Tippi Mackenzie, MD
Professor
Surgery
School of Medicine

At present, the MacKenzie group is focused on preterm labor and fetal therapies including stem cell transplantation, enzyme replacement therapy, and gene therapy.

• Are we prepared to deliver gene-targeted therapies for rare diseases?
  American journal of medical genetics. Part C, Seminars in medical genetics 2023 Yu TW, Kingsmore SF, Green RC, MacKenzie T, Wasserstein M, Caggana M, Gold NB, Kennedy A, Kishnani PS, Might M, Brooks PJ, Morris JA, Parisi MA, Urv TK
• The impact of in utero transfusions on perinatal outcomes in patients with alpha thalassemia major: the UCSF registry.
  Blood advances 2023 Schwab ME, Lianoglou BR, Gano D, Gonzalez Velez J, Allen IE, Arvon R, Baschat A, Bianchi DW, Bitanga M, Bourguignon A, Brown RN, Chen B, Chien M, Davis-Nelson S, de Laat MWM, Ekwattanakit S, Gollin Y,…
• Investigating attitudes toward prenatal diagnosis and fetal therapy for spinal muscular atrophy.
  Prenatal diagnosis 2022 Schwab ME, Shao S, Zhang L, Lianoglou B, Belter L, Jarecki J, Schroth M, Sumner CJ, MacKenzie T
• Prenatal Somatic Cell Gene Therapies: Charting a Path Toward Clinical Applications (Proceedings of the CERSI-FDA Meeting).
  Journal of clinical pharmacology 2022 Herzeg A, Almeida-Porada G, Charo RA, David AL, Gonzalez-Velez J, Gupta N, Lapteva L, Lianoglou B, Peranteau W, Porada C, Sanders SJ, Sparks TN, Stitelman DH, Struble E, Sumner CJ, MacKenzie TC
• Thymic and extrathymic Aire-expressing cells in maternal-fetal tolerance.
  Immunological reviews 2022 Sun IH, Gillis-Buck E, Mackenzie TC, Gardner JM
• Consensus statement for the perinatal management of patients with α thalassemia major.
  Blood advances 2021 MacKenzie TC, Amid A, Angastiniotis M, Butler C, Gilbert S, Gonzalez J, Keller RL, Kharbanda S, Kirby-Allen M, Koenig BA, Kyono W, Lal A, Lianoglou BR, Norton ME, Ogasawara KK, Panchalee T, Rosner M, …
• Advances in the management of α-thalassemia major: reasons to be optimistic.
  Hematology. American Society of Hematology. Education Program 2021 Horvei P, MacKenzie T, Kharbanda S
• Prenatal Gene Therapy.
  Clinical obstetrics and gynecology 2021 Schwab ME, MacKenzie TC
• Maternal and Infant Immune Repertoire Sequencing Analysis Identifies Distinct Ig and TCR Development in Term and Preterm Infants.
  Journal of immunology (Baltimore, Md. : 1950) 2021 Le BL, Sper R, Nielsen SCA, Pineda S, Nguyen QH, Lee JY, Boyd SD, MacKenzie TC, Sirota M
• Exome sequencing of fetuses with congenital diaphragmatic hernia supports a causal role for NR2F2, PTPN11, and WT1 variants.
  American journal of surgery 2021 Schwab ME, Dong S, Lianoglou BR, Aguilar Lucero AF, Schwartz GB, Norton ME, MacKenzie TC, Sanders SJ
• Extrathymic Aire-expressing cells support maternal-fetal tolerance.
  Science immunology 2021 Gillis-Buck E, Miller H, Sirota M, Sanders SJ, Ntranos V, Anderson MS, Gardner JM, MacKenzie TC
• Forever Connected: The Lifelong Biological Consequences of Fetomaternal and Maternofetal Microchimerism.
