Thomas Hoffmann, PhD, MA
Professor
Epidemiology & Biostatistics
School of Medicine

I have a broad background in statistics, genetics, and computer science, have been involved in a wide variety of theoretical and applied projects. My my applied work encompasses a wide variety of genetic association studies related to human health, including work on age-related hearing impairment, cardiovascular disease, and cancer.

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Driven by my applied research, my methodological work includes imputation, array design, rare variants, gene-environment interaction, and study design, and I have produced software packages that implement the methodology in these works so other researchers can freely use them.

Education & Training

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• Post-doc Biostatistics and Genetic Epidemiology University of California San Francisco 08/2011
• PhD Biostatistics Harvard University 06/2009
• AM Biostatistics Harvard University 06/2006
• BS Computer Science, Mathematics, Statistics University of Wisconsin Madison 06/2004

Interests

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• Biostatistics
• High-dimensional data
• Image classification
• Cancer
• Statistical computing
• Public health
• Human genetics
• Cardiovascular disease
• Age-related hearing impairment
• Statistical genetics
• Machine learning

Grants and Projects

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• Genome-wide Study of Hearing Impairment, NIH, 2013-2019
• Sequencing not required: Imputing rare variants into a cohort of 100,000 on aging, NIH, 2013-2017

Publications (186)

Top publication keywords:
Quantitative Trait LociElectronic Health RecordsGenome-Wide Association StudyPeriodontitisProstate-Specific AntigenGenetic LociNurse PractitionersModels, GeneticPhysician AssistantsProstatic NeoplasmsBronchopulmonary DysplasiaPolymorphism, Single NucleotidePresbycusisSmartphoneGenetic Predisposition to Disease

• Comparing perceptions of leading causes of death in a diverse sample of community-dwelling women in the United States.
  Heart & lung : the journal of critical care 2025 Fukuoka Y, Kim DD, Suzuki H, Sagae K, DeVon HA, Hoffmann TJ, Zhang J
• Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves prediction across ancestry groups.
  Nature genetics 2025 Hoffmann TJ, Graff RE, Madduri RK, Rodriguez AA, Cario CL, Feng K, Jiang Y, Wang A, Klein RJ, Pierce BL, Eggener S, Tong L, Blot W, Long J, Goss LB, Darst BF, Rebbeck T, Lachance J, Andrews C, Adebiyi…
• Unraveling the genetic landscape of susceptibility to multiple primary cancers.
  HGG advances 2025 Middha P, Kachuri L, Nierenberg JL, Graff RE, Cavazos TB, Hoffmann TJ, Zhang J, Alexeeff S, Habel L, Corley DA, Van Den Eeden S, Kushi LH, Ziv E, Sakoda LC, Witte JS
• Author Correction: Genetically adjusted PSA levels for prostate cancer screening.
  Nature medicine 2025 Kachuri L, Hoffmann TJ, Jiang Y, Berndt SI, Shelley JP, Schaffer KR, Machiela MJ, Freedman ND, Huang WY, Li SA, Easterlin R, Goodman PJ, Till C, Thompson I, Lilja H, Van Den Eeden SK, Chanock SJ, …
• Independent associations of high-density lipoprotein cholesterol and triglyceride levels with Alzheimer's disease and related dementias.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2025 Ferguson EL, Zimmerman SC, Jiang C, Choi M, Meyers TJ, Hoffmann TJ, Gilsanz P, Oni-Orisan A, Wang J, Whitmer RA, Risch N, Krauss RM, Schaefer CA, Glymour MM

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• Extended Treatment Duration of Artemether-Lumefantrine in Ugandan Children with HIV on Efavirenz-Based Antiretroviral Therapy: A Randomized Controlled Pharmacokinetic and Pharmacodynamic Trial.
  Journal of clinical pharmacology 2025 Whalen ME, Kajubi R, Goodwin J, Orukan F, Colt M, Huang L, Richards K, Hoffmann TJ, Aweeka FT, Parikh S, Mwebaza N
• Association between migraine and primary open-angle glaucoma: A two-sample Mendelian randomization study.
  Cephalalgia Reports 2025 Dima L Chaar, Aliya Yakubova, Chen Jiang, Thomas J Hoffmann, Alice Pressman, Denis Plotnikov, Hélène Choquet
• Computerized QT and QTc Measurements From Bedside ICU Monitors Are Similar to Those Derived From a Standard 12-Lead ECG.
  Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc 2025 Murray A, Ho K, Hoffmann TJ, Ganesh GK, Prasad S, Berger S, Sandoval C, Larsen A, Schell-Chaple H, Pelter MM
• The relationship between APOE genotype and dementia varies by genetic ancestry and race/ethnicity.
  Alzheimer's & Dementia 2024 Marian J Gilmore, Alexandra M Varga, Catherine Schaefer, Yambazi Banda, Thomas J. Hoffmann, M. Maria Glymour, Sheila A Weinmann, Hélène Choquet, Ning Smith, Paola Gilsanz, Stefan Massimino, Willa D …
• Skeletal effects of sleeve gastrectomy, by sex and menopausal status and compared to Roux-en-Y gastric bypass surgery.
  The Journal of clinical endocrinology and metabolism 2024 Wu KC, Wu PH, Kazakia G, Patel S, Black DM, Lang TF, Kim TY, King NJ, Hoffmann TJ, Chang H, Linfield G, Palilla S, Rogers SJ, Carter JT, Posselt AM, Schafer AL
• Abstract 4144376: Applying artificial intelligence chatbot to increase heart disease awareness and knowledge in women.
  Circulation 2024 Yoshimi Fukuoka, Diane Kim, Holli Devon, Jingwen Zhang, Thomas Hoffmann, Kenji Sagae
• Unraveling the genetic landscape of susceptibility to multiple primary cancers.
  medRxiv : the preprint server for health sciences 2024 Middha P, Kachuri L, Nierenberg JL, Graff RE, Cavazos TB, Hoffmann TJ, Zhang J, Alexeeff S, Habel L, Corley DA, Van Den Eeden S, Kushi LH, Ziv E, Sakoda LC, Witte JS
• Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves cross-ancestry prediction.
  medRxiv : the preprint server for health sciences 2024 Hoffmann TJ, Graff RE, Madduri RK, Rodriguez AA, Cario CL, Feng K, Jiang Y, Wang A, Klein RJ, Pierce BL, Eggener S, Tong L, Blot W, Long J, Goss LB, Darst BF, Rebbeck T, Lachance J, Andrews C, Adebiyi…
• Interoceptive brain network mechanisms of mindfulness-based training in healthy adolescents.
  Frontiers in psychology 2024 Tymofiyeva O, Sipes BS, Luks T, Hamlat EJ, Samson TE, Hoffmann TJ, Glidden DV, Jakary A, Li Y, Ngan T, Henje E, Yang TT
• Visual Impairment, Eye Conditions, and Diagnoses of Neurodegeneration and Dementia.
  JAMA network open 2024 Ferguson EL, Thoma M, Buto PT, Wang J, Glymour MM, Hoffmann TJ, Choquet H, Andrews SJ, Yaffe K, Casaletto K, Brenowitz WD
• Transcriptome-wide association analysis identifies candidate susceptibility genes for prostate-specific antigen levels in men without prostate cancer.
  HGG advances 2024 Chen DM, Dong R, Kachuri L, Hoffmann TJ, Jiang Y, Berndt SI, Shelley JP, Schaffer KR, Machiela MJ, Freedman ND, Huang WY, Li SA, Lilja H, Justice AC, Madduri RK, Rodriguez AA, Van Den Eeden SK, …
• Identification of the Molecular Components of Enhancer-Mediated Gene Expression Variation in Multiple Tissues Regulating Blood Pressure.
