Tom Arnold, MD
Associate Professor
Pediatrics
School of Medicine

Publications (35)

Top publication keywords:
Hydrothermal VentsNeovascularization, PhysiologicAlismatalesIntegrinsCentral Nervous System Vascular MalformationsMembrane Transport ProteinsInterneuronsEmbryo LossTransforming Growth Factor beta1Gene Knock-In TechniquesIntegrin beta ChainsBlood-Brain BarrierEndothelial CellsMicrogliaTransforming Growth Factor beta

• Microglia are not necessary for maintenance of blood-brain barrier properties in health, but PLX5622 alters brain endothelial cholesterol metabolism.
  Neuron 2024 Profaci CP, Harvey SS, Bajc K, Zhang TZ, Jeffrey DA, Zhang AZ, Nemec KM, Davtyan H, O'Brien CA, McKinsey GL, Longworth A, McMullen TP, Capocchi JK, Gonzalez JG, Lawson DA, Arnold TD, Davalos D, …
• Dysregulation of FLVCR1a-dependent mitochondrial calcium handling in neural progenitors causes congenital hydrocephalus.
  Cell reports. Medicine 2024 Bertino F, Mukherjee D, Bonora M, Bagowski C, Nardelli J, Metani L, Zanin Venturini DI, Chianese D, Santander N, Salaroglio IC, Hentschel A, Quarta E, Genova T, McKinney AA, Allocco AL, Fiorito V, …
• Structural and molecular basis of choline uptake into the brain by FLVCR2.
  Nature 2024 Cater RJ, Mukherjee D, Gil-Iturbe E, Erramilli SK, Chen T, Koo K, Santander N, Reckers A, Kloss B, Gawda T, Choy BC, Zhang Z, Katewa A, Larpthaveesarp A, Huang EJ, Mooney SWJ, Clarke OB, Yee SW, …
• Type-I-interferon-responsive microglia shape cortical development and behavior.
  Cell 2024 Escoubas CC, Dorman LC, Nguyen PT, Lagares-Linares C, Nakajo H, Anderson SR, Barron JJ, Wade SD, Cuevas B, Vainchtein ID, Silva NJ, Guajardo R, Xiao Y, Lidsky PV, Wang EY, Rivera BM, Taloma SE, Kim DK…
• A comparative evaluation of the strengths and potential caveats of the microglial inducible CreER mouse models.
  Cell reports 2024 Bedolla AM, McKinsey GL, Ware K, Santander N, Arnold TD, Luo Y