  Clinical chemistry 2021 Bianchi DW, Khosrotehrani K, Way SS, MacKenzie TC, Bajema I, O'Donoghue K
• Fetal and Maternal Safety Considerations for In Utero Therapy Clinical Trials: iFeTiS Consensus Statement.
  Molecular therapy : the journal of the American Society of Gene Therapy 2020 Sagar R, Almeida-Porada G, Blakemore K, Chan JKY, Choolani M, Götherström C, Jaulent A, MacKenzie TC, Mattar C, Porada CD, Peranteau WH, Schneider H, Shaw SW, Waddington SN, Westgren M, David AL
• Exome Sequencing for Prenatal Diagnosis in Nonimmune Hydrops Fetalis.
  The New England journal of medicine 2020 Sparks TN, Lianoglou BR, Adami RR, Pluym ID, Holliman K, Duffy J, Downum SL, Patel S, Faubel A, Boe NM, Field NT, Murphy A, Laurent LC, Jolley J, Uy C, Slavotinek AM, Devine P, Hodoglugil U, Van …
• Detection of microbial cell-free DNA in maternal and umbilical cord plasma in patients with chorioamnionitis using next generation sequencing.
  PloS one 2020 Witt RG, Blair L, Frascoli M, Rosen MJ, Nguyen QH, Bercovici S, Zompi S, Romero R, Mackenzie TC
• Tolerance induction and microglial engraftment after fetal therapy without conditioning in mice with Mucopolysaccharidosis type VII.
  Science translational medicine 2020 Nguyen QH, Witt RG, Wang B, Eikani C, Shea J, Smith LK, Boyle G, Cadaoas J, Sper R, MacKenzie JD, Villeda S, MacKenzie TC
• CD161 contributes to prenatal immune suppression of IFNγ-producing PLZF+ T cells.
  The Journal of clinical investigation 2019 Halkias J, Rackaityte E, Hillman SL, Aran D, Mendoza VF, Marshall LR, MacKenzie TC, Burt TD
• In Utero Gene Therapy Consensus Statement from the IFeTIS.
  Molecular therapy : the journal of the American Society of Gene Therapy 2019 Almeida-Porada G, Waddington SN, Chan JKY, Peranteau WH, MacKenzie T, Porada CD
• Evaluation of Clinical Outcomes of Sutureless vs Sutured Closure Techniques in Gastroschisis Repair.
  JAMA surgery 2019 Witt RG, Zobel M, Padilla B, Lee H, MacKenzie TC, Vu L
• Depletion of murine fetal hematopoietic stem cells with c-Kit receptor and CD47 blockade improves neonatal engraftment.
  Blood advances 2018 Witt RG, Wang B, Nguyen QH, Eikani C, Mattis AN, MacKenzie TC
• Large Differences in Small RNA Composition Between Human Biofluids.
  Cell reports 2018 Godoy PM, Bhakta NR, Barczak AJ, Cakmak H, Fisher S, MacKenzie TC, Patel T, Price RW, Smith JF, Woodruff PG, Erle DJ
• Future AAVenues for In Utero Gene Therapy.
  Cell stem cell 2018 MacKenzie TC
• Meta-Analysis of Maternal and Fetal Transcriptomic Data Elucidates the Role of Adaptive and Innate Immunity in Preterm Birth.
  Frontiers in immunology 2018 Vora B, Wang A, Kosti I, Huang H, Paranjpe I, Woodruff TJ, MacKenzie T, Sirota M
• Alloreactive fetal T cells promote uterine contractility in preterm labor via IFN-γ and TNF-α.
  Science translational medicine 2018 Frascoli M, Coniglio L, Witt R, Jeanty C, Fleck-Derderian S, Myers DE, Lee TH, Keating S, Busch MP, Norris PJ, Tang Q, Cruz G, Barcellos LF, Gomez-Lopez N, Romero R, MacKenzie TC
• Systemic multilineage engraftment in mice after in utero transplantation with human hematopoietic stem cells.
