapy 2020 Tang Y, Liu W, Wang W, Fidler T, Woods B, Levine RL, Tall AR, Wang N
• Loss of MCU prevents mitochondrial fusion in G1-S phase and blocks cell cycle progression and proliferation.
  Science signaling 2019 Koval OM, Nguyen EK, Santhana V, Fidler TP, Sebag SC, Rasmussen TP, Mittauer DJ, Strack S, Goswami PC, Abel ED, Grumbach IM
• Glucose Metabolism Is Required for Platelet Hyperactivation in a Murine Model of Type 1 Diabetes.
  Diabetes 2019 Fidler TP, Marti A, Gerth K, Middleton EA, Campbell RA, Rondina MT, Weyrich AS, Abel ED
• Macrophage Inflammation, Erythrophagocytosis, and Accelerated Atherosclerosis in Jak2 V617F Mice.
  Circulation research 2018 Wang W, Liu W, Fidler T, Wang Y, Tang Y, Woods B, Welch C, Cai B, Silvestre-Roig C, Ai D, Yang YG, Hidalgo A, Soehnlein O, Tabas I, Levine RL, Tall AR, Wang N
• Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function.
  Cell reports 2017 Fidler TP, Campbell RA, Funari T, Dunne N, Balderas Angeles E, Middleton EA, Chaudhuri D, Weyrich AS, Abel ED
• Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function.
  Cell reports 2017 Fidler TP, Campbell RA, Funari T, Dunne N, Balderas Angeles E, Middleton EA, Chaudhuri D, Weyrch AS, Abel ED
• Superoxide Dismutase 2 is dispensable for platelet function.
  Thrombosis and haemostasis 2017 Fidler TP, Rowley JW, Araujo C, Boudreau LH, Marti A, Souvenir R, Dale K, Boilard E, Weyrich AS, Abel ED
• Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function.
  Cell reports 2017 Fidler TP, Campbell RA, Funari T, Dunne N, Balderas Angeles E, Middleton EA, Chaudhuri D, Weyrich AS, Abel ED
• Erratum: SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis.
  Nature cell biology 2017 Zhang Y, Xie L, Gunasekar SK, Tong D, Mishra A, Gibson WJ, Wang C, Fidler T, Marthaler B, Klingelhutz A, Abel ED, Samuel I, Smith JK, Cao L, Sah R
• Glucose Transporter 3 Potentiates Degranulation and Is Required for Platelet Activation.
  Arteriosclerosis, thrombosis, and vascular biology 2017 Fidler TP, Middleton EA, Rowley JW, Boudreau LH, Campbell RA, Souvenir R, Funari T, Tessandier N, Boilard E, Weyrich AS, Abel ED
• Erratum: SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis.
  Nature cell biology 2017 Zhang Y, Xie L, Gunasekar SK, Tong D, Mishra A, Gibson WJ, Wang C, Fidler T, Marthaler B, Klingelhutz A, Abel ED, Samuel I, Smith JK, Cao L, Sah R
• SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis.
  Nature cell biology 2017 Zhang Y, Xie L, Gunasekar SK, Tong D, Mishra A, Gibson WJ, Wang C, Fidler T, Marthaler B, Klingelhutz A, Abel ED, Samuel I, Smith JK, Cao L, Sah R
• Metabolic pathways of inhaled glucocorticoids by the CYP3A enzymes.
  Drug metabolism and disposition: the biological fate of chemicals 2012 Moore CD, Roberts JK, Orton CR, Murai T, Fidler TP, Reilly CA, Ward RM, Yost GS
• Cytochrome P450 2S1 depletion enhances cell proliferation and migration in bronchial epithelial cells, in part, through modulation of prostaglandin E(2) synthesis.
  Drug metabolism and disposition: the biological fate of chemicals 2012 Madanayake TW, Fidler TP, Fresquez TM, Bajaj N, Rowland AM
• Correction to "improved coiled-coil design enhances interaction with bcr-abl and induces apoptosis".
  Molecular pharmaceutics 2012 Dixon AS, Miller GD, Bruno BJ, Constance JE, Woessner DW, Fidler TP, Robertson JC, Cheatham TE, Lim CS
• Improved coiled-coil design enhances interaction with Bcr-Abl and induces apoptosis.
  Molecular pharmaceutics 2011 Dixon AS, Miller GD, Bruno BJ, Constance JE, Woessner DW, Fidler TP, Robertson JC, Cheatham TE, Lim CS