  Hypertension (Dallas, Tex. : 1979) 2024 Yaacov O, Mathiyalagan P, Berk-Rauch HE, Ganesh SK, Zhu L, Hoffmann TJ, Iribarren C, Risch N, Lee D, Chakravarti A
• Multi-tissue transcriptome-wide association study identifies novel candidate susceptibility genes for cataract.
  Frontiers in ophthalmology 2024 Choquet H, Duot M, Herrera VA, Shrestha SK, Meyers TJ, Hoffmann TJ, Sangani PK, Lachke SA
• The Relationship Between Barriers to Physical Activity and Depressive Symptoms in Community-Dwelling Women.
  Women's health reports (New Rochelle, N.Y.) 2024 Figueroa CA, Aguilera A, Hoffmann TJ, Fukuoka Y
• Sex-specific genetic architecture of blood pressure.
  Nature medicine 2024 Yang ML, Xu C, Gupte T, Hoffmann TJ, Iribarren C, Zhou X, Ganesh SK
• Prenatal exposure to social adversity and infant cortisol in the first year of life.
  Stress (Amsterdam, Netherlands) 2024 Keeton VF, Hoffmann TJ, Goodwin KM, Powell B, Tupuola S, Weiss SJ
• Association between water insecurity and antiretroviral therapy adherence among pregnant and postpartum women in Greater Accra region of Ghana.
  PLOS global public health 2024 Nutor JJ, Okiring J, Yeboah I, Thompson RGA, Agbadi P, Ameyaw EK, Getahun M, Agbadi W, Hoffmann TJ, Weiser SD
• Genetic risk score for Alzheimer's disease predicts brain volume differences in mid and late life in UK biobank participants.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2024 Buto PT, Wang J, La Joie R, Zimmerman SC, Glymour MM, Ackley SF, Hoffmann TJ, Yaffe K, Zeki Al Hazzouri A, Brenowitz WD
• Multi-ancestry genome-wide meta-analysis identifies novel basal cell carcinoma loci and shared genetic effects with squamous cell carcinoma.
  Communications biology 2024 Choquet H, Jiang C, Yin J, Kim Y, Hoffmann TJ, 23andMe Research Team, Jorgenson E, Asgari MM
• Cataracts are associated with smaller gray matter brain volume among participants in the UK Biobank.
  Alzheimer's & Dementia 2023 Erin L Ferguson, Peter Buto, Mary Thoma, Jingxuan Wang, M. Maria Glymour, Thomas J. Hoffmann, Hélène Choquet, Shea J Andrews, Kristine Yaffe, Kaitlin B. Casaletto, Willa D Brenowitz
• Understanding Asian American, Native Hawaiian, and Pacific Islander participants' attitudes toward research: CARE research recruitment registry.
  Alzheimer's & Dementia 2023 Van Ta Park, Thomas J. Hoffmann, Janice Y. Tsoh, Oanh L. Meyer, Bora Nam, Marian Tzuang, Alka Kanaya, Ladson Hinton, Dolores Gallagher-Thompson, Quyen Vuong, David Kim, Joshua D Grill
• "It has changed my life": unconditional cash transfers and personalized infant feeding support- a feasibility intervention trial among women living with HIV in western Kenya.
  International breastfeeding journal 2023 Tuthill EL, Maltby AE, Odhiambo BC, Hoffmann TJ, Nyaura M, Shikari R, Cohen CR, Weiser SD
• European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation.
  Nature communications 2023 Budu-Aggrey A, Kilanowski A, Sobczyk MK, 23andMe Research Team, Shringarpure SS, Mitchell R, Reis K, Reigo A, Estonian Biobank Research Team, Mägi R, Nelis M, Tanaka N, Brumpton BM, Thomas LF, Sole-…
• Low- and High-Density Lipoprotein Cholesterol and Dementia Risk Over 17 Years of Follow-up Among Members of a Large Health Care Plan.
  Neurology 2023 Ferguson EL, Zimmerman SC, Jiang C, Choi M, Swinnerton K, Choudhary V, Meyers TJ, Hoffmann TJ, Gilsanz P, Oni-Orisan A, Whitmer RA, Risch N, Krauss RM, Schaefer CA, Glymour MM
• Agreement of Computerized QT and QTc Interval Measurements Between Both Bedside and Expert Nurses Using Electronic Calipers.
  The Journal of cardiovascular nursing 2023 Ho K, Ganesh GK, Prasad S, Hoffmann TJ, Larsen A, Sandoval C, Berger S, Schell-Chaple H, Badilini F, Mackin LA, Pelter MM
• Factors associated with mobile medical clinic use: a retrospective cohort study.
  International journal for equity in health 2023 Coaston A, Lee SJ, Johnson JK, Weiss S, Hoffmann T, Stephens C
• Maternal mental health after infant discharge: a quasi-experimental clinical trial of family integrated care versus family-centered care for preterm infants in U.S. NICUs.
  BMC pediatrics 2023 Franck LS, Gay CL, Hoffmann TJ, Kriz RM, Bisgaard R, Cormier DM, Joe P, Lothe B, Sun Y
• Association of Behavioral and Clinical Risk Factors With Cataract: A Two-Sample Mendelian Randomization Study.
  Investigative ophthalmology & visual science 2023 Jiang C, Melles RB, Sangani P, Hoffmann TJ, Hysi PG, Glymour MM, Jorgenson E, Lachke SA, Choquet H
• Influence of depression and interpersonal support on adherence to antiretroviral therapy among people living with HIV.
  AIDS research and therapy 2023 Nutor JJ, Gyamerah AO, Alhassan RK, Duah HO, Thompson RGA, Wilson N, Harris O, Gutierrez J, Hoffmann TJ, Getahun M, Santos GM
• Evaluating approaches for constructing polygenic risk scores for prostate cancer in men of African and European ancestry.
  American journal of human genetics 2023 Darst BF, Shen J, Madduri RK, Rodriguez AA, Xiao Y, Sheng X, Saunders EJ, Dadaev T, Brook MN, Hoffmann TJ, Muir K, Wan P, Le Marchand L, Wilkens L, Wang Y, Schleutker J, MacInnis RJ, Cybulski C, Neal …
• Transcriptome-wide association study identifies novel candidate susceptibility genes for migraine.
  HGG advances 2023 Meyers TJ, Yin J, Herrera VA, Pressman AR, Hoffmann TJ, Schaefer C, Avins AL, Choquet H
• Genetically adjusted PSA levels for prostate cancer screening.
  Nature medicine 2023 Kachuri L, Hoffmann TJ, Jiang Y, Berndt SI, Shelley JP, Schaffer KR, Machiela MJ, Freedman ND, Huang WY, Li SA, Easterlin R, Goodman PJ, Till C, Thompson I, Lilja H, Van Den Eeden SK, Chanock SJ, …
• Evaluating Approaches for Constructing Polygenic Risk Scores for Prostate Cancer in Men of African and European Ancestry.
  medRxiv : the preprint server for health sciences 2023 Darst BF, Shen J, Madduri RK, Rodriguez AA, Xiao Y, Sheng X, Saunders EJ, Dadaev T, Brook MN, Hoffmann TJ, Muir K, Wan P, Le Marchand L, Wilkens L, Wang Y, Schleutker J, MacInnis RJ, Cybulski C, Neal …
• Smartphone-Based Cancer and Obesity Prevention Education Program for Chinese Women (SCOPE): A Pilot RCT.