  Blood advances 2018 Witt RG, Kreger EM, Buckman LB, Moradi PW, Ho PT, Derderian SC, Tsai P, Baker C, Schramm N, Cleary R, Garcia JV, MacKenzie TC
• Esophagoesophagopexy technique for assisted fistulization of esophageal atresia.
  Pediatric surgery international 2017 Chumfong I, Lee H, Padilla BE, MacKenzie TC, Vu LT
• Non-Immune Hydrops Fetalis: Do Placentomegaly and Polyhydramnios Matter?
  Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine 2017 Berger VK, Sparks TN, Jelin AC, Derderian C, Jeanty C, Gosnell K, Mackenzie T, Gonzalez JM
• Sacrococcygeal teratoma: late recurrence warrants long-term surveillance.
  Pediatric surgery international 2017 Padilla BE, Vu L, Lee H, MacKenzie T, Bratton B, O'Day M, Derderian S
• Fetal stem cell and gene therapy.
  Seminars in fetal & neonatal medicine 2017 Witt R, MacKenzie TC, Peranteau WH
• Epidemiology of Live Born Infants with Nonimmune Hydrops Fetalis-Insights from a Population-Based Dataset.
  The Journal of pediatrics 2017 Steurer MA, Peyvandi S, Baer RJ, MacKenzie T, Li BC, Norton ME, Jelliffe-Pawlowski LL, Moon-Grady AJ
• Favorable outcomes after in utero transfusion in fetuses with alpha thalassemia major: a case series and review of the literature.
  Prenatal diagnosis 2016 Kreger EM, Singer ST, Witt RG, Sweeters N, Lianoglou B, Lal A, Mackenzie TC, Vichinsky E
• A Transient Developmental Hematopoietic Stem Cell Gives Rise to Innate-like B and T Cells.
  Cell stem cell 2016 Beaudin AE, Boyer SW, Perez-Cunningham J, Hernandez GE, Derderian SC, Jujjavarapu C, Aaserude E, MacKenzie T, Forsberg EC
• Magnetic resonance imaging of Müllerian duct anomalies in children.
  Pediatric radiology 2016 Li Y, Phelps A, Zapala MA, MacKenzie JD, MacKenzie TC, Courtier J
• Heightened Immune Activation in Fetuses with Gastroschisis May Be Blocked by Targeting IL-5.
  Journal of immunology (Baltimore, Md. : 1950) 2016 Frascoli M, Jeanty C, Fleck S, Moradi PW, Keating S, Mattis AN, Tang Q, MacKenzie TC
• Mass Effect Alone May Not Explain Pulmonary Vascular Pathology in Severe Congenital Diaphragmatic Hernia.
  Fetal diagnosis and therapy 2015 Derderian SC, Jayme CM, Cheng LS, Keller RL, Moon-Grady AJ, MacKenzie TC
• Fetal Surgical conditions and the unraveling of maternal-fetal tolerance.
  Journal of pediatric surgery 2015 MacKenzie TC
• A booster shot to cure hemoglobinopathies.
  Blood 2015 Walters MC, MacKenzie TC
• Maternal factors associated with the occurrence of gastroschisis.
  American journal of medical genetics. Part A 2015 Baer RJ, Chambers CD, Jones KL, Shew SB, MacKenzie TC, Shaw GM, Jelliffe-Pawlowski LL
• Increased maternal T cell microchimerism in the allogeneic fetus during LPS-induced preterm labor in mice.
  Chimerism 2015 Wegorzewska M, Le T, Tang Q, MacKenzie TC
• Consensus statement from the first international conference for in utero stem cell transplantation and gene therapy.
  Frontiers in pharmacology 2015 MacKenzie TC, David AL, Flake AW, Almeida-Porada G
• In utero hematopoietic cell transplantation for hemoglobinopathies.
  Frontiers in pharmacology 2015 Derderian SC, Jeanty C, Walters MC, Vichinsky E, MacKenzie TC
• Placental drug delivery for treatment of congenital hematopoietic disorders.