Show all (30 more) Hide

• PTP1B mediates the inhibitory effect of MFGE8 on insulin signaling through the β5 integrin.
  The Journal of biological chemistry 2024 Datta R, Mukherjee D, Podolsky MJ, Yang CD, Alba DL, Singh S, Arnold TD, Koliwad S, Lizama CO, Atabai K
• Structural and molecular basis of choline uptake into the brain by FLVCR2.
  bioRxiv : the preprint server for biology 2023 Cater RJ, Mukherjee D, Iturbe EG, Erramilli SK, Chen T, Koo K, Grez NS, Reckers A, Kloss B, Gawda T, Choy BC, Zheng Z, Clarke OB, Yee SW, Kossiakoff AA, Quick M, Arnold T, Mancia F
• APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFβ-mediated checkpoints.
  Nature immunology 2023 Yin Z, Rosenzweig N, Kleemann KL, Zhang X, Brandão W, Margeta MA, Schroeder C, Sivanathan KN, Silveira S, Gauthier C, Mallah D, Pitts KM, Durao A, Herron S, Shorey H, Cheng Y, Barry JL, Krishnan RK, …
• Radial glia promote microglial development through integrin αVβ8 -TGFβ1 signaling.
  bioRxiv : the preprint server for biology 2023 McKinsey GL, Santander N, Zhang X, Kleemann K, Tran L, Katewa A, Conant K, Barraza M, Waddell K, Lizama C, La Russa M, Koo HJ, Lee H, Mukherjee D, Paidassi H, Anton ES, Atabai K, Sheppard D, Butovsky …
• Finding the right tool: a comprehensive evaluation of microglial inducible cre mouse models.
  bioRxiv : the preprint server for biology 2023 Bedolla A, Mckinsey G, Ware K, Santander N, Arnold T, Luo Y
• MFGE8 links absorption of dietary fatty acids with catabolism of enterocyte lipid stores through HNF4γ-dependent transcription of CES enzymes.
  Cell reports 2023 Datta R, Gholampour MA, Yang CD, Volk R, Lin S, Podolsky MJ, Arnold T, Rieder F, Zaro BW, Verzi M, Lehner R, Abumrad N, Lizama CO, Atabai K
• The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not endothelial cells: Implications for COVID-19 vascular research.
  Stem cell reports 2022 Muhl L, He L, Sun Y, Andaloussi Mäe M, Pietilä R, Liu J, Genové G, Zhang L, Xie Y, Leptidis S, Mocci G, Stritt S, Osman A, Anisimov A, Hemanthakumar KA, Räsänen M, Hansson EM, Björkegren J, …
• Microglia are involved in the protection of memories formed during sleep deprivation.
  Neurobiology of sleep and circadian rhythms 2021 Gentry NW, McMahon T, Yamazaki M, Webb J, Arnold TD, Rosi S, Ptácek LJ, Fu YH
• αVβ8 integrin targeting to prevent posterior capsular opacification.
  JCI insight 2021 Shihan MH, Novo SG, Wang Y, Sheppard D, Atakilit A, Arnold TD, Rossi NM, Faranda AP, Duncan MK
• Bone Marrow-Derived Alk1 Mutant Endothelial Cells and Clonally Expanded Somatic Alk1 Mutant Endothelial Cells Contribute to the Development of Brain Arteriovenous Malformations in Mice.
  Translational stroke research 2021 Shaligram SS, Zhang R, Zhu W, Ma L, Luo M, Li Q, Weiss M, Arnold T, Santander N, Liang R, do Prado L, Tang C, Pan F, Oh SP, Pan P, Su H
• Enrichment of Vascular Fragments from Mouse Embryonic Brains for Endothelial Cell Analysis.
  Bio-protocol 2021 Santander N, Arnold TD
• CNS fibroblasts form a fibrotic scar in response to immune cell infiltration.
  Nature neuroscience 2021 Dorrier CE, Aran D, Haenelt EA, Sheehy RN, Hoi KK, Pintaric L, Chen Y, Lizama CO, Cautivo KM, Weiner GA, Popko B, Fancy SPJ, Arnold TD, Daneman R
• Lack of Flvcr2 impairs brain angiogenesis without affecting the blood-brain barrier.
  The Journal of clinical investigation 2020 Santander N, Lizama CO, Meky E, McKinsey GL, Jung B, Sheppard D, Betsholtz C, Arnold TD
• A new genetic strategy for targeting microglia in development and disease.
  eLife 2020 McKinsey GL, Lizama CO, Keown-Lang AE, Niu A, Santander N, Larpthaveesarp A, Chee E, Gonzalez FF, Arnold TD
• Disruption of the Extracellular Matrix Progressively Impairs Central Nervous System Vascular Maturation Downstream of β-Catenin Signaling.