  International journal of environmental research and public health 2023 Chen JL, Guo J, Zhong Q, Jiang Y, Zhang H, Mao P, Huang Q, Lin CX, Hoffmann TJ
• Transcriptome-Wide Association Analysis Identifies Novel Candidate Susceptibility Genes for Prostate-Specific Antigen Levels in Men Without Prostate Cancer.
  medRxiv : the preprint server for health sciences 2023 Chen DM, Dong R, Kachuri L, Hoffmann T, Jiang Y, Berndt SI, Shelley JP, Schaffer KR, Machiela MJ, Freedman ND, Huang WY, Li SA, Lilja H, Van Den Eeden SK, Chanock S, Haiman CA, Conti DV, Klein RJ, …
• Evaluation of premature ventricular complexes during in-hospital ECG monitoring as a predictor of ventricular tachycardia in an intensive care unit cohort.
  Research in nursing & health 2023 Suba S, Hoffmann TJ, Fleischmann KE, Schell-Chaple H, Marcus GM, Prasad P, Hu X, Badilini F, Pelter MM
• The impact of a structured onboarding program for newly hired nurse practitioners and physician assistants.
  Journal of the American Association of Nurse Practitioners 2023 Erickson M, Yee AM, Krauter R, Hoffmann T
• Rapid response nursing triage outcomes for COVID-19: factors associated with patient's participation in triage recommendations.
  BMC medical informatics and decision making 2023 Chen JL, Lin CX, Park M, Nutor JJ, de Lisser R, Hoffmann TJ, Kim HJ
• Evidence of Novel Susceptibility Variants for Prostate Cancer and a Multiancestry Polygenic Risk Score Associated with Aggressive Disease in Men of African Ancestry.
  European urology 2023 Chen F, Madduri RK, Rodriguez AA, Darst BF, Chou A, Sheng X, Wang A, Shen J, Saunders EJ, Rhie SK, Bensen JT, Ingles SA, Kittles RA, Strom SS, Rybicki BA, Nemesure B, Isaacs WB, Stanford JL, Zheng W, …
• A Novel Approach to Assess Weekly Self-efficacy for Meeting Personalized Physical Activity Goals Via a Cellphone: 12-Week Longitudinal Study.
  JMIR formative research 2023 Oh YJ, Hoffmann TJ, Fukuoka Y
• A large genome-wide association study of QT interval length utilizing electronic health records.
  Genetics 2022 Hoffmann TJ, Lu M, Oni-Orisan A, Lee C, Risch N, Iribarren C
• Neonatal outcomes from a quasi-experimental clinical trial of Family Integrated Care versus Family-Centered Care for preterm infants in U.S. NICUs.
  BMC pediatrics 2022 Franck LS, Gay CL, Hoffmann TJ, Kriz RM, Bisgaard R, Cormier DM, Joe P, Lothe B, Sun Y
• Accurate Identification of Mucinous Pancreatic Cystic Lesions Using Small-Volume Analytes.
  The Journal of surgical research 2022 Caiazza F, Conroy PC, Ivry SL, York T, Lin J, Hernandez S, Hoffmann TJ, Francis SS, Park WG, Yip-Schneider MT, Schmidt CM, Brand R, Craik CS, Kirkwood K
• Assessment of genetic susceptibility to multiple primary cancers through whole-exome sequencing in two large multi-ancestry studies.
  BMC medicine 2022 Cavazos TB, Kachuri L, Graff RE, Nierenberg JL, Thai KK, Alexeeff S, Van Den Eeden S, Corley DA, Kushi LH, Regeneron Genetics Center, Hoffmann TJ, Ziv E, Habel LA, Jorgenson E, Sakoda LC, Witte JS
• The augmin complex architecture reveals structural insights into microtubule branching.
  Nature communications 2022 Zupa E, Würtz M, Neuner A, Hoffmann T, Rettel M, Böhler A, Vermeulen BJA, Eustermann S, Schiebel E, Pfeffer S
• Polygenic Risk Score and Statin Relative Risk Reduction for Primary Prevention of Myocardial Infarction in a Real-World Population.
  Clinical pharmacology and therapeutics 2022 Oni-Orisan A, Haldar T, Cayabyab MAS, Ranatunga DK, Hoffmann TJ, Iribarren C, Krauss RM, Risch N
• State-Level Policy Environments, Discrimination, and Victimization among Sexual and Gender Minority People.
  International journal of environmental research and public health 2022 Clark KD, Lunn MR, Lev EM, Trujillo MA, Lubensky ME, Capriotti MR, Hoffmann TJ, Obedin-Maliver J, Flentje A
• 501 Meta-analyses of genome-wide association studies in multiethnic cohorts identify risk loci associated with hidradenitis suppurativa.
  Journal of Investigative Dermatology 2022 H. Choquet, J. Yin, Y. Kim, T. Hoffmann, S. Saini, S. Shringarpure, Team, E. Jorgenson, M.M. Asgari
• Modest effect of statins on fasting glucose in a longitudinal electronic health record based cohort.
  Cardiovascular diabetology 2022 Haldar T, Oni-Orisan A, Hoffmann TJ, Schaefer C, Iribarren C, Krauss RM, Medina MW, Risch N
• Ancestry- and sex-specific effects underlying inguinal hernia susceptibility identified in a multiethnic genome-wide association study meta-analysis.
  Human molecular genetics 2022 Choquet H, Li W, Yin J, Bradley R, Hoffmann TJ, Nandakumar P, 23 and Me Research Team, Mostaedi R, Tian C, Ahituv N, Jorgenson E
• Session 6: Jos Willems Early Career Investigators CompetitionPremature ventricular complexes measured 24-hours prior to a ventricular tachycardia event are not associated with its occurrence in an intensive care unit cohort.
  Journal of Electrocardiology 2022 Sukardi Suba, Thomas J. Hoffmann, Kirsten E. Fleischmann, Hildy Schell-Chaple, Gregory M. Marcus, Priya Prasad, Xiao Hu, Fabio Badilini, Michele M. Pelter
• Common genetic variation associated with Mendelian disease severity revealed through cryptic phenotype analysis.
  Nature communications 2022 Blair DR, Hoffmann TJ, Shieh JT
• Enablers and Barriers to HIV Services for Gay and Bisexual Men in the COVID-19 Era: Fusing Data Sets from Two Global Online Surveys Via File Concatenation With Adjusted Weights.
  JMIR public health and surveillance 2022 Ayala G, Arreola S, Howell S, Hoffmann TJ, Santos GM
• Premature ventricular complexes during continuous electrocardiographic monitoring in the intensive care unit: Occurrence rates and associated patient characteristics.
  Journal of clinical nursing 2022 Suba S, Hoffmann TJ, Fleischmann KE, Schell-Chaple H, Prasad P, Marcus GM, Badilini F, Hu X, Pelter MM
• Abstract 1441: Genetic determinants of PSA levels improve prostate cancer screening.
  Cancer Research 2022 Linda Kachuri, Rebecca E. Graff, Sonja I. Berndt, Mitchell Machiela, Neal D. Freedman, Stephen J. Chanock, John P. Shelley, Kerry Schaffer, Jonathan D. Mosley, Phyllis J. Goodman, Cathee Till, Ian …
• Abstract 1446: Genetic risk factors for the development of multiple primary cancers.
  Cancer Research 2022 Jovia L. Nierenberg, Linda Kachuri, Taylor B. Cavazos, Rebecca E. Graff, Thomas J. Hoffmann, Jie Zhang, Stacey Alexeeff, Laurel Habel, Douglas Corley, Stephen Van Den Eeden, Elad Ziv, Lori C. Sakoda, …
• Association of Genetic Variants Linked to Late-Onset Alzheimer Disease With Cognitive Test Performance by Midlife.
  JAMA network open 2022 Zimmerman SC, Brenowitz WD, Calmasini C, Ackley SF, Graff RE, Asiimwe SB, Staffaroni AM, Hoffmann TJ, Glymour MM
• Water Access and Adherence Intention Among HIV-Positive Pregnant Women and New Mothers Receiving Antiretroviral Therapy in Zambia.