  Journal of pediatric surgery 2014 Derderian SC, Moradi PW, MacKenzie TC
• The many faces of hydrops.
  Journal of pediatric surgery 2014 Derderian SC, Jeanty C, Fleck SR, Cheng LS, Peyvandi S, Moon-Grady AJ, Farrell J, Hirose S, Gonzalez J, Keller RL, MacKenzie TC
• Novel non-surgical prenatal approaches to treating congenital diaphragmatic hernia.
  Seminars in fetal & neonatal medicine 2014 Jeanty C, Kunisaki SM, MacKenzie TC
• Favorable outcomes in high-risk congenital pulmonary airway malformations treated with multiple courses of maternal betamethasone.
  Journal of pediatric surgery 2014 Derderian SC, Coleman AM, Jeanty C, Lim FY, Shaaban AM, Farrell JA, Hirose S, MacKenzie TC, Lee H
• Maternal-fetal cellular trafficking: clinical implications and consequences.
  Current opinion in pediatrics 2014 Jeanty C, Derderian SC, Mackenzie TC
• In utero depletion of fetal hematopoietic stem cells improves engraftment after neonatal transplantation in mice.
  Blood 2014 Derderian SC, Togarrati PP, King C, Moradi PW, Reynaud D, Czechowicz A, Weissman IL, MacKenzie TC
• Memory regulatory T cells reside in human skin.
  The Journal of clinical investigation 2014 Sanchez Rodriguez R, Pauli ML, Neuhaus IM, Yu SS, Arron ST, Harris HW, Yang SH, Anthony BA, Sverdrup FM, Krow-Lucal E, MacKenzie TC, Johnson DS, Meyer EH, Löhr A, Hsu A, Koo J, Liao W, Gupta R, …
• Outcomes of fetal intervention for primary hydrothorax.
  Journal of pediatric surgery 2014 Derderian SC, Trivedi S, Farrell J, Keller RL, Rand L, Goldstein R, Feldstein VA, Hirose S, MacKenzie TC
• Fetal intervention increases maternal T cell awareness of the foreign conceptus and can lead to immune-mediated fetal demise.
  Journal of immunology (Baltimore, Md. : 1950) 2014 Wegorzewska M, Nijagal A, Wong CM, Le T, Lescano N, Tang Q, MacKenzie TC
• Anal duplication in a one-year-old girl.
  Journal of pediatric surgery case reports 2013 Cheng LS, Courtier J, MacKenzie TC
• Fetal production of growth factors and inflammatory mediators predicts pulmonary hypertension in congenital diaphragmatic hernia.
  Pediatric research 2013 Fleck S, Bautista G, Keating SM, Lee TH, Keller RL, Moon-Grady AJ, Gonzales K, Norris PJ, Busch MP, Kim CJ, Romero R, Lee H, Miniati D, MacKenzie TC
• Direct and indirect antigen presentation lead to deletion of donor-specific T cells after in utero hematopoietic cell transplantation in mice.
  Blood 2013 Nijagal A, Derderian C, Le T, Jarvis E, Nguyen L, Tang Q, Mackenzie TC
• Clinical implications of maternal-fetal cellular trafficking.
  Seminars in pediatric surgery 2013 Nijagal A, MacKenzie TC
• Hepatic portocholecystostomy for biliary atresia: a 25-year follow-up and review.
  Journal of pediatric surgery 2013 Schecter SC, Courtier J, Cho SJ, Saadai P, Hirose S, Mackenzie TC, Miniati D
• Type IV intestinal atresia, congenital bilateral perisylvian syndrome, and chronic pulmonary hypertension secondary to multiple vascular disruption syndrome in a monochorionic twin.
  Journal of pediatric surgery 2012 Shue EH, Soares B, Courtier J, Hogue J, Shimotake T, MacKenzie TC
• The diagnosis and management of intradiaphragmatic extralobar pulmonary sequestrations: a report of 4 cases.
