Trevor Burt, MD
Assistant Professor
Pediatrics
School of Medicine
Awards
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- Preterm Birth Initiative Award - Fetal Immune Activation and Lineage Switching in Preterm Birth, Burroughs Wellcome Fund, 2014-2018
- A Novel Approach to Study Human Fetal T Cell Differentiation and Function in vitro using iPS cells., University of California San Francisco, 2014-2015
- Young Physician Scientist Award, American Society for Clinical Investigation, 2014
- “Outside the Box” AIDS Vaccine Discovery Award, UCSF-Gladstone Institute of Virology and Immunology Center for AIDS Research (CFAR), 2010-2011
- PSDP Fellowship, Pediatric Scientist Development Program (PSDP), 2006-2009
- Sarnoff Fellowship, Sarnoff Cardiovascular Research Foundation, 2000-2001
Education & Training
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- M.D. School of Medicine Harvard University 2002
Interests
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- Mechanisms of fetal-maternal tolerance
- Fetal and neonatal immune response to infections
- Use of ES and iPS cell technologies to study immune development
- Human immune system development
- Immunopathogenesis of preterm labor
Websites
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- Clinical Profile at UCSF Medical Center (ucsfhealth.org)
Grants and Projects
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Publications (31)
Top publication keywords:
CD4-Positive T-LymphocytesIkaros Transcription FactorHeme Oxygenase-1FetusMyeloid CellsSingle-Cell AnalysisT-LymphocytesNK Cell Lectin-Like Receptor Subfamily BHematopoietic Stem CellsGlycogen Storage Disease Type IIMucous MembraneImmune SystemLymphoid TissueT-Lymphocytes, RegulatoryIntestines
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Subventricular zone stem cell niche injury is associated with intestinal perforation in preterm infants and predicts future motor impairment.
Cell stem cell 2024 Epstein AA, Janos SN, Menozzi L, Pegram K, Jain V, Bisset LC, Davis JT, Morrison S, Shailaja A, Guo Y, Chao AS, Abdi K, Rikard B, Yao J, Gregory SG, Fisher K, Pittman R, Erkanli A, Gustafson KE, … -
An updated management approach of Pompe disease patients with high-sustained anti-rhGAA IgG antibody titers: experience with bortezomib-based immunomodulation.
Frontiers in immunology 2024 Desai AK, Shrivastava G, Grant CL, Wang RY, Burt TD, Kishnani PS -
Immunophenotype associated with high sustained antibody titers against enzyme replacement therapy in infantile-onset Pompe disease.
Frontiers in immunology 2024 Desai AK, Smith PB, Yi JS, Rosenberg AS, Burt TD, Kishnani PS -
Homeostatic cytokines reciprocally modulate the emergence of prenatal effector PLZF+CD4+ T cells in humans.
JCI insight 2023 Locher V, Park S, Bunis DG, Makredes S, Mayer M, Burt TD, Fragiadakis GK, Halkias J -
In utero human cytomegalovirus infection expands NK cell-like FcγRIII-expressing CD8+ T cells that mediate antibody-dependent functions.
medRxiv : the preprint server for health sciences 2023 Semmes EC, Nettere DR, Nelson AN, Hurst JH, Cain D, Burt TD, Kurtzberg J, Reeves RK, Coyne CB, Fouda GG, Pollara J, Permar SR, Walsh KM
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Human fetal T cells: Insights into developmental specialization and mechanisms of lineage transition.
Immunological reviews 2023 Burt TD, McCune JM -
Heritable vaginal bacteria influence immune tolerance and relate to early-life markers of allergic sensitization in infancy.
Cell reports. Medicine 2022 McCauley KE, Rackaityte E, LaMere B, Fadrosh DW, Fujimura KE, Panzer AR, Lin DL, Lynch KV, Halkias J, Mendoza VF, Burt TD, Bendixsen C, Barnes K, Kim H, Jones K, Ownby DR, Johnson CC, Seroogy CM, Gern… -
Increases in ambient air pollutants during pregnancy are linked to increases in methylation of IL4, IL10, and IFNγ.
Clinical epigenetics 2022 Aguilera J, Han X, Cao S, Balmes J, Lurmann F, Tyner T, Lutzker L, Noth E, Hammond SK, Sampath V, Burt T, Utz PJ, Khatri P, Aghaeepour N, Maecker H, Prunicki M, Nadeau K -
dittoSeq: universal user-friendly single-cell and bulk RNA sequencing visualization toolkit.
Bioinformatics (Oxford, England) 2021 Bunis DG, Andrews J, Fragiadakis GK, Burt TD, Sirota M -
Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla.
Nature communications 2021 Bautista JL, Cramer NT, Miller CN, Chavez J, Berrios DI, Byrnes LE, Germino J, Ntranos V, Sneddon JB, Burt TD, Gardner JM, Ye CJ, Anderson MS, Parent AV -
Understanding Early-Life Adaptive Immunity to Guide Interventions for Pediatric Health.
Frontiers in immunology 2021 Semmes EC, Chen JL, Goswami R, Burt TD, Permar SR, Fouda GG -
Corroborating evidence refutes batch effect as explanation for fetal bacteria.