  Frontiers in public health 2022 Nutor JJ, Marquez S, Slaughter-Acey JC, Hoffmann TJ, DiMaria-Ghalili RA, Momplaisir F, Opong E, Jemmott LS
• Healthcare Professionals' Attitudes toward Rapid Whole Genome Sequencing in Pediatric Acute Care.
  Children (Basel, Switzerland) 2022 Franck LS, Scheurer-Monaghan A, Bupp CP, Fakhoury JD, Hoffmann TJ, Deshpandey M, Arenchild M, Dimmock DP
• Resilience, Physical Activity, and Depression in Women Living With HIV in the San Francisco Bay Area: A Cross-sectional Study.
  The Journal of the Association of Nurses in AIDS Care : JANAC 2022 Ambrose PR, Cuca YP, Baguso GN, Hoffmann TJ, Dawson-Rose C
• Agreement between respiratory rate measurement using a combined electrocardiographic derived method versus impedance from pneumography.
  Journal of electrocardiology 2021 Bawua LK, Miaskowski C, Suba S, Badilini F, Mortara D, Hu X, Rodway GW, Hoffmann TJ, Pelter MM
• The Space in the Middle: Attitudes of Women's Health and Neonatal Nurses in the United States about Abortion.
  Women's health issues : official publication of the Jacobs Institute of Women's Health 2021 Alspaugh A, Mehra R, Coleman-Minahan K, Hoffmann TJ, Burton CW, Eagen-Torkko M, Bond TM, Franck LS, Olseon LC, Lanshaw N, Rychnovsky JD, McLemore MR
• Extension of Mendelian Randomization to Identify Earliest Manifestations of Alzheimer Disease: Association of Genetic Risk Score for Alzheimer Disease With Lower Body Mass Index by Age 50 Years.
  American journal of epidemiology 2021 Brenowitz WD, Zimmerman SC, Filshtein TJ, Yaffe K, Walter S, Hoffmann TJ, Jorgenson E, Whitmer RA, Glymour MM
• QT Interval Dynamics and Cardiovascular Outcomes: A Cohort Study in an Integrated Health Care Delivery System.
  Journal of the American Heart Association 2021 Mantri N, Lu M, Zaroff JG, Risch N, Hoffmann T, Oni-Orisan A, Lee C, Jorgenson E, Iribarren C
• Torsade de pointes: A nested case-control study in an integrated healthcare delivery system.
  Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc 2021 Mantri N, Lu M, Zaroff JG, Risch N, Hoffmann T, Oni-Orisan A, Lee C, Iribarren C
• Coffee Consumption and Incident Tachyarrhythmias: Reported Behavior, Mendelian Randomization, and Their Interactions.
  JAMA internal medicine 2021 Kim EJ, Hoffmann TJ, Nah G, Vittinghoff E, Delling F, Marcus GM
• Effect of SLCO1B1 T521C on Statin-Related Myotoxicity With Use of Lovastatin and Atorvastatin.
  Clinical pharmacology and therapeutics 2021 Lu B, Sun L, Seraydarian M, Hoffmann TJ, Medina MW, Risch N, Iribarren C, Krauss RM, Oni-Orisan A
• New and sex-specific migraine susceptibility loci identified from a multiethnic genome-wide meta-analysis.
  Communications biology 2021 Choquet H, Yin J, Jacobson AS, Horton BH, Hoffmann TJ, Jorgenson E, Avins AL, Pressman AR
• A unified framework identifies new links between plasma lipids and diseases from electronic medical records across large-scale cohorts.
  Nature genetics 2021 Veturi Y, Lucas A, Bradford Y, Hui D, Dudek S, Theusch E, Verma A, Miller JE, Kullo I, Hakonarson H, Sleiman P, Schaid D, Stein CM, Edwards DRV, Feng Q, Wei WQ, Medina MW, Krauss RM, Hoffmann TJ, …
• A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects.
  Nature communications 2021 Choquet H, Melles RB, Anand D, Yin J, Cuellar-Partida G, Wang W, 23andMe Research Team, Hoffmann TJ, Nair KS, Hysi PG, Lachke SA, Jorgenson E
• Examining the relationship between interpersonal support and retention in HIV care among HIV+ nursing mothers in Uganda.
  BMC research notes 2021 Nutor JJ, Agbadi P, Hoffmann TJ, Anguyo G, Camlin CS
• The Psychosocial Predictors and Day-Level Correlates of Substance Use Among Participants Recruited via an Online Crowdsourcing Platform in the United States: Daily Diary Study.
  JMIR public health and surveillance 2021 Jain JP, Offer C, Rowe C, Turner C, Dawson-Rose C, Hoffmann T, Santos GM
• Mobile Health Intervention Promoting Physical Activity in Adults Post Cardiac Rehabilitation: Pilot Randomized Controlled Trial.
  JMIR formative research 2021 Park LG, Elnaggar A, Lee SJ, Merek S, Hoffmann TJ, Von Oppenfeld J, Ignacio N, Whooley MA
• Publisher Correction: Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction.
  Nature genetics 2021 Conti DV, Darst BF, Moss LC, Saunders EJ, Sheng X, Chou A, Schumacher FR, Olama AAA, Benlloch S, Dadaev T, Brook MN, Sahimi A, Hoffmann TJ, Takahashi A, Matsuda K, Momozawa Y, Fujita M, Muir K, …
• Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts.
  Nature communications 2021 Graff RE, Cavazos TB, Thai KK, Kachuri L, Rashkin SR, Hoffman JD, Alexeeff SE, Blatchins M, Meyers TJ, Leong L, Tai CG, Emami NC, Corley DA, Kushi LH, Ziv E, Van Den Eeden SK, Jorgenson E, Hoffmann TJ…
• Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction.
  Nature genetics 2021 Conti DV, Darst BF, Moss LC, Saunders EJ, Sheng X, Chou A, Schumacher FR, Olama AAA, Benlloch S, Dadaev T, Brook MN, Sahimi A, Hoffmann TJ, Takahashi A, Matsuda K, Momozawa Y, Fujita M, Muir K, …
• Using Genetic Information to Explore Whether Preclinical Alzheimer’s Disease Affects Hearing Difficulty.
  Innovation in Aging 2020 Willa Brenowitz, Teresa Filshtein, Kristine Yaffe, Stefan Walter, Thomas Hoffmann, Eric Jorgenson, Rachel Whitmer, Maria Glymour
• Genetic ancestry, skin pigmentation, and the risk of cutaneous squamous cell carcinoma in Hispanic/Latino and non-Hispanic white populations.
  Communications biology 2020 Jorgenson E, Choquet H, Yin J, Hoffmann TJ, Banda Y, Kvale MN, Risch N, Schaefer C, Asgari MM
• A Large-Scale Association Study Detects Novel Rare Variants, Risk Genes, Functional Elements, and Polygenic Architecture of Prostate Cancer Susceptibility.
  Cancer research 2020 Emami NC, Cavazos TB, Rashkin SR, Cario CL, Graff RE, Tai CG, Mefford JA, Kachuri L, Wan E, Wong S, Aaronson D, Presti J, Habel LA, Shan J, Ranatunga DK, Chao CR, Ghai NR, Jorgenson E, Sakoda LC, …
• Functional hearing loss as a marker for early Alzheimer’s disease and dementia: Exploring the potential for reverse causation.
  Alzheimer's & Dementia 2020 Willa D Brenowitz, Teresa J Filshtein, Kristine Yaffe, Stefan Walter, Sarah F Ackley, Thomas Hoffmann, Eric Jorgenson, Rachel A Whitmer, M Maria Glymour
• ASSOCIATION OF HIV INFECTION WITH CLINICAL AND LABORATORY CHARACTERISTICS OF SICKLE CELL DISEASE.