  Journal of pediatric surgery 2012 Nijagal A, Jelin E, Feldstein VA, Courtier J, Urisman A, Jones KD, Lee H, Hirose S, MacKenzie TC
• Increased maternal microchimerism after open fetal surgery.
  Chimerism 2012 Saadai P, MacKenzie TC
• Alterations in maternal-fetal cellular trafficking after fetal surgery.
  Journal of pediatric surgery 2012 Saadai P, Lee TH, Bautista G, Gonzales KD, Nijagal A, Busch MP, Kim CJ, Romero R, Lee H, Hirose S, Rand L, Miniati D, Farmer DL, MacKenzie TC
• Long-term outcomes after fetal therapy for congenital high airway obstructive syndrome.
  Journal of pediatric surgery 2012 Saadai P, Jelin EB, Nijagal A, Schecter SC, Hirose S, MacKenzie TC, Rand L, Goldstein R, Farrell J, Harrison M, Lee H
• In utero hematopoietic cell transplantation for the treatment of congenital anomalies.
  Clinics in perinatology 2012 Nijagal A, Flake AW, MacKenzie TC
• Maternal microchimerism in patients with biliary atresia: Implications for allograft tolerance.
  Chimerism 2012 Nijagal A, Fleck S, MacKenzie TC
• Decreased risk of graft failure with maternal liver transplantation in patients with biliary atresia.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2011 Nijagal A, Fleck S, Hills NK, Feng S, Tang Q, Kang SM, Rosenthal P, MacKenzie TC
• Pancreatic mesenchyme regulates epithelial organogenesis throughout development.
  PLoS biology 2011 Landsman L, Nijagal A, Whitchurch TJ, Vanderlaan RL, Zimmer WE, Mackenzie TC, Hebrok M
• The maternal immune response inhibits the success of in utero hematopoietic cell transplantation.
  Chimerism 2011 Nijagal A, Wegorzewska M, Le T, Tang Q, Mackenzie TC
• A mouse model of in utero transplantation.
  Journal of visualized experiments : JoVE 2011 Nijagal A, Le T, Wegorzewska M, Mackenzie TC
• Maternal T cells limit engraftment after in utero hematopoietic cell transplantation in mice.
  The Journal of clinical investigation 2011 Nijagal A, Wegorzewska M, Jarvis E, Le T, Tang Q, MacKenzie TC
• Image of the month--quiz case. Gastric duplication cyst.
  Archives of surgery (Chicago, Ill. : 1960) 2010 Zaid HB, Rhee SJ, Hirose S, Mackenzie TC
• Long-term surgical outcomes in congenital diaphragmatic hernia: observations from a single institution.
  Journal of pediatric surgery 2010 Jancelewicz T, Vu LT, Keller RL, Bratton B, Lee H, Farmer D, Harrison M, Miniati D, Mackenzie T, Hirose S, Nobuhara K
• Persistent expression of hF.IX After tolerance induction by in utero or neonatal administration of AAV-1-F.IX in hemophilia B mice.
  Molecular therapy : the journal of the American Society of Gene Therapy 2007 Sabatino DE, Mackenzie TC, Peranteau W, Edmonson S, Campagnoli C, Liu YL, Flake AW, High KA
• Impact of continuous intraoperative monitoring on outcomes in open fetal surgery.
  Fetal diagnosis and therapy 2005 Keswani SG, Crombleholme TM, Rychik J, Tian Z, Mackenzie TC, Johnson MP, Wilson RD, Flake AW, Hedrick HL, Howell LJ, Adzick NS
• Transduction of satellite cells after prenatal intramuscular administration of lentiviral vectors.
  The journal of gene medicine 2005 MacKenzie TC, Kobinger GP, Louboutin JP, Radu A, Javazon EH, Sena-Esteves M, Wilson JM, Flake AW
• Long-term transgene expression in cardiac and skeletal muscle following fetal administration of adenoviral or adeno-associated viral vectors in mice.