Microbiome 2021 Rackaityte E, Halkias J, Fukui EM, Mendoza VF, Hayzelden C, Crawford ED, Fujimura KE, Burt TD, Lynch SV -
Single-Cell Mapping of Progressive Fetal-to-Adult Transition in Human Naive T Cells.
Cell reports 2021 Bunis DG, Bronevetsky Y, Krow-Lucal E, Bhakta NR, Kim CC, Nerella S, Jones N, Mendoza VF, Bryson YJ, Gern JE, Rutishauser RL, Ye CJ, Sirota M, McCune JM, Burt TD -
Viable bacterial colonization is highly limited in the human intestine in utero.
Nature medicine 2020 Rackaityte E, Halkias J, Fukui EM, Mendoza VF, Hayzelden C, Crawford ED, Fujimura KE, Burt TD, Lynch SV -
Helios enhances the preferential differentiation of human fetal CD4+ naïve T cells into regulatory T cells.
Science immunology 2019 Ng MSF, Roth TL, Mendoza VF, Marson A, Burt TD -
Landscape of stimulation-responsive chromatin across diverse human immune cells.
Nature genetics 2019 Calderon D, Nguyen MLT, Mezger A, Kathiria A, Müller F, Nguyen V, Lescano N, Wu B, Trombetta J, Ribado JV, Knowles DA, Gao Z, Blaeschke F, Parent AV, Burt TD, Anderson MS, Criswell LA, Greenleaf WJ, … -
CD161 contributes to prenatal immune suppression of IFNγ-producing PLZF+ T cells.
The Journal of clinical investigation 2019 Halkias J, Rackaityte E, Hillman SL, Aran D, Mendoza VF, Marshall LR, MacKenzie TC, Burt TD -
In utero priming of highly functional effector T cell responses to human malaria.
Science translational medicine 2018 Odorizzi PM, Jagannathan P, McIntyre TI, Budker R, Prahl M, Auma A, Burt TD, Nankya F, Nalubega M, Sikyomu E, Musinguzi K, Naluwu K, Kakuru A, Dorsey G, Kamya MR, Feeney ME -
Correction: Anti-TNF and thiopurine therapy in pregnant IBD patients does not significantly alter a panel of B-cell and T-cell subsets in 1-year-old infants.
Clinical and translational gastroenterology 2018 Kattah MG, Milush JM, Burt T, McCabe RP, Whang MI, Ma A, Mahadevan U -
Anti-TNF and thiopurine therapy in pregnant IBD patients does not significantly alter a panel of B-cell and T-cell subsets in 1-year-old infants.
Clinical and translational gastroenterology 2018 Kattah MG, Milush JM, Burt T, McCabe RP, Whang MI, Ma A, Mahadevan U -
Lin28b Regulates Fetal Regulatory T Cell Differentiation through Modulation of TGF-β Signaling.
Journal of immunology (Baltimore, Md. : 1950) 2016 Bronevetsky Y, Burt TD, McCune JM -
Levels of circulating myeloid subpopulations and of heme oxygenase-1 do not predict CD4(+) T cell recovery after the initiation of antiretroviral therapy for HIV disease.
AIDS research and therapy 2014 Seu L, Ortiz GM, Burt TD, Deeks SG, Martin JN, McCune JM -
Distinct functional programming of human fetal and adult monocytes.
Blood 2014 Krow-Lucal ER, Kim CC, Burt TD, McCune JM -
Fetal regulatory T cells and peripheral immune tolerance in utero: implications for development and disease.
American journal of reproductive immunology (New York, N.Y. : 1989) 2013 Burt TD -
Variations in the heme oxygenase-1 microsatellite polymorphism are associated with plasma CD14 and viral load in HIV-infected African-Americans.
Genes and immunity 2011 Seu L, Burt TD, Witte JS, Martin JN, Deeks SG, McCune JM -
Fetal and adult hematopoietic stem cells give rise to distinct T cell lineages in humans.
Science (New York, N.Y.) 2010 Mold JE, Venkatasubrahmanyam S, Burt TD, Michaëlsson J, Rivera JM, Galkina SA, Weinberg K, Stoddart CA, McCune JM -
Naive human T cells are activated and proliferate in response to the heme oxygenase-1 inhibitor tin mesoporphyrin.
Journal of immunology (Baltimore, Md. : 1950) 2010 Burt TD, Seu L, Mold JE, Kappas A, McCune JM -
Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero.
Science (New York, N.Y.) 2008 Mold JE, Michaëlsson J, Burt TD, Muench MO, Beckerman KP, Busch MP, Lee TH, Nixon DF, McCune JM -
Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression.
Proceedings of the National Academy of Sciences of the United States of America 2008 Burt TD, Agan BK, Marconi VC, He W, Kulkarni H, Mold JE, Cavrois M, Huang Y, Mahley RW, Dolan MJ, McCune JM, Ahuja SK -
Increased circulating interleukin-7 levels in HIV-1-infected women.
Journal of acquired immune deficiency syndromes (1999) 2005 Napolitano LA, Burt TD, Bacchetti P, Barrón Y, French AL, Kovacs A, Anastos K, Young M, McCune JM, Greenblatt RM -
Medial smooth muscle cell loss in arterial allografts occurs by cytolytic cell induced apoptosis.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 1998 Hirsch GM, Kearsey J, Burt T, Karnovsky MJ, Lee T