  Hematology Transfusion and Cell Therapy 2020 A.R. Belisário, P.F. Blatyta, D. Vivanco, C.D.L. Oliveira, A.B. Carneiro-Proietti, E.C. Sabino, C. Almeida-Neto, P. Loureiro, C. Máximo, S.O.G. Mateos, M.V. Flor-Park, D.O.W. Rodrigues, R.A. Mota, T.T…
• Nintedanib plus mFOLFOX6 as second-line treatment of metastatic, chemorefractory colorectal cancer: The randomised, placebo-controlled, phase II TRICC-C study (AIO-KRK-0111).
  International journal of cancer 2020 Ettrich TJ, Perkhofer L, Decker T, Hofheinz RD, Heinemann V, Hoffmann T, Hebart HF, Herrmann T, Hannig CV, Büchner-Steudel P, Güthle M, Hermann PC, Berger AW, Seufferlein T
• Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts.
  Nature communications 2020 Rashkin SR, Graff RE, Kachuri L, Thai KK, Alexeeff SE, Blatchins MA, Cavazos TB, Corley DA, Emami NC, Hoffman JD, Jorgenson E, Kushi LH, Meyers TJ, Van Den Eeden SK, Ziv E, Habel LA, Hoffmann TJ, …
• Association of genetic risk for Alzheimer disease and hearing impairment.
  Neurology 2020 Brenowitz WD, Filshtein TJ, Yaffe K, Walter S, Ackley SF, Hoffmann TJ, Jorgenson E, Whitmer RA, Glymour MM
• Association of HIV infection with clinical and laboratory characteristics of sickle cell disease.
  BMC infectious diseases 2020 Belisário AR, Blatyta PF, Vivanco D, Oliveira CDL, Carneiro-Proietti AB, Sabino EC, de Almeida-Neto C, Loureiro P, Máximo C, de Oliveira Garcia Mateos S, Flor-Park MV, de Oliveira Werneck Rodrigues D,…
• Attitudes of California Registered Nurses About Abortion.
  Journal of obstetric, gynecologic, and neonatal nursing : JOGNN 2020 Swartz A, Hoffmann TJ, Cretti E, Burton CW, Eagen-Torkko M, Levi AJ, Aztlan EA, McLemore MR
• Analysis of putative cis-regulatory elements regulating blood pressure variation.
  Human molecular genetics 2020 Nandakumar P, Lee D, Hoffmann TJ, Ehret GB, Arking D, Ranatunga D, Li M, Grove ML, Boerwinkle E, Schaefer C, Kwok PY, Iribarren C, Risch N, Chakravarti A
• Meta-Analysis of 26 638 Individuals Identifies Two Genetic Loci Associated With Left Ventricular Ejection Fraction.
  Circulation. Genomic and precision medicine 2020 Choquet H, Thai KK, Jiang C, Ranatunga DK, Hoffmann TJ, Go AS, Lindsay AC, Ehm MG, Waterworth DM, Risch N, Schaefer C
• A multiethnic genome-wide analysis of 44,039 individuals identifies 41 new loci associated with central corneal thickness.
  Communications biology 2020 Choquet H, Melles RB, Yin J, Hoffmann TJ, Thai KK, Kvale MN, Banda Y, Hardcastle AJ, Tuft SJ, Glymour MM, Schaefer C, Risch N, Nair KS, Hysi PG, Jorgenson E
• The impact of adjusting for baseline in pharmacogenomic genome-wide association studies of quantitative change.
  NPJ genomic medicine 2020 Oni-Orisan A, Haldar T, Ranatunga DK, Medina MW, Schaefer C, Krauss RM, Iribarren C, Risch N, Hoffmann TJ
• Using a genetic risk score to estimate the earliest age of Alzheimer's disease-related physiologic change in Body Mass Index.
  medRxiv 2019 Willa Brenowitz, Scott Zimmerman, Teresa Filshtein, Kristine Yaffe, Stefan Walter, Thomas Hoffmann, Eric Jorgenson, Rachel Whitmer, Maria Glymour
• Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry.
  JAMA 2019 Genetics of Glaucoma in People of African Descent (GGLAD) Consortium, Hauser MA, Allingham RR, Aung T, Van Der Heide CJ, Taylor KD, Rotter JI, Wang SJ, Bonnemaijer PWM, Williams SE, Abdullahi SM, Abu-…
• Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis.
  American journal of respiratory and critical care medicine 2019 Ley B, Torgerson DG, Oldham JM, Adegunsoye A, Liu S, Li J, Elicker BM, Henry TS, Golden JA, Jones KD, Dressen A, Yaspan BL, Arron JR, Noth I, Hoffmann TJ, Wolters PJ
• Author Correction: Association of imputed prostate cancer transcriptome with disease risk reveals novel mechanisms.
  Nature communications 2019 Emami NC, Kachuri L, Meyers TJ, Das R, Hoffman JD, Hoffmann TJ, Hu D, Shan J, Feng FY, Ziv E, Van Den Eeden SK, Witte JS
• Genetic ancestry does not explain increased atopic dermatitis susceptibility or worse disease control among African American subjects in 2 large US cohorts.
  The Journal of allergy and clinical immunology 2019 Abuabara K, You Y, Margolis DJ, Hoffmann TJ, Risch N, Jorgenson E
• Association of imputed prostate cancer transcriptome with disease risk reveals novel mechanisms.
  Nature communications 2019 Emami NC, Kachuri L, Meyers TJ, Das R, Hoffman JD, Hoffmann TJ, Hu D, Shan J, Feng FY, Ziv E, Van Den Eeden SK, Witte JS
• A genome-wide association study of prostate cancer in Latinos.
  International journal of cancer 2019 Du Z, Hopp H, Ingles SA, Huff C, Sheng X, Weaver B, Stern M, Hoffmann TJ, John EM, Van Den Eeden SK, Strom S, Leach RJ, Thompson IM, Witte JS, Conti DV, Haiman CA
• USING GENETIC INFORMATION TO IDENTIFY THE EARLIEST MANIFESTATIONS OF ALZHEIMER’S DISEASE: GENETIC RISK SCORE FOR ALZHEIMER’S DISEASE PREDICTS LOWER BMI BY AGE 58.
  Alzheimer's & Dementia 2019 Willa D. Brenowitz, Teresa J. Filshtein, Kristine Yaffe, Stefan Walter, Thomas Hoffmann, Eric Jorgenson, Rachel A. Whitmer, Maria Glymour
• Telomere length and socioeconomic status at neighborhood and individual levels among 80,000 adults in the Genetic Epidemiology Research on Adult Health and Aging cohort.
  Environmental epidemiology (Philadelphia, Pa.) 2019 Alexeeff SE, Schaefer CA, Kvale MN, Shan J, Blackburn EH, Risch N, Ranatunga DK, Jorgenson E, Hoffmann TJ, Sakoda LC, Quesenberry CP, Van Den Eeden SK
• Reply to Liu et al.: Tissue specificity of SIM1 gene expression and erectile dysfunction.
  Proceedings of the National Academy of Sciences of the United States of America 2019 Jorgenson E, Matharu N, Palmer MR, Yin J, Shan J, Hoffmann TJ, Thai KK, Zhou X, Hotaling JM, Jarvik GP, Ahituv N, Wessells H, Van Den Eeden SK
• SU23 ASSOCIATIONS OF POLYGENIC RISK OF SCHIZOPHRENIA AND MAJOR DEPRESSION IN STUDIES OF BIPOLAR DISORDER AND MAJOR DEPRESSION.