  Arteriosclerosis, thrombosis, and vascular biology 2019 Jensen LD, Hot B, Ramsköld D, Germano RFV, Yokota C, Giatrellis S, Lauschke VM, Hubmacher D, Li MX, Hupe M, Arnold TD, Sandberg R, Frisén J, Trusohamn M, Martowicz A, Wisniewska-Kruk J, Nyqvist D, …
• Impaired αVβ8 and TGFβ signaling lead to microglial dysmaturation and neuromotor dysfunction.
  The Journal of experimental medicine 2019 Arnold TD, Lizama CO, Cautivo KM, Santander N, Lin L, Qiu H, Huang EJ, Liu C, Mukouyama YS, Reichardt LF, Zovein AC, Sheppard D
• Tissue Myeloid Progenitors Differentiate into Pericytes through TGF-β Signaling in Developing Skin Vasculature.
  Cell reports 2017 Yamazaki T, Nalbandian A, Uchida Y, Li W, Arnold TD, Kubota Y, Yamamoto S, Ema M, Mukouyama YS
• Visualization of vascular mural cells in developing brain using genetically labeled transgenic reporter mice.
  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2017 Jung B, Arnold TD, Raschperger E, Gaengel K, Betsholtz C
• The αvβ1 integrin plays a critical in vivo role in tissue fibrosis.
  Science translational medicine 2015 Reed NI, Jo H, Chen C, Tsujino K, Arnold TD, DeGrado WF, Sheppard D
• LSR/angulin-1 is a tricellular tight junction protein involved in blood-brain barrier formation.
  The Journal of cell biology 2015 Sohet F, Lin C, Munji RN, Lee SY, Ruderisch N, Soung A, Arnold TD, Derugin N, Vexler ZS, Yen FT, Daneman R
• Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking αVβ8-TGFβ signaling in the brain.
  Development (Cambridge, England) 2014 Arnold TD, Niaudet C, Pang MF, Siegenthaler J, Gaengel K, Jung B, Ferrero GM, Mukouyama YS, Fuxe J, Akhurst R, Betsholtz C, Sheppard D, Reichardt LF
• Mesangial cell αvβ8-integrin regulates glomerular capillary integrity and repair.
  American journal of physiology. Renal physiology 2014 Lakhe-Reddy S, Li V, Arnold TD, Khan S, Schelling JR
• Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs.
  Nature medicine 2013 Henderson NC, Arnold TD, Katamura Y, Giacomini MM, Rodriguez JD, McCarty JH, Pellicoro A, Raschperger E, Betsholtz C, Ruminski PG, Griggs DW, Prinsen MJ, Maher JJ, Iredale JP, Lacy-Hulbert A, Adams RH…
• Deletion of integrin-linked kinase from neural crest cells in mice results in aortic aneurysms and embryonic lethality.
  Disease models & mechanisms 2013 Arnold TD, Zang K, Vallejo-Illarramendi A
• Transcriptional corepressors HIPK1 and HIPK2 control angiogenesis via TGF-β-TAK1-dependent mechanism.
  PLoS biology 2013 Shang Y, Doan CN, Arnold TD, Lee S, Tang AA, Reichardt LF, Huang EJ
• Ocean acidification and the loss of phenolic substances in marine plants.
  PloS one 2012 Arnold T, Mealey C, Leahey H, Miller AW, Hall-Spencer JM, Milazzo M, Maers K
• Defective retinal vascular endothelial cell development as a consequence of impaired integrin αVβ8-mediated activation of transforming growth factor-β.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Arnold TD, Ferrero GM, Qiu H, Phan IT, Akhurst RJ, Huang EJ, Reichardt LF
• Analysis of genomewide association signals for nonsyndromic cleft lip/palate in a Kenya African Cohort.
  American journal of medical genetics. Part A 2011 Weatherley-White RC, Ben S, Jin Y, Riccardi S, Arnold TD, Spritz RA
• From death to recovery following hypoxia ischemia: if TGFbeta is a central regulator, is integrin beta8 the switch?
  Neurotoxicity research 2010 Arnold TD, McQuillen PS
• Distribution of orofacial clefts and frequent occurrence of an unusual cleft variant in the Rift Valley of Kenya.
  The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 2007 Spritz RA, Arnold TD, Buonocore S, Carter D, Fingerlin T, Odero WW, Wambani JO, Tenge RK, Weatherley-White RC