  The journal of gene medicine 2003 Bouchard S, MacKenzie TC, Radu AP, Hayashi S, Peranteau WH, Chirmule N, Flake AW
• Efficient transduction of liver and muscle after in utero injection of lentiviral vectors with different pseudotypes.
  Molecular therapy : the journal of the American Society of Gene Therapy 2002 MacKenzie TC, Kobinger GP, Kootstra NA, Radu A, Sena-Esteves M, Bouchard S, Wilson JM, Verma IM, Flake AW
• The ex-utero intrapartum treatment.
  Current opinion in pediatrics 2002 MacKenzie TC, Crombleholme TM, Flake AW
• Engraftment of bone marrow and fetal liver cells after in utero transplantation in MDX mice.
  Journal of pediatric surgery 2002 Mackenzie TC, Shaaban AF, Radu A, Flake AW
• The natural history of prenatally diagnosed conjoined twins.
  Journal of pediatric surgery 2002 Mackenzie TC, Crombleholme TM, Johnson MP, Schnaufer L, Flake AW, Hedrick HL, Howell LJ, Adzick NS
• Human mesenchymal stem cells: insights from a surrogate in vivo assay system.
  Cells, tissues, organs 2002 MacKenzie TC, Flake AW
• Risk factors for intermediate-term survival after coronary artery bypass grafting.
  The Annals of thoracic surgery 2001 Gardner SC, Grunwald GK, Rumsfeld JS, Mackenzie T, Gao D, Perlin JB, McDonald G, Shroyer AL
• Heterogeneity of type I diabetes: analysis of monozygotic twins in Great Britain and the United States.
  Diabetologia 2001 Redondo MJ, Yu L, Hawa M, Mackenzie T, Pyke DA, Eisenbarth GS, Leslie RD
• The impact of the diabetes control and complications trial and humalog insulin on glycohemoglobin levels and severe hypoglycemia in type 1 diabetes.
  Diabetes care 2001 Chase HP, Lockspeiser T, Peery B, Shepherd M, MacKenzie T, Anderson J, Garg SK
• Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep.
  Nature medicine 2000 Liechty KW, MacKenzie TC, Shaaban AF, Radu A, Moseley AM, Deans R, Marshak DR, Flake AW
• Response to treatment as a predictor of longterm outcome in patients with lupus nephritis.
  The Journal of rheumatology 1994 Fraenkel L, MacKenzie T, Joseph L, Kashgarian M, Hayslett JP, Esdaile JM
• The time-dependence of long-term prediction in lupus nephritis.
  Arthritis and rheumatism 1994 Esdaile JM, Abrahamowicz M, MacKenzie T, Hayslett JP, Kashgarian M
• Can experienced clinicians predict the outcome of lupus nephritis?
  Lupus 1992 Esdaile JM, Mackenzie T, Barré P, Danoff D, Osterland CK, Somerville P, Quintal H, Kashgarian M, Suissa S
• Cerebrovascular deaths before and after the appearance of oral contraceptives.
  Acta neurologica Scandinavica 1987 Lidegaard O
• Systemic and renal hemodynamic consequences of manipulation of serum calcium and/or parathyroid hormone in the intact conscious mongrel dog.
  Journal of the American College of Nutrition 1987 Zawada ET, Johnson M, McClung D, TerWee J, MacKenzie T
• Hemoglobin A1 in renal transplant recipients.
  Archives of internal medicine 1985 Zawada ET, Johnson M, Mackenzie T, Sica DA, Muakkassa W, Green SJ, Goldman M
• Effect of clonidine therapy on renal hemodynamics in renal transplant hypertension.
  Archives of internal medicine 1984 Green S, Zawada ET, Muakkassa W, Johnson M, Mackenzie T, McClanahan M, Graybill A, Goldman M