  European Neuropsychopharmacology 2019 Cathy Schaefer, Khanh Thai, Eric Jorgenson, Yambazi Banda, Thomas Hoffmann, Mark Kvale, Neil Risch
• Genetic variation in the SIM1 locus is associated with erectile dysfunction.
  Proceedings of the National Academy of Sciences of the United States of America 2018 Jorgenson E, Matharu N, Palmer MR, Yin J, Shan J, Hoffmann TJ, Thai KK, Zhou X, Hotaling JM, Jarvik GP, Ahituv N, Wessells H, Van Den Eeden SK
• Characterization of Statin Low-Density Lipoprotein Cholesterol Dose-Response Using Electronic Health Records in a Large Population-Based Cohort.
  Circulation. Genomic and precision medicine 2018 Oni-Orisan A, Hoffmann TJ, Ranatunga D, Medina MW, Jorgenson E, Schaefer C, Krauss RM, Iribarren C, Risch N
• A Large Multiethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci.
  Genetics 2018 Hoffmann TJ, Choquet H, Yin J, Banda Y, Kvale MN, Glymour M, Schaefer C, Risch N, Jorgenson E
• EVALUATING REVERSE CAUSATION BETWEEN DEMENTIA AND HEARING IMPAIRMENT USING A GENETIC RISK SCORE FOR ALZHEIMER’S DISEASE.
  Alzheimer's & Dementia 2018 Willa D. Brenowitz, Teresa J. Filshtein, Thomas Hoffmann, Kristine Yaffe, Eric Jorgenson, Rachel A. Whitmer, Maria Glymour
• A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci.
  Nature communications 2018 Choquet H, Paylakhi S, Kneeland SC, Thai KK, Hoffmann TJ, Yin J, Kvale MN, Banda Y, Tolman NG, Williams PA, Schaefer C, Melles RB, Risch N, John SWM, Nair KS, Jorgenson E
• A large electronic-health-record-based genome-wide study of serum lipids.
  Nature genetics 2018 Hoffmann TJ, Theusch E, Haldar T, Ranatunga DK, Jorgenson E, Medina MW, Kvale MN, Kwok PY, Schaefer C, Krauss RM, Iribarren C, Risch N
• A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure.
  Nature communications 2017 Choquet H, Thai KK, Yin J, Hoffmann TJ, Kvale MN, Banda Y, Schaefer C, Risch N, Nair KS, Melles R, Jorgenson E
• Identification of Pleiotropic Cancer Susceptibility Variants from Genome-Wide Association Studies Reveals Functional Characteristics.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2017 Wu YH, Graff RE, Passarelli MN, Hoffman JD, Ziv E, Hoffmann TJ, Witte JS
• Two Novel Susceptibility Loci for Prostate Cancer in Men of African Ancestry.
  Journal of the National Cancer Institute 2017 Conti DV, Wang K, Sheng X, Bensen JT, Hazelett DJ, Cook MB, Ingles SA, Kittles RA, Strom SS, Rybicki BA, Nemesure B, Isaacs WB, Stanford JL, Zheng W, Sanderson M, John EM, Park JY, Xu J, Stevens VL, …
• Transcription elongation factors represent in vivo cancer dependencies in glioblastoma.
  Nature 2017 Miller TE, Liau BB, Wallace LC, Morton AR, Xie Q, Dixit D, Factor DC, Kim LJY, Morrow JJ, Wu Q, Mack SC, Hubert CG, Gillespie SM, Flavahan WA, Hoffmann T, Thummalapalli R, Hemann MT, Paddison PJ, …
• Abstract 1310: Identification of pleiotropic cancer susceptibility variants from genome-wide association studies reveals functional characteristics.
  Epidemiology 2017 Yi-Hsuan Wu, Rebecca E. Graff, Michael N. Passarelli, Thomas J. Hoffmann, Elad Ziv, John S. Witte
• Abstract 1316: Germline genetic signals across multiple aggressive prostate cancer phenotypes.
  Epidemiology 2017 Caroline G. Tai, Nima C. Emami, Thomas J. Hoffmann, Lori C. Sakoda, Eric Jorgenson, Laurel A. Habel, Jun Shan, Dilrini K. Ranatunga, Chun R. Chao, Nirupa R. Ghai, David Aaronson, Joseph Presti, …
• Birth weight interacts with a functional variant of the oxytocin receptor gene (OXTR) to predict executive functioning in children.
  Development and psychopathology 2017 Wade M, Prime H, Hoffmann TJ, Schmidt LA, O'Connor TG, Jenkins JM
• Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study.
  Molecular psychiatry 2017 Jorgenson E, Thai KK, Hoffmann TJ, Sakoda LC, Kvale MN, Banda Y, Schaefer C, Risch N, Mertens J, Weisner C, Choquet H
• Validation of Electronic Health Records for the Assessment of Statin Dosing In Research.
  Journal of Clinical Lipidology 2017 Akinyemi Oni-Orisan, Thomas Hoffmann, Marisa Medina, Eric Jorgenson, Catherine Schaefer, Ronald Krauss, Carlos Iribarren, Neil Risch
• Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer.
  Nature communications 2017 Hoffmann TJ, Passarelli MN, Graff RE, Emami NC, Sakoda LC, Jorgenson E, Habel LA, Shan J, Ranatunga DK, Quesenberry CP, Chao CR, Ghai NR, Aaronson D, Presti J, Nordström T, Wang Z, Berndt SI, Chanock …
• Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation.
  Nature genetics 2016 Hoffmann TJ, Ehret GB, Nandakumar P, Ranatunga D, Schaefer C, Kwok PY, Iribarren C, Chakravarti A, Risch N
• A Large Genome-Wide Association Study of Age-Related Hearing Impairment Using Electronic Health Records.
  PLoS genetics 2016 Hoffmann TJ, Keats BJ, Yoshikawa N, Schaefer C, Risch N, Lustig LR
• Evaluation of a novel point-of-care test for active matrix metalloproteinase-8: agreement between qualitative and quantitative measurements and relation to periodontal inflammation.
  Journal of periodontal research 2016 Lorenz K, Keller T, Noack B, Freitag A, Netuschil L, Hoffmann T
• Oxytocin and vasopressin hormone genes in children's externalizing problems: A cognitive endophenotype approach.
  Hormones and behavior 2016 Wade M, Hoffmann TJ, Knafo-Noam A, O'Connor TG, Jenkins JM
• Mutational Landscape of Aggressive Prostate Tumors in African American Men.
  Cancer research 2016 Lindquist KJ, Paris PL, Hoffmann TJ, Cardin NJ, Kazma R, Mefford JA, Simko JP, Ngo V, Chen Y, Levin AM, Chitale D, Helfand BT, Catalona WJ, Rybicki BA, Witte JS
• Impact of genetic variants on the upstream efficacy of renin-angiotensin system inhibitors for the prevention of atrial fibrillation.
  American heart journal 2016 Roberts JD, Dewland TA, Glidden DV, Hoffmann TJ, Arking DE, Chen LY, Psaty BM, Olgin JE, Alonso A, Heckbert SR, Marcus GM
• Identification of Susceptibility Loci for Cutaneous Squamous Cell Carcinoma.
  The Journal of investigative dermatology 2016 Asgari MM, Wang W, Ioannidis NM, Itnyre J, Hoffmann T, Jorgenson E, Whittemore AS
• Common coding variants in the HLA-DQB1 region confer susceptibility to age-related macular degeneration.
  European journal of human genetics : EJHG 2016 Jorgenson E, Melles RB, Hoffmann TJ, Jia X, Sakoda LC, Kvale MN, Banda Y, Schaefer C, Risch N, Shen L
• Genome-Wide Estimates of Heritability for Social Demographic Outcomes.
