Tien Peng, MD
Associate Professor
Medicine
School of Medicine

Tien is a pulmonologist by training and the lab utilizes the lung as a model organ due to its immense cellular diversity and architectural complexity.

• Dysregulated lung stroma drives emphysema exacerbation by potentiating resident lymphocytes to suppress an epithelial stem cell reservoir.
  Immunity 2023 Wang C, Hyams B, Allen NC, Cautivo K, Monahan K, Zhou M, Dahlgren MW, Lizama CO, Matthay M, Wolters P, Molofsky AB, Peng T
• Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung.
  Science (New York, N.Y.) 2022 Reyes NS, Krasilnikov M, Allen NC, Lee JY, Hyams B, Zhou M, Ravishankar S, Cassandras M, Wang C, Khan I, Matatia P, Johmura Y, Molofsky A, Matthay M, Nakanishi M, Sheppard D, Campisi J, Peng T
• Intersection of Inflammation and Senescence in the Aging Lung Stem Cell Niche.
  Frontiers in cell and developmental biology 2022 Allen NC, Reyes NS, Lee JY, Peng T
• Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells.
  Nature cell biology 2021 Kathiriya JJ, Wang C, Zhou M, Brumwell A, Cassandras M, Le Saux CJ, Cohen M, Alysandratos KD, Wang B, Wolters P, Matthay M, Kotton DN, Chapman HA, Peng T
• An inflammatory switch for stem cell plasticity.
  Nature cell biology 2021 Kathiriya JJ, Peng T
• Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung.
  Nature cell biology 2020 Cassandras M, Wang C, Kathiriya J, Tsukui T, Matatia P, Matthay M, Wolters P, Molofsky A, Sheppard D, Chapman H, Peng T
• The Role of Hedgehog Signaling in Adult Lung Regeneration and Maintenance.
  Journal of developmental biology 2019 Wang C, Cassandras M, Peng T
• Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches.
  Immunity 2019 Dahlgren MW, Jones SW, Cautivo KM, Dubinin A, Ortiz-Carpena JF, Farhat S, Yu KS, Lee K, Wang C, Molofsky AV, Tward AD, Krummel MF, Peng T, Molofsky AB
• Endothelial toll-like receptor 4 maintains lung integrity via epigenetic suppression of p16INK4a.
  Aging cell 2019 Kim SJ, Shan P, Hwangbo C, Zhang Y, Min JN, Zhang X, Ardito T, Li A, Peng T, Sauler M, Lee PJ
• Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype.
  The Journal of clinical investigation 2018 Wang C, de Mochel NSR, Christenson SA, Cassandras M, Moon R, Brumwell AN, Byrnes LE, Li A, Yokosaki Y, Shan P, Sneddon JB, Jablons D, Lee PJ, Matthay MA, Chapman HA, Peng T
• Emergence of a Wave of Wnt Signaling that Regulates Lung Alveologenesis by Controlling Epithelial Self-Renewal and Differentiation.
  Cell reports 2016 Frank DB, Peng T, Zepp JA, Snitow M, Vincent TL, Penkala IJ, Cui Z, Herriges MJ, Morley MP, Zhou S, Lu MM, Morrisey EE
• Hedgehog actively maintains adult lung quiescence and regulates repair and regeneration.
  Nature 2015 Peng T, Frank DB, Kadzik RS, Morley MP, Rathi KS, Wang T, Zhou S, Cheng L, Lu MM, Morrisey EE
• Long noncoding RNAs are spatially correlated with transcription factors and regulate lung development.
  Genes & development 2014 Herriges MJ, Swarr DT, Morley MP, Rathi KS, Peng T, Stewart KM, Morrisey EE
• Distinct functions for Wnt/β-catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis.
  Cell stem cell 2013 Choi YS, Zhang Y, Xu M, Yang Y, Ito M, Peng T, Cui Z, Nagy A, Hadjantonakis AK, Lang RA, Cotsarelis G, Andl T, Morrisey EE, Millar SE
• Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor.
  Nature 2013 Peng T, Tian Y, Boogerd CJ, Lu MM, Kadzik RS, Stewart KM, Evans SM, Morrisey EE
• Development of the pulmonary vasculature: Current understanding and concepts for the future.
  Pulmonary circulation 2013 Peng T, Morrisey EE
• Plasma levels of S100A4 in portopulmonary hypertension.
  Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2009 Peng T, Zamanian R, Krowka MJ, Benza RL, Roberts KE, Taichman DB, Rybak D, Trotter JF, Brown RS, Fallon MB, Kawut SM, Pulmonary Vascular Complications of Liver Disease Study Group
• Herpes simplex encephalitis in a patient with recurrent pituitary adenoma receiving radiation therapy.
  American journal of clinical oncology 2007 Peng T, Blakeley J, Cingolani E, Griffiths E, Grossman SA
• The 1p-encoded protein stathmin and resistance of malignant gliomas to nitrosoureas.
  Journal of the National Cancer Institute 2007 Ngo TT, Peng T, Liang XJ, Akeju O, Pastorino S, Zhang W, Kotliarov Y, Zenklusen JC, Fine HA, Maric D, Wen PY, De Girolami U, Black PM, Wu WW, Shen RF, Jeffries NO, Kang DW, Park JK
• Short hairpin RNA loop design for the facilitation of sequence verification.
  BioTechniques 2006 Akeju O, Peng T, Park JK
• Lentiviral vectors with two independent internal promoters transfer high-level expression of multiple transgenes to human hematopoietic stem-progenitor cells.
  Molecular therapy : the journal of the American Society of Gene Therapy 2003 Yu X, Zhan X, D'Costa J, Tanavde VM, Ye Z, Peng T, Malehorn MT, Yang X, Civin CI, Cheng L