Thomas Bartholow, PhD
Postdoctoral Scholar
Pharmaceutical Chemistry
School of Pharmacy

Publications (14)

Top publication keywords:
Escherichia coliPeriplasmic ProteinsMolecular Docking Simulation3-Oxoacyl-(Acyl-Carrier-Protein) SynthaseAcetyltransferasesEscherichia coli ProteinsProtein Interaction Domains and MotifsEnoyl-(Acyl-Carrier-Protein) Reductase (NADH)Hydro-LyasesAmino Acyl-tRNA SynthetasesFatty AcidsLysineLysophospholipaseFatty Acid Synthase, Type IIAcyl Carrier Protein

• Photoproximity Labeling from Single Catalyst Sites Allows Calibration and Increased Resolution for Carbene Labeling of Protein Partners In Vitro and on Cells.
  ACS central science 2023 Bartholow TG, Burroughs PWW, Elledge SK, Byrnes JR, Kirkemo LL, Garda V, Leung KK, Wells JA
• Interface Engineering of Carrier-Protein-Dependent Metabolic Pathways.
  ACS chemical biology 2023 Sztain T, Corpuz JC, Bartholow TG, Sanlley Hernandez JO, Jiang Z, Mellor DA, Heberlig GW, La Clair JJ, McCammon JA, Burkart MD
• Site-specific proximity labeling at single residue resolution for identification of protein partners in vitro and on cells.
  bioRxiv : the preprint server for biology 2023 Bartholow TG, Burroughs P, Elledge SK, Byrnes JR, Kirkemo LL, Garda V, Leung KK, Wells JA
• Carrier protein mediated cargo sensing in quorum signal synthases.
  Chemical communications (Cambridge, England) 2023 Fischer PD, Chowdhury AS, Bartholow T, Basu S, Baggs E, Cox HS, Matošin S, Burkart MD, Warner L, Nagarajan R, Arthanari H
• Control of Unsaturation in De Novo Fatty Acid Biosynthesis by FabA.
  Biochemistry 2022 Bartholow TG, Sztain T, Young MA, Lee DJ, Davis TD, Abagyan R, Burkart MD

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• Protein-protein interaction based substrate control in the E. coli octanoic acid transferase, LipB.
  RSC chemical biology 2021 Bartholow TG, Sztain T, Young MA, Davis TD, Abagyan R, Burkart MD
• Decoding allosteric regulation by the acyl carrier protein.
  Proceedings of the National Academy of Sciences of the United States of America 2021 Sztain T, Bartholow TG, Lee DJ, Casalino L, Mitchell A, Young MA, Wang J, McCammon JA, Burkart MD
• Elucidation of transient protein-protein interactions within carrier protein-dependent biosynthesis.
  Communications biology 2021 Bartholow TG, Sztain T, Patel A, Lee DJ, Young MA, Abagyan R, Burkart MD
• Gating mechanism of elongating β-ketoacyl-ACP synthases.
  Nature communications 2020 Mindrebo JT, Patel A, Kim WE, Davis TD, Chen A, Bartholow TG, La Clair JJ, McCammon JA, Noel JP, Burkart MD
• Shifting the Hydrolysis Equilibrium of Substrate Loaded Acyl Carrier Proteins.
  Biochemistry 2019 Sztain T, Bartholow TG, McCammon JA, Burkart MD
• Matching Protein Interfaces for Improved Medium-Chain Fatty Acid Production.
  ACS synthetic biology 2018 Sarria S, Bartholow TG, Verga A, Burkart MD, Peralta-Yahya P
• Comparison of intrinsic dynamics of cytochrome p450 proteins using normal mode analysis.
  Protein science : a publication of the Protein Society 2015 Dorner ME, McMunn RD, Bartholow TG, Calhoon BE, Conlon MR, Dulli JM, Fehling SC, Fisher CR, Hodgson SW, Keenan SW, Kruger AN, Mabin JW, Mazula DL, Monte CA, Olthafer A, Sexton AE, Soderholm BR, Strom …
• Effect of stacking interactions on the thermodynamics and kinetics of lumiflavin: a study with improved density functionals and density functional tight-binding protocol.
  The journal of physical chemistry. A 2014 Bresnahan CG, Reinhardt CR, Bartholow TG, Rumpel JP, North M, Bhattacharyya S
• Strictly conserved lysine of prolyl-tRNA Synthetase editing domain facilitates binding and positioning of misacylated tRNA(Pro.).
  Biochemistry 2014 Bartholow TG, Sanford BL, Cao B, Schmit HL, Johnson JM, Meitzner J, Bhattacharyya S, Musier-Forsyth K, Hati S