  Biodemography and social biology 2016 Domingue BW, Wedow R, Conley D, McQueen M, Hoffmann TJ, Boardman JD
• Strategies for Imputing and Analyzing Rare Variants in Association Studies.
  Trends in genetics : TIG 2015 Hoffmann TJ, Witte JS
• Transcriptional plasticity promotes primary and acquired resistance to BET inhibition.
  Nature 2015 Rathert P, Roth M, Neumann T, Muerdter F, Roe JS, Muhar M, Deswal S, Cerny-Reiterer S, Peter B, Jude J, Hoffmann T, Boryn LM, Axelsson E, Schweifer N, Tontsch-Grunt U, Dow LE, Gianni D, Pearson M, …
• Homogeneous matrix deposition on dried agar for MALDI imaging mass spectrometry of microbial cultures.
  Journal of the American Society for Mass Spectrometry 2015 Hoffmann T, Dorrestein PC
• Differences in the Genetic Susceptibility to Age-Related Macular Degeneration Clinical Subtypes.
  Investigative ophthalmology & visual science 2015 Shen L, Hoffmann TJ, Melles RB, Sakoda LC, Kvale MN, Banda Y, Schaefer C, Risch N, Jorgenson E
• Automated Assay of Telomere Length Measurement and Informatics for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort.
  Genetics 2015 Lapham K, Kvale MN, Lin J, Connell S, Croen LA, Dispensa BP, Fang L, Hesselson S, Hoffmann TJ, Iribarren C, Jorgenson E, Kushi LH, Ludwig D, Matsuguchi T, McGuire WB, Miles S, Quesenberry CP, Rowell S…
• Characterizing Race/Ethnicity and Genetic Ancestry for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort.
  Genetics 2015 Banda Y, Kvale MN, Hoffmann TJ, Hesselson SE, Ranatunga D, Tang H, Sabatti C, Croen LA, Dispensa BP, Henderson M, Iribarren C, Jorgenson E, Kushi LH, Ludwig D, Olberg D, Quesenberry CP, Rowell S, …
• Genotyping Informatics and Quality Control for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort.
  Genetics 2015 Kvale MN, Hesselson S, Hoffmann TJ, Cao Y, Chan D, Connell S, Croen LA, Dispensa BP, Eshragh J, Finn A, Gollub J, Iribarren C, Jorgenson E, Kushi LH, Lao R, Lu Y, Ludwig D, Mathauda GK, McGuire WB, …
• A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences.
  Cancer discovery 2015 Hoffmann TJ, Van Den Eeden SK, Sakoda LC, Jorgenson E, Habel LA, Graff RE, Passarelli MN, Cario CL, Emami NC, Chao CR, Ghai NR, Shan J, Ranatunga DK, Quesenberry CP, Aaronson D, Presti J, Wang Z, …
• Detecting gene-environment interactions in human birth defects: Study designs and statistical methods.
  Birth defects research. Part A, Clinical and molecular teratology 2015 Tai CG, Graff RE, Liu J, Passarelli MN, Mefford JA, Shaw GM, Hoffmann TJ, Witte JS
• Gene-environment interaction between the oxytocin receptor (OXTR) gene and parenting behaviour on children's theory of mind.
  Social cognitive and affective neuroscience 2015 Wade M, Hoffmann TJ, Jenkins JM
• Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response.
  Clinical pharmacology and therapeutics 2015 Wen CC, Yee SW, Liang X, Hoffmann TJ, Kvale MN, Banda Y, Jorgenson E, Schaefer C, Risch N, Giacomini KM
• Replication and heritability of prostate cancer risk variants: impact of population-specific factors.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2015 Virlogeux V, Graff RE, Hoffmann TJ, Witte JS
• Imputation of the rare HOXB13 G84E mutation and cancer risk in a large population-based cohort.
  PLoS genetics 2015 Hoffmann TJ, Sakoda LC, Shen L, Jorgenson E, Habel LA, Liu J, Kvale MN, Asgari MM, Banda Y, Corley D, Kushi LH, Quesenberry CP, Schaefer C, Van Den Eeden SK, Risch N, Witte JS
• Familial recurrence of autism spectrum disorder: evaluating genetic and environmental contributions.
  The American journal of psychiatry 2014 Risch N, Hoffmann TJ, Anderson M, Croen LA, Grether JK, Windham GC
• Genome-wide discovery of drug-dependent human liver regulatory elements.
  PLoS genetics 2014 Smith RP, Eckalbar WL, Morrissey KM, Luizon MR, Hoffmann TJ, Sun X, Jones SL, Force Aldred S, Ramamoorthy A, Desta Z, Liu Y, Skaar TC, Trinklein ND, Giacomini KM, Ahituv N
• Evidence of reproductive stoppage in families with autism spectrum disorder: a large, population-based cohort study.
  JAMA psychiatry 2014 Hoffmann TJ, Windham GC, Anderson M, Croen LA, Grether JK, Risch N
• Association between the oxytocin receptor (OXTR) gene and children's social cognition at 18 months.
  Genes, brain, and behavior 2014 Wade M, Hoffmann TJ, Wigg K, Jenkins JM
• Genome-wide association and admixture analysis of glaucoma in the Women's Health Initiative.
  Human molecular genetics 2014 Hoffmann TJ, Tang H, Thornton TA, Caan B, Haan M, Millen AE, Thomas F, Risch N
• Association between the arginine vasopressin receptor 1A (AVPR1A) gene and preschoolers' executive functioning.
  Brain and cognition 2014 Wade M, Hoffmann TJ, Jenkins JM
• Comparison of periodontal conditions among three elderly populations in Japan and Germany.
  Journal of clinical periodontology 2014 Hirotomi T, Kocher T, Yoshihara A, Biffar R, Micheelis W, Hoffmann T, Miyazaki H, Holtfreter B
• Copy number variation in bronchopulmonary dysplasia.
  American journal of medical genetics. Part A 2014 Hoffmann TJ, Shaw GM, Stevenson DK, Wang H, Quaintance CC, Oehlert J, Jelliffe-Pawlowski LL, Gould JB, Witte JS, O'Brodovich HM
• Maternal smoking, xenobiotic metabolizing enzyme gene variants, and gastroschisis risk.
  American journal of medical genetics. Part A 2014 Jenkins MM, Reefhuis J, Gallagher ML, Mulle JG, Hoffmann TJ, Koontz DA, Sturchio C, Rasmussen SA, Witte JS, Richter P, Honein MA, National Birth Defects Prevention Study
• Clinical outcomes after treatment of periodontal intrabony defects with nanocrystalline hydroxyapatite (Ostim) or enamel matrix derivatives (Emdogain): a randomized controlled clinical trial.
  BioMed research international 2014 Al Machot E, Hoffmann T, Lorenz K, Khalili I, Noack B
• Prediction of periodontal disease: modelling and validation in different general German populations.
  Journal of clinical periodontology 2014 Zhan Y, Holtfreter B, Meisel P, Hoffmann T, Micheelis W, Dietrich T, Kocher T
• Functional characterization of SIM1-associated enhancers.
  Human molecular genetics 2013 Kim MJ, Oksenberg N, Hoffmann TJ, Vaisse C, Ahituv N
• B4-4: Genome-Wide Association Study of Macular Degeneration: Early Results from the Kaiser Permanente Research Program on Genes, Environment, and Health (RPGEH).
  Clinical Medicine & Research 2013 Eric Jorgenson, Stan Sciortino, Ling Shen, Dilrini Ranatunga, Thomas Hoffmann, Mark Kvale, Yambazi Banda, Pui-Yan Kwok, Lawrence Walter, Neil Risch, Cathy Schaefer
• PS3-15: Genome-Wide Association Study of Anxiety Disorders: Early Results from Kaiser Permanente’s Research Program on Genes, Environment, and Health (RPGEH).
  Clinical Medicine & Research 2013 Ling Shen, Thomas Hoffmann, Mark Kvale, Lori Sakoda, Yambazi Banda, Pui-Yan Kwok, Neil Risch, Eric Jorgenson, Cathy Schaefer
• African American race but not genome-wide ancestry is negatively associated with atrial fibrillation among postmenopausal women in the Women's Health Initiative.
  American heart journal 2013 Perez MV, Hoffmann TJ, Tang H, Thornton T, Stefanick ML, Larson JC, Kooperberg C, Reiner AP, Caan B, Iribarren C, Risch N
• A genome-wide association study (GWAS) for bronchopulmonary dysplasia.
  Pediatrics 2013 Wang H, St Julien KR, Stevenson DK, Hoffmann TJ, Witte JS, Lazzeroni LC, Krasnow MA, Quaintance CC, Oehlert JW, Jelliffe-Pawlowski LL, Gould JB, Shaw GM, O'Brodovich HM
• Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations.
  American journal of human genetics 2013 Coram MA, Duan Q, Hoffmann TJ, Thornton T, Knowles JW, Johnson NA, Ochs-Balcom HM, Donlon TA, Martin LW, Eaton CB, Robinson JG, Risch NJ, Zhu X, Kooperberg C, Li Y, Reiner AP, Tang H
• Adiponectin pathway polymorphisms and risk of breast cancer in African Americans and Hispanics in the Women's Health Initiative.
  Breast cancer research and treatment 2013 Kaklamani VG, Hoffmann TJ, Thornton TA, Hayes G, Chlebowski R, Van Horn L, Mantzoros C
• The impact of improved microarray coverage and larger sample sizes on future genome-wide association studies.
  Genetic epidemiology 2013 Lindquist KJ, Jorgenson E, Hoffmann TJ, Witte JS
• Association of DXA-derived bone mineral density and fat mass with African ancestry.
  The Journal of clinical endocrinology and metabolism 2013 Ochs-Balcom HM, Preus L, Wactawski-Wende J, Nie J, Johnson NA, Zakharia F, Tang H, Carlson C, Carty C, Chen Z, Hoffman T, Hutter CM, Jackson RD, Kaplan RC, Li L, Liu S, Neuhouser ML, Peters U, Robbins…
• Estimating kinship in admixed populations.
  American journal of human genetics 2012 Thornton T, Tang H, Hoffmann TJ, Ochs-Balcom HM, Caan BJ, Risch N
• A genetic signature of spina bifida risk from pathway-informed comprehensive gene-variant analysis.
  PloS one 2011 Marini NJ, Hoffmann TJ, Lammer EJ, Hardin J, Lazaruk K, Stein JB, Gilbert DA, Wright C, Lipzen A, Pennacchio LA, Carmichael SL, Witte JS, Shaw GM, Rine J
• Use of principal components to aggregate rare variants in case-control and family-based association studies in the presence of multiple covariates.
  BMC proceedings 2011 Kazma R, Hoffmann TJ, Witte JS
• Design and coverage of high throughput genotyping arrays optimized for individuals of East Asian, African American, and Latino race/ethnicity using imputation and a novel hybrid SNP selection algorithm.
  Genomics 2011 Hoffmann TJ, Zhan Y, Kvale MN, Hesselson SE, Gollub J, Iribarren C, Lu Y, Mei G, Purdy MM, Quesenberry C, Rowell S, Shapero MH, Smethurst D, Somkin CP, Van den Eeden SK, Walter L, Webster T, Whitmer …
• A multi-centre randomized controlled clinical trial on the treatment of intra-bony defects with enamel matrix derivatives/synthetic bone graft or enamel matrix derivatives alone: results after 12 months.
  Journal of clinical periodontology 2011 Meyle J, Hoffmann T, Topoll H, Heinz B, Al-Machot E, Jervøe-Storm PM, Meiss C, Eickholz P, Jepsen S
• Next generation genome-wide association tool: design and coverage of a high-throughput European-optimized SNP array.
  Genomics 2011 Hoffmann TJ, Kvale MN, Hesselson SE, Zhan Y, Aquino C, Cao Y, Cawley S, Chung E, Connell S, Eshragh J, Ewing M, Gollub J, Henderson M, Hubbell E, Iribarren C, Kaufman J, Lao RZ, Lu Y, Ludwig D, …
• Parallel biocomputing.
  Source code for biology and medicine 2011 Kompass KS, Hoffmann TJ, Witte JS
• Combining disease models to test for gene-environment interaction in nuclear families.
  Biometrics 2011 Hoffmann TJ, Vansteelandt S, Lange C, Silverman EK, DeMeo DL, Laird NM
• J Stat Softw
  Parsing in command line arguments and parallel cluster/multicore batching in R with batch 2011 Hoffmann TJ
• Passing in Command Line Arguments and Parallel Cluster/Multicore Batching in R with batch.
  Journal of statistical software 2011 Hoffmann TJ
• Polygenic modeling of genome-wide association studies: an application to prostate and breast cancer.
  Omics : a journal of integrative biology 2011 Witte JS, Hoffmann TJ
• Comprehensive approach to analyzing rare genetic variants.
  PloS one 2010 Hoffmann TJ, Marini NJ, Witte JS
• Testing for non-random mating: evidence for ancestry-related assortative mating in the Framingham heart study.
  Genetic epidemiology 2010 Sebro R, Hoffman TJ, Lange C, Rogus JJ, Risch NJ
• Cluster analysis in severe emphysema subjects using phenotype and genotype data: an exploratory investigation.
  Respiratory research 2010 Cho MH, Washko GR, Hoffmann TJ, Criner GJ, Hoffman EA, Martinez FJ, Laird N, Reilly JJ, Silverman EK
• Parsing the effects of individual SNPs in candidate genes with family data.
  Human heredity 2009 Hoffmann TJ, Lange C, Vansteelandt S, Raby BA, DeMeo DL, Silverman EK, Weiss ST, Laird NM
• Gene-environment interaction tests for dichotomous traits in trios and sibships.
  Genetic epidemiology 2009 Hoffmann TJ, Lange C, Vansteelandt S, Laird NM
• More to learn about: periodontitis-related knowledge and its relationship with periodontal health behaviour.
  Journal of clinical periodontology 2009 Deinzer R, Micheelis W, Granrath N, Hoffmann T
• fgui: A Method for Automatically Creating Graphical User Interfaces for Command-Line R Packages.
  Journal of statistical software 2009 Hoffmann TJ, Laird NM
• P2BAT: a massive parallel implementation of PBAT for genome-wide association studies in R.
  Bioinformatics (Oxford, England) 2006 Hoffmann T, Lange C
• Autonomic dysfunction predicts mortality in patients with multiple organ dysfunction syndrome of different age groups.
  Critical care medicine 2005 Schmidt H, Müller-Werdan U, Hoffmann T, Francis DP, Piepoli MF, Rauchhaus M, Prondzinsky R, Loppnow H, Buerke M, Hoyer D, Werdan K
• A randomized clinical trial comparing enamel matrix derivative and membrane treatment of buccal Class II furcation involvement in mandibular molars. Part I: Study design and results for primary outcomes.
  Journal of periodontology 2004 Jepsen S, Heinz B, Jepsen K, Arjomand M, Hoffmann T, Richter S, Reich E, Sculean A, Gonzales JR, Bödeker RH, Meyle J
• Impaired chemoreflex sensitivity in adult patients with multiple organ dysfunction syndrome--the potential role of disease severity.
  Intensive care medicine 2004 Schmidt H, Müller-Werdan U, Nuding S, Hoffmann T, Francis DP, Hoyer D, Rauchhaus M, Werdan K